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Protein

Methanethiol oxidase

Gene

Selenbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity1 Publication

Catalytic activityi

Methanethiol + O2 + H2O = formaldehyde + H2S + H2O2.1 Publication

Kineticsi

  1. KM=5 nM for methanethiol1 Publication

    Pathwayi: Organosulfur degradation

    This protein is involved in Organosulfur degradation.1 Publication
    View all proteins of this organism that are known to be involved in Organosulfur degradation.

    GO - Molecular functioni

    • methanethiol oxidase activity Source: UniProtKB-EC
    • selenium binding Source: MGI

    GO - Biological processi

    • brown fat cell differentiation Source: MGI
    • protein transport Source: UniProtKB-KW

    Keywordsi

    Molecular functionOxidoreductase
    Biological processProtein transport, Transport
    LigandSelenium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methanethiol oxidase1 Publication (EC:1.8.3.41 Publication)
    Short name:
    MTO1 Publication
    Alternative name(s):
    56 kDa selenium-binding protein
    Short name:
    SBP56
    Short name:
    SP56
    Selenium-binding protein 1
    Gene namesi
    Name:Selenbp1
    Synonyms:Lpsb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 3

    Organism-specific databases

    MGIiMGI:96825 Selenbp1

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    SELENBP1 knockout results in accumulation of dimethylsulfoxide in the plasma. Methanethiol oxidase activity measured in tissues from knockout mice is significantly lower that in normal tissues.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedBy similarity
    ChainiPRO_00001746342 – 472Methanethiol oxidaseAdd BLAST471

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei2N-acetylalanineBy similarity1
    Modified residuei111PhosphoserineBy similarity1
    Modified residuei467Phosphoserine1 Publication1

    Post-translational modificationi

    The N-terminus is blocked.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiP17563
    MaxQBiP17563
    PaxDbiP17563
    PeptideAtlasiP17563
    PRIDEiP17563

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00623845
    P17563
    SWISS-2DPAGEiP17563

    PTM databases

    iPTMnetiP17563
    PhosphoSitePlusiP17563
    SwissPalmiP17563

    Expressioni

    Tissue specificityi

    Highly expressed in liver, kidney and, to a lesser extent, lung.

    Gene expression databases

    BgeeiENSMUSG00000068874
    CleanExiMM_SELENBP1
    ExpressionAtlasiP17563 baseline and differential
    GenevisibleiP17563 MM

    Interactioni

    Subunit structurei

    Interacts with USP33.By similarity

    Protein-protein interaction databases

    IntActiP17563, 1 interactor
    MINTiP17563
    STRINGi10090.ENSMUSP00000088349

    Structurei

    3D structure databases

    ProteinModelPortaliP17563
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the selenium-binding protein family.Curated

    Phylogenomic databases

    eggNOGiKOG0918 Eukaryota
    ENOG410XP4F LUCA
    GeneTreeiENSGT00390000014244
    HOGENOMiHOG000263885
    HOVERGENiHBG017779
    InParanoidiP17563
    KOiK17285
    OMAiHVWDWQR
    OrthoDBiEOG091G061L
    PhylomeDBiP17563
    TreeFamiTF315241

    Family and domain databases

    InterProiView protein in InterPro
    IPR008826 Se-bd
    PANTHERiPTHR23300 PTHR23300, 1 hit
    PfamiView protein in Pfam
    PF05694 SBP56, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17563-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MATKCTKCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
    60 70 80 90 100
    PKSPQYSQVI HRLPMPYLKD ELHHSGWNTC SSCFGDSTKS RNKLILPGLI
    110 120 130 140 150
    SSRIYVVDVG SEPRAPKLHK VIEASEIQAK CNVSSLHTSH CLASGEVMVS
    160 170 180 190 200
    TLGDLQGNGK GSFVLLDGET FEVKGTWEKP GDAAPMGYDF WYQPRHNVMV
    210 220 230 240 250
    STEWAAPNVF KDGFNPAHVE AGLYGSRIFV WDWQRHEIIQ TLQMTDGLIP
    260 270 280 290 300
    LEIRFLHDPS ATQGFVGCAL SSNIQRFYKN AEGTWSVEKV IQVPSKKVKG
    310 320 330 340 350
    WMLPEMPGLI TDILLSLDDR FLYFSNWLHG DIRQYDISNP QKPRLAGQIF
    360 370 380 390 400
    LGGSIVRGGS VQVLEDQELT CQPEPLVVKG KRIPGGPQMI QLSLDGKRLY
    410 420 430 440 450
    ATTSLYSAWD KQFYPDLIRE GSMMLQIDVD TVNGGLKLNP NFLVDFGKEP
    460 470
    LGPALAHELR YPGGDCSSDI WI
    Length:472
    Mass (Da):52,514
    Last modified:May 29, 2007 - v2
    Checksum:i099BCE085668DE36
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti270 – 272LSS → SAP in AAA40104 (PubMed:2225343).Curated3
    Sequence conflicti305 – 306EM → GV in AAA40104 (PubMed:2225343).Curated2
    Sequence conflicti453P → A in AAA40104 (PubMed:2225343).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M32032 mRNA Translation: AAA40104.1
    BC011202 mRNA Translation: AAH11202.1
    CCDSiCCDS38540.1
    PIRiS27878
    RefSeqiNP_033176.2, NM_009150.3
    UniGeneiMm.196558

    Genome annotation databases

    EnsembliENSMUST00000090839; ENSMUSP00000088349; ENSMUSG00000068874
    GeneIDi20341
    KEGGimmu:20341
    UCSCiuc008qhf.1 mouse

    Similar proteinsi

    Entry informationi

    Entry nameiSBP1_MOUSE
    AccessioniPrimary (citable) accession number: P17563
    Secondary accession number(s): Q91X87
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: May 29, 2007
    Last modified: May 23, 2018
    This is version 130 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

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