ID   HXB8_HUMAN              Reviewed;         243 AA.
AC   P17481; Q9H1I2;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   24-JAN-2024, entry version 195.
DE   RecName: Full=Homeobox protein Hox-B8;
DE   AltName: Full=Homeobox protein Hox-2.4;
DE   AltName: Full=Homeobox protein Hox-2D;
GN   Name=HOXB8; Synonyms=HOX2D;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11857506; DOI=10.1002/tera.10009;
RA   Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA   Tomita M., McGinnis W., Matsuo N.;
RT   "Complete mutation analysis panel of the 39 human HOX genes.";
RL   Teratology 65:50-62(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-211.
RC   TISSUE=Placenta;
RX   PubMed=2570724; DOI=10.1111/j.1432-0436.1989.tb00598.x;
RA   Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M.,
RA   Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E.,
RA   Peschle C.;
RT   "Differential expression of human HOX-2 genes along the anterior-posterior
RT   axis in embryonic central nervous system.";
RL   Differentiation 40:191-197(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-211.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
RN   [4]
RP   INTERACTION WITH PXB1.
RX   PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA   Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT   "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT   products of multiple murine Hox genes, some of which are themselves
RT   oncogenes.";
RL   Mol. Cell. Biol. 15:3786-3795(1995).
RN   [5]
RP   INTERACTION WITH PBX1.
RX   PubMed=9191052; DOI=10.1038/sj.onc.1201097;
RA   Knoepfler P.S., Kamps M.P.;
RT   "The highest affinity DNA element bound by Pbx complexes in t(1;19)
RT   leukemic cells fails to mediate cooperative DNA-binding or cooperative
RT   transactivation by E2a-Pbx1 and class I Hox proteins - evidence for
RT   selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.";
RL   Oncogene 14:2521-2531(1997).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:9191052}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9
CC       weeks from conception.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AY014294; AAG42143.1; -; Genomic_DNA.
DR   EMBL; AY014293; AAG42143.1; JOINED; Genomic_DNA.
DR   EMBL; X16173; CAA34295.1; -; Genomic_DNA.
DR   CCDS; CCDS11533.1; -.
DR   PIR; B37042; B37042.
DR   RefSeq; NP_076921.1; NM_024016.3.
DR   RefSeq; XP_016880053.1; XM_017024564.1.
DR   AlphaFoldDB; P17481; -.
DR   SMR; P17481; -.
DR   BioGRID; 109458; 49.
DR   ELM; P17481; -.
DR   STRING; 9606.ENSP00000239144; -.
DR   iPTMnet; P17481; -.
DR   PhosphoSitePlus; P17481; -.
DR   BioMuta; HOXB8; -.
DR   DMDM; 20141506; -.
DR   jPOST; P17481; -.
DR   MassIVE; P17481; -.
DR   MaxQB; P17481; -.
DR   PaxDb; 9606-ENSP00000239144; -.
DR   PeptideAtlas; P17481; -.
DR   ProteomicsDB; 53475; -.
DR   Pumba; P17481; -.
DR   Antibodypedia; 30298; 227 antibodies from 27 providers.
DR   DNASU; 3218; -.
DR   Ensembl; ENST00000239144.5; ENSP00000239144.4; ENSG00000120068.7.
DR   GeneID; 3218; -.
DR   KEGG; hsa:3218; -.
DR   MANE-Select; ENST00000239144.5; ENSP00000239144.4; NM_024016.4; NP_076921.1.
DR   UCSC; uc002inw.3; human.
DR   AGR; HGNC:5119; -.
DR   CTD; 3218; -.
DR   DisGeNET; 3218; -.
DR   GeneCards; HOXB8; -.
DR   HGNC; HGNC:5119; HOXB8.
DR   HPA; ENSG00000120068; Tissue enhanced (brain, epididymis, kidney).
DR   MIM; 142963; gene.
DR   neXtProt; NX_P17481; -.
DR   OpenTargets; ENSG00000120068; -.
DR   PharmGKB; PA29395; -.
DR   VEuPathDB; HostDB:ENSG00000120068; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161529; -.
DR   HOGENOM; CLU_061398_1_0_1; -.
DR   InParanoid; P17481; -.
DR   OMA; SEDCCEK; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P17481; -.
DR   TreeFam; TF316310; -.
DR   PathwayCommons; P17481; -.
DR   SignaLink; P17481; -.
DR   SIGNOR; P17481; -.
DR   BioGRID-ORCS; 3218; 10 hits in 1176 CRISPR screens.
DR   ChiTaRS; HOXB8; human.
DR   GeneWiki; HOXB8; -.
DR   GenomeRNAi; 3218; -.
DR   Pharos; P17481; Tbio.
DR   PRO; PR:P17481; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P17481; Protein.
DR   Bgee; ENSG00000120068; Expressed in corpus epididymis and 84 other cell types or tissues.
DR   ExpressionAtlas; P17481; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR46166; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46166:SF2; HOMEOBOX PROTEIN HOX-B8; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P17481; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..243
FT                   /note="Homeobox protein Hox-B8"
FT                   /id="PRO_0000200148"
FT   DNA_BIND        146..205
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          203..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           134..139
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   243 AA;  27574 MW;  36982182725F121F CRC64;
     MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG
     PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE
     EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS
     HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG
     DKK
//