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Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. dorsal spinal cord development Source: Ensembl
  4. embryonic skeletal system morphogenesis Source: Ensembl
  5. grooming behavior Source: Ensembl
  6. negative regulation of myeloid cell differentiation Source: UniProtKB
  7. sensory perception of pain Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Homeobox protein Hox-2D
Gene namesi
Name:HOXB8
Synonyms:HOX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5119. HOXB8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Homeobox protein Hox-B8PRO_0000200148Add
BLAST

Proteomic databases

PaxDbiP17481.
PRIDEiP17481.

PTM databases

PhosphoSiteiP17481.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP17481.
CleanExiHS_HOXB8.
ExpressionAtlasiP17481. baseline and differential.
GenevestigatoriP17481.

Interactioni

Protein-protein interaction databases

BioGridi109458. 2 interactions.
STRINGi9606.ENSP00000239144.

Structurei

3D structure databases

ProteinModelPortaliP17481.
SMRiP17481. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 1396Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17481.
KOiK09308.
OMAiPQIQEFY.
PhylomeDBiP17481.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17481-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
Length:243
Mass (Da):27,574
Last modified:January 23, 2002 - v2
Checksum:i36982182725F121F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
X16173 Genomic DNA. Translation: CAA34295.1.
CCDSiCCDS11533.1.
PIRiB37042.
RefSeqiNP_076921.1. NM_024016.3.
UniGeneiHs.514292.

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068.
GeneIDi3218.
KEGGihsa:3218.
UCSCiuc002inw.3. human.

Polymorphism databases

DMDMi20141506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
X16173 Genomic DNA. Translation: CAA34295.1.
CCDSiCCDS11533.1.
PIRiB37042.
RefSeqiNP_076921.1. NM_024016.3.
UniGeneiHs.514292.

3D structure databases

ProteinModelPortaliP17481.
SMRiP17481. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109458. 2 interactions.
STRINGi9606.ENSP00000239144.

PTM databases

PhosphoSiteiP17481.

Polymorphism databases

DMDMi20141506.

Proteomic databases

PaxDbiP17481.
PRIDEiP17481.

Protocols and materials databases

DNASUi3218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068.
GeneIDi3218.
KEGGihsa:3218.
UCSCiuc002inw.3. human.

Organism-specific databases

CTDi3218.
GeneCardsiGC17M046688.
HGNCiHGNC:5119. HOXB8.
MIMi142963. gene.
neXtProtiNX_P17481.
PharmGKBiPA29395.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17481.
KOiK09308.
OMAiPQIQEFY.
PhylomeDBiP17481.
TreeFamiTF316310.

Miscellaneous databases

ChiTaRSiHOXB8. human.
GeneWikiiHOXB8.
GenomeRNAii3218.
NextBioi12804.
PROiP17481.
SOURCEiSearch...

Gene expression databases

BgeeiP17481.
CleanExiHS_HOXB8.
ExpressionAtlasiP17481. baseline and differential.
GenevestigatoriP17481.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-211.
    Tissue: Placenta.
  3. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-211.

Entry informationi

Entry nameiHXB8_HUMAN
AccessioniPrimary (citable) accession number: P17481
Secondary accession number(s): Q9H1I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: January 7, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.