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P17483

- HXB4_HUMAN

UniProt

P17483 - HXB4_HUMAN

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Protein
Homeobox protein Hox-B4
Gene
HOXB4, HOX2F
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi162 – 22160Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. bone marrow development Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. definitive hemopoiesis Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. hematopoietic stem cell differentiation Source: BHF-UCL
  7. morphogenesis of an epithelial sheet Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of stem cell differentiation Source: BHF-UCL
  10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  11. somatic stem cell division Source: Ensembl
  12. spleen development Source: Ensembl
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Homeobox protein Hox-2F
Gene namesi
Name:HOXB4
Synonyms:HOX2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5115. HOXB4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Homeobox protein Hox-B4
PRO_0000200122Add
BLAST

Proteomic databases

MaxQBiP17483.
PaxDbiP17483.
PeptideAtlasiP17483.
PRIDEiP17483.

PTM databases

PhosphoSiteiP17483.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP17483.
CleanExiHS_HOXB4.
GenevestigatoriP17483.

Organism-specific databases

HPAiHPA057432.

Interactioni

Protein-protein interaction databases

BioGridi109454. 4 interactions.
STRINGi9606.ENSP00000328928.

Structurei

3D structure databases

ProteinModelPortaliP17483.
SMRiP17483. Positions 169-222.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi141 – 1466Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 139125Pro-rich (part of the transcriptional activation domain)
Add
BLAST
Compositional biasi71 – 8717Poly-Pro
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17483.
KOiK09304.
OMAiRYAACRD.
OrthoDBiEOG780RP4.
PhylomeDBiP17483.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17483-1 [UniParc]FASTAAdd to Basket

« Hide

MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP    50
EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG 100
ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV 150
STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC 200
LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA 250
L 251
Length:251
Mass (Da):27,604
Last modified:June 1, 1994 - v2
Checksum:i23EE1D0DDCCE2DB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSiCCDS11529.1.
PIRiB60492.
T46446.
RefSeqiNP_076920.1. NM_024015.4.
UniGeneiHs.664706.

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
GeneIDi3214.
KEGGihsa:3214.
UCSCiuc002inp.3. human.

Polymorphism databases

DMDMi547692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1 .
AF287967 Genomic DNA. Translation: AAG31554.1 .
AF307160 Genomic DNA. Translation: AAG45052.1 .
BC049204 mRNA. Translation: AAH49204.1 .
AL137449 mRNA. Translation: CAB70742.1 .
CCDSi CCDS11529.1.
PIRi B60492.
T46446.
RefSeqi NP_076920.1. NM_024015.4.
UniGenei Hs.664706.

3D structure databases

ProteinModelPortali P17483.
SMRi P17483. Positions 169-222.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109454. 4 interactions.
STRINGi 9606.ENSP00000328928.

PTM databases

PhosphoSitei P17483.

Polymorphism databases

DMDMi 547692.

Proteomic databases

MaxQBi P17483.
PaxDbi P17483.
PeptideAtlasi P17483.
PRIDEi P17483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332503 ; ENSP00000328928 ; ENSG00000182742 .
GeneIDi 3214.
KEGGi hsa:3214.
UCSCi uc002inp.3. human.

Organism-specific databases

CTDi 3214.
GeneCardsi GC17M046652.
HGNCi HGNC:5115. HOXB4.
HPAi HPA057432.
MIMi 142965. gene.
neXtProti NX_P17483.
PharmGKBi PA29391.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314883.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi P17483.
KOi K09304.
OMAi RYAACRD.
OrthoDBi EOG780RP4.
PhylomeDBi P17483.
TreeFami TF352857.

Miscellaneous databases

GeneWikii HOXB4.
GenomeRNAii 3214.
NextBioi 12788.
PROi P17483.
SOURCEi Search...

Gene expression databases

Bgeei P17483.
CleanExi HS_HOXB4.
Genevestigatori P17483.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2."
    Giannola D.M., Shlomchik W.D., Jegathesan M., Liebowitz D., Abrams C.S., Kadesch T., Dancis A., Emerson S.G.
    J. Exp. Med. 192:1479-1490(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-251.
    Tissue: Testis.
  6. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 160-227.
    Tissue: Placenta.
  7. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-227.

Entry informationi

Entry nameiHXB4_HUMAN
AccessioniPrimary (citable) accession number: P17483
Secondary accession number(s): Q9NTA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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