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Protein

Homeobox protein Hox-B4

Gene

HOXB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi162 – 22160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. bone marrow development Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. definitive hemopoiesis Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. hematopoietic stem cell differentiation Source: BHF-UCL
  7. morphogenesis of an epithelial sheet Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of stem cell differentiation Source: BHF-UCL
  10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  11. somatic stem cell division Source: Ensembl
  12. spleen development Source: Ensembl
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Homeobox protein Hox-2F
Gene namesi
Name:HOXB4
Synonyms:HOX2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5115. HOXB4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Homeobox protein Hox-B4PRO_0000200122Add
BLAST

Proteomic databases

MaxQBiP17483.
PaxDbiP17483.
PeptideAtlasiP17483.
PRIDEiP17483.

PTM databases

PhosphoSiteiP17483.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP17483.
CleanExiHS_HOXB4.
GenevestigatoriP17483.

Organism-specific databases

HPAiHPA057432.

Interactioni

Protein-protein interaction databases

BioGridi109454. 4 interactions.
STRINGi9606.ENSP00000328928.

Structurei

3D structure databases

ProteinModelPortaliP17483.
SMRiP17483. Positions 169-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi141 – 1466Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 139125Pro-rich (part of the transcriptional activation domain)Add
BLAST
Compositional biasi71 – 8717Poly-ProAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17483.
KOiK09304.
OMAiRYAACRD.
OrthoDBiEOG780RP4.
PhylomeDBiP17483.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP
60 70 80 90 100
EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG
110 120 130 140 150
ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV
160 170 180 190 200
STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC
210 220 230 240 250
LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA

L
Length:251
Mass (Da):27,604
Last modified:May 31, 1994 - v2
Checksum:i23EE1D0DDCCE2DB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSiCCDS11529.1.
PIRiB60492.
T46446.
RefSeqiNP_076920.1. NM_024015.4.
UniGeneiHs.664706.

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
GeneIDi3214.
KEGGihsa:3214.
UCSCiuc002inp.3. human.

Polymorphism databases

DMDMi547692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSiCCDS11529.1.
PIRiB60492.
T46446.
RefSeqiNP_076920.1. NM_024015.4.
UniGeneiHs.664706.

3D structure databases

ProteinModelPortaliP17483.
SMRiP17483. Positions 169-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109454. 4 interactions.
STRINGi9606.ENSP00000328928.

PTM databases

PhosphoSiteiP17483.

Polymorphism databases

DMDMi547692.

Proteomic databases

MaxQBiP17483.
PaxDbiP17483.
PeptideAtlasiP17483.
PRIDEiP17483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
GeneIDi3214.
KEGGihsa:3214.
UCSCiuc002inp.3. human.

Organism-specific databases

CTDi3214.
GeneCardsiGC17M046652.
HGNCiHGNC:5115. HOXB4.
HPAiHPA057432.
MIMi142965. gene.
neXtProtiNX_P17483.
PharmGKBiPA29391.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17483.
KOiK09304.
OMAiRYAACRD.
OrthoDBiEOG780RP4.
PhylomeDBiP17483.
TreeFamiTF352857.

Miscellaneous databases

GeneWikiiHOXB4.
GenomeRNAii3214.
NextBioi12788.
PROiP17483.
SOURCEiSearch...

Gene expression databases

BgeeiP17483.
CleanExiHS_HOXB4.
GenevestigatoriP17483.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(1999)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2."
    Giannola D.M., Shlomchik W.D., Jegathesan M., Liebowitz D., Abrams C.S., Kadesch T., Dancis A., Emerson S.G.
    J. Exp. Med. 192:1479-1490(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-251.
    Tissue: Testis.
  6. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 160-227.
    Tissue: Placenta.
  7. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-227.

Entry informationi

Entry nameiHXB4_HUMAN
AccessioniPrimary (citable) accession number: P17483
Secondary accession number(s): Q9NTA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1990
Last sequence update: May 31, 1994
Last modified: January 6, 2015
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.