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Protein

Chymotrypsinogen B

Gene

CTRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Enzyme and pathway databases

BioCyciZFISH:HS15730-MONOMER.
ReactomeiR-HSA-1592389. Activation of Matrix Metalloproteinases.
R-HSA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB1Imported
Synonyms:CTRBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2521. CTRB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1504.
OpenTargetsiENSG00000168925.

Chemistry databases

ChEMBLiCHEMBL4796.
DrugBankiDB06692. Aprotinin.

Polymorphism and mutation databases

DMDMi117617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000002763819 – 263Chymotrypsinogen BAdd BLAST245
ChainiPRO_000002763919 – 31Chymotrypsin B chain AAdd BLAST13
ChainiPRO_000002764034 – 164Chymotrypsin B chain BAdd BLAST131
ChainiPRO_0000027641167 – 263Chymotrypsin B chain CAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Modified residuei93PhosphoserineBy similarity1
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiP17538.
PeptideAtlasiP17538.
PRIDEiP17538.

PTM databases

iPTMnetiP17538.
PhosphoSitePlusiP17538.

Expressioni

Gene expression databases

BgeeiENSG00000168925.
CleanExiHS_CTRB1.
ExpressionAtlasiP17538. baseline and differential.
GenevisibleiP17538. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303963.

Chemistry databases

BindingDBiP17538.

Structurei

3D structure databases

ProteinModelPortaliP17538.
SMRiP17538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP17538.
OrthoDBiEOG091G0AH5.
PhylomeDBiP17538.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLWLLSCF SLVGAAFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS
60 70 80 90 100
LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV
110 120 130 140 150
LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA
160 170 180 190 200
GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST SSPGVYARVT
260
KLIPWVQKIL AAN
Length:263
Mass (Da):27,713
Last modified:November 2, 2016 - v2
Checksum:iEDA816A133D42DE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → F in AAA52128 (PubMed:2917002).Curated1
Sequence conflicti3S → F in AAP36020 (Ref. 2) Curated1
Sequence conflicti3S → F in AAH05385 (PubMed:15489334).Curated1
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAA52128 (PubMed:2917002).Curated7
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAP36020 (Ref. 2) Curated7
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAH05385 (PubMed:15489334).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057158222D → H.Corresponds to variant rs8061550dbSNPEnsembl.1
Natural variantiVAR_014566250T → A.Corresponds to variant rs4737dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24400 mRNA. Translation: AAA52128.1.
BT007356 mRNA. Translation: AAP36020.1.
AC009078 Genomic DNA. No translation available.
BC005385 mRNA. Translation: AAH05385.1.
CCDSiCCDS32490.1.
PIRiA31299.
RefSeqiNP_001316119.1. NM_001329190.1.
NP_001897.4. NM_001906.5.
UniGeneiHs.610926.

Genome annotation databases

EnsembliENST00000361017; ENSP00000354294; ENSG00000168925.
GeneIDi1504.
UCSCiuc002fds.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Chymotrypsin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24400 mRNA. Translation: AAA52128.1.
BT007356 mRNA. Translation: AAP36020.1.
AC009078 Genomic DNA. No translation available.
BC005385 mRNA. Translation: AAH05385.1.
CCDSiCCDS32490.1.
PIRiA31299.
RefSeqiNP_001316119.1. NM_001329190.1.
NP_001897.4. NM_001906.5.
UniGeneiHs.610926.

3D structure databases

ProteinModelPortaliP17538.
SMRiP17538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303963.

Chemistry databases

BindingDBiP17538.
ChEMBLiCHEMBL4796.
DrugBankiDB06692. Aprotinin.

PTM databases

iPTMnetiP17538.
PhosphoSitePlusiP17538.

Polymorphism and mutation databases

DMDMi117617.

Proteomic databases

PaxDbiP17538.
PeptideAtlasiP17538.
PRIDEiP17538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361017; ENSP00000354294; ENSG00000168925.
GeneIDi1504.
UCSCiuc002fds.4. human.

Organism-specific databases

DisGeNETi1504.
GeneCardsiCTRB1.
H-InvDBHIX0013242.
HGNCiHGNC:2521. CTRB1.
MIMi118890. gene.
neXtProtiNX_P17538.
OpenTargetsiENSG00000168925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP17538.
OrthoDBiEOG091G0AH5.
PhylomeDBiP17538.
TreeFamiTF330455.

Enzyme and pathway databases

BioCyciZFISH:HS15730-MONOMER.
ReactomeiR-HSA-1592389. Activation of Matrix Metalloproteinases.
R-HSA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

PROiP17538.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168925.
CleanExiHS_CTRB1.
ExpressionAtlasiP17538. baseline and differential.
GenevisibleiP17538. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB1_HUMAN
AccessioniPrimary (citable) accession number: P17538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 2, 2016
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.