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Protein

C-X-C motif chemokine 10

Gene

Cxcl10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
C7
Interferon-gamma induced protein CRG-2
Small-inducible cytokine B10
Gene namesi
Name:Cxcl10
Synonyms:Crg2, Ifi10, Inp10, Scyb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352450. Cxcl10.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 9877C-X-C motif chemokine 10PRO_0000005104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261CitrullineBy similarity
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PRIDEiP17515.

PTM databases

PhosphoSiteiP17515.

Expressioni

Tissue specificityi

Expressed in the spleen, thymus, lymph nodes and liver.1 Publication

Inductioni

By interferon gamma.

Gene expression databases

BgeeiP17515.
CleanExiMM_CXCL10.
ExpressionAtlasiP17515. baseline and differential.
GenevestigatoriP17515.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi42 – 443Combined sources
Beta strandi47 – 515Combined sources
Beta strandi55 – 595Combined sources
Beta strandi61 – 655Combined sources
Turni67 – 693Combined sources
Beta strandi72 – 754Combined sources
Helixi80 – 867Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R3ZX-ray2.50A/B/C/D23-89[»]
ProteinModelPortaliP17515.
SMRiP17515. Positions 22-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47968.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP17515.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
PhylomeDBiP17515.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI
60 70 80 90
IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP
Length:98
Mass (Da):10,789
Last modified:August 1, 1990 - v1
Checksum:i42B0E6A0CC56FE36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33266 mRNA. Translation: AAA02968.1.
M86829 mRNA. Translation: AAA21489.1.
L07417 Genomic DNA. Translation: AAA75249.1.
BC030067 mRNA. Translation: AAH30067.1.
CCDSiCCDS39153.1.
PIRiA45492.
RefSeqiNP_067249.1. NM_021274.2.
UniGeneiMm.877.

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneIDi15945.
KEGGimmu:15945.
UCSCiuc008ycz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33266 mRNA. Translation: AAA02968.1.
M86829 mRNA. Translation: AAA21489.1.
L07417 Genomic DNA. Translation: AAA75249.1.
BC030067 mRNA. Translation: AAH30067.1.
CCDSiCCDS39153.1.
PIRiA45492.
RefSeqiNP_067249.1. NM_021274.2.
UniGeneiMm.877.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R3ZX-ray2.50A/B/C/D23-89[»]
ProteinModelPortaliP17515.
SMRiP17515. Positions 22-89.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP17515.

Proteomic databases

PRIDEiP17515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneIDi15945.
KEGGimmu:15945.
UCSCiuc008ycz.2. mouse.

Organism-specific databases

CTDi3627.
MGIiMGI:1352450. Cxcl10.

Phylogenomic databases

eggNOGiNOG47968.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP17515.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
PhylomeDBiP17515.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP17515.
NextBioi288680.
PROiP17515.
SOURCEiSearch...

Gene expression databases

BgeeiP17515.
CleanExiMM_CXCL10.
ExpressionAtlasiP17515. baseline and differential.
GenevestigatoriP17515.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A macrophage LPS-inducible early gene encodes the murine homologue of IP-10."
    Ohmori Y., Hamilton T.A.
    Biochem. Biophys. Res. Commun. 168:1261-1267(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine."
    Vanguri P., Farber J.M.
    J. Biol. Chem. 265:15049-15057(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter."
    Ohmori Y., Hamilton T.A.
    J. Biol. Chem. 268:6677-6688(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. "Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes."
    Gattass C.R., King L.B., Luster A.D., Ashwell J.D.
    J. Exp. Med. 179:1373-1378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-89, DISULFIDE BONDS.

Entry informationi

Entry nameiCXL10_MOUSE
AccessioniPrimary (citable) accession number: P17515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 27, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.