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P17509

- HXB6_HUMAN

UniProt

P17509 - HXB6_HUMAN

Protein

Homeobox protein Hox-B6

Gene

HOXB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 4 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system morphogenesis Source: Ensembl
    3. erythrocyte homeostasis Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B6
    Alternative name(s):
    Homeobox protein Hox-2.2
    Homeobox protein Hox-2B
    Homeobox protein Hu-2
    Gene namesi
    Name:HOXB6
    Synonyms:HOX2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5117. HOXB6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29393.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Homeobox protein Hox-B6PRO_0000200135Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei214 – 2141Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP17509.
    PRIDEiP17509.

    PTM databases

    PhosphoSiteiP17509.

    Expressioni

    Gene expression databases

    BgeeiP17509.
    CleanExiHS_HOXB6.
    GenevestigatoriP17509.

    Organism-specific databases

    HPAiHPA042063.

    Interactioni

    Protein-protein interaction databases

    BioGridi109456. 7 interactions.
    IntActiP17509. 3 interactions.
    MINTiMINT-1437085.
    STRINGi9606.ENSP00000225648.

    Structurei

    3D structure databases

    ProteinModelPortaliP17509.
    SMRiP17509. Positions 150-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi127 – 1326Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi216 – 2205Poly-Glu

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG305812.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP17509.
    KOiK09306.
    OMAiQEPFLGQ.
    OrthoDBiEOG780RP4.
    PhylomeDBiP17509.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD    50
    KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH 100
    PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR 150
    QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK 200
    WKKESKLLSA SQLSAEEEEE KQAE 224
    Length:224
    Mass (Da):25,432
    Last modified:October 17, 2006 - v4
    Checksum:iF60292D4D664099C
    GO
    Isoform 2 (identifier: P17509-2) [UniParc]FASTAAdd to Basket

    Also known as: Homeobox-less

    The sequence of this isoform differs from the canonical sequence as follows:
         140-140: S → E
         141-224: Missing.

    Show »
    Length:140
    Mass (Da):15,172
    Checksum:i6B18215988D4750F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 252QL → HV in CAA41335. (PubMed:1672751)Curated
    Sequence conflicti24 – 252QL → HV in CAB65909. 1 PublicationCurated
    Sequence conflicti33 – 331A → R in CAA41335. (PubMed:1672751)Curated
    Sequence conflicti60 – 601P → R in CAA41335. (PubMed:1672751)Curated
    Sequence conflicti73 – 731D → A in CAA41335. (PubMed:1672751)Curated
    Sequence conflicti149 – 1502GR → A in AAA36004. (PubMed:2573064)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei140 – 1401S → E in isoform 2. CuratedVSP_002388
    Alternative sequencei141 – 22484Missing in isoform 2. CuratedVSP_002389Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58431 Genomic DNA. Translation: CAA41335.1.
    X58431 Genomic DNA. Translation: CAA41336.1.
    AJ270993 mRNA. Translation: CAB65909.1.
    AF287967 Genomic DNA. Translation: AAG31552.1.
    AK292200 mRNA. Translation: BAF84889.1.
    CH471109 Genomic DNA. Translation: EAW94728.1.
    CH471109 Genomic DNA. Translation: EAW94729.1.
    CH471109 Genomic DNA. Translation: EAW94730.1.
    CH471109 Genomic DNA. Translation: EAW94731.1.
    BC014651 mRNA. Translation: AAH14651.1.
    M30597 mRNA. Translation: AAA36004.1.
    K02571 Genomic DNA. No translation available.
    CCDSiCCDS11531.1. [P17509-1]
    PIRiA05266.
    S26400.
    RefSeqiNP_061825.2. NM_018952.4. [P17509-1]
    XP_005257340.1. XM_005257283.2. [P17509-1]
    XP_005257341.1. XM_005257284.2. [P17509-1]
    XP_006721919.1. XM_006721856.1. [P17509-1]
    UniGeneiHs.98428.

