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P17489

- LAC1_EMENI

UniProt

P17489 - LAC1_EMENI

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Protein

Laccase-1

Gene

yA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the conversion of the yellow polyketide pigment synthesized by wA to the conidial green pigment.1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per subunit. The copper ions are bound as 3 distinct Cu centers known as type 1 or blue, type 2 or normal, and type 3 or coupled binuclear (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Copper 1; type 2Curated
Metal bindingi81 – 811Copper 2; type 3Curated
Metal bindingi123 – 1231Copper 2; type 3Curated
Metal bindingi125 – 1251Copper 3; type 3Curated
Metal bindingi508 – 5081Copper 4; type 1Curated
Metal bindingi511 – 5111Copper 1; type 2Curated
Metal bindingi513 – 5131Copper 3; type 3Curated
Metal bindingi585 – 5851Copper 3; type 3Curated
Metal bindingi586 – 5861Copper 4; type 1Curated
Metal bindingi587 – 5871Copper 2; type 3Curated
Metal bindingi591 – 5911Copper 4; type 1Curated
Metal bindingi596 – 5961Copper 4; type 1Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: ASPGD

GO - Biological processi

  1. conidium formation Source: ASPGD
  2. pigment metabolic process involved in developmental pigmentation Source: ASPGD
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Conidiation, Sporulation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Conidial laccase
Diphenol oxidase 1
Laccase I
Urishiol oxidase 1
Gene namesi
Name:yA
ORF Names:AN6635
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 609589Laccase-1PRO_0000002927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Specifically expressed late during asexual development.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 14197Plastocyanin-like 1Add
BLAST
Domaini270 – 372103Plastocyanin-like 2Add
BLAST
Domaini463 – 602140Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000168741.
InParanoidiP17489.
OMAiCHITTHQ.
OrthoDBiEOG718KNW.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17489-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYLSTVLFPL LALNLGLSHA RFVRETLELT WEYGSPNGGT PREMVFTNGE
60 70 80 90 100
YPGPDLIFDE DDDVEVLVIN NLPFNTTVHW HGLEMRETPE ADGVPGLTQT
110 120 130 140 150
PIEPGATFTY RFRAYPAGTF WYHSHYKGLM QDGQVGAMYI RRKPDALRPY
160 170 180 190 200
AVITEDPREL AEIQYAEDNP YLMLATDWTY LTSAEYHNIE VESGYNVFCV
210 220 230 240 250
DSLLINGRGS VYCPGYQYLE EVSDDGLTAV LEGTHLTEKG CLQPDLHNVQ
260 270 280 290 300
GDYGPWNLSA VPTEVVFNCT PSSVEPPVIY VDPEFNGWVS LNFIGGAAQK
310 320 330 340 350
AITFSVDNHP MWVYEVDGQF VEPREVEMVG VYSGARYAVM IKLDQTPGDY
360 370 380 390 400
AIRIAVNGGD QVMSVYAILS YVNQDWIHRE NVPKAAIGPH TDTVGYMNYG
410 420 430 440 450
GGNTSADVRQ LLFTENLPAF GVPPPPPSSE VSTTLRTGMI RVNNSYSWSL
460 470 480 490 500
GNNVLYEPEM TSSTPLLFEP DPLAVIAPKY ALTTENNTWV DIVLEITADP
510 520 530 540 550
RDLIHPPHPI HKHGNRAYII GNGVGKFRWE NVSAAEAEVP DLFYVNETAA
560 570 580 590 600
LRDTFVTDFF DSRLMDGAWI VIRYFVQDKF PSILHCHIAS HQMGGMALAL

LDGVDVWDS
Length:609
Mass (Da):67,981
Last modified:May 26, 2009 - v3
Checksum:i529A20B2DD9AA73E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2295DGLTA → TALLS in CAA36787. (PubMed:2192364)Curated
Sequence conflicti359 – 3591G → A in CAA36787. (PubMed:2192364)Curated
Sequence conflicti421 – 4211G → A in CAA36787. (PubMed:2192364)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52552 Genomic DNA. Translation: CAA36787.1.
AACD01000110 Genomic DNA. Translation: EAA58164.1.
BN001301 Genomic DNA. Translation: CBF71142.1.
PIRiS10149. KSASL1.
RefSeqiXP_664239.1. XM_659147.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007416; CADANIAP00007416; CADANIAG00007416.
GeneIDi2870381.
KEGGiani:AN6635.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52552 Genomic DNA. Translation: CAA36787.1 .
AACD01000110 Genomic DNA. Translation: EAA58164.1 .
BN001301 Genomic DNA. Translation: CBF71142.1 .
PIRi S10149. KSASL1.
RefSeqi XP_664239.1. XM_659147.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00007416 ; CADANIAP00007416 ; CADANIAG00007416 .
GeneIDi 2870381.
KEGGi ani:AN6635.2.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000168741.
InParanoidi P17489.
OMAi CHITTHQ.
OrthoDBi EOG718KNW.

Family and domain databases

Gene3Di 2.60.40.420. 4 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and molecular structure of the Aspergillus nidulans yA (laccase I) gene."
    Aramayo R., Timberlake W.E.
    Nucleic Acids Res. 18:3415-3415(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139 and Winter.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  4. "Molecular characterization of the Aspergillus nidulans yA locus."
    O'Hara E.B., Timberlake W.E.
    Genetics 121:249-254(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiLAC1_EMENI
AccessioniPrimary (citable) accession number: P17489
Secondary accession number(s): C8V1C0, Q5AYJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3