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Protein

Superoxide dismutase [Fe]

Gene

chrC

Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Miscellaneous

This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26IronBy similarity1
Metal bindingi75IronBy similarity1
Metal bindingi157IronBy similarity1
Metal bindingi161IronBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: CACAO

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processChromate resistance
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:chrC
Ordered Locus Names:Rmet_6201
ORF Names:RMe0091
Encoded oniPlasmid pMOL280 Publication
OrganismiCupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Taxonomic identifieri266264 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002429 Componenti: Plasmid pMOL28

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600111 – 197Superoxide dismutase [Fe]Add BLAST197

Expressioni

Inductioni

By chromate; induction increases when cells are grown in the presence of high sulfate concentrations (3 mM NaSO42-).1 Publication

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP17550
SMRiP17550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000013583
KOiK04564
OMAiYEHAYFI
OrthoDBiPOG091H03Q7

Family and domain databases

Gene3Di2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019832 Mn/Fe_SOD_C
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit

Sequencei

Sequence statusi: Complete.

P17550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM
60 70 80 90 100
ATAPVFTLNG LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF
110 120 130 140 150
GSVERWQAEF TAMGKALGGG SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG
160 170 180 190
TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ NIHWQRAATR FAAAVRD
Length:197
Mass (Da):21,565
Last modified:May 27, 2002 - v3
Checksum:iD0F101A425DA38BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90708 Genomic DNA Translation: CAI30235.1
CP000355 Genomic DNA Translation: ABF13060.1
AJ313327 Genomic DNA Translation: CAC42412.1
PIRiC35177
RefSeqiWP_011239974.1, NC_007972.2
YP_161713.1, NC_006525.1

Genome annotation databases

EnsemblBacteriaiABF13060; ABF13060; Rmet_6201
GeneIDi24148904
3187387
KEGGirme:Rmet_6201

Similar proteinsi

Entry informationi

Entry nameiSODM_CUPMC
AccessioniPrimary (citable) accession number: P17550
Secondary accession number(s): Q5NUZ9, Q93JN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 27, 2002
Last modified: March 28, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health