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Protein

Uteroglobin

Gene

Scgb1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

  • phospholipase A2 inhibitor activity Source: UniProtKB-KW
  • polychlorinated biphenyl binding Source: RGD

GO - Biological processi

  • negative regulation of interferon-gamma production Source: Ensembl
  • negative regulation of interleukin-13 production Source: Ensembl
  • negative regulation of interleukin-4 production Source: Ensembl
  • negative regulation of interleukin-5 production Source: Ensembl
  • negative regulation of T cell proliferation Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of inflammatory response Source: Ensembl
  • regulation of mRNA stability Source: Ensembl
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to glucocorticoid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic substance Source: RGD
  • response to ozone Source: RGD
  • response to silicon dioxide Source: RGD
  • response to xenobiotic stimulus Source: RGD
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene namesi
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3934. Scgb1a1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • nuclear envelope Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 9677UteroglobinPRO_0000036367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-90)
Disulfide bondi90 – 90Interchain (with C-24)

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP17559.

PTM databases

iPTMnetiP17559.
PhosphoSiteiP17559.

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Inductioni

By glucocorticoids.

Gene expression databases

BgeeiENSRNOG00000020196.
GenevisibleiP17559. RN.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027342.

Structurei

Secondary structure

1
96
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3410Combined sources
Helixi39 – 468Combined sources
Turni47 – 493Combined sources
Helixi53 – 6816Combined sources
Helixi71 – 8414Combined sources
Turni88 – 903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CCDX-ray3.00A20-96[»]
1UTRNMR-A/B1-96[»]
ProteinModelPortaliP17559.
SMRiP17559. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17559.

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP17559.
OMAiASAEICP.
OrthoDBiEOG091G15B2.
PhylomeDBiP17559.
TreeFamiTF338407.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAITITVL MLSICCSSAS SDICPGFLQV LEALLLGSES NYEAALKPFN
60 70 80 90
PASDLQNAGT QLKRLVDTLP QETRINIVKL TEKILTSPLC EQDLRV
Length:96
Mass (Da):10,449
Last modified:November 1, 1990 - v2
Checksum:i1A12988677B9EBEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05536 mRNA. Translation: AAA41817.1.
BC069174 mRNA. Translation: AAH69174.1.
X51318 Genomic DNA. Translation: CAA35701.1.
PIRiA36581.
RefSeqiNP_037183.1. NM_013051.1.
UniGeneiRn.2206.

Genome annotation databases

EnsembliENSRNOT00000027342; ENSRNOP00000027342; ENSRNOG00000020196.
GeneIDi25575.
KEGGirno:25575.
UCSCiRGD:3934. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05536 mRNA. Translation: AAA41817.1.
BC069174 mRNA. Translation: AAH69174.1.
X51318 Genomic DNA. Translation: CAA35701.1.
PIRiA36581.
RefSeqiNP_037183.1. NM_013051.1.
UniGeneiRn.2206.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CCDX-ray3.00A20-96[»]
1UTRNMR-A/B1-96[»]
ProteinModelPortaliP17559.
SMRiP17559. Positions 20-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027342.

PTM databases

iPTMnetiP17559.
PhosphoSiteiP17559.

Proteomic databases

PaxDbiP17559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027342; ENSRNOP00000027342; ENSRNOG00000020196.
GeneIDi25575.
KEGGirno:25575.
UCSCiRGD:3934. rat.

Organism-specific databases

CTDi7356.
RGDi3934. Scgb1a1.

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP17559.
OMAiASAEICP.
OrthoDBiEOG091G15B2.
PhylomeDBiP17559.
TreeFamiTF338407.

Miscellaneous databases

EvolutionaryTraceiP17559.
PROiP17559.

Gene expression databases

BgeeiENSRNOG00000020196.
GenevisibleiP17559. RN.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTER_RAT
AccessioniPrimary (citable) accession number: P17559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.