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P17538 (CTRB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsinogen B

EC=3.4.21.1
Gene names
Name:CTRB1
Synonyms:CTRB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 263245Chymotrypsinogen B
PRO_0000027638
Chain19 – 3113Chymotrypsin B chain A
PRO_0000027639
Chain34 – 164131Chymotrypsin B chain B
PRO_0000027640
Chain167 – 26397Chymotrypsin B chain C
PRO_0000027641

Regions

Domain34 – 261228Peptidase S1

Sites

Active site751Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2131Charge relay system By similarity

Amino acid modifications

Disulfide bond19 ↔ 140 By similarity
Disulfide bond60 ↔ 76 By similarity
Disulfide bond154 ↔ 219 By similarity
Disulfide bond186 ↔ 200 By similarity
Disulfide bond209 ↔ 238 By similarity

Natural variations

Natural variant2221D → H.
Corresponds to variant rs8061550 [ dbSNP | Ensembl ].
VAR_057158
Natural variant2501T → A.
Corresponds to variant rs4737 [ dbSNP | Ensembl ].
VAR_014566

Sequences

Sequence LengthMass (Da)Tools
P17538 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 4C1C055A490B8701

FASTA26327,870
        10         20         30         40         50         60 
MAFLWLLSCW ALLGTTFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS LQDKTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV LKIAKVFKNP KFSILTVNND 

       130        140        150        160        170        180 
ITLLKLATPA RFSQTVSAVC LPSADDDFPA GTLCATTGWG KTKYNANKTP DKLQQAALPL 

       190        200        210        220        230        240 
LSNAECKKSW GRRITDVMIC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST 

       250        260 
SSPGVYARVT KLIPWVQKIL AAN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA."
Tomita N., Izumoto Y., Horii A., Doi S., Yokouchi H., Ogawa M., Mori T., Matsubara K.
Biochem. Biophys. Res. Commun. 158:569-575(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Web resources

Wikipedia

Chymotrypsin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24400 mRNA. Translation: AAA52128.1.
BT007356 mRNA. Translation: AAP36020.1.
BC005385 mRNA. Translation: AAH05385.1.
PIRA31299.
UniGeneHs.610926.

3D structure databases

ProteinModelPortalP17538.
SMRP17538. Positions 19-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000354294.

Chemistry

BindingDBP17538.
ChEMBLCHEMBL4796.

PTM databases

PhosphoSiteP17538.

Polymorphism databases

DMDM117617.

Proteomic databases

PaxDbP17538.
PRIDEP17538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361017; ENSP00000354294; ENSG00000168925.

Organism-specific databases

GeneCardsGC16P075252.
H-InvDBHIX0013242.
HGNCHGNC:2521. CTRB1.
MIM118890. gene.
neXtProtNX_P17538.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP17538.
OrthoDBEOG7MKW6Q.
PhylomeDBP17538.
TreeFamTF330455.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeP17538.
CleanExHS_CTRB1.
GenevestigatorP17538.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP17538.
SOURCESearch...

Entry information

Entry nameCTRB1_HUMAN
AccessionPrimary (citable) accession number: P17538
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM