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P17512

- MT2_CAEEL

UniProt

P17512 - MT2_CAEEL

Protein

Metallothionein-2

Gene

mtl-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein binds cations of several transition elements.

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Cadmium, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-2
    Short name:
    MT-2
    Alternative name(s):
    MT-Ce
    Metallothionein-II
    Short name:
    MT-II
    Metallothionein-like protein
    Gene namesi
    Name:mtl-2
    Synonyms:met-2
    ORF Names:T08G5.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiT08G5.10; CE25109; WBGene00003474; mtl-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6362Metallothionein-2PRO_0000197359Add
    BLAST

    Proteomic databases

    PaxDbiP17512.
    PRIDEiP17512.

    Expressioni

    Inductioni

    By cadmium.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T08G5.10.

    Structurei

    3D structure databases

    ProteinModelPortaliP17512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG331613.
    GeneTreeiENSGT00390000017933.
    HOGENOMiHOG000021508.
    InParanoidiP17512.
    OMAiSTRPRWA.
    OrthoDBiEOG7NPG1Q.

    Family and domain databases

    InterProiIPR000853. Metalthion_nemt.
    [Graphical view]
    PRINTSiPR00876. MTNEMATODE.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17512-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG   50
    CKCANCECAQ AAH 63
    Length:63
    Mass (Da):6,594
    Last modified:January 23, 2007 - v2
    Checksum:i5D55EF8A1CBDFADA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32386 mRNA. Translation: AAA28117.1.
    M32387 mRNA. Translation: AAA28118.1.
    X53245 mRNA. Translation: CAA37335.1.
    M92910 Genomic DNA. Translation: AAA28111.1.
    D17365 Genomic DNA. Translation: BAA04181.1.
    Z81589 Genomic DNA. Translation: CAB61028.1.
    PIRiA45206. A34905.
    RefSeqiNP_506482.1. NM_074081.5.
    UniGeneiCel.19721.
    Cel.33662.

    Genome annotation databases

    EnsemblMetazoaiT08G5.10; T08G5.10; WBGene00003474.
    GeneIDi179899.
    KEGGicel:CELE_T08G5.10.
    UCSCiR05D3.11. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32386 mRNA. Translation: AAA28117.1 .
    M32387 mRNA. Translation: AAA28118.1 .
    X53245 mRNA. Translation: CAA37335.1 .
    M92910 Genomic DNA. Translation: AAA28111.1 .
    D17365 Genomic DNA. Translation: BAA04181.1 .
    Z81589 Genomic DNA. Translation: CAB61028.1 .
    PIRi A45206. A34905.
    RefSeqi NP_506482.1. NM_074081.5.
    UniGenei Cel.19721.
    Cel.33662.

    3D structure databases

    ProteinModelPortali P17512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T08G5.10.

    Proteomic databases

    PaxDbi P17512.
    PRIDEi P17512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T08G5.10 ; T08G5.10 ; WBGene00003474 .
    GeneIDi 179899.
    KEGGi cel:CELE_T08G5.10.
    UCSCi R05D3.11. c. elegans.

    Organism-specific databases

    CTDi 179899.
    WormBasei T08G5.10 ; CE25109 ; WBGene00003474 ; mtl-2.

    Phylogenomic databases

    eggNOGi NOG331613.
    GeneTreei ENSGT00390000017933.
    HOGENOMi HOG000021508.
    InParanoidi P17512.
    OMAi STRPRWA.
    OrthoDBi EOG7NPG1Q.

    Miscellaneous databases

    NextBioi 907322.

    Family and domain databases

    InterProi IPR000853. Metalthion_nemt.
    [Graphical view ]
    PRINTSi PR00876. MTNEMATODE.
    ProtoNeti Search...

    Publicationsi

    1. "Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans."
      Slice L.W., Freedman J.H., Rubin C.S.
      J. Biol. Chem. 265:256-263(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of metallothionein cDNAs induced by cadmium in the nematode Caenorhabditis elegans."
      Imagawa M., Onozawa T., Okumura K., Osada S., Nishihara T., Kondo M.
      Biochem. J. 268:237-240(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-15.
      Strain: Bristol N2.
    3. "The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression."
      Freedman J.H., Slice L.W., Dixon D., Fire A., Rubin C.S.
      J. Biol. Chem. 268:2554-2564(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Metallothionein genes in the nematode Caenorhabditis elegans and metal inducibility in mammalian culture cells."
      Kugawa F., Yamamoto H., Osada S., Aoki M., Imagawa M., Nishihara T.
      Biomed. Environ. Sci. 7:222-231(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bristol N2.
    5. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMT2_CAEEL
    AccessioniPrimary (citable) accession number: P17512
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Metallothioneins
      Classification of metallothioneins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3