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Protein

Homeobox protein Hox-B9

Gene

HOXB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 244HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP17482.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Homeobox protein Hox-2E
Gene namesi
Name:HOXB9
Synonyms:HOX2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5120. HOXB9.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3219.
OpenTargetsiENSG00000170689.
PharmGKBiPA29396.

Polymorphism and mutation databases

BioMutaiHOXB9.
DMDMi20141507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001551 – 250Homeobox protein Hox-B9Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP17482.
PeptideAtlasiP17482.
PRIDEiP17482.

PTM databases

iPTMnetiP17482.
PhosphoSitePlusiP17482.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000170689.
CleanExiHS_HOXB9.
GenevisibleiP17482. HS.

Organism-specific databases

HPAiHPA031463.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109459. 46 interactors.
IntActiP17482. 60 interactors.
MINTiMINT-118223.
STRINGi9606.ENSP00000309439.

Structurei

3D structure databases

ProteinModelPortaliP17482.
SMRiP17482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP17482.
KOiK09294.
OMAiCSFQPKP.
OrthoDBiEOG091G0H4X.
PhylomeDBiP17482.
TreeFamiTF317819.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P17482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC
60 70 80 90 100
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE
110 120 130 140 150
PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN
160 170 180 190 200
QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL
210 220 230 240 250
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
Length:250
Mass (Da):28,059
Last modified:January 23, 2002 - v2
Checksum:iF06ECBC08FBBED2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173T → A in CAA34294 (PubMed:2570724).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
AK315480 mRNA. Translation: BAG37864.1.
CH471109 Genomic DNA. Translation: EAW94721.1.
BC015565 mRNA. Translation: AAH15565.1.
X16172 Genomic DNA. Translation: CAA34294.1.
CCDSiCCDS11534.1.
PIRiA37042.
RefSeqiNP_076922.1. NM_024017.4.
UniGeneiHs.463350.

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689.
GeneIDi3219.
KEGGihsa:3219.
UCSCiuc002inx.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHXB9_HUMAN
AccessioniPrimary (citable) accession number: P17482
Secondary accession number(s): B2RDB7, Q9H1I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: June 7, 2017
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families