Reviewed, UniProtKB/Swiss-Prot P17544 (ATF7_HUMAN)

Names and origin

Protein names

Recommended name:
    Cyclic AMP-dependent transcription factor ATF-7
      Short name=cAMP-dependent transcription factor ATF-7
Alternative name(s):
    Activating transcription factor 7
    Transcription factor ATF-A

Gene names

Name:	ATF7
Synonyms:	ATFA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.
Subunit structure	Binds DNA as a dimer.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP domain. Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Ref.3 Inferred from direct assay. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Ref.3 Non-traceable author statement. Source: UniProtKB
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Ref.1 Non-traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: P17544-1)

Also known as: ATF-A1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P17544-2)

Also known as: ATF-A;

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: Missing.
     125-145: Missing.

Isoform 2 (identifier: P17544-3)

Also known as: ATF-A-delta;

The sequence of this isoform differs from the canonical sequence as follows:
     125-145: Missing.

Isoform 4 (identifier: P17544-4)

Also known as: ATF-A0;

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: Missing.
     146-321: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Cyclic AMP-dependent transcription factor ATF-7		PRO_0000076592
Regions
	Domain	371 – 399	29	Leucine-zipper
	Zinc finger	7 – 31	25	C2H2-type
	DNA binding	342 – 365	24	Basic motif
Amino acid modifications
	Modified residue	42	1	Phosphothreonine Ref.10
	Modified residue	51	1	Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.9
	Modified residue	53	1	Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.9
	Modified residue	55	1	Phosphothreonine Ref.9
	Modified residue	108	1	Phosphoserine Ref.10 Ref.8 Ref.7
	Modified residue	111	1	Phosphoserine Ref.6
	Modified residue	112	1	Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.7
	Modified residue	127	1	Phosphoserine Ref.6
	Modified residue	128	1	Phosphoserine Ref.6
	Modified residue	132	1	Phosphoserine Ref.6
	Modified residue	135	1	Phosphoserine Ref.6
	Modified residue	136	1	Phosphoserine Ref.6
	Modified residue	139	1	Phosphoserine Ref.6
	Modified residue	424	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	89 – 99	11	Missing in isoform 1 and isoform 4.		VSP_000594
	Alternative sequence	125 – 145	21	Missing in isoform 1 and isoform 2.		VSP_000595
	Alternative sequence	146 – 321	176	Missing in isoform 4.		VSP_034543

