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P17515

- CXL10_MOUSE

UniProt

P17515 - CXL10_MOUSE

Protein

C-X-C motif chemokine 10

Gene

Cxcl10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB
    2. CXCR3 chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. cellular response to heat Source: Ensembl
    3. cellular response to lipopolysaccharide Source: MGI
    4. chemotaxis Source: UniProtKB
    5. defense response to virus Source: MGI
    6. G-protein coupled receptor signaling pathway Source: UniProtKB
    7. immune response Source: Ensembl
    8. inflammatory response Source: UniProtKB-KW
    9. negative regulation of angiogenesis Source: Ensembl
    10. positive regulation of cAMP-mediated signaling Source: UniProtKB
    11. positive regulation of cAMP metabolic process Source: UniProtKB
    12. positive regulation of cell proliferation Source: InterPro
    13. positive regulation of leukocyte chemotaxis Source: Ensembl
    14. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    15. positive regulation of T cell migration Source: MGI
    16. protein secretion Source: Ensembl
    17. regulation of cell proliferation Source: UniProtKB
    18. response to auditory stimulus Source: Ensembl
    19. response to cold Source: Ensembl
    20. response to gamma radiation Source: Ensembl
    21. response to vitamin D Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 10
    Alternative name(s):
    10 kDa interferon gamma-induced protein
    Short name:
    Gamma-IP10
    Short name:
    IP-10
    C7
    Interferon-gamma induced protein CRG-2
    Small-inducible cytokine B10
    Gene namesi
    Name:Cxcl10
    Synonyms:Crg2, Ifi10, Inp10, Scyb10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1352450. Cxcl10.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 9877C-X-C motif chemokine 10PRO_0000005104Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261CitrullineBy similarity
    Disulfide bondi30 ↔ 571 Publication
    Disulfide bondi32 ↔ 741 Publication

    Keywords - PTMi

    Citrullination, Disulfide bond

    Proteomic databases

    PRIDEiP17515.

    PTM databases

    PhosphoSiteiP17515.

    Expressioni

    Tissue specificityi

    Expressed in the spleen, thymus, lymph nodes and liver.1 Publication

    Inductioni

    By interferon gamma.

    Gene expression databases

    ArrayExpressiP17515.
    BgeeiP17515.
    CleanExiMM_CXCL10.
    GenevestigatoriP17515.

    Structurei

    Secondary structure

    1
    98
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 316
    Beta strandi42 – 443
    Beta strandi47 – 515
    Beta strandi55 – 595
    Beta strandi61 – 655
    Turni67 – 693
    Beta strandi72 – 754
    Helixi80 – 867

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R3ZX-ray2.50A/B/C/D23-89[»]
    ProteinModelPortaliP17515.
    SMRiP17515. Positions 22-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17515.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47968.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiP17515.
    KOiK12671.
    OMAiSQSCPRV.
    OrthoDBiEOG7HHWVH.
    PhylomeDBiP17515.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR027220. Chemokine_CXCL10.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF5. PTHR10179:SF5. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17515-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI   50
    IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP 98
    Length:98
    Mass (Da):10,789
    Last modified:August 1, 1990 - v1
    Checksum:i42B0E6A0CC56FE36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33266 mRNA. Translation: AAA02968.1.
    M86829 mRNA. Translation: AAA21489.1.
    L07417 Genomic DNA. Translation: AAA75249.1.
    BC030067 mRNA. Translation: AAH30067.1.
    CCDSiCCDS39153.1.
    PIRiA45492.
    RefSeqiNP_067249.1. NM_021274.2.
    UniGeneiMm.877.

    Genome annotation databases

    EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
    GeneIDi15945.
    KEGGimmu:15945.
    UCSCiuc008ycz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33266 mRNA. Translation: AAA02968.1 .
    M86829 mRNA. Translation: AAA21489.1 .
    L07417 Genomic DNA. Translation: AAA75249.1 .
    BC030067 mRNA. Translation: AAH30067.1 .
    CCDSi CCDS39153.1.
    PIRi A45492.
    RefSeqi NP_067249.1. NM_021274.2.
    UniGenei Mm.877.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R3Z X-ray 2.50 A/B/C/D 23-89 [» ]
    ProteinModelPortali P17515.
    SMRi P17515. Positions 22-89.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P17515.

    Proteomic databases

    PRIDEi P17515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038816 ; ENSMUSP00000047646 ; ENSMUSG00000034855 .
    GeneIDi 15945.
    KEGGi mmu:15945.
    UCSCi uc008ycz.2. mouse.

    Organism-specific databases

    CTDi 3627.
    MGIi MGI:1352450. Cxcl10.

    Phylogenomic databases

    eggNOGi NOG47968.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi P17515.
    KOi K12671.
    OMAi SQSCPRV.
    OrthoDBi EOG7HHWVH.
    PhylomeDBi P17515.
    TreeFami TF333433.

    Miscellaneous databases

    EvolutionaryTracei P17515.
    NextBioi 288680.
    PROi P17515.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17515.
    Bgeei P17515.
    CleanExi MM_CXCL10.
    Genevestigatori P17515.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR027220. Chemokine_CXCL10.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF5. PTHR10179:SF5. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A macrophage LPS-inducible early gene encodes the murine homologue of IP-10."
      Ohmori Y., Hamilton T.A.
      Biochem. Biophys. Res. Commun. 168:1261-1267(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine."
      Vanguri P., Farber J.M.
      J. Biol. Chem. 265:15049-15057(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter."
      Ohmori Y., Hamilton T.A.
      J. Biol. Chem. 268:6677-6688(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    5. "Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes."
      Gattass C.R., King L.B., Luster A.D., Ashwell J.D.
      J. Exp. Med. 179:1373-1378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-89, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCXL10_MOUSE
    AccessioniPrimary (citable) accession number: P17515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3