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P17538

- CTRB1_HUMAN

UniProt

P17538 - CTRB1_HUMAN

Protein

Chymotrypsinogen B

Gene

CTRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei213 – 2131Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. cobalamin metabolic process Source: Reactome
    2. digestion Source: UniProtKB-KW
    3. extracellular matrix disassembly Source: Reactome
    4. extracellular matrix organization Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. vitamin metabolic process Source: Reactome
    7. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Enzyme and pathway databases

    ReactomeiREACT_118682. Activation of Matrix Metalloproteinases.
    REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsinogen B (EC:3.4.21.1)
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CTRB1
    Synonyms:CTRB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2521. CTRB1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 263245Chymotrypsinogen BPRO_0000027638Add
    BLAST
    Chaini19 – 3113Chymotrypsin B chain APRO_0000027639Add
    BLAST
    Chaini34 – 164131Chymotrypsin B chain BPRO_0000027640Add
    BLAST
    Chaini167 – 26397Chymotrypsin B chain CPRO_0000027641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP17538.
    PRIDEiP17538.

    PTM databases

    PhosphoSiteiP17538.

    Expressioni

    Gene expression databases

    BgeeiP17538.
    CleanExiHS_CTRB1.
    GenevestigatoriP17538.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000354294.

    Structurei

    3D structure databases

    ProteinModelPortaliP17538.
    SMRiP17538. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP17538.
    OrthoDBiEOG7MKW6Q.
    PhylomeDBiP17538.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17538-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFLWLLSCW ALLGTTFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS    50
    LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV 100
    LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA 150
    GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC 200
    AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST SSPGVYARVT 250
    KLIPWVQKIL AAN 263
    Length:263
    Mass (Da):27,870
    Last modified:August 1, 1990 - v1
    Checksum:i4C1C055A490B8701
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221D → H.
    Corresponds to variant rs8061550 [ dbSNP | Ensembl ].
    VAR_057158
    Natural varianti250 – 2501T → A.
    Corresponds to variant rs4737 [ dbSNP | Ensembl ].
    VAR_014566

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24400 mRNA. Translation: AAA52128.1.
    BT007356 mRNA. Translation: AAP36020.1.
    BC005385 mRNA. Translation: AAH05385.1.
    CCDSiCCDS32490.1.
    PIRiA31299.
    UniGeneiHs.610926.

    Genome annotation databases

    EnsembliENST00000361017; ENSP00000354294; ENSG00000168925.

    Polymorphism databases

    DMDMi117617.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Chymotrypsin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24400 mRNA. Translation: AAA52128.1 .
    BT007356 mRNA. Translation: AAP36020.1 .
    BC005385 mRNA. Translation: AAH05385.1 .
    CCDSi CCDS32490.1.
    PIRi A31299.
    UniGenei Hs.610926.

    3D structure databases

    ProteinModelPortali P17538.
    SMRi P17538. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000354294.

    Chemistry

    BindingDBi P17538.
    ChEMBLi CHEMBL4796.

    PTM databases

    PhosphoSitei P17538.

    Polymorphism databases

    DMDMi 117617.

    Proteomic databases

    PaxDbi P17538.
    PRIDEi P17538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361017 ; ENSP00000354294 ; ENSG00000168925 .

    Organism-specific databases

    GeneCardsi GC16P075252.
    H-InvDB HIX0013242.
    HGNCi HGNC:2521. CTRB1.
    MIMi 118890. gene.
    neXtProti NX_P17538.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P17538.
    OrthoDBi EOG7MKW6Q.
    PhylomeDBi P17538.
    TreeFami TF330455.

    Enzyme and pathway databases

    Reactomei REACT_118682. Activation of Matrix Metalloproteinases.
    REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

    Miscellaneous databases

    PROi P17538.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17538.
    CleanExi HS_CTRB1.
    Genevestigatori P17538.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA."
      Tomita N., Izumoto Y., Horii A., Doi S., Yokouchi H., Ogawa M., Mori T., Matsubara K.
      Biochem. Biophys. Res. Commun. 158:569-575(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiCTRB1_HUMAN
    AccessioniPrimary (citable) accession number: P17538
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3