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Protein

Homeobox protein Hox-B9

Gene

HOXB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 24460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Homeobox protein Hox-2E
Gene namesi
Name:HOXB9
Synonyms:HOX2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5120. HOXB9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29396.

Polymorphism and mutation databases

BioMutaiHOXB9.
DMDMi20141507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-B9PRO_0000200155Add
BLAST

Proteomic databases

PaxDbiP17482.
PRIDEiP17482.

PTM databases

PhosphoSiteiP17482.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP17482.
CleanExiHS_HOXB9.
GenevestigatoriP17482.

Organism-specific databases

HPAiHPA031463.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-745290,EBI-739580
GOLGA2Q083793EBI-745290,EBI-618309
KRTAP10-9P604113EBI-745290,EBI-10172052
KRTAP5-9P263713EBI-745290,EBI-3958099
MDFIQ997503EBI-745290,EBI-724076
MID2Q9UJV3-23EBI-745290,EBI-10172526
PNMA1Q8ND903EBI-745290,EBI-302345
SATQ6ICU93EBI-745290,EBI-10178867
SAT1P216733EBI-745290,EBI-711613
TRIP6Q156543EBI-745290,EBI-742327

Protein-protein interaction databases

BioGridi109459. 30 interactions.
IntActiP17482. 17 interactions.
MINTiMINT-118223.
STRINGi9606.ENSP00000309439.

Structurei

3D structure databases

ProteinModelPortaliP17482.
SMRiP17482. Positions 185-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG325913.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP17482.
KOiK09294.
OMAiNDPSANW.
OrthoDBiEOG7RRF81.
PhylomeDBiP17482.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC
60 70 80 90 100
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE
110 120 130 140 150
PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN
160 170 180 190 200
QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL
210 220 230 240 250
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
Length:250
Mass (Da):28,059
Last modified:January 23, 2002 - v2
Checksum:iF06ECBC08FBBED2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731T → A in CAA34294 (PubMed:2570724).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
AK315480 mRNA. Translation: BAG37864.1.
CH471109 Genomic DNA. Translation: EAW94721.1.
BC015565 mRNA. Translation: AAH15565.1.
X16172 Genomic DNA. Translation: CAA34294.1.
CCDSiCCDS11534.1.
PIRiA37042.
RefSeqiNP_076922.1. NM_024017.4.
UniGeneiHs.463350.

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689.
GeneIDi3219.
KEGGihsa:3219.
UCSCiuc002inx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
AK315480 mRNA. Translation: BAG37864.1.
CH471109 Genomic DNA. Translation: EAW94721.1.
BC015565 mRNA. Translation: AAH15565.1.
X16172 Genomic DNA. Translation: CAA34294.1.
CCDSiCCDS11534.1.
PIRiA37042.
RefSeqiNP_076922.1. NM_024017.4.
UniGeneiHs.463350.

3D structure databases

ProteinModelPortaliP17482.
SMRiP17482. Positions 185-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109459. 30 interactions.
IntActiP17482. 17 interactions.
MINTiMINT-118223.
STRINGi9606.ENSP00000309439.

PTM databases

PhosphoSiteiP17482.

Polymorphism and mutation databases

BioMutaiHOXB9.
DMDMi20141507.

Proteomic databases

PaxDbiP17482.
PRIDEiP17482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689.
GeneIDi3219.
KEGGihsa:3219.
UCSCiuc002inx.3. human.

Organism-specific databases

CTDi3219.
GeneCardsiGC17M046694.
HGNCiHGNC:5120. HOXB9.
HPAiHPA031463.
MIMi142964. gene.
neXtProtiNX_P17482.
PharmGKBiPA29396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325913.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP17482.
KOiK09294.
OMAiNDPSANW.
OrthoDBiEOG7RRF81.
PhylomeDBiP17482.
TreeFamiTF317819.

Miscellaneous databases

ChiTaRSiHOXB9. human.
GeneWikiiHOXB9.
GenomeRNAii3219.
NextBioi12808.
PROiP17482.
SOURCEiSearch...

Gene expression databases

BgeeiP17482.
CleanExiHS_HOXB9.
GenevestigatoriP17482.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-250.
    Tissue: Placenta.
  6. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-250.

Entry informationi

Entry nameiHXB9_HUMAN
AccessioniPrimary (citable) accession number: P17482
Secondary accession number(s): B2RDB7, Q9H1I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: April 29, 2015
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.