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P17515 (CXL10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name=Gamma-IP10
Short name=IP-10
C7
Interferon-gamma induced protein CRG-2
Small-inducible cytokine B10
Gene names
Name:Cxcl10
Synonyms:Crg2, Ifi10, Inp10, Scyb10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

Subcellular location

Secreted.

Tissue specificity

Expressed in the spleen, thymus, lymph nodes and liver. Ref.5

Induction

By interferon gamma.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMCitrullination
Disulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

cell chemotaxis

Inferred from sequence or structural similarity. Source: GOC

cellular response to heat

Inferred from electronic annotation. Source: Ensembl

chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

defense response to virus

Inferred from direct assay PubMed 17277142. Source: MGI

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cAMP-mediated signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from electronic annotation. Source: InterPro

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

protein secretion

Inferred from electronic annotation. Source: Ensembl

regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

response to auditory stimulus

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to vitamin D

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 19008373. Source: MGI

extracellular space

Inferred from direct assay PubMed 11894098PubMed 17277142. Source: MGI

   Molecular_functionCXCR3 chemokine receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

chemokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 9877C-X-C motif chemokine 10
PRO_0000005104

Amino acid modifications

Modified residue261Citrulline By similarity
Disulfide bond30 ↔ 57 Ref.6
Disulfide bond32 ↔ 74 Ref.6

Secondary structure

................. 98
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17515 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 42B0E6A0CC56FE36

FASTA9810,789
        10         20         30         40         50         60 
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI IPASLSCPRV 

        70         80         90 
EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP 

« Hide

References

« Hide 'large scale' references
[1]"A macrophage LPS-inducible early gene encodes the murine homologue of IP-10."
Ohmori Y., Hamilton T.A.
Biochem. Biophys. Res. Commun. 168:1261-1267(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine."
Vanguri P., Farber J.M.
J. Biol. Chem. 265:15049-15057(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter."
Ohmori Y., Hamilton T.A.
J. Biol. Chem. 268:6677-6688(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBA/2J.
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[5]"Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes."
Gattass C.R., King L.B., Luster A.D., Ashwell J.D.
J. Exp. Med. 179:1373-1378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Structure of mouse IP-10, a chemokine."
Jabeen T., Leonard P., Jamaluddin H., Acharya K.R.
Acta Crystallogr. D 64:611-619(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-89, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33266 mRNA. Translation: AAA02968.1.
M86829 mRNA. Translation: AAA21489.1.
L07417 Genomic DNA. Translation: AAA75249.1.
BC030067 mRNA. Translation: AAH30067.1.
PIRA45492.
RefSeqNP_067249.1. NM_021274.2.
UniGeneMm.877.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2R3ZX-ray2.50A/B/C/D23-89[»]
ProteinModelPortalP17515.
SMRP17515. Positions 22-89.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP17515.

Proteomic databases

PRIDEP17515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneID15945.
KEGGmmu:15945.
UCSCuc008ycz.2. mouse.

Organism-specific databases

CTD3627.
MGIMGI:1352450. Cxcl10.

Phylogenomic databases

eggNOGNOG47968.
HOGENOMHOG000220915.
HOVERGENHBG107789.
InParanoidP17515.
KOK12671.
OMASCPRVEI.
OrthoDBEOG7HHWVH.
PhylomeDBP17515.
TreeFamTF333433.

Gene expression databases

ArrayExpressP17515.
BgeeP17515.
CleanExMM_CXCL10.
GenevestigatorP17515.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10/11.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17515.
NextBio288680.
PROP17515.
SOURCESearch...

Entry information

Entry nameCXL10_MOUSE
AccessionPrimary (citable) accession number: P17515
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot