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Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP17481.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Homeobox protein Hox-2D
Gene namesi
Name:HOXB8
Synonyms:HOX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000120068.6.
HGNCiHGNC:5119. HOXB8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3218.
OpenTargetsiENSG00000120068.
PharmGKBiPA29395.

Polymorphism and mutation databases

BioMutaiHOXB8.
DMDMi20141506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001481 – 243Homeobox protein Hox-B8Add BLAST243

Proteomic databases

MaxQBiP17481.
PaxDbiP17481.
PeptideAtlasiP17481.
PRIDEiP17481.

PTM databases

iPTMnetiP17481.
PhosphoSitePlusiP17481.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000120068.
CleanExiHS_HOXB8.
ExpressionAtlasiP17481. baseline and differential.
GenevisibleiP17481. HS.

Organism-specific databases

HPAiHPA075905.

Interactioni

Protein-protein interaction databases

BioGridi109458. 3 interactors.
ELMiP17481.
STRINGi9606.ENSP00000239144.

Structurei

3D structure databases

ProteinModelPortaliP17481.
SMRiP17481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi134 – 139Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP17481.
KOiK09308.
OMAiAGGTFQH.
OrthoDBiEOG091G09XD.
PhylomeDBiP17481.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P17481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
Length:243
Mass (Da):27,574
Last modified:January 23, 2002 - v2
Checksum:i36982182725F121F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014294, AY014293 Genomic DNA. Translation: AAG42143.1.
X16173 Genomic DNA. Translation: CAA34295.1.
CCDSiCCDS11533.1.
PIRiB37042.
RefSeqiNP_076921.1. NM_024016.3.
XP_016880053.1. XM_017024564.1.
UniGeneiHs.514292.

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068.
GeneIDi3218.
KEGGihsa:3218.
UCSCiuc002inw.3. human.

Similar proteinsi

Entry informationi

Entry nameiHXB8_HUMAN
AccessioniPrimary (citable) accession number: P17481
Secondary accession number(s): Q9H1I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: September 27, 2017
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families