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Protein

T-cell acute lymphocytic leukemia protein 1

Gene

TAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162367-MONOMER.
SignaLinkiP17542.
SIGNORiP17542.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1
Short name:
TAL-1
Alternative name(s):
Class A basic helix-loop-helix protein 17
Short name:
bHLHa17
Stem cell protein
T-cell leukemia/lymphoma protein 5
Gene namesi
Name:TAL1
Synonyms:BHLHA17, SCL, TCL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11556. TAL1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear chromatin Source: BHF-UCL
  • nucleus Source: BHF-UCL
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi6886.
MalaCardsiTAL1.
OpenTargetsiENSG00000162367.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA36326.

Polymorphism and mutation databases

DMDMi134305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274541 – 331T-cell acute lymphocytic leukemia protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).By similarity
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17542.
PaxDbiP17542.
PeptideAtlasiP17542.
PRIDEiP17542.

PTM databases

iPTMnetiP17542.
PhosphoSitePlusiP17542.

Miscellaneous databases

PMAP-CutDBP17542.

Expressioni

Tissue specificityi

Leukemic stem cell.

Gene expression databases

BgeeiENSG00000162367.
CleanExiHS_TAL1.
GenevisibleiP17542. HS.

Organism-specific databases

HPAiCAB017805.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ETS1P149212EBI-1753878,EBI-913209
Lmo2P258015EBI-1753878,EBI-3903256From a different organism.
RUNX1Q011962EBI-1753878,EBI-925904
TCF3P159235EBI-1753878,EBI-769630

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • histone deacetylase binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112749. 49 interactors.
DIPiDIP-40640N.
IntActiP17542. 15 interactors.
MINTiMINT-2801392.
STRINGi9606.ENSP00000294339.

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi184 – 211Combined sources28
Helixi225 – 245Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPAX-ray2.80A180-253[»]
2YPBX-ray2.87A180-253[»]
ProteinModelPortaliP17542.
SMRiP17542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 239bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 132Pro-richAdd BLAST44
Compositional biasi263 – 274Poly-GlyAdd BLAST12

Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG005018.
InParanoidiP17542.
KOiK09068.
OMAiEMPVIEL.
OrthoDBiEOG091G0ESI.
PhylomeDBiP17542.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: The splicing pattern is cell-lineage dependent.
Isoform PP42-TAL1 (identifier: P17542-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP
60 70 80 90 100
VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
310 320 330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R
Length:331
Mass (Da):34,271
Last modified:November 1, 1991 - v2
Checksum:i33BBE31589DBB7C7
GO
Isoform PP39-TAL1 (identifier: P17542-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:306
Mass (Da):31,617
Checksum:i4457C743678771FE
GO
Isoform PP22-TAL1 (identifier: P17542-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:156
Mass (Da):16,548
Checksum:i5BC0D5F12E261CDE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0021541 – 175Missing in isoform PP22-TAL1. CuratedAdd BLAST175
Alternative sequenceiVSP_0021531 – 25Missing in isoform PP39-TAL1. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61108 mRNA. Translation: AAA36600.1.
M61103 Genomic DNA. No translation available.
M61104 Genomic DNA. No translation available.
M61105 Genomic DNA. No translation available.
M63572 Genomic DNA. No translation available.
M63589, M63576, M63584 Genomic DNA. Translation: AAA36599.1.
AL135960 Genomic DNA. Translation: CAB72103.1.
CH471059 Genomic DNA. Translation: EAX06875.1.
CH471059 Genomic DNA. Translation: EAX06876.1.
CH471059 Genomic DNA. Translation: EAX06877.1.
X58621 Genomic DNA. Translation: CAA41476.1. Sequence problems.
X58622 Genomic DNA. Translation: CAA41477.1.
M29038 mRNA. Translation: AAA36598.1.
X51990 mRNA. Translation: CAA36246.1.
CCDSiCCDS547.1. [P17542-1]
PIRiA36358.
I38253.
RefSeqiNP_001274276.1. NM_001287347.2. [P17542-1]
NP_001277332.1. NM_001290403.1. [P17542-1]
NP_001277333.1. NM_001290404.1. [P17542-1]
NP_001277334.1. NM_001290405.1. [P17542-1]
NP_001277335.1. NM_001290406.1.
NP_003180.1. NM_003189.5. [P17542-1]
XP_005271217.1. XM_005271160.4. [P17542-1]
XP_016857676.1. XM_017002187.1. [P17542-1]
XP_016857677.1. XM_017002188.1. [P17542-1]
XP_016857678.1. XM_017002189.1. [P17542-1]
XP_016857679.1. XM_017002190.1. [P17542-1]
XP_016857680.1. XM_017002191.1. [P17542-1]
UniGeneiHs.705618.
Hs.737706.

