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Protein

Polyporopepsin

Gene
N/A
Organism
Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Milk clotting activity, broad specificity, but fails to cleave 15-Leu-|-Tyr-16 or 16-Tyr-|-Leu-17 of insulin B chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321
Active sitei212 – 2121

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyporopepsin (EC:3.4.23.29)
Alternative name(s):
Aspartic proteinase
OrganismiIrpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae)
Taxonomic identifieri5319 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPolyporales incertae sedisIrpex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340PolyporopepsinPRO_0000199512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Beta strandi14 – 207Combined sources
Turni21 – 244Combined sources
Beta strandi25 – 328Combined sources
Beta strandi42 – 443Combined sources
Beta strandi53 – 6210Combined sources
Beta strandi67 – 7913Combined sources
Beta strandi82 – 9716Combined sources
Beta strandi102 – 1065Combined sources
Helixi110 – 1134Combined sources
Beta strandi116 – 1194Combined sources
Helixi128 – 1347Combined sources
Beta strandi137 – 14610Combined sources
Beta strandi151 – 16414Combined sources
Helixi167 – 1693Combined sources
Beta strandi175 – 1784Combined sources
Helixi185 – 1873Combined sources
Beta strandi188 – 19710Combined sources
Turni198 – 2003Combined sources
Beta strandi201 – 21111Combined sources
Beta strandi217 – 2204Combined sources
Helixi222 – 23211Combined sources
Turni238 – 2403Combined sources
Beta strandi241 – 2455Combined sources
Helixi247 – 2515Combined sources
Beta strandi256 – 2605Combined sources
Beta strandi263 – 2675Combined sources
Helixi270 – 2723Combined sources
Helixi276 – 2827Combined sources
Beta strandi289 – 2913Combined sources
Beta strandi293 – 2953Combined sources
Beta strandi306 – 3083Combined sources
Helixi310 – 3134Combined sources
Beta strandi315 – 3217Combined sources
Turni322 – 3254Combined sources
Beta strandi326 – 3316Combined sources
Turni333 – 3364Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WKRX-ray1.30A1-340[»]
ProteinModelPortaliP17576.
SMRiP17576. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 330317Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAGSVPATNQ LVDYVVNVGV GSPATTYSLL VDTGSSNTWL GADKSYVKTS
60 70 80 90 100
TSSATSDKVS VTYGSGSFSG TEYTDTVTLG SLTIPKQSIG VASRDSGFDG
110 120 130 140 150
VDGILGVGPV DLTVGTLSPH TSTSIPTVTD NLFSQGTIPT NLLAVSFEPT
160 170 180 190 200
TSESSTNGEL TFGATDSSKY TGSITYTPIT STSPASAYWG INQTIRYGSS
210 220 230 240 250
TSILSSTAGI VDTGTTLTLI ASDAFAKYKK ATGAVADNNT GLLRLTTAQY
260 270 280 290 300
ANLQSLFFTI GGQTFELTAN AQIWPRNLNT AIGGSASSVY LIVGDLGSDS
310 320 330 340
GEGLDFINGL TFLERFYSVY DTTNKRLGLA TTSFTTATSN
Length:340
Mass (Da):35,051
Last modified:August 1, 1990 - v1
Checksum:i9BAF837264D42FEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00589 mRNA. Translation: BAA00467.1.
PIRiJU0057. PEIKL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00589 mRNA. Translation: BAA00467.1.
PIRiJU0057. PEIKL.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WKRX-ray1.30A1-340[»]
ProteinModelPortaliP17576.
SMRiP17576. Positions 1-340.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17576.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of cDNA for Irpex lacteus aspartic proteinase."
    Kobayashi H., Sekibata S., Shibuya H., Yoshida S., Kusakabe I., Murakami K.
    Agric. Biol. Chem. 53:1927-1933(1989)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-24.

Entry informationi

Entry nameiCARP_IRPLA
AccessioniPrimary (citable) accession number: P17576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 13, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.