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P17482

- HXB9_HUMAN

UniProt

P17482 - HXB9_HUMAN

Protein

Homeobox protein Hox-B9

Gene

HOXB9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi185 – 24460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. canonical Wnt signaling pathway Source: UniProtKB
    3. cell chemotaxis Source: UniProtKB
    4. embryonic skeletal system development Source: Ensembl
    5. mammary gland development Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B9
    Alternative name(s):
    Homeobox protein Hox-2.5
    Homeobox protein Hox-2E
    Gene namesi
    Name:HOXB9
    Synonyms:HOX2E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5120. HOXB9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29396.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Homeobox protein Hox-B9PRO_0000200155Add
    BLAST

    Proteomic databases

    PaxDbiP17482.
    PRIDEiP17482.

    PTM databases

    PhosphoSiteiP17482.

    Expressioni

    Developmental stagei

    Expressed in whole embryos and fetuses at 5-9 weeks from conception.

    Gene expression databases

    ArrayExpressiP17482.
    BgeeiP17482.
    CleanExiHS_HOXB9.
    GenevestigatoriP17482.

    Organism-specific databases

    HPAiHPA031463.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDFIQ997503EBI-745290,EBI-724076
    SAT1P216733EBI-745290,EBI-711613

    Protein-protein interaction databases

    BioGridi109459. 17 interactions.
    IntActiP17482. 8 interactions.
    MINTiMINT-118223.
    STRINGi9606.ENSP00000309439.

    Structurei

    3D structure databases

    ProteinModelPortaliP17482.
    SMRiP17482. Positions 185-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG325913.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiP17482.
    KOiK09294.
    OMAiCSFQPKP.
    OrthoDBiEOG7RRF81.
    PhylomeDBiP17482.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17482-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC    50
    SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE 100
    PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN 150
    QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL 200
    EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE 250
    Length:250
    Mass (Da):28,059
    Last modified:January 23, 2002 - v2
    Checksum:iF06ECBC08FBBED2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731T → A in CAA34294. (PubMed:2570724)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
    AK315480 mRNA. Translation: BAG37864.1.
    CH471109 Genomic DNA. Translation: EAW94721.1.
    BC015565 mRNA. Translation: AAH15565.1.
    X16172 Genomic DNA. Translation: CAA34294.1.
    CCDSiCCDS11534.1.
    PIRiA37042.
    RefSeqiNP_076922.1. NM_024017.4.
    UniGeneiHs.463350.

    Genome annotation databases

    EnsembliENST00000311177; ENSP00000309439; ENSG00000170689.
    GeneIDi3219.
    KEGGihsa:3219.
    UCSCiuc002inx.3. human.

    Polymorphism databases

    DMDMi20141507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014296 , AY014295 Genomic DNA. Translation: AAG42144.1 .
    AK315480 mRNA. Translation: BAG37864.1 .
    CH471109 Genomic DNA. Translation: EAW94721.1 .
    BC015565 mRNA. Translation: AAH15565.1 .
    X16172 Genomic DNA. Translation: CAA34294.1 .
    CCDSi CCDS11534.1.
    PIRi A37042.
    RefSeqi NP_076922.1. NM_024017.4.
    UniGenei Hs.463350.

    3D structure databases

    ProteinModelPortali P17482.
    SMRi P17482. Positions 185-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109459. 17 interactions.
    IntActi P17482. 8 interactions.
    MINTi MINT-118223.
    STRINGi 9606.ENSP00000309439.

    PTM databases

    PhosphoSitei P17482.

    Polymorphism databases

    DMDMi 20141507.

    Proteomic databases

    PaxDbi P17482.
    PRIDEi P17482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311177 ; ENSP00000309439 ; ENSG00000170689 .
    GeneIDi 3219.
    KEGGi hsa:3219.
    UCSCi uc002inx.3. human.

    Organism-specific databases

    CTDi 3219.
    GeneCardsi GC17M046694.
    HGNCi HGNC:5120. HOXB9.
    HPAi HPA031463.
    MIMi 142964. gene.
    neXtProti NX_P17482.
    PharmGKBi PA29396.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325913.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi P17482.
    KOi K09294.
    OMAi CSFQPKP.
    OrthoDBi EOG7RRF81.
    PhylomeDBi P17482.
    TreeFami TF317819.

    Miscellaneous databases

    GeneWikii HOXB9.
    GenomeRNAii 3219.
    NextBioi 12808.
    PROi P17482.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17482.
    Bgeei P17482.
    CleanExi HS_HOXB9.
    Genevestigatori P17482.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
      Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
      Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-250.
      Tissue: Placenta.
    6. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-250.

    Entry informationi

    Entry nameiHXB9_HUMAN
    AccessioniPrimary (citable) accession number: P17482
    Secondary accession number(s): B2RDB7, Q9H1I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3