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P17583 (CYNX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyanate transport protein CynX
Gene names
Name:cynX
Ordered Locus Names:b0341, JW0332
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is part of an active transport system that transports exogenous cyanate into E.coli cells.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Ref.5.

Sequence similarities

Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. [View classification]

Sequence caution

The sequence AAB18065.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcyanate catabolic process

Inferred from expression pattern Ref.1. Source: EcoCyc

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Cyanate transport protein CynX
PRO_0000205707

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane287 – 30721Helical; Potential
Transmembrane322 – 34221Helical; Potential
Transmembrane354 – 37421Helical; Potential

Experimental info

Sequence conflict271R → A in AAA23627. Ref.1
Sequence conflict336 – 38449APWFS…WVKEA → PRGFLACCVVSAAIT Ref.1

Sequences

Sequence LengthMass (Da)Tools
P17583 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 05A579C7988E90A7

FASTA38441,361
        10         20         30         40         50         60 
MLLVLVLIGL NMRPLLTSVG PLLPQLRQAS GMSFSVAALL TALPVVTMGG LALAGSWLHQ 

        70         80         90        100        110        120 
HVSERRSVAI SLLLIAVGAL MRELYPQSAL LLSSALLGGV GIGIIQAVMP SVIKRRFQQR 

       130        140        150        160        170        180 
TPLVMGLWSA ALMGGGGLGA AITPWLVQHS ETWYQTLAWW ALPAVVALFA WWWQSAREVA 

       190        200        210        220        230        240 
SSHKTTTTPV RVVFTPRAWT LGVYFGLING GYASLIAWLP AFYIEIGASA QYSGSLLALM 

       250        260        270        280        290        300 
TLGQAAGALL MPAMARHQDR RKLLMLALVL QLVGFCGFIW LPMQLPVLWA MVCGLGLGGA 

       310        320        330        340        350        360 
FPLCLLLALD HSVQPAIAGK LVAFMQGIGF IIAGLAPWFS GVLRSISGNY LMDWAFHALC 

       370        380 
VVGLMIITLR FAPVRFPQLW VKEA

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the cyn operon in Escherichia coli K12."
Sung Y.-C., Fuchs J.A.
J. Biol. Chem. 263:14769-14775(1988) [PubMed: 3049588] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M23219 Genomic DNA. Translation: AAA23627.1.
U73857 Genomic DNA. Translation: AAB18065.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73444.1.
AP009048 Genomic DNA. Translation: BAE76123.1.
PIRBVECCX. E64761.
RefSeqNP_414875.1. NC_000913.2.

3D structure databases

ProteinModelPortalP17583.
SMRP17583. Positions 355-381.
ModBaseSearch...

Protein family/group databases

TCDB2.A.1.17.1. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000002819; EBESCP00000002819; EBESCG00000002298.
EBESCT00000015368; EBESCP00000014659; EBESCG00000014428.
GeneID946770.
GenomeReviewsGene locus JW0332 in contig AP009048_GR.
Gene locus b0341 in contig U00096_GR.
KEGGecj:JW0332.
eco:b0341.
PATRIC32115815. VBIEscCol129921_0349.

Organism-specific databases

EchoBASEEB0174.
EcoGeneEG10177. cynX.

Phylogenomic databases

eggNOGCOG2807.
GeneTreeEBGT00050000008822.
HOGENOMHBG696945.
OMASMVAWLP.
PhylomeDBP17583.
ProtClustDBPRK09705.

Enzyme and pathway databases

BioCycEcoCyc:CYNX-MONOMER.

Gene expression databases

GenevestigatorP17583.

Family and domain databases

InterProIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
KOK03449.
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00896. CynX. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYNX_ECOLI
AccessionPrimary (citable) accession number: P17583
Secondary accession number(s): P71308, P75695, Q2MC83
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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