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P17491

- INHBB_RAT

UniProt

P17491 - INHBB_RAT

Protein

Inhibin beta B chain

Gene

Inhbb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (09 Nov 2004)
      Previous versions | rss
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    Functioni

    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

    GO - Molecular functioni

    1. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. activin receptor signaling pathway Source: UniProtKB
    2. cellular response to cholesterol Source: UniProtKB
    3. cellular response to insulin stimulus Source: UniProtKB
    4. cellular response to starvation Source: UniProtKB
    5. fat cell differentiation Source: UniProtKB
    6. growth Source: InterPro
    7. negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
    8. negative regulation of hepatocyte growth factor biosynthetic process Source: UniProtKB
    9. negative regulation of insulin secretion Source: UniProtKB
    10. positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
    11. positive regulation of ovulation Source: UniProtKB
    12. response to mechanical stimulus Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor, Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibin beta B chain
    Alternative name(s):
    Activin beta-B chain
    Gene namesi
    Name:Inhbb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2913. Inhbb.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Propeptidei29 – 296268Sequence AnalysisPRO_0000033728Add
    BLAST
    Chaini297 – 411115Inhibin beta B chainPRO_0000033729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi300 ↔ 308By similarity
    Disulfide bondi307 ↔ 376By similarity
    Disulfide bondi336 ↔ 408By similarity
    Disulfide bondi340 ↔ 410By similarity
    Disulfide bondi375 – 375InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP17491.

    Expressioni

    Tissue specificityi

    Alpha- and beta-B subunits are the predominant forms found in rat testis. Also expressed in ovary.

    Inductioni

    Increased expression in methimazole-induced goiter.

    Gene expression databases

    GenevestigatoriP17491.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003302.

    Structurei

    3D structure databases

    ProteinModelPortaliP17491.
    SMRiP17491. Positions 297-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 4819Pro-richAdd
    BLAST
    Compositional biasi59 – 646Poly-Gly

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG278663.
    HOGENOMiHOG000220890.
    HOVERGENiHBG105613.
    InParanoidiP17491.
    KOiK04667.
    PhylomeDBiP17491.
    TreeFamiTF351791.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR000381. Inhibin_betaB.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PTHR11848:SF29. PTHR11848:SF29. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00671. INHIBINBB.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17491-1 [UniParc]FASTAAdd to Basket

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    MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG    50
    SQDTCTSCGG GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH 100
    AVPKAAMVTA LRKLHAGKVR EDGRVEIPHL DGHASPGADG QERVSEIISF 150
    AETDGLASSR VRLYFFVSNE GNQNLFVVQA SLWLYLKLLP YVLEKGSRRK 200
    VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ ALFERGERRL 250
    NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC 300
    DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS 350
    ASSFHTAVVN QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV 400
    PNMIVEECGC A 411
    Length:411
    Mass (Da):45,183
    Last modified:November 9, 2004 - v2
    Checksum:i85D4D4CAD9D74620
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti270 – 2701D → H in beta-B20. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32757, M32756 Genomic DNA. Translation: AAA41438.1.
    AF478684 mRNA. Translation: AAM46787.1.
    PIRiB41398.
    RefSeqiNP_542949.1. NM_080771.1.
    UniGeneiRn.35074.

    Genome annotation databases

    GeneIDi25196.
    KEGGirno:25196.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32757 , M32756 Genomic DNA. Translation: AAA41438.1 .
    AF478684 mRNA. Translation: AAM46787.1 .
    PIRi B41398.
    RefSeqi NP_542949.1. NM_080771.1.
    UniGenei Rn.35074.

    3D structure databases

    ProteinModelPortali P17491.
    SMRi P17491. Positions 297-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003302.

    Proteomic databases

    PaxDbi P17491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25196.
    KEGGi rno:25196.

    Organism-specific databases

    CTDi 3625.
    RGDi 2913. Inhbb.

    Phylogenomic databases

    eggNOGi NOG278663.
    HOGENOMi HOG000220890.
    HOVERGENi HBG105613.
    InParanoidi P17491.
    KOi K04667.
    PhylomeDBi P17491.
    TreeFami TF351791.

    Miscellaneous databases

    NextBioi 605709.
    PROi P17491.

    Gene expression databases

    Genevestigatori P17491.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR000381. Inhibin_betaB.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    PTHR11848:SF29. PTHR11848:SF29. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00671. INHIBINBB.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms."
      Feng Z.-M., Li Y.-P., Chen C.-L.C.
      Mol. Endocrinol. 3:1914-1925(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-174.
      Tissue: Liver.
    2. "Two messenger ribonucleic acids encoding the common beta B-chain of inhibin and activin have distinct 5'-initiation sites and are differentially regulated in rat granulosa cells."
      Dykema J.C., Mayo K.E.
      Endocrinology 135:702-711(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-7.
      Tissue: Granulocyte.
    3. "Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins."
      Esch F.S., Shimasaki S., Cooksey K., Mercado M., Mason A.J., Ying S.-Y., Ueno N., Ling N.
      Mol. Endocrinol. 1:388-396(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 133-411, VARIANT BETA-B20 HIS-270.
      Tissue: Ovary.
    4. "Activin betaB expression in rat experimental goiter and human thyroid tumors."
      Matsuo S.E., Ebina K.N., Kulcsar M.A., Friguglietti C.U., Kimura E.T.
      Thyroid 13:239-247(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 158-266.
      Strain: Wistar.
      Tissue: Thyroid.

    Entry informationi

    Entry nameiINHBB_RAT
    AccessioniPrimary (citable) accession number: P17491
    Secondary accession number(s): Q8K471
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 9, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3