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Protein

Metallothionein-2

Gene

mtl-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
MT-Ce
Metallothionein-II
Short name:
MT-II
Metallothionein-like protein
Gene namesi
Name:mtl-2
Synonyms:met-2
ORF Names:T08G5.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT08G5.10; CE25109; WBGene00003474; mtl-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973592 – 63Metallothionein-2Add BLAST62

Proteomic databases

PaxDbiP17512.
PeptideAtlasiP17512.

Expressioni

Inductioni

By cadmium.

Gene expression databases

BgeeiWBGene00003474.

Interactioni

Protein-protein interaction databases

STRINGi6239.T08G5.10.

Structurei

3D structure databases

ProteinModelPortaliP17512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
GeneTreeiENSGT00390000017933.
HOGENOMiHOG000021508.
InParanoidiP17512.
OMAiCANCECA.
OrthoDBiEOG09371CPZ.

Family and domain databases

InterProiView protein in InterPro
IPR000853. Metalthion_nemt.
PRINTSiPR00876. MTNEMATODE.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG
60
CKCANCECAQ AAH
Length:63
Mass (Da):6,594
Last modified:January 23, 2007 - v2
Checksum:i5D55EF8A1CBDFADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32386 mRNA. Translation: AAA28117.1.
M32387 mRNA. Translation: AAA28118.1.
X53245 mRNA. Translation: CAA37335.1.
M92910 Genomic DNA. Translation: AAA28111.1.
D17365 Genomic DNA. Translation: BAA04181.1.
Z81589 Genomic DNA. Translation: CAB61028.1.
PIRiA45206. A34905.
RefSeqiNP_506482.1. NM_074081.5.
UniGeneiCel.19721.
Cel.33662.

Genome annotation databases

EnsemblMetazoaiT08G5.10; T08G5.10; WBGene00003474.
GeneIDi179899.
KEGGicel:CELE_T08G5.10.
UCSCiR05D3.11. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT2_CAEEL
AccessioniPrimary (citable) accession number: P17512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families