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Protein

Homeobox protein Hox-B6

Gene

HOXB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. erythrocyte homeostasis Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2
Gene namesi
Name:HOXB6
Synonyms:HOX2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5117. HOXB6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Homeobox protein Hox-B6PRO_0000200135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17509.
PaxDbiP17509.
PRIDEiP17509.

PTM databases

PhosphoSiteiP17509.

Expressioni

Gene expression databases

BgeeiP17509.
CleanExiHS_HOXB6.
GenevestigatoriP17509.

Organism-specific databases

HPAiHPA042063.

Interactioni

Protein-protein interaction databases

BioGridi109456. 9 interactions.
IntActiP17509. 3 interactions.
MINTiMINT-1437085.
STRINGi9606.ENSP00000225648.

Structurei

3D structure databases

ProteinModelPortaliP17509.
SMRiP17509. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2205Poly-Glu

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305812.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17509.
KOiK09306.
OMAiQEPFLGQ.
OrthoDBiEOG780RP4.
PhylomeDBiP17509.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD
60 70 80 90 100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH
110 120 130 140 150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR
160 170 180 190 200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
210 220
WKKESKLLSA SQLSAEEEEE KQAE
Length:224
Mass (Da):25,432
Last modified:October 17, 2006 - v4
Checksum:iF60292D4D664099C
GO
Isoform 2 (identifier: P17509-2) [UniParc]FASTAAdd to Basket

Also known as: Homeobox-less

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Show »
Length:140
Mass (Da):15,172
Checksum:i6B18215988D4750F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 252QL → HV in CAA41335. (PubMed:1672751)Curated
Sequence conflicti24 – 252QL → HV in CAB65909. 1 PublicationCurated
Sequence conflicti33 – 331A → R in CAA41335. (PubMed:1672751)Curated
Sequence conflicti60 – 601P → R in CAA41335. (PubMed:1672751)Curated
Sequence conflicti73 – 731D → A in CAA41335. (PubMed:1672751)Curated
Sequence conflicti149 – 1502GR → A in AAA36004. (PubMed:2573064)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 1401S → E in isoform 2. CuratedVSP_002388
Alternative sequencei141 – 22484Missing in isoform 2. CuratedVSP_002389Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58431 Genomic DNA. Translation: CAA41335.1.
X58431 Genomic DNA. Translation: CAA41336.1.
AJ270993 mRNA. Translation: CAB65909.1.
AF287967 Genomic DNA. Translation: AAG31552.1.
AK292200 mRNA. Translation: BAF84889.1.
CH471109 Genomic DNA. Translation: EAW94728.1.
CH471109 Genomic DNA. Translation: EAW94729.1.
CH471109 Genomic DNA. Translation: EAW94730.1.
CH471109 Genomic DNA. Translation: EAW94731.1.
BC014651 mRNA. Translation: AAH14651.1.
M30597 mRNA. Translation: AAA36004.1.
K02571 Genomic DNA. No translation available.
CCDSiCCDS11531.1. [P17509-1]
PIRiA05266.
S26400.
RefSeqiNP_061825.2. NM_018952.4. [P17509-1]
XP_005257340.1. XM_005257283.2. [P17509-1]
XP_005257341.1. XM_005257284.2. [P17509-1]
XP_006721919.1. XM_006721856.1. [P17509-1]
UniGeneiHs.98428.

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511. [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511. [P17509-1]
GeneIDi3216.
KEGGihsa:3216.
UCSCiuc002ins.1. human. [P17509-1]
uc002int.1. human. [P17509-2]

Polymorphism databases

DMDMi116242515.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58431 Genomic DNA. Translation: CAA41335.1.
X58431 Genomic DNA. Translation: CAA41336.1.
AJ270993 mRNA. Translation: CAB65909.1.
AF287967 Genomic DNA. Translation: AAG31552.1.
AK292200 mRNA. Translation: BAF84889.1.
CH471109 Genomic DNA. Translation: EAW94728.1.
CH471109 Genomic DNA. Translation: EAW94729.1.
CH471109 Genomic DNA. Translation: EAW94730.1.
CH471109 Genomic DNA. Translation: EAW94731.1.
BC014651 mRNA. Translation: AAH14651.1.
M30597 mRNA. Translation: AAA36004.1.
K02571 Genomic DNA. No translation available.
CCDSiCCDS11531.1. [P17509-1]
PIRiA05266.
S26400.
RefSeqiNP_061825.2. NM_018952.4. [P17509-1]
XP_005257340.1. XM_005257283.2. [P17509-1]
XP_005257341.1. XM_005257284.2. [P17509-1]
XP_006721919.1. XM_006721856.1. [P17509-1]
UniGeneiHs.98428.

3D structure databases

ProteinModelPortaliP17509.
SMRiP17509. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109456. 9 interactions.
IntActiP17509. 3 interactions.
MINTiMINT-1437085.
STRINGi9606.ENSP00000225648.

PTM databases

PhosphoSiteiP17509.

Polymorphism databases

DMDMi116242515.

Proteomic databases

MaxQBiP17509.
PaxDbiP17509.
PRIDEiP17509.

Protocols and materials databases

DNASUi3216.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511. [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511. [P17509-1]
GeneIDi3216.
KEGGihsa:3216.
UCSCiuc002ins.1. human. [P17509-1]
uc002int.1. human. [P17509-2]

Organism-specific databases

CTDi3216.
GeneCardsiGC17M046673.
HGNCiHGNC:5117. HOXB6.
HPAiHPA042063.
MIMi142961. gene.
neXtProtiNX_P17509.
PharmGKBiPA29393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305812.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17509.
KOiK09306.
OMAiQEPFLGQ.
OrthoDBiEOG780RP4.
PhylomeDBiP17509.
TreeFamiTF316310.

Miscellaneous databases

GeneWikiiHOXB6.
GenomeRNAii3216.
NextBioi12796.
PROiP17509.
SOURCEiSearch...

Gene expression databases

BgeeiP17509.
CleanExiHS_HOXB6.
GenevestigatoriP17509.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues."
    Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.
    Nucleic Acids Res. 19:539-545(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: Placenta.
  2. "Expression of HOX genes in T lymphocytes and hairy leukemia cell lines."
    Frezza D., D'Esposito M., Migliaccio E., Santini S.M., Fruscalzo A.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
    Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-224.
  8. "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
    Levine M., Rubin G.M., Tjian R.
    Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 136-224.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHXB6_HUMAN
AccessioniPrimary (citable) accession number: P17509
Secondary accession number(s): A8K835
, D3DTV5, P09068, Q9HB11, Q9UGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: February 4, 2015
This is version 159 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.