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P17482 (HXB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Homeobox protein Hox-2E
Gene names
Name:HOXB9
Synonyms:HOX2E
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Homeobox protein Hox-B9
PRO_0000200155

Regions

DNA binding185 – 24460Homeobox

Experimental info

Sequence conflict1731T → A in CAA34294. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P17482 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: F06ECBC08FBBED2C

FASTA25028,059
        10         20         30         40         50         60 
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG 

        70         80         90        100        110        120 
ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP 

       130        140        150        160        170        180 
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL 

       190        200        210        220        230        240 
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM 

       250 
KKMNKEQGKE 

« Hide

References

« Hide 'large scale' references
[1]"Complete mutation analysis panel of the 39 human HOX genes."
Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K., Tomita M., McGinnis W., Matsuo N.
Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-250.
Tissue: Placenta.
[6]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-250.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
AK315480 mRNA. Translation: BAG37864.1.
CH471109 Genomic DNA. Translation: EAW94721.1.
BC015565 mRNA. Translation: AAH15565.1.
X16172 Genomic DNA. Translation: CAA34294.1.
CCDSCCDS11534.1.
PIRA37042.
RefSeqNP_076922.1. NM_024017.4.
UniGeneHs.463350.

3D structure databases

ProteinModelPortalP17482.
SMRP17482. Positions 185-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109459. 17 interactions.
IntActP17482. 8 interactions.
MINTMINT-118223.
STRING9606.ENSP00000309439.

PTM databases

PhosphoSiteP17482.

Polymorphism databases

DMDM20141507.

Proteomic databases

PaxDbP17482.
PRIDEP17482.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311177; ENSP00000309439; ENSG00000170689.
GeneID3219.
KEGGhsa:3219.
UCSCuc002inx.3. human.

Organism-specific databases

CTD3219.
GeneCardsGC17M046694.
HGNCHGNC:5120. HOXB9.
HPAHPA031463.
MIM142964. gene.
neXtProtNX_P17482.
PharmGKBPA29396.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325913.
HOGENOMHOG000231180.
HOVERGENHBG016849.
InParanoidP17482.
KOK09294.
OMACSFQPKP.
OrthoDBEOG7RRF81.
PhylomeDBP17482.
TreeFamTF317819.

Gene expression databases

ArrayExpressP17482.
BgeeP17482.
CleanExHS_HOXB9.
GenevestigatorP17482.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB9.
GenomeRNAi3219.
NextBio12808.
PROP17482.
SOURCESearch...

Entry information

Entry nameHXB9_HUMAN
AccessionPrimary (citable) accession number: P17482
Secondary accession number(s): B2RDB7, Q9H1I1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries