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P17532 (TPH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 5-hydroxylase 1

EC=1.14.16.4
Alternative name(s):
Tryptophan 5-monooxygenase 1
Gene names
Name:Tph1
Synonyms:Tph
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion.

Pathway

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Tryptophan 5-hydroxylase 1
PRO_0000205569

Regions

Domain22 – 9776ACT

Sites

Metal binding2751Iron By similarity
Metal binding2801Iron By similarity
Metal binding3201Iron By similarity
Binding site2381Tryptophan By similarity
Binding site2601Tryptophan By similarity
Binding site2681Tryptophan By similarity
Binding site3391Tryptophan By similarity
Binding site3691Tryptophan; via carbonyl oxygen By similarity

Amino acid modifications

Modified residue611Phosphoserine; by PKA Potential

Sequences

Sequence LengthMass (Da)Tools
P17532 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 16C839F22A138BCA

FASTA44751,343
        10         20         30         40         50         60 
MIEDNKENKE NKDHSSERGR VTLIFSLENE VGGLIKVLKI FQENHVSLLH IESRKSKQRN 

        70         80         90        100        110        120 
SEFEIFVDCD ISREQLNDIF PLLKSHATVL SVDSPDQLTA KEDVMETVPW FPKKISDLDF 

       130        140        150        160        170        180 
CANRVLLYGS ELDADHPGFK DNVYRRRRKY FAELAMNYKH GDPIPKIEFT EEEIKTWGTI 

       190        200        210        220        230        240 
FRELNKLYPT HACREYLRNL PLLSKYCGYR EDNIPQLEDV SNFLKERTGF SIRPVAGYLS 

       250        260        270        280        290        300 
PRDFLSGLAF RVFHCTQYVR HSSDPLYTPE PDTCHELLGH VPLLAEPSFA QFSQEIGLAS 

       310        320        330        340        350        360 
LGASEETVQK LATCYFFTVE FGLCKQDGQL RVFGAGLLSS ISELKHALSG HAKVKPFDPK 

       370        380        390        400        410        420 
IACKQECLIT SFQDVYFVSE SFEDAKEKMR EFAKTVKRPF GLKYNPYTQS VQVLRDTKSI 

       430        440 
TSAMNELRYD LDVISDALAR VTRWPSV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line."
Stoll J., Kozak C.A., Goldman D.
Genomics 7:88-96(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04758 mRNA. Translation: AAA63401.1.
BC072582 mRNA. Translation: AAH72582.1.
CCDSCCDS21280.1.
PIRA34582.
RefSeqNP_001129556.1. NM_001136084.2.
NP_033440.1. NM_009414.3.
XP_006540850.1. XM_006540787.1.
UniGeneMm.248684.
Mm.398047.

3D structure databases

ProteinModelPortalP17532.
SMRP17532. Positions 6-441.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP17532.

Proteomic databases

PaxDbP17532.
PRIDEP17532.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049298; ENSMUSP00000037752; ENSMUSG00000040046.
ENSMUST00000107669; ENSMUSP00000103296; ENSMUSG00000040046.
GeneID21990.
KEGGmmu:21990.
UCSCuc009gyq.2. mouse.

Organism-specific databases

CTD7166.
MGIMGI:98796. Tph1.

Phylogenomic databases

eggNOGCOG3186.
HOGENOMHOG000233373.
HOVERGENHBG006841.
InParanoidP17532.
KOK00502.
OMATWGTVFQ.
OrthoDBEOG7KM5T1.
PhylomeDBP17532.
TreeFamTF313327.

Enzyme and pathway databases

UniPathwayUPA00846; UER00799.

Gene expression databases

ArrayExpressP17532.
BgeeP17532.
CleanExMM_TPH1.
GenevestigatorP17532.

Family and domain databases

Gene3D1.10.800.10. 1 hit.
InterProIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERPTHR11473. PTHR11473. 1 hit.
PfamPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. SSF56534. 1 hit.
TIGRFAMsTIGR01270. Trp_5_monoox. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301724.
PROP17532.
SOURCESearch...

Entry information

Entry nameTPH1_MOUSE
AccessionPrimary (citable) accession number: P17532
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot