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Protein

Selenium-binding protein 1

Gene

Selenbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity

GO - Molecular functioni

  • selenium binding Source: MGI

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Selenium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenium-binding protein 1
Alternative name(s):
56 kDa selenium-binding protein
Short name:
SBP56
Short name:
SP56
Gene namesi
Name:Selenbp1
Synonyms:Lpsb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96825. Selenbp1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytosol By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

  • Note: May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 472471Selenium-binding protein 1PRO_0000174634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei111 – 1111PhosphoserineBy similarity
Modified residuei467 – 4671Phosphoserine1 Publication

Post-translational modificationi

The N-terminus is blocked.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP17563.
MaxQBiP17563.
PaxDbiP17563.
PeptideAtlasiP17563.
PRIDEiP17563.

2D gel databases

REPRODUCTION-2DPAGEIPI00623845.
P17563.
SWISS-2DPAGEP17563.

PTM databases

iPTMnetiP17563.
PhosphoSiteiP17563.

Expressioni

Tissue specificityi

Highly expressed in liver, kidney and, to a lesser extent, lung.

Gene expression databases

BgeeiP17563.
CleanExiMM_SELENBP1.
ExpressionAtlasiP17563. baseline and differential.
GenevisibleiP17563. MM.

Interactioni

Subunit structurei

Interacts with USP33.By similarity

Protein-protein interaction databases

IntActiP17563. 1 interaction.
MINTiMINT-1854683.
STRINGi10090.ENSMUSP00000088349.

Structurei

3D structure databases

ProteinModelPortaliP17563.
SMRiP17563. Positions 12-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenium-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
GeneTreeiENSGT00390000014244.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiP17563.
KOiK17285.
OMAiIDIPGKL.
OrthoDBiEOG7B05H4.
PhylomeDBiP17563.
TreeFamiTF315241.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKCTKCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
60 70 80 90 100
PKSPQYSQVI HRLPMPYLKD ELHHSGWNTC SSCFGDSTKS RNKLILPGLI
110 120 130 140 150
SSRIYVVDVG SEPRAPKLHK VIEASEIQAK CNVSSLHTSH CLASGEVMVS
160 170 180 190 200
TLGDLQGNGK GSFVLLDGET FEVKGTWEKP GDAAPMGYDF WYQPRHNVMV
210 220 230 240 250
STEWAAPNVF KDGFNPAHVE AGLYGSRIFV WDWQRHEIIQ TLQMTDGLIP
260 270 280 290 300
LEIRFLHDPS ATQGFVGCAL SSNIQRFYKN AEGTWSVEKV IQVPSKKVKG
310 320 330 340 350
WMLPEMPGLI TDILLSLDDR FLYFSNWLHG DIRQYDISNP QKPRLAGQIF
360 370 380 390 400
LGGSIVRGGS VQVLEDQELT CQPEPLVVKG KRIPGGPQMI QLSLDGKRLY
410 420 430 440 450
ATTSLYSAWD KQFYPDLIRE GSMMLQIDVD TVNGGLKLNP NFLVDFGKEP
460 470
LGPALAHELR YPGGDCSSDI WI
Length:472
Mass (Da):52,514
Last modified:May 29, 2007 - v2
Checksum:i099BCE085668DE36
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2723LSS → SAP in AAA40104 (PubMed:2225343).Curated
Sequence conflicti305 – 3062EM → GV in AAA40104 (PubMed:2225343).Curated
Sequence conflicti453 – 4531P → A in AAA40104 (PubMed:2225343).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32032 mRNA. Translation: AAA40104.1.
BC011202 mRNA. Translation: AAH11202.1.
CCDSiCCDS38540.1.
PIRiS27878.
RefSeqiNP_033176.2. NM_009150.3.
UniGeneiMm.196558.

Genome annotation databases

EnsembliENSMUST00000090839; ENSMUSP00000088349; ENSMUSG00000068874.
GeneIDi20341.
KEGGimmu:20341.
UCSCiuc008qhf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32032 mRNA. Translation: AAA40104.1.
BC011202 mRNA. Translation: AAH11202.1.
CCDSiCCDS38540.1.
PIRiS27878.
RefSeqiNP_033176.2. NM_009150.3.
UniGeneiMm.196558.

3D structure databases

ProteinModelPortaliP17563.
SMRiP17563. Positions 12-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17563. 1 interaction.
MINTiMINT-1854683.
STRINGi10090.ENSMUSP00000088349.

PTM databases

iPTMnetiP17563.
PhosphoSiteiP17563.

2D gel databases

REPRODUCTION-2DPAGEIPI00623845.
P17563.
SWISS-2DPAGEP17563.

Proteomic databases

EPDiP17563.
MaxQBiP17563.
PaxDbiP17563.
PeptideAtlasiP17563.
PRIDEiP17563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090839; ENSMUSP00000088349; ENSMUSG00000068874.
GeneIDi20341.
KEGGimmu:20341.
UCSCiuc008qhf.1. mouse.

Organism-specific databases

CTDi8991.
MGIiMGI:96825. Selenbp1.

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
GeneTreeiENSGT00390000014244.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiP17563.
KOiK17285.
OMAiIDIPGKL.
OrthoDBiEOG7B05H4.
PhylomeDBiP17563.
TreeFamiTF315241.

Miscellaneous databases

PROiP17563.
SOURCEiSearch...

Gene expression databases

BgeeiP17563.
CleanExiMM_SELENBP1.
ExpressionAtlasiP17563. baseline and differential.
GenevisibleiP17563. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention."
    Bansel M.P., Mukhopadhyay T., Scott J., Cook R.G., Mukhopadhyay R., Medina D.
    Carcinogenesis 11:2071-2073(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
    Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
    Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-467.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSBP1_MOUSE
AccessioniPrimary (citable) accession number: P17563
Secondary accession number(s): Q91X87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.