Reviewed, UniProtKB/Swiss-Prot P17535 (JUND_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor jun-D

Gene names

Name:

JUND

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds an AP-1 site and upon cotransfection stimulates the activity of a promoter that bears an AP-1 site.
Subunit structure	Binds DNA as a dimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Jun subfamily. Contains 1 bZIP domain.
Sequence caution	The sequence CAA40010.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromatin Ref.1 Traceable author statement. Source: ProtInc nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Transcription factor jun-D		PRO_0000076442
Regions
	Domain	296 – 324	29	Leucine-zipper
	DNA binding	273 – 292	20	Basic motif
	Compositional bias	158 – 166	9	Poly-Ala
Amino acid modifications
	Modified residue	251	1	Phosphoserine Ref.8
	Modified residue	255	1	Phosphoserine Ref.8 Ref.6 Ref.7
	Modified residue	259	1	Phosphoserine Ref.8 Ref.7
Natural variations
	Natural variant	20	1	G → V		VAR_055247
Experimental info
	Sequence conflict	24	1	S → T in CAA40010. Ref.1
	Sequence conflict	157	1	A → R in CAA40010. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P17535-1 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: FE85A1AA2B5B9597	FASTA	347	35,174
	10 20 30 40 50 60 METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL TLSLSEQVAA 70 80 90 100 110 120 ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS 130 140 150 160 170 180 SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ NQLGAGAAAA AAAAAAGGPS GTATGSAPPG 190 200 210 220 230 240 ELAPAAAAPE APVYANLSSY AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK 250 260 270 280 290 300 DEPQTVPDVP SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV 310 320 330 340 KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and function of human jun-D." Berger I., Shaul Y. Oncogene 6:561-566(1991) [PubMed: 1903194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIEHS-SNPs program for genomic applications Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Isolation of human cDNA clones of jun-related genes, jun-B and jun-D." Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. Nucleic Acids Res. 18:3047-3048(1990) [PubMed: 2112242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; SER-255 AND SER-259, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X56681 mRNA. Translation: CAA40010.1. Frameshift. EF044249 Genomic DNA. Translation: ABJ53425.1. AK223630 mRNA. Translation: BAD97350.1. CH471106 Genomic DNA. Translation: EAW84684.1. X51346 mRNA. Translation: CAA35739.1.
IPI	IPI00289547.
PIR	A43815. TVHUJD. S10184.
RefSeq	NP_005345.3.
UniGene	Hs.2780
3D structure databases
HSSP	HSSP built from PDB template 1JNM based on UniProtKB P05412.
SMR	P17535. Positions 269-330.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1053N. DIP:24213N.
PTM databases
PhosphoSite	P17535.
Proteomic databases
PRIDE	P17535.
Genome annotation databases
Ensembl	ENSG00000130522. Homo sapiens. [Contig view]
GeneID	3727.
Organism-specific databases
GeneCards	GC19M018254.
H-InvDB	HIX0040163.
HGNC	HGNC:6206. JUND.
HPA	CAB005268.
MIM	165162. gene.
PharmGKB	PA30008.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P17535.
HOVERGEN	P17535.
Gene expression databases
ArrayExpress	P17535.
Bgee	P17535.
CleanEx	HS_JUND.
GermOnline	ENSG00000130522. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR005643. JNK. IPR002112. Leuzip_Jun. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. PF03957. Jun. 1 hit. [Graphical view]
PRINTS	PR00043. LEUZIPPRJUN.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

JUND_HUMAN

Accession

Primary (citable) accession number: P17535
Secondary accession number(s): Q53EK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	May 5, 2009
Last modified:	June 16, 2009
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)