P17550 (SODM_RALME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Fe]
EC=1.15.1.1

Gene names

Name:	chrC
Ordered Locus Names:	Rmet_6201
ORF Names:	RMe0091

Encoded on

Plasmid pMOL28

Organism

Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [Complete proteome] [HAMAP]

Taxonomic identifier

266264 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › Cupriavidus metallidurans

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Subunit structure	Homotetramer Probable. Ref.1
Induction	By chromate; induction increases when cells are grown in the presence of high sulfate concentrations (3 mM NaSO42-). Ref.1
Miscellaneous	This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Biological process	Chromate resistance
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological_process	response to chromate Inferred from electronic annotation. Source: UniProtKB-KW superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Superoxide dismutase [Fe]		PRO_0000160011
Sites
	Metal binding	26	1	Iron By similarity
	Metal binding	75	1	Iron By similarity
	Metal binding	157	1	Iron By similarity
	Metal binding	161	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	P17550 [UniParc]. Last modified May 27, 2002. Version 3. Checksum: D0F101A425DA38BD	FASTA	197	21,565
	10 20 30 40 50 60 MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM ATAPVFTLNG 70 80 90 100 110 120 LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF GSVERWQAEF TAMGKALGGG 130 140 150 160 170 180 SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ 190 NIHWQRAATR FAAAVRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New genes involved in chromate resistance in Ralstonia metallidurans strain CH34." Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H. Arch. Microbiol. 179:15-25(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUPEROXIDE DISMUTASE ACTIVITY, SUGGESTION OF METAL-BINDING, SUBUNIT, INDUCTION.
[2]	"Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus." Nies A., Nies D.H., Silver S. J. Biol. Chem. 265:5648-5653(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
[3]	"Sequence and features of the Ralstonia metallidurans CH34 heavy metal plasmids pMOL28 and pMOL30." van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J., Benotmane M., Vallaeys T., Lapidus A., Mergeay M. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequence of plasmid pMOL28 of Ralstonia metallidurans CH34." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Mergeay M., Benotmane M.A., Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S., van der Lelie D., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH34 / ATCC 43123 / DSM 2839.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90708 Genomic DNA. Translation: CAI30235.1. CP000355 Genomic DNA. Translation: ABF13060.1. AJ313327 Genomic DNA. Translation: CAC42412.1.
PIR	C35177.
RefSeq	YP_161713.1. NC_006525.1. YP_582010.1. NC_007972.2.
3D structure databases
ProteinModelPortal	P17550.
ModBase	Search...
Protein-protein interaction databases
STRING	266264.Rmet_6201.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF13060; ABF13060; Rmet_6201.
GeneID	3187387. 4036639.
KEGG	rme:Rmet_6201.
PATRIC	20284229. VBIRalMet4734_0232.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0605.
HOGENOM	HOG000013583.
KO	K04564.
OMA	YHMDYGA.
ProtClustDB	CLSK811348.
Enzyme and pathway databases
BioCyc	CMET266264:GJ5G-6699-MONOMER.
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM_RALME

Accession

Primary (citable) accession number: P17550
Secondary accession number(s): Q5NUZ9, Q93JN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	May 27, 2002
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program