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P17550

- SODM_RALME

UniProt

P17550 - SODM_RALME

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Protein

Superoxide dismutase [Fe]

Gene

chrC

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261IronBy similarity
Metal bindingi75 – 751IronBy similarity
Metal bindingi157 – 1571IronBy similarity
Metal bindingi161 – 1611IronBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: CACAO

GO - Biological processi

  1. removal of superoxide radicals Source: GOC
  2. response to chromate Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Chromate resistance

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCMET266264:GJ5G-6699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:chrC
Ordered Locus Names:Rmet_6201
ORF Names:RMe0091
Encoded oniPlasmid pMOL280 Publication
OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002429: Plasmid pMOL28

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Superoxide dismutase [Fe]PRO_0000160011Add
BLAST

Expressioni

Inductioni

By chromate; induction increases when cells are grown in the presence of high sulfate concentrations (3 mM NaSO42-).1 Publication

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi266264.Rmet_6201.

Structurei

3D structure databases

ProteinModelPortaliP17550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
KOiK04564.
OMAiYHMDYGA.
OrthoDBiEOG6MPWTR.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.

Sequencei

Sequence statusi: Complete.

P17550-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM
60 70 80 90 100
ATAPVFTLNG LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF
110 120 130 140 150
GSVERWQAEF TAMGKALGGG SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG
160 170 180 190
TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ NIHWQRAATR FAAAVRD
Length:197
Mass (Da):21,565
Last modified:May 27, 2002 - v3
Checksum:iD0F101A425DA38BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90708 Genomic DNA. Translation: CAI30235.1.
CP000355 Genomic DNA. Translation: ABF13060.1.
AJ313327 Genomic DNA. Translation: CAC42412.1.
PIRiC35177.
RefSeqiWP_011239974.1. NC_007972.2.
YP_161713.1. NC_006525.1.
YP_582010.1. NC_007972.2.

Genome annotation databases

EnsemblBacteriaiABF13060; ABF13060; Rmet_6201.
GeneIDi3187387.
4036639.
KEGGirme:Rmet_6201.
PATRICi20284229. VBIRalMet4734_0232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90708 Genomic DNA. Translation: CAI30235.1 .
CP000355 Genomic DNA. Translation: ABF13060.1 .
AJ313327 Genomic DNA. Translation: CAC42412.1 .
PIRi C35177.
RefSeqi WP_011239974.1. NC_007972.2.
YP_161713.1. NC_006525.1.
YP_582010.1. NC_007972.2.

3D structure databases

ProteinModelPortali P17550.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266264.Rmet_6201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF13060 ; ABF13060 ; Rmet_6201 .
GeneIDi 3187387.
4036639.
KEGGi rme:Rmet_6201.
PATRICi 20284229. VBIRalMet4734_0232.

Phylogenomic databases

eggNOGi COG0605.
HOGENOMi HOG000013583.
KOi K04564.
OMAi YHMDYGA.
OrthoDBi EOG6MPWTR.

Enzyme and pathway databases

BioCyci CMET266264:GJ5G-6699-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New genes involved in chromate resistance in Ralstonia metallidurans strain CH34."
    Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H.
    Arch. Microbiol. 179:15-25(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUPEROXIDE DISMUTASE ACTIVITY, SUGGESTION OF METAL-BINDING, SUBUNIT, INDUCTION.
  2. "Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus."
    Nies A., Nies D.H., Silver S.
    J. Biol. Chem. 265:5648-5653(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
  3. "Sequence and features of the Ralstonia metallidurans CH34 heavy metal plasmids pMOL28 and pMOL30."
    van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J., Benotmane M., Vallaeys T., Lapidus A., Mergeay M.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH34 / ATCC 43123 / DSM 2839.

Entry informationi

Entry nameiSODM_RALME
AccessioniPrimary (citable) accession number: P17550
Secondary accession number(s): Q5NUZ9, Q93JN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 27, 2002
Last modified: November 26, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions.

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3