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P17512 (MT2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-2

Short name=MT-2
Alternative name(s):
MT-Ce
Metallothionein-II
Short name=MT-II
Metallothionein-like protein
Gene names
Name:mtl-2
Synonyms:met-2
ORF Names:T08G5.10
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein binds cations of several transition elements.

Induction

By cadmium.

Domain

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similarities

Belongs to the metallothionein superfamily. Type 6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 6362Metallothionein-2
PRO_0000197359

Sequences

Sequence LengthMass (Da)Tools
P17512 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 5D55EF8A1CBDFADA

FASTA636,594
        10         20         30         40         50         60 
MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG CKCANCECAQ 


AAH 

« Hide

References

« Hide 'large scale' references
[1]"Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans."
Slice L.W., Freedman J.H., Rubin C.S.
J. Biol. Chem. 265:256-263(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of metallothionein cDNAs induced by cadmium in the nematode Caenorhabditis elegans."
Imagawa M., Onozawa T., Okumura K., Osada S., Nishihara T., Kondo M.
Biochem. J. 268:237-240(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-15.
Strain: Bristol N2.
[3]"The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression."
Freedman J.H., Slice L.W., Dixon D., Fire A., Rubin C.S.
J. Biol. Chem. 268:2554-2564(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Metallothionein genes in the nematode Caenorhabditis elegans and metal inducibility in mammalian culture cells."
Kugawa F., Yamamoto H., Osada S., Aoki M., Imagawa M., Nishihara T.
Biomed. Environ. Sci. 7:222-231(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[5]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32386 mRNA. Translation: AAA28117.1.
M32387 mRNA. Translation: AAA28118.1.
X53245 mRNA. Translation: CAA37335.1.
M92910 Genomic DNA. Translation: AAA28111.1.
D17365 Genomic DNA. Translation: BAA04181.1.
Z81589 Genomic DNA. Translation: CAB61028.1.
PIRA34905. A45206.
RefSeqNP_506482.1. NM_074081.5.
UniGeneCel.19721.
Cel.33662.

3D structure databases

ProteinModelPortalP17512.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T08G5.10.

Proteomic databases

PaxDbP17512.
PRIDEP17512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT08G5.10; T08G5.10; WBGene00003474.
GeneID179899.
KEGGcel:CELE_T08G5.10.
UCSCR05D3.11. c. elegans.

Organism-specific databases

CTD179899.
WormBaseT08G5.10; CE25109; WBGene00003474; mtl-2.

Phylogenomic databases

eggNOGNOG331613.
GeneTreeENSGT00390000017933.
HOGENOMHOG000021508.
InParanoidP17512.
OMASTRPRWA.
OrthoDBEOG7NPG1Q.

Family and domain databases

InterProIPR000853. Metalthion_nemt.
[Graphical view]
PRINTSPR00876. MTNEMATODE.
ProtoNetSearch...

Other

NextBio907322.

Entry information

Entry nameMT2_CAEEL
AccessionPrimary (citable) accession number: P17512
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase