Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P17544 (ATF7_HUMAN)

Last modified January 19, 2010. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cyclic AMP-dependent transcription factor ATF-7
      Short name=cAMP-dependent transcription factor ATF-7
Alternative name(s):
    Activating transcription factor 7
    Transcription factor ATF-A
Gene names
Name: ATF7
Synonyms: ATFA
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.

Subunit structure

Binds DNA as a dimer.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP domain.

Contains 1 C2H2-type zinc finger.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: P17544-1)

Also known as: ATF-A1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P17544-2)

Also known as: ATF-A;

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: Missing.
     125-145: Missing.
Isoform 2 (identifier: P17544-3)

Also known as: ATF-A-delta;

The sequence of this isoform differs from the canonical sequence as follows:
     125-145: Missing.
Isoform 4 (identifier: P17544-4)

Also known as: ATF-A0;

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: Missing.
     146-321: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Cyclic AMP-dependent transcription factor ATF-7
PRO_0000076592

Regions

Domain371 – 39929Leucine-zipper
Zinc finger7 – 3125C2H2-type
DNA binding342 – 36524Basic motif

Amino acid modifications

Modified residue421Phosphothreonine Ref.10
Modified residue511Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.9
Modified residue531Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.9
Modified residue551Phosphothreonine Ref.9
Modified residue1081Phosphoserine Ref.10 Ref.8 Ref.7
Modified residue1111Phosphoserine Ref.6
Modified residue1121Phosphothreonine Ref.10 Ref.6 Ref.8 Ref.7
Modified residue1271Phosphoserine Ref.6
Modified residue1281Phosphoserine Ref.6
Modified residue1321Phosphoserine Ref.6
Modified residue1351Phosphoserine Ref.6
Modified residue1361Phosphoserine Ref.6
Modified residue1391Phosphoserine Ref.6
Modified residue4241Phosphoserine Ref.9

Natural variations

Alternative sequence89 – 9911Missing in isoform 1 and isoform 4.
VSP_000594
Alternative sequence125 – 14521Missing in isoform 1 and isoform 2.
VSP_000595
Alternative sequence146 – 321176Missing in isoform 4.
VSP_034543

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 (ATF-A1) [UniParc].

Last modified January 24, 2001. Version 2.
Checksum: 511EAF79C6503300

FASTA49452,967
        10         20         30         40         50         60 
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 

        70         80         90        100        110        120 
CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA AAGPLDMSLP STPDIKIKEE 

       130        140        150        160        170        180 
EPVEVDSSPP DSPASSPCSP PLKEKEVTPK PVLISTPTPT IVRPGSLPLH LGYDPLHPTL 

       190        200        210        220        230        240 
PSPTSVITQA PPSNRQMGSP TGSLPLVMHL ANGQTMPVLP GPPVQMPSVI SLARPVSMVP 

       250        260        270        280        290        300 
NIPGIPGPPV NSSGSISPSG HPIPSEAKMR LKATLTHQVS SINGGCGMVV GTASTMVTAR 

       310        320        330        340        350        360 
PEQSQILIQH PDAPSPAQPQ VSPAQPTPST GGRRRRTVDE DPDERRQRFL ERNRAAASRC 

       370        380        390        400        410        420 
RQKRKLWVSS LEKKAEELTS QNIQLSNEVT LLRNEVAQLK QLLLAHKDCP VTALQKKTQG 

       430        440        450        460        470        480 
YLESPKESSE PTGSPAPVIQ HSSATAPSNG LSVRSAAEAV ATSVLTQMAS QRTELSMPIQ 

       490 
SHVIMTPQSQ SAGR 

« Hide

Isoform 1 (ATF-A).

Checksum: 92AB6DF8D2A954CD
Show »

FASTA46249,650
Isoform 2 (ATF-A-delta).

Checksum: 6CB9C4D7A0128AA9
Show »

FASTA47350,860
Isoform 4 (ATF-A0).

Checksum: 01665BFA649C6CA1
Show »

FASTA30733,681

References

« Hide 'large scale' references
[1]"Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells."
Gaire M., Chatton B., Kedinger C.
Nucleic Acids Res. 18:3467-3473(1990) [PubMed: 1694576] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"ATF-a1, a new member of the human ATF family."
Chatton B., Gaire M., Goetz J., Hauss C., Kedinger C.
Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers."
Pescini R., Kaszubska W., Whelan J., DeLamarter J.F., Hooft van Huijsduijnen R.
J. Biol. Chem. 269:1159-1165(1994) [PubMed: 8288576] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; SER-111; THR-112; SER-127; SER-128; SER-132; SER-135; SER-136 AND SER-139, MASS SPECTROMETRY.
Tissue: Epithelium.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND THR-112, MASS SPECTROMETRY.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; SER-108 AND THR-112, MASS SPECTROMETRY.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; THR-53; THR-55 AND SER-424, MASS SPECTROMETRY.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42; THR-51; THR-53; SER-108 AND THR-112, MASS SPECTROMETRY.
Tissue: T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52943 mRNA. Translation: CAA37118.1.
X57197 mRNA. Translation: CAA40483.1.
AK298853 mRNA. Translation: BAG60976.1.
CH471054 Genomic DNA. Translation: EAW96723.1.
IPIIPI00009975.
IPI00015147.
IPI00218344.
IPI00909393.
PIRS12741.
RefSeqNP_001123531.1.
NP_001123532.1.
NP_006847.1.
UniGeneHs.12286

3D structure databases

SMRP17544. Positions 1-38, 345-405.
ModBaseSearch...

Protein-protein interaction databases

STRINGP17544.

PTM databases

PhosphoSiteP17544.

Proteomic databases

PRIDEP17544.

Genome annotation databases

EnsemblENST00000328463; ENSP00000329212; ENSG00000170653; Homo sapiens. [Genome view]
GeneID11016.
KEGGhsa:11016.
NMPDRfig|9606.3.peg.7644.
UCSCuc001sdy.1. human.

Organism-specific databases

CTD11016.
GeneCardsGC12M052196.
H-InvDBHIX0010676.
HIX0026384.
HGNCHGNC:792. ATF7.
HPAHPA003384.
MIM606371. gene.
PharmGKBPA25092.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12169.
HOGENOMHBG714930.
HOVERGENP17544.
InParanoidP17544.
OMAEFKKASD.
PhylomeDBP17544.

Gene expression databases

ArrayExpressP17544.
BgeeP17544.
CleanExHS_ATF7.
GenevestigatorP17544.
GermOnlineENSG00000170653. Homo sapiens.

Family and domain databases

InterProIPR011616. bZIP_1.
IPR004827. TF_bZIP.
IPR016378. TF_cAMP-dep.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio41853.
SOURCESearch...

Entry information

Entry nameATF7_HUMAN
AccessionPrimary (citable) accession number: P17544
Secondary accession number(s): B4DQL4, Q13814, Q9UD83
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 24, 2001
Last modified: January 19, 2010
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents