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Protein

Polyporopepsin

Gene
N/A
Organism
Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Milk clotting activity, broad specificity, but fails to cleave 15-Leu-|-Tyr-16 or 16-Tyr-|-Leu-17 of insulin B chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei321
Active sitei2121

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyporopepsin (EC:3.4.23.29)
Alternative name(s):
Aspartic proteinase
OrganismiIrpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae)
Taxonomic identifieri5319 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPolyporales incertae sedisIrpex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995121 – 340PolyporopepsinAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi238N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi14 – 20Combined sources7
Turni21 – 24Combined sources4
Beta strandi25 – 32Combined sources8
Beta strandi42 – 44Combined sources3
Beta strandi53 – 62Combined sources10
Beta strandi67 – 79Combined sources13
Beta strandi82 – 97Combined sources16
Beta strandi102 – 106Combined sources5
Helixi110 – 113Combined sources4
Beta strandi116 – 119Combined sources4
Helixi128 – 134Combined sources7
Beta strandi137 – 146Combined sources10
Beta strandi151 – 164Combined sources14
Helixi167 – 169Combined sources3
Beta strandi175 – 178Combined sources4
Helixi185 – 187Combined sources3
Beta strandi188 – 197Combined sources10
Turni198 – 200Combined sources3
Beta strandi201 – 211Combined sources11
Beta strandi217 – 220Combined sources4
Helixi222 – 232Combined sources11
Turni238 – 240Combined sources3
Beta strandi241 – 245Combined sources5
Helixi247 – 251Combined sources5
Beta strandi256 – 260Combined sources5
Beta strandi263 – 267Combined sources5
Helixi270 – 272Combined sources3
Helixi276 – 282Combined sources7
Beta strandi289 – 291Combined sources3
Beta strandi293 – 295Combined sources3
Beta strandi306 – 308Combined sources3
Helixi310 – 313Combined sources4
Beta strandi315 – 321Combined sources7
Turni322 – 325Combined sources4
Beta strandi326 – 331Combined sources6
Turni333 – 336Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKRX-ray1.30A1-340[»]
ProteinModelPortaliP17576.
SMRiP17576.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 330Peptidase A1PROSITE-ProRule annotationAdd BLAST317

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAGSVPATNQ LVDYVVNVGV GSPATTYSLL VDTGSSNTWL GADKSYVKTS
60 70 80 90 100
TSSATSDKVS VTYGSGSFSG TEYTDTVTLG SLTIPKQSIG VASRDSGFDG
110 120 130 140 150
VDGILGVGPV DLTVGTLSPH TSTSIPTVTD NLFSQGTIPT NLLAVSFEPT
160 170 180 190 200
TSESSTNGEL TFGATDSSKY TGSITYTPIT STSPASAYWG INQTIRYGSS
210 220 230 240 250
TSILSSTAGI VDTGTTLTLI ASDAFAKYKK ATGAVADNNT GLLRLTTAQY
260 270 280 290 300
ANLQSLFFTI GGQTFELTAN AQIWPRNLNT AIGGSASSVY LIVGDLGSDS
310 320 330 340
GEGLDFINGL TFLERFYSVY DTTNKRLGLA TTSFTTATSN
Length:340
Mass (Da):35,051
Last modified:August 1, 1990 - v1
Checksum:i9BAF837264D42FEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00589 mRNA. Translation: BAA00467.1.
PIRiJU0057. PEIKL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00589 mRNA. Translation: BAA00467.1.
PIRiJU0057. PEIKL.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKRX-ray1.30A1-340[»]
ProteinModelPortaliP17576.
SMRiP17576.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17576.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARP_IRPLA
AccessioniPrimary (citable) accession number: P17576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.