Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallothionein-1

Gene

mtl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

GO - Biological processi

  • response to lead ion Source: WormBase
  • response to mercury ion Source: WormBase

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:mtl-1
Synonyms:met-1
ORF Names:K11G9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK11G9.6; CE07379; WBGene00003473; mtl-1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973582 – 75Metallothionein-1Add BLAST74

Proteomic databases

PaxDbiP17511.
PeptideAtlasiP17511.

Expressioni

Inductioni

By cadmium.

Gene expression databases

BgeeiWBGene00003473.

Interactioni

Protein-protein interaction databases

IntActiP17511. 2 interactors.
STRINGi6239.K11G9.6.

Structurei

3D structure databases

ProteinModelPortaliP17511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
GeneTreeiENSGT00390000017933.
HOGENOMiHOG000021508.
InParanoidiP17511.
KOiK14739.
OMAiCCEEASE.
OrthoDBiEOG093718IZ.

Family and domain databases

InterProiView protein in InterPro
IPR000853. Metalthion_nemt.
PRINTSiPR00876. MTNEMATODE.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKCDCKNK QCKCGDKCEC SGDKCCEKYC CEEASEKKCC PAGCKGDCKC
60 70
ANCHCAEQKQ CGDKTHQHQG TAAAH
Length:75
Mass (Da):8,090
Last modified:January 23, 2007 - v2
Checksum:iDA0D5FAFC43D26FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → G AA sequence (PubMed:2344361).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53244 mRNA. Translation: CAA37334.1.
M92909 Genomic DNA. Translation: AAA28110.1.
D17364 Genomic DNA. Translation: BAA04180.1.
FO081629 Genomic DNA. Translation: CCD72928.1.
PIRiB45206.
RefSeqiNP_504696.1. NM_072295.5.
UniGeneiCel.19722.

Genome annotation databases

EnsemblMetazoaiK11G9.6; K11G9.6; WBGene00003473.
GeneIDi179060.
KEGGicel:CELE_K11G9.6.
UCSCiC43E11.3a. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT1_CAEEL
AccessioniPrimary (citable) accession number: P17511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families