C-X-C motif chemokine 10 precursor - Mus musculus (Mouse)

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P17515 (CXL10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 127. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 10

Alternative name(s):
10 kDa interferon gamma-induced protein
Short name=Gamma-IP10
Short name=IP-10
C7
Interferon-gamma induced protein CRG-2
Small-inducible cytokine B10

Gene names

Name:	Cxcl10
Synonyms:	Crg2, Ifi10, Inp10, Scyb10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
Subcellular location	Secreted.
Tissue specificity	Expressed in the spleen, thymus, lymph nodes and liver. Ref.5
Induction	By interferon gamma.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Citrullination Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to heat Inferred from electronic annotation. Source: Compara chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW defense response to virus Inferred from direct assay PubMed 17277142. Source: MGI immune response Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: InterPro positive regulation of leukocyte chemotaxis Inferred from electronic annotation. Source: Compara protein secretion Inferred from electronic annotation. Source: Compara response to auditory stimulus Inferred from electronic annotation. Source: Compara response to cold Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to vitamin D Inferred from electronic annotation. Source: Compara signal transduction Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 19008373. Source: MGI extracellular space Inferred from direct assay PubMed 11894098 PubMed 17277142. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Potential

Chain

22 – 98

C-X-C motif chemokine 10

PRO_0000005104

Amino acid modifications

Modified residue

Citrulline By similarity

Disulfide bond

Disulfide bond

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P17515 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 42B0E6A0CC56FE36
Show »

FASTA

10,789

        10         20         30         40         50         60 
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI IPASLSCPRV 

        70         80         90 
EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A macrophage LPS-inducible early gene encodes the murine homologue of IP-10." Ohmori Y., Hamilton T.A. Biochem. Biophys. Res. Commun. 168:1261-1267(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine." Vanguri P., Farber J.M. J. Biol. Chem. 265:15049-15057(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter." Ohmori Y., Hamilton T.A. J. Biol. Chem. 268:6677-6688(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DBA/2J. Tissue: Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Thymus.
[5]	"Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes." Gattass C.R., King L.B., Luster A.D., Ashwell J.D. J. Exp. Med. 179:1373-1378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Structure of mouse IP-10, a chemokine." Jabeen T., Leonard P., Jamaluddin H., Acharya K.R. Acta Crystallogr. D 64:611-619(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-89, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M33266 mRNA. Translation: AAA02968.1.
M86829 mRNA. Translation: AAA21489.1.
L07417 Genomic DNA. Translation: AAA75249.1.
BC030067 mRNA. Translation: AAH30067.1.

IPI

IPI00109915.

PIR

A45492.

RefSeq

NP_067249.1. NM_021274.2.

UniGene

Mm.877.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2R3Z	X-ray	2.50	A/B/C/D	23-89	[»]

ProteinModelPortal

P17515.

SMR

P17515. Positions 22-89.

ModBase

Search...

PTM databases

PhosphoSite

P17515.

Proteomic databases

PRIDE

P17515.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.

GeneID

15945.

KEGG

mmu:15945.

Organism-specific databases

CTD

3627.

MGI

MGI:1352450. Cxcl10.

Phylogenomic databases

eggNOG

NOG47968.

HOGENOM

HOG000220915.

HOVERGEN

HBG107789.

InParanoid

P17515.

K12671.

OMA

SCPRVEI.

OrthoDB

EOG4G7C0Z.

Gene expression databases

ArrayExpress

P17515.

Bgee

P17515.

CleanEx

MM_CXCL10.

Genevestigator

P17515.

GermOnline

ENSMUSG00000034855. Mus musculus.

Family and domain databases

InterPro

IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]

PANTHER

PTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.

Pfam

PF00048. IL8. 1 hit.
[Graphical view]

PRINTS

PR00437. SMALLCYTKCXC.

SMART

SM00199. SCY. 1 hit.
[Graphical view]

SUPFAM

SSF54117. Chemokine_IL8. 1 hit.

PROSITE

PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P17515.

NextBio

288680.

SOURCE

Search...

Entry information

Entry name

CXL10_MOUSE

Accession

Primary (citable) accession number: P17515

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents