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P17535

- JUND_HUMAN

UniProt

P17535 - JUND_HUMAN

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Protein

Transcription factor jun-D

Gene

JUND

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.1 Publication

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. enzyme binding Source: UniProt
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to calcium ion Source: Ensembl
  3. circadian rhythm Source: Ensembl
  4. osteoblast development Source: Ensembl
  5. positive regulation of osteoblast differentiation Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. response to light stimulus Source: Ensembl
  9. response to lipopolysaccharide Source: Ensembl
  10. response to mechanical stimulus Source: Ensembl
  11. response to organic cyclic compound Source: Ensembl
  12. response to peptide hormone Source: Ensembl
  13. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP17535.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:JUND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6206. JUND.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: ProtInc
  2. nucleus Source: HPA
  3. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Transcription factor jun-DPRO_0000076442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei251 – 2511Phosphoserine1 Publication
Modified residuei255 – 2551Phosphoserine3 Publications
Modified residuei259 – 2591Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17535.
PaxDbiP17535.
PRIDEiP17535.

PTM databases

PhosphoSiteiP17535.

Expressioni

Gene expression databases

BgeeiP17535.
CleanExiHS_JUND.
ExpressionAtlasiP17535. baseline and differential.
GenevestigatoriP17535.

Organism-specific databases

HPAiCAB005268.
HPA042102.

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTR3P611582EBI-2682803,EBI-351428
FOSP011004EBI-2682803,EBI-852851
MDM2Q009873EBI-2682803,EBI-389668

Protein-protein interaction databases

BioGridi109930. 30 interactions.
DIPiDIP-1053N.
IntActiP17535. 8 interactions.
MINTiMINT-260192.
STRINGi9606.ENSP00000252818.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U86X-ray2.84B27-39[»]
ProteinModelPortaliP17535.
SMRiP17535. Positions 273-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 33164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 29528Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni296 – 32429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1669Poly-Ala

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283376.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP17535.
KOiK04449.
OMAiTQFLYPK.
OrthoDBiEOG75MVXV.
PhylomeDBiP17535.
TreeFamiTF323952.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17535-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL
60 70 80 90 100
TLSLSEQVAA ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
NQLGAGAAAA AAAAAAGGPS GTATGSAPPG ELAPAAAAPE APVYANLSSY
210 220 230 240 250
AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK DEPQTVPDVP
260 270 280 290 300
SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV
310 320 330 340
KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY
Length:347
Mass (Da):35,174
Last modified:May 5, 2009 - v3
Checksum:iFE85A1AA2B5B9597
GO

Sequence cautioni

The sequence CAA40010.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241S → T in CAA40010. (PubMed:1903194)Curated
Sequence conflicti157 – 1571A → R in CAA40010. (PubMed:1903194)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201G → V.1 Publication
Corresponds to variant rs41478151 [ dbSNP | Ensembl ].
VAR_055247

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56681 mRNA. Translation: CAA40010.1. Frameshift.
EF044249 Genomic DNA. Translation: ABJ53425.1.
AK223630 mRNA. Translation: BAD97350.1.
CH471106 Genomic DNA. Translation: EAW84684.1.
X51346 mRNA. Translation: CAA35739.1.
CCDSiCCDS32959.1.
PIRiA43815.
S10184. TVHUJD.
RefSeqiNP_001273897.1. NM_001286968.1.
NP_005345.3. NM_005354.5.
UniGeneiHs.2780.

Genome annotation databases

EnsembliENST00000252818; ENSP00000252818; ENSG00000130522.
GeneIDi3727.
KEGGihsa:3727.
UCSCiuc002nip.2. human.

Polymorphism databases

DMDMi229462969.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56681 mRNA. Translation: CAA40010.1 . Frameshift.
EF044249 Genomic DNA. Translation: ABJ53425.1 .
AK223630 mRNA. Translation: BAD97350.1 .
CH471106 Genomic DNA. Translation: EAW84684.1 .
X51346 mRNA. Translation: CAA35739.1 .
CCDSi CCDS32959.1.
PIRi A43815.
S10184. TVHUJD.
RefSeqi NP_001273897.1. NM_001286968.1.
NP_005345.3. NM_005354.5.
UniGenei Hs.2780.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U86 X-ray 2.84 B 27-39 [» ]
ProteinModelPortali P17535.
SMRi P17535. Positions 273-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109930. 30 interactions.
DIPi DIP-1053N.
IntActi P17535. 8 interactions.
MINTi MINT-260192.
STRINGi 9606.ENSP00000252818.

PTM databases

PhosphoSitei P17535.

Polymorphism databases

DMDMi 229462969.

Proteomic databases

MaxQBi P17535.
PaxDbi P17535.
PRIDEi P17535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252818 ; ENSP00000252818 ; ENSG00000130522 .
GeneIDi 3727.
KEGGi hsa:3727.
UCSCi uc002nip.2. human.

Organism-specific databases

CTDi 3727.
GeneCardsi GC19M018391.
H-InvDB HIX0040163.
HGNCi HGNC:6206. JUND.
HPAi CAB005268.
HPA042102.
MIMi 165162. gene.
neXtProti NX_P17535.
PharmGKBi PA30008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283376.
GeneTreei ENSGT00390000009929.
HOGENOMi HOG000006648.
HOVERGENi HBG001722.
InParanoidi P17535.
KOi K04449.
OMAi TQFLYPK.
OrthoDBi EOG75MVXV.
PhylomeDBi P17535.
TreeFami TF323952.

Enzyme and pathway databases

SignaLinki P17535.

Miscellaneous databases

ChiTaRSi JUND. human.
GeneWikii JunD.
GenomeRNAii 3727.
NextBioi 14591.
PROi P17535.
SOURCEi Search...

Gene expression databases

Bgeei P17535.
CleanExi HS_JUND.
ExpressionAtlasi P17535. baseline and differential.
Genevestigatori P17535.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view ]
PRINTSi PR00043. LEUZIPPRJUN.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of human jun-D."
    Berger I., Shaul Y.
    Oncogene 6:561-566(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIEHS SNPs program
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D."
    Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
    Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347.
  6. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
    Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.
    Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MEN1.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiJUND_HUMAN
AccessioniPrimary (citable) accession number: P17535
Secondary accession number(s): Q53EK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3