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Protein

Disintegrin trigramin-beta-2

Gene
N/A
Organism
Trimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits fibrinogen interaction with platelets. Acts by binding to the alpha-IIb/beta-3 receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.1 Publication

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin trigramin-beta-2
Alternative name(s):
Platelet aggregation activation inhibitor
Cleaved into the following chain:
OrganismiTrimeresurus gramineus (Bamboo pit viper) (Indian green tree viper)
Taxonomic identifieri8767 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000458891 – 73Disintegrin trigramin-beta-2Add BLAST73
ChainiPRO_00000458901 – 72Disintegrin trigramin-beta-1Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 15PROSITE-ProRule annotation
Disulfide bondi8 ↔ 16PROSITE-ProRule annotation
Disulfide bondi21 ↔ 35PROSITE-ProRule annotation
Disulfide bondi29 ↔ 59PROSITE-ProRule annotation
Disulfide bondi34 ↔ 38PROSITE-ProRule annotation
Disulfide bondi47 ↔ 66PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (disintegrin).By similarity

Structurei

3D structure databases

ProteinModelPortaliP17495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73DisintegrinPROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 53Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EAGKDCDCGS PANPCCDAAT CKLLPGAQCG EGPCCDQCSF MKKGTICRRA
60 70
RGDDLDDYCN GRSAGCPRNP FHA
Length:73
Mass (Da):7,634
Last modified:August 1, 1990 - v1
Checksum:iE080C4B34367C734
GO

Sequence databases

PIRiD35982.

Cross-referencesi

Sequence databases

PIRiD35982.

3D structure databases

ProteinModelPortaliP17495.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVM2B_TRIGA
AccessioniPrimary (citable) accession number: P17495
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 15, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.