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 (ATF-A1) [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 511EAF79C6503300	FASTA	494	52,967
	10 20 30 40 50 60 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 70 80 90 100 110 120 CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA AAGPLDMSLP STPDIKIKEE 130 140 150 160 170 180 EPVEVDSSPP DSPASSPCSP PLKEKEVTPK PVLISTPTPT IVRPGSLPLH LGYDPLHPTL 190 200 210 220 230 240 PSPTSVITQA PPSNRQMGSP TGSLPLVMHL ANGQTMPVLP GPPVQMPSVI SLARPVSMVP 250 260 270 280 290 300 NIPGIPGPPV NSSGSISPSG HPIPSEAKMR LKATLTHQVS SINGGCGMVV GTASTMVTAR 310 320 330 340 350 360 PEQSQILIQH PDAPSPAQPQ VSPAQPTPST GGRRRRTVDE DPDERRQRFL ERNRAAASRC 370 380 390 400 410 420 RQKRKLWVSS LEKKAEELTS QNIQLSNEVT LLRNEVAQLK QLLLAHKDCP VTALQKKTQG 430 440 450 460 470 480 YLESPKESSE PTGSPAPVIQ HSSATAPSNG LSVRSAAEAV ATSVLTQMAS QRTELSMPIQ 490 SHVIMTPQSQ SAGR
	Isoform 1 (ATF-A). Checksum: 92AB6DF8D2A954CD	FASTA	462	49,650
	10 20 30 40 50 60 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 70 80 90 100 110 120 CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS TPDIKIKEEE PVEEVTPKPV 130 140 150 160 170 180 LISTPTPTIV RPGSLPLHLG YDPLHPTLPS PTSVITQAPP SNRQMGSPTG SLPLVMHLAN 190 200 210 220 230 240 GQTMPVLPGP PVQMPSVISL ARPVSMVPNI PGIPGPPVNS SGSISPSGHP IPSEAKMRLK 250 260 270 280 290 300 ATLTHQVSSI NGGCGMVVGT ASTMVTARPE QSQILIQHPD APSPAQPQVS PAQPTPSTGG 310 320 330 340 350 360 RRRRTVDEDP DERRQRFLER NRAAASRCRQ KRKLWVSSLE KKAEELTSQN IQLSNEVTLL 370 380 390 400 410 420 RNEVAQLKQL LLAHKDCPVT ALQKKTQGYL ESPKESSEPT GSPAPVIQHS SATAPSNGLS 430 440 450 460 VRSAAEAVAT SVLTQMASQR TELSMPIQSH VIMTPQSQSA GR
	Isoform 2 (ATF-A-delta). Checksum: 6CB9C4D7A0128AA9	FASTA	473	50,860
	10 20 30 40 50 60 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 70 80 90 100 110 120 CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA AAGPLDMSLP STPDIKIKEE 130 140 150 160 170 180 EPVEEVTPKP VLISTPTPTI VRPGSLPLHL GYDPLHPTLP SPTSVITQAP PSNRQMGSPT 190 200 210 220 230 240 GSLPLVMHLA NGQTMPVLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN SSGSISPSGH 250 260 270 280 290 300 PIPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP DAPSPAQPQV 310 320 330 340 350 360 SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR QKRKLWVSSL EKKAEELTSQ 370 380 390 400 410 420 NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV TALQKKTQGY LESPKESSEP TGSPAPVIQH 430 440 450 460 470 SSATAPSNGL SVRSAAEAVA TSVLTQMASQ RTELSMPIQS HVIMTPQSQS AGR
	Isoform 4 (ATF-A0). Checksum: 01665BFA649C6CA1	FASTA	307	33,681
	10 20 30 40 50 60 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 70 80 90 100 110 120 CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS TPDIKIKEEE PVEVDSSPPD 130 140 150 160 170 180 SPASSPCSPP LKEKSPAQPT PSTGGRRRRT VDEDPDERRQ RFLERNRAAA SRCRQKRKLW 190 200 210 220 230 240 VSSLEKKAEE LTSQNIQLSN EVTLLRNEVA QLKQLLLAHK DCPVTALQKK TQGYLESPKE 250 260 270 280 290 300 SSEPTGSPAP VIQHSSATAP SNGLSVRSAA EAVATSVLTQ MASQRTELSM PIQSHVIMTP QSQSAGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells." Gaire M., Chatton B., Kedinger C. Nucleic Acids Res. 18:3467-3473(1990) [PubMed: 1694576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"ATF-a1, a new member of the human ATF family." Chatton B., Gaire M., Goetz J., Hauss C., Kedinger C. Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers." Pescini R., Kaszubska W., Whelan J., DeLamarter J.F., Hooft van Huijsduijnen R. J. Biol. Chem. 269:1159-1165(1994) [PubMed: 8288576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; SER-111; THR-112; SER-127; SER-128; SER-132; SER-135; SER-136 AND SER-139, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND THR-112, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; SER-108 AND THR-112, MASS SPECTROMETRY.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; THR-55 AND SER-424, MASS SPECTROMETRY.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42; THR-51; THR-53; SER-108 AND THR-112, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52943 mRNA. Translation: CAA37118.1. X57197 mRNA. Translation: CAA40483.1. AK298853 mRNA. Translation: BAG60976.1. CH471054 Genomic DNA. Translation: EAW96723.1.
IPI	IPI00009975. IPI00015147. IPI00218344. IPI00909393.
PIR	S12741.
RefSeq	NP_001123531.1. NP_001123532.1. NP_006847.1.
UniGene	Hs.12286
3D structure databases
SMR	P17544. Positions 1-38, 345-405.
ModBase	Search...
Protein-protein interaction databases
STRING	P17544.
PTM databases
PhosphoSite	P17544.
Proteomic databases
PRIDE	P17544.
Genome annotation databases
Ensembl	ENST00000328463; ENSP00000329212; ENSG00000170653; Homo sapiens. [Genome view]
GeneID	11016.
KEGG	hsa:11016.
NMPDR	fig|9606.3.peg.7644.
UCSC	uc001sdy.1. human.
Organism-specific databases
CTD	11016.
GeneCards	GC12M052196.
H-InvDB	HIX0010676. HIX0026384.
HGNC	HGNC:792. ATF7.
HPA	HPA003384.
MIM	606371. gene.
PharmGKB	PA25092.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12169.
HOGENOM	HBG714930.
HOVERGEN	P17544.
InParanoid	P17544.
OMA	EFKKASD.
PhylomeDB	P17544.
Gene expression databases
ArrayExpress	P17544.
Bgee	P17544.
CleanEx	HS_ATF7.
Genevestigator	P17544.
GermOnline	ENSG00000170653. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR004827. TF_bZIP. IPR016378. TF_cAMP-dep. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PIRSF	PIRSF003153. ATF2_CRE-BP1. 1 hit.
SMART	SM00338. BRLZ. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	41853.
SOURCE	Search...

Entry information

Entry name

ATF7_HUMAN

Accession

Primary (citable) accession number: P17544
Secondary accession number(s): B4DQL4, Q13814, Q9UD83

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	January 24, 2001
Last modified:	January 19, 2010
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.