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Protein

Inhibin alpha chain

Gene

Inha

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • inhibin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:Inha
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2912. Inha.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • inhibin A complex Source: RGD
  • inhibin B complex Source: RGD
  • inhibin-betaglycan-ActRII complex Source: Ensembl
  • neuronal cell body Source: RGD
  • photoreceptor inner segment Source: RGD
  • photoreceptor outer segment Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Propeptidei21 – 6343By similarityPRO_0000033694Add
BLAST
Propeptidei64 – 233170Inhibin alpha N-terminal regionBy similarityPRO_0000033695Add
BLAST
Chaini234 – 366133Inhibin alpha chainPRO_0000033696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi263 ↔ 328By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)By similarity
Disulfide bondi292 ↔ 363By similarity
Disulfide bondi296 ↔ 365By similarity
Disulfide bondi327 – 327InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei63 – 642CleavageBy similarity
Sitei233 – 2342CleavageBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17490.
PRIDEiP17490.

Expressioni

Tissue specificityi

Mainly expressed in ovary and testis. Alpha- and beta-B-subunits are the predominant forms found in testis. Also found in placenta, pituitary, adrenal gland, bone marrow, kidney, spinal chord and brain.1 Publication

Gene expression databases

GenevisibleiP17490. RN.

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • inhibin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027227.

Structurei

3D structure databases

ProteinModelPortaliP17490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiP17490.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG7BS4BB.
PhylomeDBiP17490.
TreeFamiTF331531.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIQPSLLLL LLLTLQDVDS CQGPELVREL VLAKVKALFL DALGPPAMDG
60 70 80 90 100
EGGGPGIRRL PRRHALGGFM HRTSEPEEED VSQAILFPAT GATCEDQAAA
110 120 130 140 150
GGLAQEPEEG LFTYVFRPSQ HIRSHQVTSA QLWFHTGLDR KSTAASNSSR
160 170 180 190 200
PLLDLLVLSS GGPMAVPVSL GQSPPRWAVL HLAASAFPLL THPILVLLLR
210 220 230 240 250
CPLCSCSGRP ETTPFLVAHT RARAPSAGER ARRSAPSMPW PWSPAALRLL
260 270 280 290 300
QRPPEEPSAH AFCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGSCGMPT
310 320 330 340 350
SDLPLPVPGA PPTPAQPLFL VPGAKPCCAA LPGSMRSLRV RTTSDGGYSF
360
KYEMVPNLIT QHCACI
Length:366
Mass (Da):39,497
Last modified:August 1, 1990 - v1
Checksum:i327A233B9FEDFCDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32755, M32754 Genomic DNA. Translation: AAA41437.1.
M36453 mRNA. Translation: AAA41435.1.
BC083564 mRNA. Translation: AAH83564.1.
PIRiA41398. A40056.
RefSeqiNP_036722.1. NM_012590.2.
UniGeneiRn.8831.

Genome annotation databases

EnsembliENSRNOT00000027227; ENSRNOP00000027227; ENSRNOG00000020097.
GeneIDi24504.
KEGGirno:24504.
UCSCiRGD:2912. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32755, M32754 Genomic DNA. Translation: AAA41437.1.
M36453 mRNA. Translation: AAA41435.1.
BC083564 mRNA. Translation: AAH83564.1.
PIRiA41398. A40056.
RefSeqiNP_036722.1. NM_012590.2.
UniGeneiRn.8831.

3D structure databases

ProteinModelPortaliP17490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027227.

Proteomic databases

PaxDbiP17490.
PRIDEiP17490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027227; ENSRNOP00000027227; ENSRNOG00000020097.
GeneIDi24504.
KEGGirno:24504.
UCSCiRGD:2912. rat.

Organism-specific databases

CTDi3623.
RGDi2912. Inha.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiP17490.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG7BS4BB.
PhylomeDBiP17490.
TreeFamiTF331531.

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.

Miscellaneous databases

PROiP17490.

Gene expression databases

GenevisibleiP17490. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms."
    Feng Z.-M., Li Y.-P., Chen C.-L.C.
    Mol. Endocrinol. 3:1914-1925(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  2. "Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary."
    Woodruff T.K., Meunier H., Jones P.B.C., Hsueh A.J.W., Mayo K.E.
    Mol. Endocrinol. 1:561-568(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins."
    Esch F.S., Shimasaki S., Cooksey K., Mercado M., Mason A.J., Ying S.-Y., Ueno N., Ling N.
    Mol. Endocrinol. 1:388-396(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions."
    Meunier H., Rivier C., Evans R.M., Vale W.
    Proc. Natl. Acad. Sci. U.S.A. 85:247-251(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiINHA_RAT
AccessioniPrimary (citable) accession number: P17490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.