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Protein

Homeobox protein Hox-B4

Gene

HOXB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 221HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33676-MONOMER.
ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Homeobox protein Hox-2F
Gene namesi
Name:HOXB4
Synonyms:HOX2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5115. HOXB4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3214.
OpenTargetsiENSG00000182742.
PharmGKBiPA29391.

Polymorphism and mutation databases

BioMutaiHOXB4.
DMDMi547692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001221 – 251Homeobox protein Hox-B4Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17483.
PaxDbiP17483.
PeptideAtlasiP17483.
PRIDEiP17483.

PTM databases

iPTMnetiP17483.
PhosphoSitePlusiP17483.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000182742.
CleanExiHS_HOXB4.
GenevisibleiP17483. HS.

Organism-specific databases

HPAiHPA057432.

Interactioni

Protein-protein interaction databases

BioGridi109454. 4 interactors.
STRINGi9606.ENSP00000328928.

Structurei

3D structure databases

ProteinModelPortaliP17483.
SMRiP17483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi141 – 146Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 139Pro-rich (part of the transcriptional activation domain)Add BLAST125
Compositional biasi71 – 87Poly-ProAdd BLAST17

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17483.
KOiK09304.
OMAiPRSACNE.
OrthoDBiEOG091G09XD.
PhylomeDBiP17483.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP
60 70 80 90 100
EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG
110 120 130 140 150
ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV
160 170 180 190 200
STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC
210 220 230 240 250
LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA

L
Length:251
Mass (Da):27,604
Last modified:June 1, 1994 - v2
Checksum:i23EE1D0DDCCE2DB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSiCCDS11529.1.
PIRiB60492.
T46446.
RefSeqiNP_076920.1. NM_024015.4.
UniGeneiHs.664706.

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
GeneIDi3214.
KEGGihsa:3214.
UCSCiuc002inp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSiCCDS11529.1.
PIRiB60492.
T46446.
RefSeqiNP_076920.1. NM_024015.4.
UniGeneiHs.664706.

3D structure databases

ProteinModelPortaliP17483.
SMRiP17483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109454. 4 interactors.
STRINGi9606.ENSP00000328928.

PTM databases

iPTMnetiP17483.
PhosphoSitePlusiP17483.

Polymorphism and mutation databases

BioMutaiHOXB4.
DMDMi547692.

Proteomic databases

MaxQBiP17483.
PaxDbiP17483.
PeptideAtlasiP17483.
PRIDEiP17483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
GeneIDi3214.
KEGGihsa:3214.
UCSCiuc002inp.4. human.

Organism-specific databases

CTDi3214.
DisGeNETi3214.
GeneCardsiHOXB4.
HGNCiHGNC:5115. HOXB4.
HPAiHPA057432.
MIMi142965. gene.
neXtProtiNX_P17483.
OpenTargetsiENSG00000182742.
PharmGKBiPA29391.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17483.
KOiK09304.
OMAiPRSACNE.
OrthoDBiEOG091G09XD.
PhylomeDBiP17483.
TreeFamiTF352857.

Enzyme and pathway databases

BioCyciZFISH:G66-33676-MONOMER.
ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Miscellaneous databases

GeneWikiiHOXB4.
GenomeRNAii3214.
PROiP17483.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182742.
CleanExiHS_HOXB4.
GenevisibleiP17483. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXB4_HUMAN
AccessioniPrimary (citable) accession number: P17483
Secondary accession number(s): Q9NTA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.