    Genome annotation databases

    EnsembliENST00000225648; ENSP00000225648; ENSG00000108511. [P17509-1]
    ENST00000484302; ENSP00000420009; ENSG00000108511. [P17509-1]
    GeneIDi3216.
    KEGGihsa:3216.
    UCSCiuc002ins.1. human. [P17509-1]
    uc002int.1. human. [P17509-2]

    Polymorphism databases

    DMDMi116242515.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58431 Genomic DNA. Translation: CAA41335.1 .
    X58431 Genomic DNA. Translation: CAA41336.1 .
    AJ270993 mRNA. Translation: CAB65909.1 .
    AF287967 Genomic DNA. Translation: AAG31552.1 .
    AK292200 mRNA. Translation: BAF84889.1 .
    CH471109 Genomic DNA. Translation: EAW94728.1 .
    CH471109 Genomic DNA. Translation: EAW94729.1 .
    CH471109 Genomic DNA. Translation: EAW94730.1 .
    CH471109 Genomic DNA. Translation: EAW94731.1 .
    BC014651 mRNA. Translation: AAH14651.1 .
    M30597 mRNA. Translation: AAA36004.1 .
    K02571 Genomic DNA. No translation available.
    CCDSi CCDS11531.1. [P17509-1 ]
    PIRi A05266.
    S26400.
    RefSeqi NP_061825.2. NM_018952.4. [P17509-1 ]
    XP_005257340.1. XM_005257283.2. [P17509-1 ]
    XP_005257341.1. XM_005257284.2. [P17509-1 ]
    XP_006721919.1. XM_006721856.1. [P17509-1 ]
    UniGenei Hs.98428.

    3D structure databases

    ProteinModelPortali P17509.
    SMRi P17509. Positions 150-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109456. 7 interactions.
    IntActi P17509. 3 interactions.
    MINTi MINT-1437085.
    STRINGi 9606.ENSP00000225648.

    PTM databases

    PhosphoSitei P17509.

    Polymorphism databases

    DMDMi 116242515.

    Proteomic databases

    PaxDbi P17509.
    PRIDEi P17509.

    Protocols and materials databases

    DNASUi 3216.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225648 ; ENSP00000225648 ; ENSG00000108511 . [P17509-1 ]
    ENST00000484302 ; ENSP00000420009 ; ENSG00000108511 . [P17509-1 ]
    GeneIDi 3216.
    KEGGi hsa:3216.
    UCSCi uc002ins.1. human. [P17509-1 ]
    uc002int.1. human. [P17509-2 ]

    Organism-specific databases

    CTDi 3216.
    GeneCardsi GC17M046673.
    HGNCi HGNC:5117. HOXB6.
    HPAi HPA042063.
    MIMi 142961. gene.
    neXtProti NX_P17509.
    PharmGKBi PA29393.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305812.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P17509.
    KOi K09306.
    OMAi QEPFLGQ.
    OrthoDBi EOG780RP4.
    PhylomeDBi P17509.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXB6.
    GenomeRNAii 3216.
    NextBioi 12796.
    PROi P17509.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17509.
    CleanExi HS_HOXB6.
    Genevestigatori P17509.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues."
      Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.
      Nucleic Acids Res. 19:539-545(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Tissue: Placenta.
    2. "Expression of HOX genes in T lymphocytes and hairy leukemia cell lines."
      Frezza D., D'Esposito M., Migliaccio E., Santini S.M., Fruscalzo A.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
      Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
      Am. J. Hum. Genet. 67:235-235(2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    7. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
      Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
      Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-224.
    8. "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
      Levine M., Rubin G.M., Tjian R.
      Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 136-224.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHXB6_HUMAN
    AccessioniPrimary (citable) accession number: P17509
    Secondary accession number(s): A8K835
    , D3DTV5, P09068, Q9HB11, Q9UGH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 156 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3