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P17482

- HXB9_HUMAN

UniProt

P17482 - HXB9_HUMAN

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Protein
Homeobox protein Hox-B9
Gene
HOXB9, HOX2E
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 24460Homeobox
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. canonical Wnt signaling pathway Source: UniProtKB
  3. cell chemotaxis Source: UniProtKB
  4. embryonic skeletal system development Source: Ensembl
  5. mammary gland development Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Homeobox protein Hox-2E
Gene namesi
Name:HOXB9
Synonyms:HOX2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5120. HOXB9.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-B9
PRO_0000200155Add
BLAST

Proteomic databases

PaxDbiP17482.
PRIDEiP17482.

PTM databases

PhosphoSiteiP17482.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

ArrayExpressiP17482.
BgeeiP17482.
CleanExiHS_HOXB9.
GenevestigatoriP17482.

Organism-specific databases

HPAiHPA031463.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-745290,EBI-724076
SAT1P216733EBI-745290,EBI-711613

Protein-protein interaction databases

BioGridi109459. 17 interactions.
IntActiP17482. 8 interactions.
MINTiMINT-118223.
STRINGi9606.ENSP00000309439.

Structurei

3D structure databases

ProteinModelPortaliP17482.
SMRiP17482. Positions 185-244.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG325913.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP17482.
KOiK09294.
OMAiCSFQPKP.
OrthoDBiEOG7RRF81.
PhylomeDBiP17482.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17482-1 [UniParc]FASTAAdd to Basket

« Hide

MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC    50
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE 100
PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN 150
QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL 200
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE 250
Length:250
Mass (Da):28,059
Last modified:January 23, 2002 - v2
Checksum:iF06ECBC08FBBED2C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731T → A in CAA34294. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014296, AY014295 Genomic DNA. Translation: AAG42144.1.
AK315480 mRNA. Translation: BAG37864.1.
CH471109 Genomic DNA. Translation: EAW94721.1.
BC015565 mRNA. Translation: AAH15565.1.
X16172 Genomic DNA. Translation: CAA34294.1.
CCDSiCCDS11534.1.
PIRiA37042.
RefSeqiNP_076922.1. NM_024017.4.
UniGeneiHs.463350.

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689.
GeneIDi3219.
KEGGihsa:3219.
UCSCiuc002inx.3. human.

Polymorphism databases

DMDMi20141507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014296 , AY014295 Genomic DNA. Translation: AAG42144.1 .
AK315480 mRNA. Translation: BAG37864.1 .
CH471109 Genomic DNA. Translation: EAW94721.1 .
BC015565 mRNA. Translation: AAH15565.1 .
X16172 Genomic DNA. Translation: CAA34294.1 .
CCDSi CCDS11534.1.
PIRi A37042.
RefSeqi NP_076922.1. NM_024017.4.
UniGenei Hs.463350.

3D structure databases

ProteinModelPortali P17482.
SMRi P17482. Positions 185-244.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109459. 17 interactions.
IntActi P17482. 8 interactions.
MINTi MINT-118223.
STRINGi 9606.ENSP00000309439.

PTM databases

PhosphoSitei P17482.

Polymorphism databases

DMDMi 20141507.

Proteomic databases

PaxDbi P17482.
PRIDEi P17482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311177 ; ENSP00000309439 ; ENSG00000170689 .
GeneIDi 3219.
KEGGi hsa:3219.
UCSCi uc002inx.3. human.

Organism-specific databases

CTDi 3219.
GeneCardsi GC17M046694.
HGNCi HGNC:5120. HOXB9.
HPAi HPA031463.
MIMi 142964. gene.
neXtProti NX_P17482.
PharmGKBi PA29396.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325913.
HOGENOMi HOG000231180.
HOVERGENi HBG016849.
InParanoidi P17482.
KOi K09294.
OMAi CSFQPKP.
OrthoDBi EOG7RRF81.
PhylomeDBi P17482.
TreeFami TF317819.

Miscellaneous databases

GeneWikii HOXB9.
GenomeRNAii 3219.
NextBioi 12808.
PROi P17482.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17482.
Bgeei P17482.
CleanExi HS_HOXB9.
Genevestigatori P17482.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view ]
PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-250.
    Tissue: Placenta.
  6. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-250.

Entry informationi

Entry nameiHXB9_HUMAN
AccessioniPrimary (citable) accession number: P17482
Secondary accession number(s): B2RDB7, Q9H1I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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