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P17550

- SODM_RALME

UniProt

P17550 - SODM_RALME

Protein

Superoxide dismutase [Fe]

Gene

chrC

Organism
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (27 May 2002)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi26 – 261IronBy similarity
    Metal bindingi75 – 751IronBy similarity
    Metal bindingi157 – 1571IronBy similarity
    Metal bindingi161 – 1611IronBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: CACAO

    GO - Biological processi

    1. removal of superoxide radicals Source: GOC
    2. response to chromate Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Chromate resistance

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCMET266264:GJ5G-6699-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Fe] (EC:1.15.1.1)
    Gene namesi
    Name:chrC
    Ordered Locus Names:Rmet_6201
    ORF Names:RMe0091
    Encoded oniPlasmid pMOL280 Publication
    OrganismiRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
    Taxonomic identifieri266264 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002429: Plasmid pMOL28

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Superoxide dismutase [Fe]PRO_0000160011Add
    BLAST

    Expressioni

    Inductioni

    By chromate; induction increases when cells are grown in the presence of high sulfate concentrations (3 mM NaSO42-).1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Protein-protein interaction databases

    STRINGi266264.Rmet_6201.

    Structurei

    3D structure databases

    ProteinModelPortaliP17550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiYHMDYGA.
    OrthoDBiEOG6MPWTR.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P17550-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM    50
    ATAPVFTLNG LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF 100
    GSVERWQAEF TAMGKALGGG SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG 150
    TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ NIHWQRAATR FAAAVRD 197
    Length:197
    Mass (Da):21,565
    Last modified:May 27, 2002 - v3
    Checksum:iD0F101A425DA38BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90708 Genomic DNA. Translation: CAI30235.1.
    CP000355 Genomic DNA. Translation: ABF13060.1.
    AJ313327 Genomic DNA. Translation: CAC42412.1.
    PIRiC35177.
    RefSeqiWP_011239974.1. NC_007972.2.
    YP_161713.1. NC_006525.1.
    YP_582010.1. NC_007972.2.

    Genome annotation databases

    EnsemblBacteriaiABF13060; ABF13060; Rmet_6201.
    GeneIDi3187387.
    4036639.
    KEGGirme:Rmet_6201.
    PATRICi20284229. VBIRalMet4734_0232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90708 Genomic DNA. Translation: CAI30235.1 .
    CP000355 Genomic DNA. Translation: ABF13060.1 .
    AJ313327 Genomic DNA. Translation: CAC42412.1 .
    PIRi C35177.
    RefSeqi WP_011239974.1. NC_007972.2.
    YP_161713.1. NC_006525.1.
    YP_582010.1. NC_007972.2.

    3D structure databases

    ProteinModelPortali P17550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266264.Rmet_6201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF13060 ; ABF13060 ; Rmet_6201 .
    GeneIDi 3187387.
    4036639.
    KEGGi rme:Rmet_6201.
    PATRICi 20284229. VBIRalMet4734_0232.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi YHMDYGA.
    OrthoDBi EOG6MPWTR.

    Enzyme and pathway databases

    BioCyci CMET266264:GJ5G-6699-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "New genes involved in chromate resistance in Ralstonia metallidurans strain CH34."
      Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H.
      Arch. Microbiol. 179:15-25(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUPEROXIDE DISMUTASE ACTIVITY, SUGGESTION OF METAL-BINDING, SUBUNIT, INDUCTION.
    2. "Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus."
      Nies A., Nies D.H., Silver S.
      J. Biol. Chem. 265:5648-5653(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
    3. "Sequence and features of the Ralstonia metallidurans CH34 heavy metal plasmids pMOL28 and pMOL30."
      van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J., Benotmane M., Vallaeys T., Lapidus A., Mergeay M.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH34 / ATCC 43123 / DSM 2839.

    Entry informationi

    Entry nameiSODM_RALME
    AccessioniPrimary (citable) accession number: P17550
    Secondary accession number(s): Q5NUZ9, Q93JN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions.

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3