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P17481

- HXB8_HUMAN

UniProt

P17481 - HXB8_HUMAN

Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. dorsal spinal cord development Source: Ensembl
    4. embryonic skeletal system morphogenesis Source: Ensembl
    5. grooming behavior Source: Ensembl
    6. negative regulation of myeloid cell differentiation Source: UniProtKB
    7. sensory perception of pain Source: Ensembl
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B8
    Alternative name(s):
    Homeobox protein Hox-2.4
    Homeobox protein Hox-2D
    Gene namesi
    Name:HOXB8
    Synonyms:HOX2D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5119. HOXB8.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Homeobox protein Hox-B8PRO_0000200148Add
    BLAST

    Proteomic databases

    PaxDbiP17481.
    PRIDEiP17481.

    PTM databases

    PhosphoSiteiP17481.

    Expressioni

    Developmental stagei

    Expressed in whole embryos and fetuses at 5-9 weeks from conception.

    Gene expression databases

    ArrayExpressiP17481.
    BgeeiP17481.
    CleanExiHS_HOXB8.
    GenevestigatoriP17481.

    Interactioni

    Protein-protein interaction databases

    BioGridi109458. 2 interactions.
    STRINGi9606.ENSP00000239144.

    Structurei

    3D structure databases

    ProteinModelPortaliP17481.
    SMRiP17481. Positions 150-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi134 – 1396Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP17481.
    KOiK09308.
    OMAiMERAQEV.
    PhylomeDBiP17481.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17481-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH    50
    PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ 100
    DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR 150
    QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK 200
    WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK 243
    Length:243
    Mass (Da):27,574
    Last modified:January 23, 2002 - v2
    Checksum:i36982182725F121F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
    X16173 Genomic DNA. Translation: CAA34295.1.
    CCDSiCCDS11533.1.
    PIRiB37042.
    RefSeqiNP_076921.1. NM_024016.3.
    UniGeneiHs.514292.

    Genome annotation databases

    EnsembliENST00000239144; ENSP00000239144; ENSG00000120068.
    GeneIDi3218.
    KEGGihsa:3218.
    UCSCiuc002inw.3. human.

    Polymorphism databases

    DMDMi20141506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014294 , AY014293 Genomic DNA. Translation: AAG42143.1 .
    X16173 Genomic DNA. Translation: CAA34295.1 .
    CCDSi CCDS11533.1.
    PIRi B37042.
    RefSeqi NP_076921.1. NM_024016.3.
    UniGenei Hs.514292.

    3D structure databases

    ProteinModelPortali P17481.
    SMRi P17481. Positions 150-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109458. 2 interactions.
    STRINGi 9606.ENSP00000239144.

    PTM databases

    PhosphoSitei P17481.

    Polymorphism databases

    DMDMi 20141506.

    Proteomic databases

    PaxDbi P17481.
    PRIDEi P17481.

    Protocols and materials databases

    DNASUi 3218.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239144 ; ENSP00000239144 ; ENSG00000120068 .
    GeneIDi 3218.
    KEGGi hsa:3218.
    UCSCi uc002inw.3. human.

    Organism-specific databases

    CTDi 3218.
    GeneCardsi GC17M046688.
    HGNCi HGNC:5119. HOXB8.
    MIMi 142963. gene.
    neXtProti NX_P17481.
    PharmGKBi PA29395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314669.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P17481.
    KOi K09308.
    OMAi MERAQEV.
    PhylomeDBi P17481.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXB8.
    GenomeRNAii 3218.
    NextBioi 12804.
    PROi P17481.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17481.
    Bgeei P17481.
    CleanExi HS_HOXB8.
    Genevestigatori P17481.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
      Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
      Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-211.
      Tissue: Placenta.
    3. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-211.

    Entry informationi

    Entry nameiHXB8_HUMAN
    AccessioniPrimary (citable) accession number: P17481
    Secondary accession number(s): Q9H1I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3