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P17481 (HXB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Homeobox protein Hox-2D
Gene names
Name:HOXB8
Synonyms:HOX2D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Homeobox protein Hox-B8
PRO_0000200148

Regions

DNA binding146 – 20560Homeobox
Motif134 – 1396Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P17481 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 36982182725F121F

FASTA24327,574
        10         20         30         40         50         60 
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 

        70         80         90        100        110        120 
PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 

       130        140        150        160        170        180 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 

       190        200        210        220        230        240 
HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG 


DKK 

« Hide

References

[1]"Complete mutation analysis panel of the 39 human HOX genes."
Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K., Tomita M., McGinnis W., Matsuo N.
Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-211.
Tissue: Placenta.
[3]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-211.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
X16173 Genomic DNA. Translation: CAA34295.1.
CCDSCCDS11533.1.
PIRB37042.
RefSeqNP_076921.1. NM_024016.3.
UniGeneHs.514292.

3D structure databases

ProteinModelPortalP17481.
SMRP17481. Positions 150-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109458. 2 interactions.
STRING9606.ENSP00000239144.

PTM databases

PhosphoSiteP17481.

Polymorphism databases

DMDM20141506.

Proteomic databases

PaxDbP17481.
PRIDEP17481.

Protocols and materials databases

DNASU3218.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000239144; ENSP00000239144; ENSG00000120068.
GeneID3218.
KEGGhsa:3218.
UCSCuc002inw.3. human.

Organism-specific databases

CTD3218.
GeneCardsGC17M046688.
HGNCHGNC:5119. HOXB8.
MIM142963. gene.
neXtProtNX_P17481.
PharmGKBPA29395.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314669.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP17481.
KOK09308.
OMAMERAQEV.
PhylomeDBP17481.
TreeFamTF316310.

Gene expression databases

ArrayExpressP17481.
BgeeP17481.
CleanExHS_HOXB8.
GenevestigatorP17481.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB8.
GenomeRNAi3218.
NextBio12804.
PROP17481.
SOURCESearch...

Entry information

Entry nameHXB8_HUMAN
AccessionPrimary (citable) accession number: P17481
Secondary accession number(s): Q9H1I2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries