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P17542

- TAL1_HUMAN

UniProt

P17542 - TAL1_HUMAN

Protein

T-cell acute lymphocytic leukemia protein 1

Gene

TAL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 2 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. E-box binding Source: BHF-UCL
    3. enzyme binding Source: BHF-UCL
    4. histone deacetylase binding Source: BHF-UCL
    5. protein binding Source: UniProtKB
    6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    7. RNA polymerase II transcription factor binding Source: BHF-UCL
    8. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    9. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    10. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. astrocyte fate commitment Source: Ensembl
    3. basophil differentiation Source: BHF-UCL
    4. cell fate commitment Source: BHF-UCL
    5. definitive hemopoiesis Source: Ensembl
    6. embryonic hemopoiesis Source: UniProtKB
    7. erythrocyte differentiation Source: BHF-UCL
    8. erythrocyte maturation Source: Ensembl
    9. hemangioblast cell differentiation Source: Ensembl
    10. hematopoietic stem cell differentiation Source: Ensembl
    11. hemopoiesis Source: BHF-UCL
    12. locomotory behavior Source: Ensembl
    13. megakaryocyte development Source: Ensembl
    14. megakaryocyte differentiation Source: BHF-UCL
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. platelet formation Source: Ensembl
    17. positive regulation of cell division Source: BHF-UCL
    18. positive regulation of chromatin assembly or disassembly Source: BHF-UCL
    19. positive regulation of erythrocyte differentiation Source: UniProtKB
    20. positive regulation of mitotic cell cycle Source: BHF-UCL
    21. positive regulation of protein complex assembly Source: BHF-UCL
    22. positive regulation of transcription, DNA-templated Source: UniProtKB
    23. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    24. regulation of cell proliferation Source: Ensembl
    25. regulation of mast cell differentiation Source: Ensembl
    26. regulation of stem cell maintenance Source: Ensembl
    27. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. spinal cord association neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP17542.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Short name:
    TAL-1
    Alternative name(s):
    Class A basic helix-loop-helix protein 17
    Short name:
    bHLHa17
    Stem cell protein
    T-cell leukemia/lymphoma protein 5
    Gene namesi
    Name:TAL1
    Synonyms:BHLHA17, SCL, TCL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11556. TAL1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: BHF-UCL
    2. nucleus Source: BHF-UCL
    3. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBiPA36326.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331T-cell acute lymphocytic leukemia protein 1PRO_0000127454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia By similarity.By similarity
    Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP17542.
    PaxDbiP17542.
    PRIDEiP17542.

    PTM databases

    PhosphoSiteiP17542.

    Miscellaneous databases

    PMAP-CutDBP17542.

    Expressioni

    Tissue specificityi

    Leukemic stem cell.

    Gene expression databases

    ArrayExpressiP17542.
    BgeeiP17542.
    CleanExiHS_TAL1.
    GenevestigatoriP17542.

    Organism-specific databases

    HPAiCAB017805.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ETS1P149212EBI-1753878,EBI-913209
    Lmo2P258015EBI-1753878,EBI-3903256From a different organism.
    RUNX1Q011962EBI-1753878,EBI-925904
    TCF3P159235EBI-1753878,EBI-769630

    Protein-protein interaction databases

    BioGridi112749. 50 interactions.
    DIPiDIP-40640N.
    IntActiP17542. 15 interactions.
    MINTiMINT-2801392.
    STRINGi9606.ENSP00000294339.

    Structurei

    Secondary structure

    1
    331
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi184 – 21128
    Helixi225 – 24521

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YPAX-ray2.80A180-253[»]
    2YPBX-ray2.87A180-253[»]
    ProteinModelPortaliP17542.
    SMRiP17542. Positions 182-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 23953bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi89 – 13244Pro-richAdd
    BLAST
    Compositional biasi263 – 27412Poly-GlyAdd
    BLAST

    Domaini

    The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307510.
    HOGENOMiHOG000113414.
    HOVERGENiHBG005018.
    KOiK09068.
    OrthoDBiEOG7SN8DF.
    PhylomeDBiP17542.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: The splicing pattern is cell-lineage dependent.

    Isoform PP42-TAL1 (identifier: P17542-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP    50
    VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA 100
    PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG 150
    FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ 200
    QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 250
    TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS 300
    PDSYTEEPAP KHTARSLHPA MLPAADGAGP R 331
    Length:331
    Mass (Da):34,271
    Last modified:November 1, 1991 - v2
    Checksum:i33BBE31589DBB7C7
    GO
    Isoform PP39-TAL1 (identifier: P17542-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: Missing.

    Show »
    Length:306
    Mass (Da):31,617
    Checksum:i4457C743678771FE
    GO
    Isoform PP22-TAL1 (identifier: P17542-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-175: Missing.

    Show »
    Length:156
    Mass (Da):16,548
    Checksum:i5BC0D5F12E261CDE
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 175175Missing in isoform PP22-TAL1. CuratedVSP_002154Add
    BLAST
    Alternative sequencei1 – 2525Missing in isoform PP39-TAL1. CuratedVSP_002153Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61108 mRNA. Translation: AAA36600.1.
    M61103 Genomic DNA. No translation available.
    M61104 Genomic DNA. No translation available.
    M61105 Genomic DNA. No translation available.
    M63572 Genomic DNA. No translation available.
    M63589, M63576, M63584 Genomic DNA. Translation: AAA36599.1.
    AL135960 Genomic DNA. Translation: CAB72103.1.
    CH471059 Genomic DNA. Translation: EAX06875.1.
    CH471059 Genomic DNA. Translation: EAX06876.1.
    CH471059 Genomic DNA. Translation: EAX06877.1.
    X58621 Genomic DNA. Translation: CAA41476.1. Sequence problems.
    X58622 Genomic DNA. Translation: CAA41477.1.
    M29038 mRNA. Translation: AAA36598.1.
    X51990 mRNA. Translation: CAA36246.1.
    CCDSiCCDS547.1. [P17542-1]
    PIRiA36358.
    I38253.
    RefSeqiNP_001274276.1. NM_001287347.2. [P17542-1]
    NP_001277332.1. NM_001290403.1. [P17542-1]
    NP_001277333.1. NM_001290404.1. [P17542-1]
    NP_001277334.1. NM_001290405.1. [P17542-1]
    NP_001277335.1. NM_001290406.1.
    NP_003180.1. NM_003189.5. [P17542-1]
    XP_005271216.1. XM_005271159.2. [P17542-1]
    XP_005271217.1. XM_005271160.2. [P17542-1]
    XP_006710925.1. XM_006710862.1. [P17542-1]
    UniGeneiHs.705618.
    Hs.737706.

    Genome annotation databases

    EnsembliENST00000294339; ENSP00000294339; ENSG00000162367. [P17542-1]
    ENST00000371884; ENSP00000360951; ENSG00000162367. [P17542-1]
    GeneIDi6886.
    KEGGihsa:6886.
    UCSCiuc001cqx.2. human. [P17542-1]

    Polymorphism databases

    DMDMi134305.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61108 mRNA. Translation: AAA36600.1 .
    M61103 Genomic DNA. No translation available.
    M61104 Genomic DNA. No translation available.
    M61105 Genomic DNA. No translation available.
    M63572 Genomic DNA. No translation available.
    M63589 , M63576 , M63584 Genomic DNA. Translation: AAA36599.1 .
    AL135960 Genomic DNA. Translation: CAB72103.1 .
    CH471059 Genomic DNA. Translation: EAX06875.1 .
    CH471059 Genomic DNA. Translation: EAX06876.1 .
    CH471059 Genomic DNA. Translation: EAX06877.1 .
    X58621 Genomic DNA. Translation: CAA41476.1 . Sequence problems.
    X58622 Genomic DNA. Translation: CAA41477.1 .
    M29038 mRNA. Translation: AAA36598.1 .
    X51990 mRNA. Translation: CAA36246.1 .
    CCDSi CCDS547.1. [P17542-1 ]
    PIRi A36358.
    I38253.
    RefSeqi NP_001274276.1. NM_001287347.2. [P17542-1 ]
    NP_001277332.1. NM_001290403.1. [P17542-1 ]
    NP_001277333.1. NM_001290404.1. [P17542-1 ]
    NP_001277334.1. NM_001290405.1. [P17542-1 ]
    NP_001277335.1. NM_001290406.1.
    NP_003180.1. NM_003189.5. [P17542-1 ]
    XP_005271216.1. XM_005271159.2. [P17542-1 ]
    XP_005271217.1. XM_005271160.2. [P17542-1 ]
    XP_006710925.1. XM_006710862.1. [P17542-1 ]
    UniGenei Hs.705618.
    Hs.737706.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YPA X-ray 2.80 A 180-253 [» ]
    2YPB X-ray 2.87 A 180-253 [» ]
    ProteinModelPortali P17542.
    SMRi P17542. Positions 182-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112749. 50 interactions.
    DIPi DIP-40640N.
    IntActi P17542. 15 interactions.
    MINTi MINT-2801392.
    STRINGi 9606.ENSP00000294339.

    PTM databases

    PhosphoSitei P17542.

    Polymorphism databases

    DMDMi 134305.

    Proteomic databases

    MaxQBi P17542.
    PaxDbi P17542.
    PRIDEi P17542.

    Protocols and materials databases

    DNASUi 6886.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294339 ; ENSP00000294339 ; ENSG00000162367 . [P17542-1 ]
    ENST00000371884 ; ENSP00000360951 ; ENSG00000162367 . [P17542-1 ]
    GeneIDi 6886.
    KEGGi hsa:6886.
    UCSCi uc001cqx.2. human. [P17542-1 ]

    Organism-specific databases

    CTDi 6886.
    GeneCardsi GC01M047681.
    H-InvDB HIX0029300.
    HGNCi HGNC:11556. TAL1.
    HPAi CAB017805.
    MIMi 187040. gene.
    neXtProti NX_P17542.
    Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBi PA36326.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307510.
    HOGENOMi HOG000113414.
    HOVERGENi HBG005018.
    KOi K09068.
    OrthoDBi EOG7SN8DF.
    PhylomeDBi P17542.
    TreeFami TF315153.

    Enzyme and pathway databases

    SignaLinki P17542.

    Miscellaneous databases

    GeneWikii TAL1.
    GenomeRNAii 6886.
    NextBioi 26909.
    PMAP-CutDB P17542.
    PROi P17542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17542.
    Bgeei P17542.
    CleanExi HS_TAL1.
    Genevestigatori P17542.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SCL gene is formed from a transcriptionally complex locus."
      Aplan P.D., Begley C.G., Bertness V., Nussmeier M., Ezquerra A., Coligan J., Kirsch I.R.
      Mol. Cell. Biol. 10:6426-6435(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia."
      Chen Q., Yang C.Y.C., Tsan J.T., Xia Y., Ragab A.H., Peiper S.C., Carroll A., Baer R.
      J. Exp. Med. 172:1403-1408(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-148.
    5. "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif."
      Begley C.G., Aplan P.D., Denning S.M., Haynes B.F., Waldmann T.A., Kirsch I.R.
      Proc. Natl. Acad. Sci. U.S.A. 86:10128-10132(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-331.
      Tissue: Bone marrow.
    6. "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein."
      Chen Q., Cheng J.-T., Tsai L.H., Schneider N., Buchanan G., Carroll A., Crist W., Ozanne B., Siciliano M.J., Baer R.
      EMBO J. 9:415-424(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-331.
    7. "The SCL gene product: a positive regulator of erythroid differentiation."
      Aplan P.D., Nakahara K., Orkin S.H., Kirsch I.R.
      EMBO J. 11:4073-4081(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues."
      Cheng J.-T., Hsu H.-L., Hwang L.-Y., Baer R.
      Oncogene 8:677-683(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiTAL1_HUMAN
    AccessioniPrimary (citable) accession number: P17542
    Secondary accession number(s): D3DQ24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3