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P17480

- UBF1_HUMAN

UniProt

P17480 - UBF1_HUMAN

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Protein
Nucleolar transcription factor 1
Gene
UBTF, UBF, UBF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi112 – 18069HMG box 1
Add
BLAST
DNA bindingi196 – 26469HMG box 2
Add
BLAST
DNA bindingi298 – 36265HMG box 3
Add
BLAST
DNA bindingi407 – 47569HMG box 4
Add
BLAST
DNA bindingi482 – 54968HMG box 5
Add
BLAST
DNA bindingi568 – 63467HMG box 6
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. chromatin silencing at rDNA Source: Ensembl
  2. gene expression Source: Reactome
  3. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
  4. regulation of transcription from RNA polymerase I promoter Source: ProtInc
  5. termination of RNA polymerase I transcription Source: Reactome
  6. transcription elongation from RNA polymerase I promoter Source: Reactome
  7. transcription from RNA polymerase I promoter Source: Reactome
  8. transcription initiation from RNA polymerase I promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_2232. RNA Polymerase I Promoter Opening.
REACT_953. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar transcription factor 1
Alternative name(s):
Autoantigen NOR-90
Upstream-binding factor 1
Short name:
UBF-1
Gene namesi
Name:UBTF
Synonyms:UBF, UBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12511. UBTF.

Subcellular locationi

Nucleusnucleolus By similarity 1 Publication

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Nucleolar transcription factor 1
PRO_0000048625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei201 – 2011Phosphothreonine1 Publication
Modified residuei273 – 2731Phosphoserine By similarity
Modified residuei336 – 3361Phosphoserine By similarity
Modified residuei364 – 3641Phosphoserine By similarity
Modified residuei389 – 3891Phosphoserine By similarity
Modified residuei412 – 4121Phosphoserine2 Publications
Modified residuei433 – 4331Phosphoserine By similarity
Modified residuei484 – 4841Phosphoserine2 Publications
Modified residuei495 – 4951Phosphoserine1 Publication
Modified residuei546 – 5461Phosphoserine By similarity
Modified residuei584 – 5841Phosphoserine By similarity
Modified residuei638 – 6381Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated and activated by PIK3CA By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP17480.
PaxDbiP17480.
PRIDEiP17480.

PTM databases

PhosphoSiteiP17480.

Expressioni

Gene expression databases

ArrayExpressiP17480.
BgeeiP17480.
CleanExiHS_UBTF.
GenevestigatoriP17480.

Organism-specific databases

HPAiCAB004611.
HPA006385.

Interactioni

Subunit structurei

Homodimer. Interacts with TBP. Interacts with RASL11A, TAF1A and TAF1D. Binds to IRS1 and PIK3CA By similarity. Interacts with DHX33. Interacts with PHF6.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-396235,EBI-447544
SETQ011054EBI-396235,EBI-1053182

Protein-protein interaction databases

BioGridi113190. 44 interactions.
DIPiDIP-640N.
IntActiP17480. 10 interactions.
MINTiMINT-1348764.
STRINGi9606.ENSP00000302640.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi107 – 1115
Helixi118 – 13114
Helixi140 – 15213
Helixi158 – 17619
Helixi177 – 1815
Helixi488 – 50316
Turni504 – 5063
Helixi508 – 52114
Helixi524 – 54522
Helixi551 – 5533
Beta strandi554 – 5585

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K99NMR-A103-192[»]
1L8YNMR-A479-560[»]
1L8ZNMR-A479-560[»]
2HDZX-ray2.00A479-560[»]
ProteinModelPortaliP17480.
SMRiP17480. Positions 103-192, 288-383, 394-472, 481-546, 567-655.

Miscellaneous databases

EvolutionaryTraceiP17480.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi675 – 76490Asp/Glu/Ser-rich (acidic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG327891.
HOGENOMiHOG000232068.
HOVERGENiHBG008708.
InParanoidiP17480.
KOiK09273.
OMAiCSQRWKL.
OrthoDBiEOG7P2XTJ.
PhylomeDBiP17480.
TreeFamiTF328989.

