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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

NDUFB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Cell adhesion protein SQM1
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:NDUFB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7702. NDUFB7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial intermembrane space Source: UniProtKB
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31513.

Chemistry

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFB7.
DMDMi12644140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 137136NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7PRO_0000118811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Disulfide bondi59 ↔ 90Sequence analysis
Disulfide bondi69 ↔ 80Sequence analysis
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP17568.
MaxQBiP17568.
PaxDbiP17568.
PeptideAtlasiP17568.
PRIDEiP17568.

PTM databases

iPTMnetiP17568.
PhosphoSiteiP17568.

Expressioni

Gene expression databases

BgeeiP17568.
CleanExiHS_NDUFB7.
ExpressionAtlasiP17568. baseline and differential.
GenevisibleiP17568. HS.

Organism-specific databases

HPAiHPA002817.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110793. 37 interactions.
IntActiP17568. 14 interactions.
STRINGi9606.ENSP00000215565.

Structurei

3D structure databases

ProteinModelPortaliP17568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 6911C-X9-C motif 1Add
BLAST
Motifi80 – 9011C-X9-C motif 2Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.1 Publication

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiP17568.
KOiK03963.
OMAiIAYQACR.
OrthoDBiEOG7ZSHW5.
PhylomeDBiP17568.
TreeFamiTF315152.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAHLVRRYL GDASVEPDPL QMPTFPPDYG FPERKEREMV ATQQEMMDAQ
60 70 80 90 100
LRLQLRDYCA HHLIRLLKCK RDSFPNFLAC KQERHDWDYC EHRDYVMRMK
110 120 130
EFERERRLLQ RKKRREKKAA ELAKGQGPGE VDPKVAL
Length:137
Mass (Da):16,402
Last modified:January 23, 2007 - v4
Checksum:i2743716544288776
GO

Sequence cautioni

The sequence AAA35675.1 differs from that shown. Reason: Frameshift at several positions. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061R → G.
Corresponds to variant rs3752220 [ dbSNP | Ensembl ].
VAR_050591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33374 mRNA. Translation: AAA35675.1. Frameshift.
AF217091 mRNA. Translation: AAF91223.1.
AF112200 mRNA. Translation: AAF17188.1.
CR450354 mRNA. Translation: CAG29350.1.
CH471106 Genomic DNA. Translation: EAW84436.1.
BC002595 mRNA. Translation: AAH02595.1.
CCDSiCCDS12314.1.
PIRiA34653.
RefSeqiNP_004137.2. NM_004146.5.
UniGeneiHs.532853.

Genome annotation databases

EnsembliENST00000215565; ENSP00000215565; ENSG00000099795.
GeneIDi4713.
KEGGihsa:4713.
UCSCiuc002mzg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33374 mRNA. Translation: AAA35675.1. Frameshift.
AF217091 mRNA. Translation: AAF91223.1.
AF112200 mRNA. Translation: AAF17188.1.
CR450354 mRNA. Translation: CAG29350.1.
CH471106 Genomic DNA. Translation: EAW84436.1.
BC002595 mRNA. Translation: AAH02595.1.
CCDSiCCDS12314.1.
PIRiA34653.
RefSeqiNP_004137.2. NM_004146.5.
UniGeneiHs.532853.

3D structure databases

ProteinModelPortaliP17568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110793. 37 interactions.
IntActiP17568. 14 interactions.
STRINGi9606.ENSP00000215565.

Chemistry

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiP17568.
PhosphoSiteiP17568.

Polymorphism and mutation databases

BioMutaiNDUFB7.
DMDMi12644140.

Proteomic databases

EPDiP17568.
MaxQBiP17568.
PaxDbiP17568.
PeptideAtlasiP17568.
PRIDEiP17568.

Protocols and materials databases

DNASUi4713.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215565; ENSP00000215565; ENSG00000099795.
GeneIDi4713.
KEGGihsa:4713.
UCSCiuc002mzg.4. human.

Organism-specific databases

CTDi4713.
GeneCardsiNDUFB7.
HGNCiHGNC:7702. NDUFB7.
HPAiHPA002817.
MIMi603842. gene.
neXtProtiNX_P17568.
PharmGKBiPA31513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3468. Eukaryota.
ENOG411230N. LUCA.
GeneTreeiENSGT00390000018759.
HOGENOMiHOG000199343.
HOVERGENiHBG001948.
InParanoidiP17568.
KOiK03963.
OMAiIAYQACR.
OrthoDBiEOG7ZSHW5.
PhylomeDBiP17568.
TreeFamiTF315152.

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNDUFB7. human.
GeneWikiiNDUFB7.
GenomeRNAii4713.
PROiP17568.
SOURCEiSearch...

Gene expression databases

BgeeiP17568.
CleanExiHS_NDUFB7.
ExpressionAtlasiP17568. baseline and differential.
GenevisibleiP17568. HS.

Family and domain databases

InterProiIPR008698. NADH_UbQ_OxRdtase_B18_su.
[Graphical view]
PANTHERiPTHR20900. PTHR20900. 1 hit.
PfamiPF05676. NDUF_B7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells."
    Wong Y.-C., Tsao S.-W., Kakefuda M., Bernal S.D.
    Biochem. Biophys. Res. Commun. 166:984-992(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients."
    Triepels R., Smeitink J., Loeffen J., Smeets R., Trijbels F., van den Heuvel L.
    Hum. Genet. 106:385-391(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  7. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I."
    Szklarczyk R., Wanschers B.F., Nabuurs S.B., Nouws J., Nijtmans L.G., Huynen M.A.
    FEBS Lett. 585:737-743(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DOMAIN, MOTIF.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUB7_HUMAN
AccessioniPrimary (citable) accession number: P17568
Secondary accession number(s): Q6ICN9, Q9UI16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 157 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.