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Protein

Major envelope glycoprotein

Gene

GP64

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Class III viral fusion protein. Envelope phosphoglycoprotein which mediates the fusion of viral and host endosomal membranes leading to virus entry into the host cell. After receptor-mediated internalization of the virus, gp64 undergoes conformational change into a fusion-competent state at low pH, and the nucleocapsid is released into the cytoplasm after cell fusion. May also play role in budding.3 Publications

GO - Biological processi

  • fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  • membrane fusion involved in viral entry into host cell Source: UniProtKB
  • modulation by virus of host morphology or physiology Source: InterPro
  • viral budding from plasma membrane Source: UniProtKB
  • viral entry into host cell Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi1.G.15.1.1. the autographa californica nuclear polyhedrosis virus major envelope glycoprotein gp64 (gp64) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Major envelope glycoprotein
Alternative name(s):
gp64
Gene namesi
Name:GP64
Synonyms:GP67
ORF Names:ORF128
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
Proteomesi
  • UP000008292 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei482 – 50423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • host cell plasma membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • viral envelope Source: UniProtKB
  • virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi503 – 5031C → A or S: Abolishes palmitoylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 512492Major envelope glycoproteinPRO_0000036746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-372)1 Publication
Disulfide bondi111 ↔ 1641 Publication
Disulfide bondi128 ↔ 1581 Publication
Glycosylationi159 – 1591N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi177 ↔ 1841 Publication
Glycosylationi197 – 1971N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi228 ↔ 2461 Publication
Disulfide bondi262 ↔ 2671 Publication
Glycosylationi354 – 3541N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi382 ↔ 402Interchain (with C-24)1 Publication
Glycosylationi384 – 3841N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi426 – 4261N-linked (GlcNAc...); by hostSequence analysis
Lipidationi503 – 5031N-palmitoyl cysteine; by host1 Publication

Post-translational modificationi

Palmitoylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

SwissPalmiP17501.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.2 Publications

Protein-protein interaction databases

DIPiDIP-46361N.

Structurei

Secondary structure

1
512
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 283Combined sources
Beta strandi44 – 5815Combined sources
Beta strandi60 – 7819Combined sources
Turni80 – 823Combined sources
Beta strandi87 – 959Combined sources
Helixi99 – 10810Combined sources
Beta strandi111 – 1133Combined sources
Beta strandi117 – 1215Combined sources
Helixi122 – 1265Combined sources
Helixi127 – 1304Combined sources
Beta strandi136 – 1405Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi155 – 17723Combined sources
Turni179 – 1813Combined sources
Beta strandi184 – 1896Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi204 – 2063Combined sources
Beta strandi209 – 2157Combined sources
Beta strandi219 – 23113Combined sources
Beta strandi243 – 2508Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi266 – 2705Combined sources
Helixi299 – 34244Combined sources
Helixi348 – 3525Combined sources
Beta strandi357 – 3659Combined sources
Beta strandi367 – 3715Combined sources
Turni390 – 3923Combined sources
Helixi433 – 4353Combined sources
Helixi437 – 45216Combined sources
Beta strandi455 – 4584Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DUZX-ray2.95A21-499[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17501.

Family & Domainsi

Sequence similaritiesi

Belongs to the baculoviridae gp64 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR004955. Baculovirus_Gp64.
[Graphical view]
PfamiPF03273. Baculo_gp64. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAIVLYVL LAAAAHSAFA AEHCNAQMKT GPYKIKNLDI TPPKETLQKD
60 70 80 90 100
VEITIVETDY NENVIIGYKG YYQAYAYNGG SLDPNTRVEE TMKTLNVGKE
110 120 130 140 150
DLLMWSIRQQ CEVGEELIDR WGSDSDDCFR DNEGRGQWVK GKELVKRQNN
160 170 180 190 200
NHFAHHTCNK SWRCGISTSK MYSRLECQDD TDECQVYILD AEGNPINVTV
210 220 230 240 250
DTVLHRDGVS MILKQKSTFT TRQIKAACLL IKDDKNNPES VTREHCLIDN
260 270 280 290 300
DIYDLSKNTW NCKFNRCIKR KVEHRVKKRP PTWRHNVRAK YTEGDTATKG
310 320 330 340 350
DLMHIQEELM YENDLLKMNI ELMHAHINKL NNMLHDLIVS VAKVDERLIG
360 370 380 390 400
NLMNNSVSST FLSDDTFLLM PCTNPPAHTS NCYNNSIYKE GRWVANTDSS
410 420 430 440 450
QCIDFSNYKE LAIDDDVEFW IPTIGNTTYH DSWKDASGWS FIAQQKSNLI
460 470 480 490 500
TTMENTKFGG VGTSLSDITS MAEGELAAKL TSFMFGHVVN FVIILIVILF
510
LYCMIRNRNR QY
Length:512
Mass (Da):58,566
Last modified:November 1, 1995 - v2
Checksum:iA3BC357846C7D2E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti406 – 4061S → R in AAA72760 (PubMed:2644449).Curated
Sequence conflicti414 – 4141D → H (PubMed:2644449).Curated
Sequence conflicti416 – 4161Missing (PubMed:2644449).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25420 Genomic DNA. Translation: AAA72760.1.
L22858 Genomic DNA. Translation: AAA66758.2.
PIRiA72866.
RefSeqiNP_054158.1. NC_001623.1.

Genome annotation databases

GeneIDi1403961.
KEGGivg:1403961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25420 Genomic DNA. Translation: AAA72760.1.
L22858 Genomic DNA. Translation: AAA66758.2.
PIRiA72866.
RefSeqiNP_054158.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DUZX-ray2.95A21-499[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46361N.

Protein family/group databases

TCDBi1.G.15.1.1. the autographa californica nuclear polyhedrosis virus major envelope glycoprotein gp64 (gp64) family.

PTM databases

SwissPalmiP17501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1403961.
KEGGivg:1403961.

Miscellaneous databases

EvolutionaryTraceiP17501.

Family and domain databases

InterProiIPR004955. Baculovirus_Gp64.
[Graphical view]
PfamiPF03273. Baculo_gp64. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUS_NPVAC
AccessioniPrimary (citable) accession number: P17501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.