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P17491 (INHBB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inhibin beta B chain
Alternative name(s):
Activin beta-B chain
Gene names
Name:Inhbb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure

Homodimer or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Alpha- and beta-B subunits are the predominant forms found in rat testis. Also expressed in ovary.

Induction

Increased expression in methimazole-induced goiter.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionGrowth factor
Hormone
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivin receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to cholesterol

Inferred from direct assay PubMed 19464342. Source: UniProtKB

cellular response to insulin stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to starvation

Inferred from sequence or structural similarity. Source: UniProtKB

fat cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

growth

Inferred from electronic annotation. Source: InterPro

negative regulation of follicle-stimulating hormone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of hepatocyte growth factor biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of insulin secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of follicle-stimulating hormone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ovulation

Inferred from sequence or structural similarity. Source: UniProtKB

response to mechanical stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 296268 Potential
PRO_0000033728
Chain297 – 411115Inhibin beta B chain
PRO_0000033729

Regions

Compositional bias30 – 4819Pro-rich
Compositional bias59 – 646Poly-Gly

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Disulfide bond300 ↔ 308 By similarity
Disulfide bond307 ↔ 376 By similarity
Disulfide bond336 ↔ 408 By similarity
Disulfide bond340 ↔ 410 By similarity
Disulfide bond375Interchain By similarity

Natural variations

Natural variant2701D → H in beta-B20. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P17491 [UniParc].

Last modified November 9, 2004. Version 2.
Checksum: 85D4D4CAD9D74620

FASTA41145,183
        10         20         30         40         50         60 
MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG SQDTCTSCGG 

        70         80         90        100        110        120 
GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH AVPKAAMVTA LRKLHAGKVR 

       130        140        150        160        170        180 
EDGRVEIPHL DGHASPGADG QERVSEIISF AETDGLASSR VRLYFFVSNE GNQNLFVVQA 

       190        200        210        220        230        240 
SLWLYLKLLP YVLEKGSRRK VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ 

       250        260        270        280        290        300 
ALFERGERRL NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC 

       310        320        330        340        350        360 
DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS ASSFHTAVVN 

       370        380        390        400        410 
QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV PNMIVEECGC A 

« Hide

References

[1]"Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms."
Feng Z.-M., Li Y.-P., Chen C.-L.C.
Mol. Endocrinol. 3:1914-1925(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-174.
Tissue: Liver.
[2]"Two messenger ribonucleic acids encoding the common beta B-chain of inhibin and activin have distinct 5'-initiation sites and are differentially regulated in rat granulosa cells."
Dykema J.C., Mayo K.E.
Endocrinology 135:702-711(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-7.
Tissue: Granulocyte.
[3]"Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins."
Esch F.S., Shimasaki S., Cooksey K., Mercado M., Mason A.J., Ying S.-Y., Ueno N., Ling N.
Mol. Endocrinol. 1:388-396(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 133-411, VARIANT BETA-B20 HIS-270.
Tissue: Ovary.
[4]"Activin betaB expression in rat experimental goiter and human thyroid tumors."
Matsuo S.E., Ebina K.N., Kulcsar M.A., Friguglietti C.U., Kimura E.T.
Thyroid 13:239-247(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 158-266.
Strain: Wistar.
Tissue: Thyroid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32757, M32756 Genomic DNA. Translation: AAA41438.1.
AF478684 mRNA. Translation: AAM46787.1.
PIRB41398.
RefSeqNP_542949.1. NM_080771.1.
UniGeneRn.35074.

3D structure databases

ProteinModelPortalP17491.
SMRP17491. Positions 297-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000003302.

Proteomic databases

PaxDbP17491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25196.
KEGGrno:25196.

Organism-specific databases

CTD3625.
RGD2913. Inhbb.

Phylogenomic databases

eggNOGNOG278663.
HOGENOMHOG000220890.
HOVERGENHBG105613.
InParanoidP17491.
KOK04667.
PhylomeDBP17491.
TreeFamTF351791.

Gene expression databases

GenevestigatorP17491.

Family and domain databases

InterProIPR000381. Inhibin_betaB.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF29. PTHR11848:SF29. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00671. INHIBINBB.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605709.
PROP17491.

Entry information

Entry nameINHBB_RAT
AccessionPrimary (citable) accession number: P17491
Secondary accession number(s): Q8K471
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 9, 2004
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families