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P17483 (HXB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Homeobox protein Hox-2F
Gene names
Name:HOXB4
Synonyms:HOX2F
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

bone marrow development

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from electronic annotation. Source: Ensembl

definitive hemopoiesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

hematopoietic stem cell differentiation

Inferred from direct assay PubMed 18932205. Source: BHF-UCL

morphogenesis of an epithelial sheet

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of stem cell differentiation

Inferred from direct assay PubMed 18932205. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18932205. Source: BHF-UCL

somatic stem cell division

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Homeobox protein Hox-B4
PRO_0000200122

Regions

DNA binding162 – 22160Homeobox
Motif141 – 1466Antp-type hexapeptide
Compositional bias15 – 139125Pro-rich (part of the transcriptional activation domain)
Compositional bias71 – 8717Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P17483 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: 23EE1D0DDCCE2DB4

FASTA25127,604
        10         20         30         40         50         60 
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC 

        70         80         90        100        110        120 
TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP 

       130        140        150        160        170        180 
PCAQNPLHPS PSHSACKEPV VYPWMRKVHV STVNPNYAGG EPKRSRTAYT RQQVLELEKE 

       190        200        210        220        230        240 
FHYNRYLTRR RRVEIAHALC LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP 

       250 
PGRPNGGPRA L 

« Hide

References

« Hide 'large scale' references
[1]"Expression of HOX homeogenes in human neuroblastoma cell culture lines."
Peverali F.A., D'Esposito M., Acampora D., Bunone G., Negri M., Faiella A., Stornaiuolo A., Pannese M., Migliaccio E., Simeone A., Valle G.D., Boncinelli E.
Differentiation 45:61-69(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
Am. J. Hum. Genet. 67:235-235(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2."
Giannola D.M., Shlomchik W.D., Jegathesan M., Liebowitz D., Abrams C.S., Kadesch T., Dancis A., Emerson S.G.
J. Exp. Med. 192:1479-1490(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-251.
Tissue: Testis.
[6]"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 160-227.
Tissue: Placenta.
[7]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-227.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16174 Genomic DNA. Translation: CAA34296.1.
AF287967 Genomic DNA. Translation: AAG31554.1.
AF307160 Genomic DNA. Translation: AAG45052.1.
BC049204 mRNA. Translation: AAH49204.1.
AL137449 mRNA. Translation: CAB70742.1.
CCDSCCDS11529.1.
PIRB60492.
T46446.
RefSeqNP_076920.1. NM_024015.4.
UniGeneHs.664706.

3D structure databases

ProteinModelPortalP17483.
SMRP17483. Positions 169-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109454. 4 interactions.
STRING9606.ENSP00000328928.

PTM databases

PhosphoSiteP17483.

Polymorphism databases

DMDM547692.

Proteomic databases

MaxQBP17483.
PaxDbP17483.
PeptideAtlasP17483.
PRIDEP17483.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332503; ENSP00000328928; ENSG00000182742.
GeneID3214.
KEGGhsa:3214.
UCSCuc002inp.3. human.

Organism-specific databases

CTD3214.
GeneCardsGC17M046652.
HGNCHGNC:5115. HOXB4.
HPAHPA057432.
MIM142965. gene.
neXtProtNX_P17483.
PharmGKBPA29391.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314883.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidP17483.
KOK09304.
OMARYAACRD.
OrthoDBEOG780RP4.
PhylomeDBP17483.
TreeFamTF352857.

Gene expression databases

BgeeP17483.
CleanExHS_HOXB4.
GenevestigatorP17483.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB4.
GenomeRNAi3214.
NextBio12788.
PROP17483.
SOURCESearch...

Entry information

Entry nameHXB4_HUMAN
AccessionPrimary (citable) accession number: P17483
Secondary accession number(s): Q9NTA0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries