P17509 (HXB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B6

Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2

Gene names

Name:	HOXB6
Synonyms:	HOX2B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification, embryo Non-traceable author statement. Source: UniProtKB embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara erythrocyte homeostasis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P17509-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P17509-2)

Also known as: Homeobox-less;

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Homeobox protein Hox-B6		PRO_0000200135
Regions
	DNA binding	146 – 205	60	Homeobox
	Motif	127 – 132	6	Antp-type hexapeptide
	Compositional bias	216 – 220	5	Poly-Glu
Amino acid modifications
	Modified residue	214	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	140	1	S → E in isoform 2.		VSP_002388
	Alternative sequence	141 – 224	84	Missing in isoform 2.		VSP_002389
Experimental info
	Sequence conflict	24 – 25	2	QL → HV in CAA41335. Ref.1
	Sequence conflict	24 – 25	2	QL → HV in CAB65909. Ref.2
	Sequence conflict	33	1	A → R in CAA41335. Ref.1
	Sequence conflict	60	1	P → R in CAA41335. Ref.1
	Sequence conflict	73	1	D → A in CAA41335. Ref.1
	Sequence conflict	149 – 150	2	GR → A in AAA36004. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 4. Checksum: F60292D4D664099C	FASTA	224	25,432
	10 20 30 40 50 60 MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP 70 80 90 100 110 120 PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 130 140 150 160 170 180 QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA 190 200 210 220 HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KQAE
	Isoform 2 (Homeobox-less) [UniParc]. Checksum: 6B18215988D4750F	FASTA	140	15,172
	10 20 30 40 50 60 MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP 70 80 90 100 110 120 PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 130 140 QKCSTPVYPW MQRMNSCNSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues." Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C. Nucleic Acids Res. 19:539-545(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Tissue: Placenta.
[2]	"Expression of HOX genes in T lymphocytes and hairy leukemia cell lines." Frezza D., D'Esposito M., Migliaccio E., Santini S.M., Fruscalzo A. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster." Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J. Am. J. Hum. Genet. 67:235-235(2000) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[7]	"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines." Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J. Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-224.
[8]	"Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila." Levine M., Rubin G.M., Tjian R. Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 136-224.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X58431 Genomic DNA. Translation: CAA41335.1. X58431 Genomic DNA. Translation: CAA41336.1. AJ270993 mRNA. Translation: CAB65909.1. AF287967 Genomic DNA. Translation: AAG31552.1. AK292200 mRNA. Translation: BAF84889.1. CH471109 Genomic DNA. Translation: EAW94728.1. CH471109 Genomic DNA. Translation: EAW94729.1. CH471109 Genomic DNA. Translation: EAW94730.1. CH471109 Genomic DNA. Translation: EAW94731.1. BC014651 mRNA. Translation: AAH14651.1. M30597 mRNA. Translation: AAA36004.1. K02571 Genomic DNA. No translation available.
IPI	IPI00015075. IPI00216597.
PIR	A05266. S26400.
RefSeq	NP_061825.2. NM_018952.4.
UniGene	Hs.98428.
3D structure databases
ProteinModelPortal	P17509.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17509. 3 interactions.
MINT	MINT-1437085.
STRING	9606.ENSP00000225648.
PTM databases
PhosphoSite	P17509.
Polymorphism databases
DMDM	116242515.
Proteomic databases
PaxDb	P17509.
PRIDE	P17509.
Protocols and materials databases
DNASU	3216.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225648; ENSP00000225648; ENSG00000108511. ENST00000484302; ENSP00000420009; ENSG00000108511.
GeneID	3216.
KEGG	hsa:3216.
UCSC	uc002ins.1. human. uc002int.1. human.
Organism-specific databases
CTD	3216.
GeneCards	GC17M046673.
HGNC	HGNC:5117. HOXB6.
HPA	HPA042063.
MIM	142961. gene.
neXtProt	NX_P17509.
PharmGKB	PA29393.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305812.
HOGENOM	HOG000231181.
HOVERGEN	HBG016849.
InParanoid	P17509.
KO	K09306.
OMA	AEGSCAF.
OrthoDB	EOG4G7C0G.
PhylomeDB	P17509.
Gene expression databases
Bgee	P17509.
CleanEx	HS_HOXB6.
Genevestigator	P17509.
GermOnline	ENSG00000108511. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3216.
NextBio	12796.
SOURCE	Search...

Entry information

Entry name

HXB6_HUMAN

Accession

Primary (citable) accession number: P17509
Secondary accession number(s): A8K835 , D3DTV5, P09068, Q9HB11, Q9UGH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 145 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.