Reviewed,
UniProtKB/Swiss-Prot P17535 (JUND_HUMAN)
Last modified
June 16, 2009.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription factor jun-D | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 347 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds an AP-1 site and upon cotransfection stimulates the activity of a promoter that bears an AP-1 site. |
| Subunit structure | Binds DNA as a dimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the bZIP family. Jun subfamily. Contains 1 bZIP domain. |
| Sequence caution | The sequence CAA40010.1 differs from that shown. Reason: Frameshift at several positions. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Ligand | DNA-binding |
| Molecular function | Activator |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chromatin Ref.1 Traceable author statement. Source: ProtInc nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein dimerization activityInferred from electronic annotation. Source: InterPro sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 347 | 347 | Transcription factor jun-D | PRO_0000076442 | |||||
Regions | |||||||||
| Domain | 296 – 324 | 29 | Leucine-zipper | ||||||
| DNA binding | 273 – 292 | 20 | Basic motif | ||||||
| Compositional bias | 158 – 166 | 9 | Poly-Ala | ||||||
Amino acid modifications | |||||||||
| Modified residue | 251 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 255 | 1 | Phosphoserine Ref.8 Ref.6 Ref.7 | ||||||
| Modified residue | 259 | 1 | Phosphoserine Ref.8 Ref.7 | ||||||
Natural variations | |||||||||
| Natural variant | 20 | 1 | G → V | VAR_055247 | |||||
Experimental info | |||||||||
| Sequence conflict | 24 | 1 | S → T in CAA40010. Ref.1 | ||||||
| Sequence conflict | 157 | 1 | A → R in CAA40010. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure and function of human jun-D." Berger I., Shaul Y. Oncogene 6:561-566(1991) [PubMed: 1903194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIEHS-SNPs program for genomic applications Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20. |
| [3] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D." Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. Nucleic Acids Res. 18:3047-3048(1990) [PubMed: 2112242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347. |
| [6] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; SER-255 AND SER-259, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X56681 mRNA. Translation: CAA40010.1. Frameshift. EF044249 Genomic DNA. Translation: ABJ53425.1. AK223630 mRNA. Translation: BAD97350.1. CH471106 Genomic DNA. Translation: EAW84684.1. X51346 mRNA. Translation: CAA35739.1. | |
| IPI | IPI00289547. |
| PIR | A43815. TVHUJD. S10184. |
| RefSeq | NP_005345.3. |
| UniGene | Hs.2780 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JNM based on UniProtKB P05412. |
| SMR | P17535. Positions 269-330. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:1053N. DIP:24213N. |
PTM databases | |
| PhosphoSite | P17535. |
Proteomic databases | |
| PRIDE | P17535. |
Genome annotation databases | |
| Ensembl | ENSG00000130522. Homo sapiens. [Contig view] |
| GeneID | 3727. |
Organism-specific databases | |
| GeneCards | GC19M018254. |
| H-InvDB | HIX0040163. |
| HGNC | HGNC:6206. JUND. |
| HPA | CAB005268. |
| MIM | 165162. gene. |
| PharmGKB | PA30008. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P17535. |
| HOVERGEN | P17535. |
Gene expression databases | |
| ArrayExpress | P17535. |
| Bgee | P17535. |
| CleanEx | HS_JUND. |
| GermOnline | ENSG00000130522. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011616. bZIP_1. IPR005643. JNK. IPR002112. Leuzip_Jun. IPR004827. TF_bZIP. [Graphical view] |
| Pfam | PF00170. bZIP_1. 1 hit. PF03957. Jun. 1 hit. [Graphical view] |
| PRINTS | PR00043. LEUZIPPRJUN. |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | JUND_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17535 Secondary accession number(s): Q53EK9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


