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Protein

Metallothionein-1

Gene

mtl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

GO - Biological processi

  • response to lead ion Source: WormBase
  • response to mercury ion Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Cadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:mtl-1
Synonyms:met-1
ORF Names:K11G9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK11G9.6; CE07379; WBGene00003473; mtl-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973582 – 75Metallothionein-1Add BLAST74

Proteomic databases

PaxDbiP17511.
PeptideAtlasiP17511.

Expressioni

Inductioni

By cadmium.

Gene expression databases

BgeeiWBGene00003473.

Interactioni

Protein-protein interaction databases

IntActiP17511. 2 interactors.
STRINGi6239.K11G9.6.

Structurei

3D structure databases

ProteinModelPortaliP17511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
GeneTreeiENSGT00390000017933.
HOGENOMiHOG000021508.
InParanoidiP17511.
KOiK14739.
OMAiCCEEASE.
OrthoDBiEOG091G040P.

Family and domain databases

InterProiIPR000853. Metalthion_nemt.
[Graphical view]
PRINTSiPR00876. MTNEMATODE.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKCDCKNK QCKCGDKCEC SGDKCCEKYC CEEASEKKCC PAGCKGDCKC
60 70
ANCHCAEQKQ CGDKTHQHQG TAAAH
Length:75
Mass (Da):8,090
Last modified:January 23, 2007 - v2
Checksum:iDA0D5FAFC43D26FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → G AA sequence (PubMed:2344361).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53244 mRNA. Translation: CAA37334.1.
M92909 Genomic DNA. Translation: AAA28110.1.
D17364 Genomic DNA. Translation: BAA04180.1.
FO081629 Genomic DNA. Translation: CCD72928.1.
PIRiB45206.
RefSeqiNP_504696.1. NM_072295.5.
UniGeneiCel.19722.

Genome annotation databases

EnsemblMetazoaiK11G9.6; K11G9.6; WBGene00003473.
GeneIDi179060.
KEGGicel:CELE_K11G9.6.
UCSCiC43E11.3a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53244 mRNA. Translation: CAA37334.1.
M92909 Genomic DNA. Translation: AAA28110.1.
D17364 Genomic DNA. Translation: BAA04180.1.
FO081629 Genomic DNA. Translation: CCD72928.1.
PIRiB45206.
RefSeqiNP_504696.1. NM_072295.5.
UniGeneiCel.19722.

3D structure databases

ProteinModelPortaliP17511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17511. 2 interactors.
STRINGi6239.K11G9.6.

Proteomic databases

PaxDbiP17511.
PeptideAtlasiP17511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK11G9.6; K11G9.6; WBGene00003473.
GeneIDi179060.
KEGGicel:CELE_K11G9.6.
UCSCiC43E11.3a. c. elegans.

Organism-specific databases

CTDi179060.
WormBaseiK11G9.6; CE07379; WBGene00003473; mtl-1.

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
GeneTreeiENSGT00390000017933.
HOGENOMiHOG000021508.
InParanoidiP17511.
KOiK14739.
OMAiCCEEASE.
OrthoDBiEOG091G040P.

Miscellaneous databases

PROiP17511.

Gene expression databases

BgeeiWBGene00003473.

Family and domain databases

InterProiIPR000853. Metalthion_nemt.
[Graphical view]
PRINTSiPR00876. MTNEMATODE.
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_CAEEL
AccessioniPrimary (citable) accession number: P17511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.