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P17512

- MT2_CAEEL

UniProt

P17512 - MT2_CAEEL

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Protein

Metallothionein-2

Gene

mtl-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Cadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
MT-Ce
Metallothionein-II
Short name:
MT-II
Metallothionein-like protein
Gene namesi
Name:mtl-2
Synonyms:met-2
ORF Names:T08G5.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiT08G5.10; CE25109; WBGene00003474; mtl-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6362Metallothionein-2PRO_0000197359Add
BLAST

Proteomic databases

PaxDbiP17512.
PRIDEiP17512.

Expressioni

Inductioni

By cadmium.

Interactioni

Protein-protein interaction databases

STRINGi6239.T08G5.10.

Structurei

3D structure databases

ProteinModelPortaliP17512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG331613.
GeneTreeiENSGT00390000017933.
HOGENOMiHOG000021508.
InParanoidiP17512.
OMAiSTRPRWA.
OrthoDBiEOG7NPG1Q.

Family and domain databases

InterProiIPR000853. Metalthion_nemt.
[Graphical view]
PRINTSiPR00876. MTNEMATODE.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17512-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG
60
CKCANCECAQ AAH
Length:63
Mass (Da):6,594
Last modified:January 23, 2007 - v2
Checksum:i5D55EF8A1CBDFADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32386 mRNA. Translation: AAA28117.1.
M32387 mRNA. Translation: AAA28118.1.
X53245 mRNA. Translation: CAA37335.1.
M92910 Genomic DNA. Translation: AAA28111.1.
D17365 Genomic DNA. Translation: BAA04181.1.
Z81589 Genomic DNA. Translation: CAB61028.1.
PIRiA45206. A34905.
RefSeqiNP_506482.1. NM_074081.5.
UniGeneiCel.19721.
Cel.33662.

Genome annotation databases

EnsemblMetazoaiT08G5.10; T08G5.10; WBGene00003474.
GeneIDi179899.
KEGGicel:CELE_T08G5.10.
UCSCiR05D3.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32386 mRNA. Translation: AAA28117.1 .
M32387 mRNA. Translation: AAA28118.1 .
X53245 mRNA. Translation: CAA37335.1 .
M92910 Genomic DNA. Translation: AAA28111.1 .
D17365 Genomic DNA. Translation: BAA04181.1 .
Z81589 Genomic DNA. Translation: CAB61028.1 .
PIRi A45206. A34905.
RefSeqi NP_506482.1. NM_074081.5.
UniGenei Cel.19721.
Cel.33662.

3D structure databases

ProteinModelPortali P17512.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T08G5.10.

Proteomic databases

PaxDbi P17512.
PRIDEi P17512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T08G5.10 ; T08G5.10 ; WBGene00003474 .
GeneIDi 179899.
KEGGi cel:CELE_T08G5.10.
UCSCi R05D3.11. c. elegans.

Organism-specific databases

CTDi 179899.
WormBasei T08G5.10 ; CE25109 ; WBGene00003474 ; mtl-2.

Phylogenomic databases

eggNOGi NOG331613.
GeneTreei ENSGT00390000017933.
HOGENOMi HOG000021508.
InParanoidi P17512.
OMAi STRPRWA.
OrthoDBi EOG7NPG1Q.

Miscellaneous databases

NextBioi 907322.

Family and domain databases

InterProi IPR000853. Metalthion_nemt.
[Graphical view ]
PRINTSi PR00876. MTNEMATODE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans."
    Slice L.W., Freedman J.H., Rubin C.S.
    J. Biol. Chem. 265:256-263(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of metallothionein cDNAs induced by cadmium in the nematode Caenorhabditis elegans."
    Imagawa M., Onozawa T., Okumura K., Osada S., Nishihara T., Kondo M.
    Biochem. J. 268:237-240(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-15.
    Strain: Bristol N2.
  3. "The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression."
    Freedman J.H., Slice L.W., Dixon D., Fire A., Rubin C.S.
    J. Biol. Chem. 268:2554-2564(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Metallothionein genes in the nematode Caenorhabditis elegans and metal inducibility in mammalian culture cells."
    Kugawa F., Yamamoto H., Osada S., Aoki M., Imagawa M., Nishihara T.
    Biomed. Environ. Sci. 7:222-231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  5. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMT2_CAEEL
AccessioniPrimary (citable) accession number: P17512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3