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P17483

- HXB4_HUMAN

UniProt

P17483 - HXB4_HUMAN

Protein

Homeobox protein Hox-B4

Gene

HOXB4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi162 – 22160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. bone marrow development Source: Ensembl
    3. cell proliferation Source: Ensembl
    4. definitive hemopoiesis Source: Ensembl
    5. embryonic skeletal system morphogenesis Source: Ensembl
    6. hematopoietic stem cell differentiation Source: BHF-UCL
    7. morphogenesis of an epithelial sheet Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. positive regulation of stem cell differentiation Source: BHF-UCL
    10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    11. somatic stem cell division Source: Ensembl
    12. spleen development Source: Ensembl
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B4
    Alternative name(s):
    Homeobox protein Hox-2.6
    Homeobox protein Hox-2F
    Gene namesi
    Name:HOXB4
    Synonyms:HOX2F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5115. HOXB4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29391.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Homeobox protein Hox-B4PRO_0000200122Add
    BLAST

    Proteomic databases

    MaxQBiP17483.
    PaxDbiP17483.
    PeptideAtlasiP17483.
    PRIDEiP17483.

    PTM databases

    PhosphoSiteiP17483.

    Expressioni

    Developmental stagei

    Expressed in whole embryos and fetuses at 5-9 weeks from conception.

    Gene expression databases

    BgeeiP17483.
    CleanExiHS_HOXB4.
    GenevestigatoriP17483.

    Organism-specific databases

    HPAiHPA057432.

    Interactioni

    Protein-protein interaction databases

    BioGridi109454. 4 interactions.
    STRINGi9606.ENSP00000328928.

    Structurei

    3D structure databases

    ProteinModelPortaliP17483.
    SMRiP17483. Positions 169-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi141 – 1466Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 139125Pro-rich (part of the transcriptional activation domain)Add
    BLAST
    Compositional biasi71 – 8717Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314883.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP17483.
    KOiK09304.
    OMAiRYAACRD.
    OrthoDBiEOG780RP4.
    PhylomeDBiP17483.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP    50
    EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG 100
    ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV 150
    STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC 200
    LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA 250
    L 251
    Length:251
    Mass (Da):27,604
    Last modified:June 1, 1994 - v2
    Checksum:i23EE1D0DDCCE2DB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16174 Genomic DNA. Translation: CAA34296.1.
    AF287967 Genomic DNA. Translation: AAG31554.1.
    AF307160 Genomic DNA. Translation: AAG45052.1.
    BC049204 mRNA. Translation: AAH49204.1.
    AL137449 mRNA. Translation: CAB70742.1.
    CCDSiCCDS11529.1.
    PIRiB60492.
    T46446.
    RefSeqiNP_076920.1. NM_024015.4.
    UniGeneiHs.664706.

    Genome annotation databases

    EnsembliENST00000332503; ENSP00000328928; ENSG00000182742.
    GeneIDi3214.
    KEGGihsa:3214.
    UCSCiuc002inp.3. human.

    Polymorphism databases

    DMDMi547692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16174 Genomic DNA. Translation: CAA34296.1 .
    AF287967 Genomic DNA. Translation: AAG31554.1 .
    AF307160 Genomic DNA. Translation: AAG45052.1 .
    BC049204 mRNA. Translation: AAH49204.1 .
    AL137449 mRNA. Translation: CAB70742.1 .
    CCDSi CCDS11529.1.
    PIRi B60492.
    T46446.
    RefSeqi NP_076920.1. NM_024015.4.
    UniGenei Hs.664706.

    3D structure databases

    ProteinModelPortali P17483.
    SMRi P17483. Positions 169-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109454. 4 interactions.
    STRINGi 9606.ENSP00000328928.

    PTM databases

    PhosphoSitei P17483.

    Polymorphism databases

    DMDMi 547692.

    Proteomic databases

    MaxQBi P17483.
    PaxDbi P17483.
    PeptideAtlasi P17483.
    PRIDEi P17483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332503 ; ENSP00000328928 ; ENSG00000182742 .
    GeneIDi 3214.
    KEGGi hsa:3214.
    UCSCi uc002inp.3. human.

    Organism-specific databases

    CTDi 3214.
    GeneCardsi GC17M046652.
    HGNCi HGNC:5115. HOXB4.
    HPAi HPA057432.
    MIMi 142965. gene.
    neXtProti NX_P17483.
    PharmGKBi PA29391.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314883.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P17483.
    KOi K09304.
    OMAi RYAACRD.
    OrthoDBi EOG780RP4.
    PhylomeDBi P17483.
    TreeFami TF352857.

    Miscellaneous databases

    GeneWikii HOXB4.
    GenomeRNAii 3214.
    NextBioi 12788.
    PROi P17483.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17483.
    CleanExi HS_HOXB4.
    Genevestigatori P17483.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
      Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
      Am. J. Hum. Genet. 67:235-235(2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2."
      Giannola D.M., Shlomchik W.D., Jegathesan M., Liebowitz D., Abrams C.S., Kadesch T., Dancis A., Emerson S.G.
      J. Exp. Med. 192:1479-1490(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-251.
      Tissue: Testis.
    6. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
      Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
      Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 160-227.
      Tissue: Placenta.
    7. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-227.

    Entry informationi

    Entry nameiHXB4_HUMAN
    AccessioniPrimary (citable) accession number: P17483
    Secondary accession number(s): Q9NTA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3