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P17509

- HXB6_HUMAN

UniProt

P17509 - HXB6_HUMAN

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Protein
Homeobox protein Hox-B6
Gene
HOXB6, HOX2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560Homeobox
Add
BLAST

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. erythrocyte homeostasis Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2
Gene namesi
Name:HOXB6
Synonyms:HOX2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5117. HOXB6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Homeobox protein Hox-B6
PRO_0000200135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP17509.
PRIDEiP17509.

PTM databases

PhosphoSiteiP17509.

Expressioni

Gene expression databases

BgeeiP17509.
CleanExiHS_HOXB6.
GenevestigatoriP17509.

Organism-specific databases

HPAiHPA042063.

Interactioni

Protein-protein interaction databases

BioGridi109456. 7 interactions.
IntActiP17509. 3 interactions.
MINTiMINT-1437085.
STRINGi9606.ENSP00000225648.

Structurei

3D structure databases

ProteinModelPortaliP17509.
SMRiP17509. Positions 150-205.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2205Poly-Glu

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305812.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17509.
KOiK09306.
OMAiQEPFLGQ.
OrthoDBiEOG780RP4.
PhylomeDBiP17509.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD    50
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH 100
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR 150
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK 200
WKKESKLLSA SQLSAEEEEE KQAE 224
Length:224
Mass (Da):25,432
Last modified:October 17, 2006 - v4
Checksum:iF60292D4D664099C
GO
Isoform 2 (identifier: P17509-2) [UniParc]FASTAAdd to Basket

Also known as: Homeobox-less

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Show »
Length:140
Mass (Da):15,172
Checksum:i6B18215988D4750F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 1401S → E in isoform 2.
VSP_002388
Alternative sequencei141 – 22484Missing in isoform 2.
VSP_002389Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 252QL → HV in CAA41335. 1 Publication
Sequence conflicti24 – 252QL → HV in CAB65909. 1 Publication
Sequence conflicti33 – 331A → R in CAA41335. 1 Publication
Sequence conflicti60 – 601P → R in CAA41335. 1 Publication
Sequence conflicti73 – 731D → A in CAA41335. 1 Publication
Sequence conflicti149 – 1502GR → A in AAA36004. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58431 Genomic DNA. Translation: CAA41335.1.
X58431 Genomic DNA. Translation: CAA41336.1.
AJ270993 mRNA. Translation: CAB65909.1.
AF287967 Genomic DNA. Translation: AAG31552.1.
AK292200 mRNA. Translation: BAF84889.1.
CH471109 Genomic DNA. Translation: EAW94728.1.
CH471109 Genomic DNA. Translation: EAW94729.1.
CH471109 Genomic DNA. Translation: EAW94730.1.
CH471109 Genomic DNA. Translation: EAW94731.1.
BC014651 mRNA. Translation: AAH14651.1.
M30597 mRNA. Translation: AAA36004.1.
K02571 Genomic DNA. No translation available.
CCDSiCCDS11531.1. [P17509-1]
PIRiA05266.
S26400.
RefSeqiNP_061825.2. NM_018952.4. [P17509-1]
XP_005257340.1. XM_005257283.2. [P17509-1]
XP_005257341.1. XM_005257284.2. [P17509-1]
XP_006721919.1. XM_006721856.1. [P17509-1]
UniGeneiHs.98428.

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511. [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511. [P17509-1]
GeneIDi3216.
KEGGihsa:3216.
UCSCiuc002ins.1. human. [P17509-1]
uc002int.1. human. [P17509-2]

Polymorphism databases

DMDMi116242515.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58431 Genomic DNA. Translation: CAA41335.1 .
X58431 Genomic DNA. Translation: CAA41336.1 .
AJ270993 mRNA. Translation: CAB65909.1 .
AF287967 Genomic DNA. Translation: AAG31552.1 .
AK292200 mRNA. Translation: BAF84889.1 .
CH471109 Genomic DNA. Translation: EAW94728.1 .
CH471109 Genomic DNA. Translation: EAW94729.1 .
CH471109 Genomic DNA. Translation: EAW94730.1 .
CH471109 Genomic DNA. Translation: EAW94731.1 .
BC014651 mRNA. Translation: AAH14651.1 .
M30597 mRNA. Translation: AAA36004.1 .
K02571 Genomic DNA. No translation available.
CCDSi CCDS11531.1. [P17509-1 ]
PIRi A05266.
S26400.
RefSeqi NP_061825.2. NM_018952.4. [P17509-1 ]
XP_005257340.1. XM_005257283.2. [P17509-1 ]
XP_005257341.1. XM_005257284.2. [P17509-1 ]
XP_006721919.1. XM_006721856.1. [P17509-1 ]
UniGenei Hs.98428.

3D structure databases

ProteinModelPortali P17509.
SMRi P17509. Positions 150-205.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109456. 7 interactions.
IntActi P17509. 3 interactions.
MINTi MINT-1437085.
STRINGi 9606.ENSP00000225648.

PTM databases

PhosphoSitei P17509.

Polymorphism databases

DMDMi 116242515.

Proteomic databases

PaxDbi P17509.
PRIDEi P17509.

Protocols and materials databases

DNASUi 3216.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225648 ; ENSP00000225648 ; ENSG00000108511 . [P17509-1 ]
ENST00000484302 ; ENSP00000420009 ; ENSG00000108511 . [P17509-1 ]
GeneIDi 3216.
KEGGi hsa:3216.
UCSCi uc002ins.1. human. [P17509-1 ]
uc002int.1. human. [P17509-2 ]

Organism-specific databases

CTDi 3216.
GeneCardsi GC17M046673.
HGNCi HGNC:5117. HOXB6.
HPAi HPA042063.
MIMi 142961. gene.
neXtProti NX_P17509.
PharmGKBi PA29393.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305812.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P17509.
KOi K09306.
OMAi QEPFLGQ.
OrthoDBi EOG780RP4.
PhylomeDBi P17509.
TreeFami TF316310.

Miscellaneous databases

GeneWikii HOXB6.
GenomeRNAii 3216.
NextBioi 12796.
PROi P17509.
SOURCEi Search...

Gene expression databases

Bgeei P17509.
CleanExi HS_HOXB6.
Genevestigatori P17509.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues."
    Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.
    Nucleic Acids Res. 19:539-545(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: Placenta.
  2. "Expression of HOX genes in T lymphocytes and hairy leukemia cell lines."
    Frezza D., D'Esposito M., Migliaccio E., Santini S.M., Fruscalzo A.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
    Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-224.
  8. "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
    Levine M., Rubin G.M., Tjian R.
    Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 136-224.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHXB6_HUMAN
AccessioniPrimary (citable) accession number: P17509
Secondary accession number(s): A8K835
, D3DTV5, P09068, Q9HB11, Q9UGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

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