Reviewed,
UniProtKB/Swiss-Prot P17542 (TAL1_HUMAN)
Last modified
June 16, 2009.
Version 98.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: T-cell acute lymphocytic leukemia protein 1 Short name=TAL-1 Alternative name(s): Stem cell protein T-cell leukemia/lymphoma protein 5 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 331 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation By similarity. |
| Subunit structure | Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 By similarity. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Leukemic stem cell. |
| Domain | The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1. |
| Post-translational modification | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia By similarity. Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells By similarity. |
| Involvement in disease | A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. |
| Sequence similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CRK | P46108 | 1 | EBI-1753878,EBI-886 | |
| DRG1 | Q9Y295 | 2 | EBI-1753878,EBI-719554 | |
| TCF4 | P15884 | 2 | EBI-1753878,EBI-533224 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] Note: The splicing pattern is cell-lineage dependent. | ||||||
| Isoform PP42-TAL1 (identifier: P17542-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform PP39-TAL1 (identifier: P17542-2) The sequence of this isoform differs from the canonical sequence as follows: 1-25: Missing. | ||||||
| Isoform PP22-TAL1 (identifier: P17542-3) The sequence of this isoform differs from the canonical sequence as follows: 1-175: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 331 | 331 | T-cell acute lymphocytic leukemia protein 1 | PRO_0000127454 | |||||
Regions | |||||||||
| Domain | 200 – 240 | 41 | Helix-loop-helix motif | ||||||
| DNA binding | 187 – 199 | 13 | Basic motif | ||||||
| Compositional bias | 89 – 132 | 44 | Pro-rich | ||||||
| Compositional bias | 263 – 274 | 12 | Poly-Gly | ||||||
Amino acid modifications | |||||||||
| Modified residue | 122 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 175 | 175 | Missing in isoform PP22-TAL1. | VSP_002154 | |||||
| Alternative sequence | 1 – 25 | 25 | Missing in isoform PP39-TAL1. | VSP_002153 | |||||
Sequences
| ||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The SCL gene is formed from a transcriptionally complex locus." Aplan P.D., Begley C.G., Bertness V., Nussmeier M., Ezquerra A., Coligan J., Kirsch I.R. Mol. Cell. Biol. 10:6426-6435(1990) [PubMed: 2247063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia." Chen Q., Yang C.Y.C., Tsan J.T., Xia Y., Ragab A.H., Peiper S.C., Carroll A., Baer R. J. Exp. Med. 172:1403-1408(1990) [PubMed: 2230650] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-148. |
| [4] | "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif." Begley C.G., Aplan P.D., Denning S.M., Haynes B.F., Waldmann T.A., Kirsch I.R. Proc. Natl. Acad. Sci. U.S.A. 86:10128-10132(1989) [PubMed: 2602361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-331. Tissue: Bone marrow. |
| [5] | "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein." Chen Q., Cheng J.-T., Tsai L.H., Schneider N., Buchanan G., Carroll A., Crist W., Ozanne B., Siciliano M.J., Baer R. EMBO J. 9:415-424(1990) [PubMed: 2303035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-331. |
| [6] | "The SCL gene product: a positive regulator of erythroid differentiation." Aplan P.D., Nakahara K., Orkin S.H., Kirsch I.R. EMBO J. 11:4073-4081(1992) [PubMed: 1396592] [Abstract] Cited for: FUNCTION. |
| [7] | "Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues." Cheng J.-T., Hsu H.-L., Hwang L.-Y., Baer R. Oncogene 8:677-683(1993) [PubMed: 8437851] [Abstract] Cited for: PHOSPHORYLATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M61108 mRNA. Translation: AAA36600.1. M61103 Genomic DNA. No translation available. M61104 Genomic DNA. No translation available. M61105 Genomic DNA. No translation available. M63572 Genomic DNA. No translation available. M63589, M63576, M63584 Genomic DNA. Translation: AAA36599.1. AL135960 Genomic DNA. Translation: CAB72103.1. X58621 Genomic DNA. Translation: CAA41476.1. Sequence problems. X58622 Genomic DNA. Translation: CAA41477.1. M29038 mRNA. Translation: AAA36598.1. X51990 mRNA. Translation: CAA36246.1. | |
| IPI | IPI00218206. IPI00471993. IPI00747776. |
| PIR | A36358. I38253. |
| RefSeq | NP_003180.1. |
| UniGene | Hs.705618 Hs.709194 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P17542. 5 interactions. |
PTM databases | |
| PhosphoSite | P17542. |
Proteomic databases | |
| PRIDE | P17542. |
Genome annotation databases | |
| Ensembl | ENSG00000162367. Homo sapiens. [Contig view] |
| GeneID | 6886. |
| KEGG | hsa:6886. |
Organism-specific databases | |
| GeneCards | GC01M047454. |
| H-InvDB | HIX0000560. HIX0029300. |
| HGNC | HGNC:11556. TAL1. |
| HPA | CAB017805. |
| MIM | 187040. gene. |
| Orphanet | 513. Leukemia, lymphoblastic, acute. |
| PharmGKB | PA28200. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P17542. |
Gene expression databases | |
| ArrayExpress | P17542. |
| Bgee | P17542. |
| CleanEx | HS_TAL1. |
| GermOnline | ENSG00000162367. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit. |
| Pfam | PF00010. HLH. 1 hit. [Graphical view] |
| SMART | SM00353. HLH. 1 hit. [Graphical view] |
| PROSITE | PS50888. HLH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 26909. |
| PMAP-CutDB | P17542. |
| SOURCE | Search... |
Entry information
| Entry name | TAL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17542 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


