ID   MT2_CAEEL               Reviewed;          63 AA.
AC   P17512;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=Metallothionein-2;
DE            Short=MT-2;
DE   AltName: Full=MT-Ce;
DE   AltName: Full=Metallothionein-II;
DE            Short=MT-II;
DE   AltName: Full=Metallothionein-like protein;
GN   Name=mtl-2; Synonyms=met-2; ORFNames=T08G5.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2294106; DOI=10.1016/s0021-9258(19)40224-x;
RA   Slice L.W., Freedman J.H., Rubin C.S.;
RT   "Purification, characterization, and cDNA cloning of a novel
RT   metallothionein-like, cadmium-binding protein from Caenorhabditis
RT   elegans.";
RL   J. Biol. Chem. 265:256-263(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-15.
RC   STRAIN=Bristol N2;
RX   PubMed=2344361; DOI=10.1042/bj2680237;
RA   Imagawa M., Onozawa T., Okumura K., Osada S., Nishihara T., Kondo M.;
RT   "Characterization of metallothionein cDNAs induced by cadmium in the
RT   nematode Caenorhabditis elegans.";
RL   Biochem. J. 268:237-240(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8428932; DOI=10.1016/s0021-9258(18)53810-2;
RA   Freedman J.H., Slice L.W., Dixon D., Fire A., Rubin C.S.;
RT   "The novel metallothionein genes of Caenorhabditis elegans. Structural
RT   organization and inducible, cell-specific expression.";
RL   J. Biol. Chem. 268:2554-2564(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7848551;
RA   Kugawa F., Yamamoto H., Osada S., Aoki M., Imagawa M., Nishihara T.;
RT   "Metallothionein genes in the nematode Caenorhabditis elegans and metal
RT   inducibility in mammalian culture cells.";
RL   Biomed. Environ. Sci. 7:222-231(1994).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: This protein binds cations of several transition elements.
CC   -!- INDUCTION: By cadmium.
CC   -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC       thought to be the metal-binding sites in other metallothioneins.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 6 family.
CC       {ECO:0000305}.
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DR   EMBL; M32386; AAA28117.1; -; mRNA.
DR   EMBL; M32387; AAA28118.1; -; mRNA.
DR   EMBL; X53245; CAA37335.1; -; mRNA.
DR   EMBL; M92910; AAA28111.1; -; Genomic_DNA.
DR   EMBL; D17365; BAA04181.1; -; Genomic_DNA.
DR   EMBL; Z81589; CAB61028.1; -; Genomic_DNA.
DR   PIR; A45206; A34905.
DR   RefSeq; NP_506482.1; NM_074081.5.
DR   AlphaFoldDB; P17512; -.
DR   BioGRID; 44911; 4.
DR   STRING; 6239.T08G5.10.1; -.
DR   PaxDb; 6239-T08G5-10; -.
DR   PeptideAtlas; P17512; -.
DR   EnsemblMetazoa; T08G5.10.1; T08G5.10.1; WBGene00003474.
DR   GeneID; 179899; -.
DR   KEGG; cel:CELE_T08G5.10; -.
DR   UCSC; R05D3.11; c. elegans.
DR   AGR; WB:WBGene00003474; -.
DR   WormBase; T08G5.10; CE25109; WBGene00003474; mtl-2.
DR   eggNOG; KOG4738; Eukaryota.
DR   GeneTree; ENSGT00970000198152; -.
DR   HOGENOM; CLU_199958_0_0_1; -.
DR   InParanoid; P17512; -.
DR   OMA; CANCECA; -.
DR   OrthoDB; 5640013at2759; -.
DR   PRO; PR:P17512; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003474; Expressed in adult organism and 4 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000853; Metalthion_nemt.
DR   PRINTS; PR00876; MTNEMATODE.
PE   1: Evidence at protein level;
KW   Cadmium; Direct protein sequencing; Metal-binding; Metal-thiolate cluster;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2344361"
FT   CHAIN           2..63
FT                   /note="Metallothionein-2"
FT                   /id="PRO_0000197359"
SQ   SEQUENCE   63 AA;  6594 MW;  5D55EF8A1CBDFADA CRC64;
     MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG CKCANCECAQ
     AAH
//