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P17515

- CXL10_MOUSE

UniProt

P17515 - CXL10_MOUSE

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Protein
C-X-C motif chemokine 10
Gene
Cxcl10, Crg2, Ifi10, Inp10, Scyb10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

GO - Molecular functioni

  1. CXCR3 chemokine receptor binding Source: UniProtKB
  2. chemokine activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. cell chemotaxis Source: GOC
  3. cellular response to heat Source: Ensembl
  4. cellular response to lipopolysaccharide Source: MGI
  5. chemotaxis Source: UniProtKB
  6. defense response to virus Source: MGI
  7. immune response Source: Ensembl
  8. inflammatory response Source: UniProtKB-KW
  9. negative regulation of angiogenesis Source: Ensembl
  10. positive regulation of T cell migration Source: MGI
  11. positive regulation of cAMP metabolic process Source: UniProtKB
  12. positive regulation of cAMP-mediated signaling Source: UniProtKB
  13. positive regulation of cell proliferation Source: InterPro
  14. positive regulation of leukocyte chemotaxis Source: Ensembl
  15. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  16. protein secretion Source: Ensembl
  17. regulation of cell proliferation Source: UniProtKB
  18. response to auditory stimulus Source: Ensembl
  19. response to cold Source: Ensembl
  20. response to gamma radiation Source: Ensembl
  21. response to vitamin D Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
C7
Interferon-gamma induced protein CRG-2
Small-inducible cytokine B10
Gene namesi
Name:Cxcl10
Synonyms:Crg2, Ifi10, Inp10, Scyb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1352450. Cxcl10.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 9877C-X-C motif chemokine 10
PRO_0000005104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Citrulline By similarity
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PRIDEiP17515.

PTM databases

PhosphoSiteiP17515.

Expressioni

Tissue specificityi

Expressed in the spleen, thymus, lymph nodes and liver.1 Publication

Inductioni

By interferon gamma.

Gene expression databases

ArrayExpressiP17515.
BgeeiP17515.
CleanExiMM_CXCL10.
GenevestigatoriP17515.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316
Beta strandi42 – 443
Beta strandi47 – 515
Beta strandi55 – 595
Beta strandi61 – 655
Turni67 – 693
Beta strandi72 – 754
Helixi80 – 867

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R3ZX-ray2.50A/B/C/D23-89[»]
ProteinModelPortaliP17515.
SMRiP17515. Positions 22-89.

Miscellaneous databases

EvolutionaryTraceiP17515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47968.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP17515.
KOiK12671.
OMAiSQSCPRV.
OrthoDBiEOG7HHWVH.
PhylomeDBiP17515.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17515-1 [UniParc]FASTAAdd to Basket

« Hide

MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI   50
IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP 98
Length:98
Mass (Da):10,789
Last modified:August 1, 1990 - v1
Checksum:i42B0E6A0CC56FE36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33266 mRNA. Translation: AAA02968.1.
M86829 mRNA. Translation: AAA21489.1.
L07417 Genomic DNA. Translation: AAA75249.1.
BC030067 mRNA. Translation: AAH30067.1.
CCDSiCCDS39153.1.
PIRiA45492.
RefSeqiNP_067249.1. NM_021274.2.
UniGeneiMm.877.

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneIDi15945.
KEGGimmu:15945.
UCSCiuc008ycz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33266 mRNA. Translation: AAA02968.1 .
M86829 mRNA. Translation: AAA21489.1 .
L07417 Genomic DNA. Translation: AAA75249.1 .
BC030067 mRNA. Translation: AAH30067.1 .
CCDSi CCDS39153.1.
PIRi A45492.
RefSeqi NP_067249.1. NM_021274.2.
UniGenei Mm.877.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2R3Z X-ray 2.50 A/B/C/D 23-89 [» ]
ProteinModelPortali P17515.
SMRi P17515. Positions 22-89.
ModBasei Search...

PTM databases

PhosphoSitei P17515.

Proteomic databases

PRIDEi P17515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038816 ; ENSMUSP00000047646 ; ENSMUSG00000034855 .
GeneIDi 15945.
KEGGi mmu:15945.
UCSCi uc008ycz.2. mouse.

Organism-specific databases

CTDi 3627.
MGIi MGI:1352450. Cxcl10.

Phylogenomic databases

eggNOGi NOG47968.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
InParanoidi P17515.
KOi K12671.
OMAi SQSCPRV.
OrthoDBi EOG7HHWVH.
PhylomeDBi P17515.
TreeFami TF333433.

Miscellaneous databases

EvolutionaryTracei P17515.
NextBioi 288680.
PROi P17515.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17515.
Bgeei P17515.
CleanExi MM_CXCL10.
Genevestigatori P17515.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A macrophage LPS-inducible early gene encodes the murine homologue of IP-10."
    Ohmori Y., Hamilton T.A.
    Biochem. Biophys. Res. Commun. 168:1261-1267(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine."
    Vanguri P., Farber J.M.
    J. Biol. Chem. 265:15049-15057(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter."
    Ohmori Y., Hamilton T.A.
    J. Biol. Chem. 268:6677-6688(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. "Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes."
    Gattass C.R., King L.B., Luster A.D., Ashwell J.D.
    J. Exp. Med. 179:1373-1378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-89, DISULFIDE BONDS.

Entry informationi

Entry nameiCXL10_MOUSE
AccessioniPrimary (citable) accession number: P17515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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