Genome annotation databases

EnsembliENST00000294339; ENSP00000294339; ENSG00000162367. [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367. [P17542-1]
GeneIDi6886.
KEGGihsa:6886.
UCSCiuc001cqx.4. human. [P17542-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61108 mRNA. Translation: AAA36600.1.
M61103 Genomic DNA. No translation available.
M61104 Genomic DNA. No translation available.
M61105 Genomic DNA. No translation available.
M63572 Genomic DNA. No translation available.
M63589, M63576, M63584 Genomic DNA. Translation: AAA36599.1.
AL135960 Genomic DNA. Translation: CAB72103.1.
CH471059 Genomic DNA. Translation: EAX06875.1.
CH471059 Genomic DNA. Translation: EAX06876.1.
CH471059 Genomic DNA. Translation: EAX06877.1.
X58621 Genomic DNA. Translation: CAA41476.1. Sequence problems.
X58622 Genomic DNA. Translation: CAA41477.1.
M29038 mRNA. Translation: AAA36598.1.
X51990 mRNA. Translation: CAA36246.1.
CCDSiCCDS547.1. [P17542-1]
PIRiA36358.
I38253.
RefSeqiNP_001274276.1. NM_001287347.2. [P17542-1]
NP_001277332.1. NM_001290403.1. [P17542-1]
NP_001277333.1. NM_001290404.1. [P17542-1]
NP_001277334.1. NM_001290405.1. [P17542-1]
NP_001277335.1. NM_001290406.1.
NP_003180.1. NM_003189.5. [P17542-1]
XP_005271217.1. XM_005271160.4. [P17542-1]
XP_016857676.1. XM_017002187.1. [P17542-1]
XP_016857677.1. XM_017002188.1. [P17542-1]
XP_016857678.1. XM_017002189.1. [P17542-1]
XP_016857679.1. XM_017002190.1. [P17542-1]
XP_016857680.1. XM_017002191.1. [P17542-1]
UniGeneiHs.705618.
Hs.737706.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPAX-ray2.80A180-253[»]
2YPBX-ray2.87A180-253[»]
ProteinModelPortaliP17542.
SMRiP17542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112749. 49 interactors.
DIPiDIP-40640N.
IntActiP17542. 15 interactors.
MINTiMINT-2801392.
STRINGi9606.ENSP00000294339.

PTM databases

iPTMnetiP17542.
PhosphoSitePlusiP17542.

Polymorphism and mutation databases

DMDMi134305.

Proteomic databases

MaxQBiP17542.
PaxDbiP17542.
PeptideAtlasiP17542.
PRIDEiP17542.

Protocols and materials databases

DNASUi6886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294339; ENSP00000294339; ENSG00000162367. [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367. [P17542-1]
GeneIDi6886.
KEGGihsa:6886.
UCSCiuc001cqx.4. human. [P17542-1]

Organism-specific databases

CTDi6886.
DisGeNETi6886.
GeneCardsiTAL1.
H-InvDBHIX0029300.
HGNCiHGNC:11556. TAL1.
HPAiCAB017805.
MalaCardsiTAL1.
MIMi187040. gene.
neXtProtiNX_P17542.
OpenTargetsiENSG00000162367.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA36326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG005018.
InParanoidiP17542.
KOiK09068.
OMAiEMPVIEL.
OrthoDBiEOG091G0ESI.
PhylomeDBiP17542.
TreeFamiTF315153.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162367-MONOMER.
SignaLinkiP17542.
SIGNORiP17542.

Miscellaneous databases

ChiTaRSiTAL1. human.
GeneWikiiTAL1.
GenomeRNAii6886.
PMAP-CutDBP17542.
PROiP17542.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162367.
CleanExiHS_TAL1.
GenevisibleiP17542. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL1_HUMAN
AccessioniPrimary (citable) accession number: P17542
Secondary accession number(s): D3DQ24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.