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Protein

Tropomyosin-1

Gene

TPM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin lateral binding Source: SGD

GO - Biological processi

  • actin filament bundle assembly Source: SGD
  • actin filament organization Source: SGD
  • actin filament reorganization Source: SGD
  • actin polymerization or depolymerization Source: SGD
  • budding cell apical bud growth Source: SGD
  • budding cell isotropic bud growth Source: SGD
  • establishment of cell polarity Source: SGD
  • exocytosis Source: SGD
  • filamentous growth Source: SGD
  • intracellular mRNA localization Source: SGD
  • mitochondrion inheritance Source: SGD
  • pseudohyphal growth Source: SGD
  • vacuole inheritance Source: SGD
  • vesicle-mediated transport Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33108-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin-1
Gene namesi
Name:TPM1
Ordered Locus Names:YNL079C
ORF Names:N2332
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL079C
SGDiS000005023 TPM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056921 – 199Tropomyosin-1Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17536
PaxDbiP17536
PRIDEiP17536

PTM databases

iPTMnetiP17536

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HHT2P618302EBI-19408,EBI-8098

GO - Molecular functioni

  • actin lateral binding Source: SGD

Protein-protein interaction databases

BioGridi35744, 678 interactors
DIPiDIP-2992N
IntActiP17536, 8 interactors
MINTiP17536
STRINGi4932.YNL079C

Structurei

3D structure databases

ProteinModelPortaliP17536
SMRiP17536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 199By similarityAdd BLAST199

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00730000113677
HOGENOMiHOG000180129
InParanoidiP17536
KOiK17945
OMAiQHGTQNE
OrthoDBiEOG092C0U40

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF12718 Tropomyosin_1, 1 hit

Sequencei

Sequence statusi: Complete.

P17536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKIREKLSN LKLEAESWQE KYEELKEKNK DLEQENVEKE NQIKSLTVKN
60 70 80 90 100
QQLEDEIEKL EAGLSDSKQT EQDNVEKENQ IKSLTVKNHQ LEEEIEKLEA
110 120 130 140 150
ELAESKQLSE DSHHLQSNND NFSKKNQQLE EDLEESDTKL KETTEKLRES
160 170 180 190
DLKADQLERR VAALEEQREE WERKNEELTV KYEDAKKELD EIAASLENL
Length:199
Mass (Da):23,541
Last modified:August 1, 1990 - v1
Checksum:i845F3DB4387083BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25501 Genomic DNA Translation: AAA35174.1
DQ115393 Genomic DNA Translation: AAZ22529.1
X86470 Genomic DNA Translation: CAA60179.1
Z71355 Genomic DNA Translation: CAA95953.1
AY692838 Genomic DNA Translation: AAT92857.1
BK006947 Genomic DNA Translation: DAA10466.1
PIRiA32183
RefSeqiNP_014320.1, NM_001182917.1

Genome annotation databases

EnsemblFungiiYNL079C; YNL079C; YNL079C
GeneIDi855645
KEGGisce:YNL079C

Similar proteinsi

Entry informationi

Entry nameiTPM1_YEAST
AccessioniPrimary (citable) accession number: P17536
Secondary accession number(s): D6W1A0, Q45TY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health