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P17509 (HXB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 155. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2
Gene names
Name:HOXB6
Synonyms:HOX2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17509-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17509-2)

Also known as: Homeobox-less;

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Homeobox protein Hox-B6
PRO_0000200135

Regions

DNA binding146 – 20560Homeobox
Motif127 – 1326Antp-type hexapeptide
Compositional bias216 – 2205Poly-Glu

Amino acid modifications

Modified residue2141Phosphoserine Ref.9

Natural variations

Alternative sequence1401S → E in isoform 2.
VSP_002388
Alternative sequence141 – 22484Missing in isoform 2.
VSP_002389

Experimental info

Sequence conflict24 – 252QL → HV in CAA41335. Ref.1
Sequence conflict24 – 252QL → HV in CAB65909. Ref.2
Sequence conflict331A → R in CAA41335. Ref.1
Sequence conflict601P → R in CAA41335. Ref.1
Sequence conflict731D → A in CAA41335. Ref.1
Sequence conflict149 – 1502GR → A in AAA36004. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: F60292D4D664099C

FASTA22425,432
        10         20         30         40         50         60 
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP 

        70         80         90        100        110        120 
PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 

       130        140        150        160        170        180 
QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA 

       190        200        210        220 
HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KQAE 

« Hide

Isoform 2 (Homeobox-less) [UniParc].

Checksum: 6B18215988D4750F
Show »

FASTA14015,172

References

« Hide 'large scale' references
[1]"Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues."
Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.
Nucleic Acids Res. 19:539-545(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Tissue: Placenta.
[2]"Expression of HOX genes in T lymphocytes and hairy leukemia cell lines."
Frezza D., D'Esposito M., Migliaccio E., Santini S.M., Fruscalzo A.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
Am. J. Hum. Genet. 67:235-235(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[7]"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-224.
[8]"Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
Levine M., Rubin G.M., Tjian R.
Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 136-224.
[9]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58431 Genomic DNA. Translation: CAA41335.1.
X58431 Genomic DNA. Translation: CAA41336.1.
AJ270993 mRNA. Translation: CAB65909.1.
AF287967 Genomic DNA. Translation: AAG31552.1.
AK292200 mRNA. Translation: BAF84889.1.
CH471109 Genomic DNA. Translation: EAW94728.1.
CH471109 Genomic DNA. Translation: EAW94729.1.
CH471109 Genomic DNA. Translation: EAW94730.1.
CH471109 Genomic DNA. Translation: EAW94731.1.
BC014651 mRNA. Translation: AAH14651.1.
M30597 mRNA. Translation: AAA36004.1.
K02571 Genomic DNA. No translation available.
CCDSCCDS11531.1. [P17509-1]
PIRA05266.
S26400.
RefSeqNP_061825.2. NM_018952.4. [P17509-1]
XP_005257340.1. XM_005257283.2. [P17509-1]
XP_005257341.1. XM_005257284.2. [P17509-1]
XP_006721919.1. XM_006721856.1. [P17509-1]
UniGeneHs.98428.

3D structure databases

ProteinModelPortalP17509.
SMRP17509. Positions 150-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109456. 7 interactions.
IntActP17509. 3 interactions.
MINTMINT-1437085.
STRING9606.ENSP00000225648.

PTM databases

PhosphoSiteP17509.

Polymorphism databases

DMDM116242515.

Proteomic databases

PaxDbP17509.
PRIDEP17509.

Protocols and materials databases

DNASU3216.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225648; ENSP00000225648; ENSG00000108511. [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511. [P17509-1]
GeneID3216.
KEGGhsa:3216.
UCSCuc002ins.1. human. [P17509-1]
uc002int.1. human. [P17509-2]

Organism-specific databases

CTD3216.
GeneCardsGC17M046673.
HGNCHGNC:5117. HOXB6.
HPAHPA042063.
MIM142961. gene.
neXtProtNX_P17509.
PharmGKBPA29393.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305812.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP17509.
KOK09306.
OMAQEPFLGQ.
OrthoDBEOG780RP4.
PhylomeDBP17509.
TreeFamTF316310.

Gene expression databases

BgeeP17509.
CleanExHS_HOXB6.
GenevestigatorP17509.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB6.
GenomeRNAi3216.
NextBio12796.
PROP17509.
SOURCESearch...

Entry information

Entry nameHXB6_HUMAN
AccessionPrimary (citable) accession number: P17509
Secondary accession number(s): A8K835 expand/collapse secondary AC list , D3DTV5, P09068, Q9HB11, Q9UGH2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries