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P17550 (SODM_RALME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Fe]

EC=1.15.1.1
Gene names
Name:chrC
Ordered Locus Names:Rmet_6201
ORF Names:RMe0091
Encoded onPlasmid pMOL28
OrganismRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]
Taxonomic identifier266264 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 iron ion per subunit By similarity.

Subunit structure

Homotetramer Probable. Ref.1

Induction

By chromate; induction increases when cells are grown in the presence of high sulfate concentrations (3 mM NaSO42-). Ref.1

Miscellaneous

This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
   Biological processChromate resistance
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processresponse to chromate

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from direct assay Ref.1. Source: CACAO

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197Superoxide dismutase [Fe]
PRO_0000160011

Sites

Metal binding261Iron By similarity
Metal binding751Iron By similarity
Metal binding1571Iron By similarity
Metal binding1611Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
P17550 [UniParc].

Last modified May 27, 2002. Version 3.
Checksum: D0F101A425DA38BD

FASTA19721,565
        10         20         30         40         50         60 
MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM ATAPVFTLNG 

        70         80         90        100        110        120 
LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF GSVERWQAEF TAMGKALGGG 

       130        140        150        160        170        180 
SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ 

       190 
NIHWQRAATR FAAAVRD 

« Hide

References

« Hide 'large scale' references
[1]"New genes involved in chromate resistance in Ralstonia metallidurans strain CH34."
Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H.
Arch. Microbiol. 179:15-25(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUPEROXIDE DISMUTASE ACTIVITY, SUGGESTION OF METAL-BINDING, SUBUNIT, INDUCTION.
[2]"Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus."
Nies A., Nies D.H., Silver S.
J. Biol. Chem. 265:5648-5653(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
[3]"Sequence and features of the Ralstonia metallidurans CH34 heavy metal plasmids pMOL28 and pMOL30."
van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J., Benotmane M., Vallaeys T., Lapidus A., Mergeay M.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Complete sequence of plasmid pMOL28 of Ralstonia metallidurans CH34."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90708 Genomic DNA. Translation: CAI30235.1.
CP000355 Genomic DNA. Translation: ABF13060.1.
AJ313327 Genomic DNA. Translation: CAC42412.1.
PIRC35177.
RefSeqYP_161713.1. NC_006525.1.
YP_582010.1. NC_007972.2.

3D structure databases

ProteinModelPortalP17550.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266264.Rmet_6201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF13060; ABF13060; Rmet_6201.
GeneID3187387.
4036639.
KEGGrme:Rmet_6201.
PATRIC20284229. VBIRalMet4734_0232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0605.
HOGENOMHOG000013583.
KOK04564.
OMAYHMDYGA.
OrthoDBEOG6MPWTR.
ProtClustDBCLSK811348.

Enzyme and pathway databases

BioCycCMET266264:GJ5G-6699-MONOMER.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSODM_RALME
AccessionPrimary (citable) accession number: P17550
Secondary accession number(s): Q5NUZ9, Q93JN0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 27, 2002
Last modified: February 19, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families