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P17491

- INHBB_RAT

UniProt

P17491 - INHBB_RAT

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Protein

Inhibin beta B chain

Gene

Inhbb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. activin receptor signaling pathway Source: UniProtKB
  2. cellular response to cholesterol Source: UniProtKB
  3. cellular response to insulin stimulus Source: UniProtKB
  4. cellular response to starvation Source: UniProtKB
  5. fat cell differentiation Source: UniProtKB
  6. growth Source: InterPro
  7. negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
  8. negative regulation of hepatocyte growth factor biosynthetic process Source: UniProtKB
  9. negative regulation of insulin secretion Source: UniProtKB
  10. positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
  11. positive regulation of ovulation Source: UniProtKB
  12. response to mechanical stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta B chain
Alternative name(s):
Activin beta-B chain
Gene namesi
Name:Inhbb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2913. Inhbb.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 296268Sequence AnalysisPRO_0000033728Add
BLAST
Chaini297 – 411115Inhibin beta B chainPRO_0000033729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi300 ↔ 308By similarity
Disulfide bondi307 ↔ 376By similarity
Disulfide bondi336 ↔ 408By similarity
Disulfide bondi340 ↔ 410By similarity
Disulfide bondi375 – 375InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17491.

Expressioni

Tissue specificityi

Alpha- and beta-B subunits are the predominant forms found in rat testis. Also expressed in ovary.

Inductioni

Increased expression in methimazole-induced goiter.

Gene expression databases

GenevestigatoriP17491.

Interactioni

Subunit structurei

Homodimer or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003302.

Structurei

3D structure databases

ProteinModelPortaliP17491.
SMRiP17491. Positions 297-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 4819Pro-richAdd
BLAST
Compositional biasi59 – 646Poly-Gly

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278663.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP17491.
KOiK04667.
PhylomeDBiP17491.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000381. Inhibin_betaB.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF29. PTHR11848:SF29. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00671. INHIBINBB.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17491-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG
60 70 80 90 100
SQDTCTSCGG GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH
110 120 130 140 150
AVPKAAMVTA LRKLHAGKVR EDGRVEIPHL DGHASPGADG QERVSEIISF
160 170 180 190 200
AETDGLASSR VRLYFFVSNE GNQNLFVVQA SLWLYLKLLP YVLEKGSRRK
210 220 230 240 250
VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ ALFERGERRL
260 270 280 290 300
NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC
310 320 330 340 350
DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS
360 370 380 390 400
ASSFHTAVVN QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV
410
PNMIVEECGC A
Length:411
Mass (Da):45,183
Last modified:November 9, 2004 - v2
Checksum:i85D4D4CAD9D74620
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701D → H in beta-B20. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32757, M32756 Genomic DNA. Translation: AAA41438.1.
AF478684 mRNA. Translation: AAM46787.1.
PIRiB41398.
RefSeqiNP_542949.1. NM_080771.1.
UniGeneiRn.35074.

Genome annotation databases

GeneIDi25196.
KEGGirno:25196.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32757 , M32756 Genomic DNA. Translation: AAA41438.1 .
AF478684 mRNA. Translation: AAM46787.1 .
PIRi B41398.
RefSeqi NP_542949.1. NM_080771.1.
UniGenei Rn.35074.

3D structure databases

ProteinModelPortali P17491.
SMRi P17491. Positions 297-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003302.

Proteomic databases

PaxDbi P17491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25196.
KEGGi rno:25196.

Organism-specific databases

CTDi 3625.
RGDi 2913. Inhbb.

Phylogenomic databases

eggNOGi NOG278663.
HOGENOMi HOG000220890.
HOVERGENi HBG105613.
InParanoidi P17491.
KOi K04667.
PhylomeDBi P17491.
TreeFami TF351791.

Miscellaneous databases

NextBioi 605709.
PROi P17491.

Gene expression databases

Genevestigatori P17491.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR000381. Inhibin_betaB.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
PTHR11848:SF29. PTHR11848:SF29. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00671. INHIBINBB.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms."
    Feng Z.-M., Li Y.-P., Chen C.-L.C.
    Mol. Endocrinol. 3:1914-1925(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-174.
    Tissue: Liver.
  2. "Two messenger ribonucleic acids encoding the common beta B-chain of inhibin and activin have distinct 5'-initiation sites and are differentially regulated in rat granulosa cells."
    Dykema J.C., Mayo K.E.
    Endocrinology 135:702-711(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-7.
    Tissue: Granulocyte.
  3. "Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins."
    Esch F.S., Shimasaki S., Cooksey K., Mercado M., Mason A.J., Ying S.-Y., Ueno N., Ling N.
    Mol. Endocrinol. 1:388-396(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 133-411, VARIANT BETA-B20 HIS-270.
    Tissue: Ovary.
  4. "Activin betaB expression in rat experimental goiter and human thyroid tumors."
    Matsuo S.E., Ebina K.N., Kulcsar M.A., Friguglietti C.U., Kimura E.T.
    Thyroid 13:239-247(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 158-266.
    Strain: Wistar.
    Tissue: Thyroid.

Entry informationi

Entry nameiINHBB_RAT
AccessioniPrimary (citable) accession number: P17491
Secondary accession number(s): Q8K471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 9, 2004
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3