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P17481

- HXB8_HUMAN

UniProt

P17481 - HXB8_HUMAN

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Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. dorsal spinal cord development Source: Ensembl
  4. embryonic skeletal system morphogenesis Source: Ensembl
  5. grooming behavior Source: Ensembl
  6. negative regulation of myeloid cell differentiation Source: UniProtKB
  7. sensory perception of pain Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Homeobox protein Hox-2D
Gene namesi
Name:HOXB8
Synonyms:HOX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5119. HOXB8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Homeobox protein Hox-B8PRO_0000200148Add
BLAST

Proteomic databases

PaxDbiP17481.
PRIDEiP17481.

PTM databases

PhosphoSiteiP17481.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP17481.
CleanExiHS_HOXB8.
ExpressionAtlasiP17481. baseline and differential.
GenevestigatoriP17481.

Interactioni

Protein-protein interaction databases

BioGridi109458. 2 interactions.
STRINGi9606.ENSP00000239144.

Structurei

3D structure databases

ProteinModelPortaliP17481.
SMRiP17481. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 1396Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17481.
KOiK09308.
OMAiMERAQEV.
PhylomeDBiP17481.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17481-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
Length:243
Mass (Da):27,574
Last modified:January 23, 2002 - v2
Checksum:i36982182725F121F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
X16173 Genomic DNA. Translation: CAA34295.1.
CCDSiCCDS11533.1.
PIRiB37042.
RefSeqiNP_076921.1. NM_024016.3.
UniGeneiHs.514292.

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068.
GeneIDi3218.
KEGGihsa:3218.
UCSCiuc002inw.3. human.

Polymorphism databases

DMDMi20141506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014294 , AY014293 Genomic DNA. Translation: AAG42143.1 .
X16173 Genomic DNA. Translation: CAA34295.1 .
CCDSi CCDS11533.1.
PIRi B37042.
RefSeqi NP_076921.1. NM_024016.3.
UniGenei Hs.514292.

3D structure databases

ProteinModelPortali P17481.
SMRi P17481. Positions 150-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109458. 2 interactions.
STRINGi 9606.ENSP00000239144.

PTM databases

PhosphoSitei P17481.

Polymorphism databases

DMDMi 20141506.

Proteomic databases

PaxDbi P17481.
PRIDEi P17481.

Protocols and materials databases

DNASUi 3218.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239144 ; ENSP00000239144 ; ENSG00000120068 .
GeneIDi 3218.
KEGGi hsa:3218.
UCSCi uc002inw.3. human.

Organism-specific databases

CTDi 3218.
GeneCardsi GC17M046688.
HGNCi HGNC:5119. HOXB8.
MIMi 142963. gene.
neXtProti NX_P17481.
PharmGKBi PA29395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314669.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P17481.
KOi K09308.
OMAi MERAQEV.
PhylomeDBi P17481.
TreeFami TF316310.

Miscellaneous databases

GeneWikii HOXB8.
GenomeRNAii 3218.
NextBioi 12804.
PROi P17481.
SOURCEi Search...

Gene expression databases

Bgeei P17481.
CleanExi HS_HOXB8.
ExpressionAtlasi P17481. baseline and differential.
Genevestigatori P17481.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-211.
    Tissue: Placenta.
  3. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-211.

Entry informationi

Entry nameiHXB8_HUMAN
AccessioniPrimary (citable) accession number: P17481
Secondary accession number(s): Q9H1I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: October 29, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3