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Protein

Transcription factor jun-D

Gene

JUND

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP17535.
SIGNORiP17535.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:JUND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6206. JUND.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: ProtInc
  • nuclear chromatin Source: GO_Central
  • nucleus Source: HPA
  • protein-DNA complex Source: Ensembl
  • transcription factor AP-1 complex Source: CAFA

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3727.
OpenTargetsiENSG00000130522.
PharmGKBiPA30008.

Polymorphism and mutation databases

DMDMi229462969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764421 – 347Transcription factor jun-DAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17535.
MaxQBiP17535.
PaxDbiP17535.
PeptideAtlasiP17535.
PRIDEiP17535.

PTM databases

iPTMnetiP17535.
PhosphoSitePlusiP17535.

Expressioni

Gene expression databases

BgeeiENSG00000130522.
CleanExiHS_JUND.
ExpressionAtlasiP17535. baseline and differential.
GenevisibleiP17535. HS.

Organism-specific databases

HPAiCAB005268.
HPA063029.

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • ligand-dependent nuclear receptor binding Source: Ensembl
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109930. 43 interactors.
DIPiDIP-1053N.
IntActiP17535. 23 interactors.
MINTiMINT-260192.
STRINGi9606.ENSP00000252818.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U86X-ray2.84B27-39[»]
ProteinModelPortaliP17535.
SMRiP17535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 295Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni296 – 324Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 166Poly-Ala9

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP17535.
KOiK04449.
OMAiAPVYANL.
OrthoDBiEOG091G0N0L.
PhylomeDBiP17535.
TreeFamiTF323952.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
IPR005643. JNK.
IPR029823. JunD.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
PANTHERiPTHR11462:SF44. PTHR11462:SF44. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P17535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL
60 70 80 90 100
TLSLSEQVAA ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
NQLGAGAAAA AAAAAAGGPS GTATGSAPPG ELAPAAAAPE APVYANLSSY
210 220 230 240 250
AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK DEPQTVPDVP
260 270 280 290 300
SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV
310 320 330 340
KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY
Length:347
Mass (Da):35,174
Last modified:May 5, 2009 - v3
Checksum:iFE85A1AA2B5B9597
GO

Sequence cautioni

The sequence CAA40010 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → T in CAA40010 (PubMed:1903194).Curated1
Sequence conflicti157A → R in CAA40010 (PubMed:1903194).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05524720G → V1 PublicationCorresponds to variant dbSNP:rs41478151Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56681 mRNA. Translation: CAA40010.1. Frameshift.
EF044249 Genomic DNA. Translation: ABJ53425.1.
AK223630 mRNA. Translation: BAD97350.1.
CH471106 Genomic DNA. Translation: EAW84684.1.
X51346 mRNA. Translation: CAA35739.1.
CCDSiCCDS32959.1.
PIRiA43815.
S10184. TVHUJD.
RefSeqiNP_001273897.1. NM_001286968.1.
NP_005345.3. NM_005354.5.
UniGeneiHs.2780.

Genome annotation databases

EnsembliENST00000252818; ENSP00000252818; ENSG00000130522.
GeneIDi3727.
KEGGihsa:3727.
UCSCiuc002nip.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiJUND_HUMAN
AccessioniPrimary (citable) accession number: P17535
Secondary accession number(s): Q53EK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 5, 2009
Last modified: July 5, 2017
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families