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P17535

- JUND_HUMAN

UniProt

P17535 - JUND_HUMAN

Protein

Transcription factor jun-D

Gene

JUND

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Transcription factor binding AP-1 sites.1 Publication

    GO - Molecular functioni

    1. double-stranded DNA binding Source: Ensembl
    2. enzyme binding Source: UniProt
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to calcium ion Source: Ensembl
    3. circadian rhythm Source: Ensembl
    4. osteoblast development Source: Ensembl
    5. positive regulation of osteoblast differentiation Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. response to light stimulus Source: Ensembl
    9. response to lipopolysaccharide Source: Ensembl
    10. response to mechanical stimulus Source: Ensembl
    11. response to organic cyclic compound Source: Ensembl
    12. response to peptide hormone Source: Ensembl
    13. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP17535.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor jun-D
    Gene namesi
    Name:JUND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6206. JUND.

    Subcellular locationi

    GO - Cellular componenti

    1. chromatin Source: ProtInc
    2. nucleus Source: HPA
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30008.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Transcription factor jun-DPRO_0000076442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei251 – 2511Phosphoserine1 Publication
    Modified residuei255 – 2551Phosphoserine3 Publications
    Modified residuei259 – 2591Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP17535.
    PaxDbiP17535.
    PRIDEiP17535.

    PTM databases

    PhosphoSiteiP17535.

    Expressioni

    Gene expression databases

    BgeeiP17535.
    CleanExiHS_JUND.
    GenevestigatoriP17535.

    Organism-specific databases

    HPAiCAB005268.
    HPA042102.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer By similarity. Interacts with MEN1; this interaction represses transcriptional activation.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACTR3P611582EBI-2682803,EBI-351428
    FOSP011004EBI-2682803,EBI-852851
    MDM2Q009873EBI-2682803,EBI-389668

    Protein-protein interaction databases

    BioGridi109930. 27 interactions.
    DIPiDIP-1053N.
    IntActiP17535. 8 interactions.
    MINTiMINT-260192.
    STRINGi9606.ENSP00000252818.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3U86X-ray2.84B27-39[»]
    ProteinModelPortaliP17535.
    SMRiP17535. Positions 273-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini268 – 33164bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni268 – 29528Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni296 – 32429Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi158 – 1669Poly-Ala

    Sequence similaritiesi

    Belongs to the bZIP family. Jun subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283376.
    HOGENOMiHOG000006648.
    HOVERGENiHBG001722.
    InParanoidiP17535.
    KOiK04449.
    OMAiTQFLYPK.
    OrthoDBiEOG75MVXV.
    PhylomeDBiP17535.
    TreeFamiTF323952.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view]
    PRINTSiPR00043. LEUZIPPRJUN.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17535-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL    50
    TLSLSEQVAA ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS 100
    PELERLIIQS NGLVTTTPTS SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ 150
    NQLGAGAAAA AAAAAAGGPS GTATGSAPPG ELAPAAAAPE APVYANLSSY 200
    AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK DEPQTVPDVP 250
    SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV 300
    KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY 347
    Length:347
    Mass (Da):35,174
    Last modified:May 5, 2009 - v3
    Checksum:iFE85A1AA2B5B9597
    GO

    Sequence cautioni

    The sequence CAA40010.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241S → T in CAA40010. (PubMed:1903194)Curated
    Sequence conflicti157 – 1571A → R in CAA40010. (PubMed:1903194)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201G → V.1 Publication
    Corresponds to variant rs41478151 [ dbSNP | Ensembl ].
    VAR_055247

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56681 mRNA. Translation: CAA40010.1. Frameshift.
    EF044249 Genomic DNA. Translation: ABJ53425.1.
    AK223630 mRNA. Translation: BAD97350.1.
    CH471106 Genomic DNA. Translation: EAW84684.1.
    X51346 mRNA. Translation: CAA35739.1.
    CCDSiCCDS32959.1.
    PIRiA43815.
    S10184. TVHUJD.
    RefSeqiNP_001273897.1. NM_001286968.1.
    NP_005345.3. NM_005354.5.
    UniGeneiHs.2780.

    Genome annotation databases

    EnsembliENST00000252818; ENSP00000252818; ENSG00000130522.
    GeneIDi3727.
    KEGGihsa:3727.
    UCSCiuc002nip.2. human.

    Polymorphism databases

    DMDMi229462969.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56681 mRNA. Translation: CAA40010.1 . Frameshift.
    EF044249 Genomic DNA. Translation: ABJ53425.1 .
    AK223630 mRNA. Translation: BAD97350.1 .
    CH471106 Genomic DNA. Translation: EAW84684.1 .
    X51346 mRNA. Translation: CAA35739.1 .
    CCDSi CCDS32959.1.
    PIRi A43815.
    S10184. TVHUJD.
    RefSeqi NP_001273897.1. NM_001286968.1.
    NP_005345.3. NM_005354.5.
    UniGenei Hs.2780.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3U86 X-ray 2.84 B 27-39 [» ]
    ProteinModelPortali P17535.
    SMRi P17535. Positions 273-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109930. 27 interactions.
    DIPi DIP-1053N.
    IntActi P17535. 8 interactions.
    MINTi MINT-260192.
    STRINGi 9606.ENSP00000252818.

    PTM databases

    PhosphoSitei P17535.

    Polymorphism databases

    DMDMi 229462969.

    Proteomic databases

    MaxQBi P17535.
    PaxDbi P17535.
    PRIDEi P17535.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252818 ; ENSP00000252818 ; ENSG00000130522 .
    GeneIDi 3727.
    KEGGi hsa:3727.
    UCSCi uc002nip.2. human.

    Organism-specific databases

    CTDi 3727.
    GeneCardsi GC19M018391.
    H-InvDB HIX0040163.
    HGNCi HGNC:6206. JUND.
    HPAi CAB005268.
    HPA042102.
    MIMi 165162. gene.
    neXtProti NX_P17535.
    PharmGKBi PA30008.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283376.
    HOGENOMi HOG000006648.
    HOVERGENi HBG001722.
    InParanoidi P17535.
    KOi K04449.
    OMAi TQFLYPK.
    OrthoDBi EOG75MVXV.
    PhylomeDBi P17535.
    TreeFami TF323952.

    Enzyme and pathway databases

    SignaLinki P17535.

    Miscellaneous databases

    ChiTaRSi JUND. human.
    GeneWikii JunD.
    GenomeRNAii 3727.
    NextBioi 14591.
    PROi P17535.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17535.
    CleanExi HS_JUND.
    Genevestigatori P17535.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view ]
    PRINTSi PR00043. LEUZIPPRJUN.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and function of human jun-D."
      Berger I., Shaul Y.
      Oncogene 6:561-566(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIEHS SNPs program
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D."
      Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
      Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347.
    6. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
      Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.
      Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MEN1.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiJUND_HUMAN
    AccessioniPrimary (citable) accession number: P17535
    Secondary accession number(s): Q53EK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 140 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3