Family and domain databases

Gene3Di1.10.30.10. 6 hits.
InterProiIPR029215. HMG_box_5.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 3 hits.
PF09011. HMG_box_2. 1 hit.
PF14887. HMG_box_5. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 6 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 6 hits.
PROSITEiPS50118. HMG_BOX_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform UBF1 (identifier: P17480-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE    50
SHMDWEKVAF KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY 100
KGKKLKKHPD FPKKPLTPYF RFFMEKRAKY AKLHPEMSNL DLTKILSKKY 150
KELPEKKKMK YIQDFQREKQ EFERNLARFR EDHPDLIQNA KKSDIPEKPK 200
TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK KRLKWIHKAL 250
EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP 300
PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK 350
KKDYEVELLR FLESLPEEEQ QRVLGEEKML NINKKQATSP ASKKPAQEGG 400
KGGSEKPKRP VSAMFIFSEE KRRQLQEERP ELSESELTRL LARMWNDLSE 450
KKKAKYKARE AALKAQSERK PGGEREERGK LPESPKRAEE IWQQSVIGDY 500
LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR YERELSEMRA 550
PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI 600
GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS 650
NKRKSMTKLR GPNPKSSRTT LQSKSESEED DEEDEDDEDE DEEEEDDENG 700
DSSEDGGDSS ESSSEDESED GDENEEDDED EDDDEDDDED EDNESEGSSS 750
SSSSSGDSSD SDSN 764
Length:764
Mass (Da):89,406
Last modified:August 1, 1990 - v1
Checksum:iD4F0F8BB180E757D
GO
Isoform UBF2 (identifier: P17480-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     221-257: Missing.

Show »
Length:727
Mass (Da):84,937
Checksum:i9E5ECB321567DB64
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 25737Missing in isoform UBF2.
VSP_002193Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53390 mRNA. Translation: CAA37469.1.
X53461 mRNA. Translation: CAA37548.1.
X56687 mRNA. Translation: CAA40016.1.
AK291733 mRNA. Translation: BAF84422.1.
AK292518 mRNA. Translation: BAF85207.1.
BC042297 mRNA. Translation: AAH42297.1.
CCDSiCCDS11480.1. [P17480-1]
CCDS42346.1. [P17480-2]
PIRiS09318.
S18193.
RefSeqiNP_001070151.1. NM_001076683.1. [P17480-2]
NP_001070152.1. NM_001076684.2. [P17480-2]
NP_055048.1. NM_014233.3. [P17480-1]
XP_006722122.1. XM_006722059.1. [P17480-1]
XP_006722123.1. XM_006722060.1. [P17480-1]
XP_006722124.1. XM_006722061.1. [P17480-1]
UniGeneiHs.89781.

Genome annotation databases

EnsembliENST00000302904; ENSP00000302640; ENSG00000108312. [P17480-1]
ENST00000343638; ENSP00000345297; ENSG00000108312. [P17480-2]
ENST00000393606; ENSP00000377231; ENSG00000108312. [P17480-2]
ENST00000436088; ENSP00000390669; ENSG00000108312. [P17480-1]
ENST00000526094; ENSP00000432925; ENSG00000108312. [P17480-2]
ENST00000529383; ENSP00000435708; ENSG00000108312. [P17480-1]
ENST00000533177; ENSP00000437180; ENSG00000108312. [P17480-2]
GeneIDi7343.
KEGGihsa:7343.
UCSCiuc002igc.3. human. [P17480-2]
uc010czs.3. human. [P17480-1]

Polymorphism databases

DMDMi136652.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53390 mRNA. Translation: CAA37469.1 .
X53461 mRNA. Translation: CAA37548.1 .
X56687 mRNA. Translation: CAA40016.1 .
AK291733 mRNA. Translation: BAF84422.1 .
AK292518 mRNA. Translation: BAF85207.1 .
BC042297 mRNA. Translation: AAH42297.1 .
CCDSi CCDS11480.1. [P17480-1 ]
CCDS42346.1. [P17480-2 ]
PIRi S09318.
S18193.
RefSeqi NP_001070151.1. NM_001076683.1. [P17480-2 ]
NP_001070152.1. NM_001076684.2. [P17480-2 ]
NP_055048.1. NM_014233.3. [P17480-1 ]
XP_006722122.1. XM_006722059.1. [P17480-1 ]
XP_006722123.1. XM_006722060.1. [P17480-1 ]
XP_006722124.1. XM_006722061.1. [P17480-1 ]
UniGenei Hs.89781.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K99 NMR - A 103-192 [» ]
1L8Y NMR - A 479-560 [» ]
1L8Z NMR - A 479-560 [» ]
2HDZ X-ray 2.00 A 479-560 [» ]
ProteinModelPortali P17480.
SMRi P17480. Positions 103-192, 288-383, 394-472, 481-546, 567-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113190. 44 interactions.
DIPi DIP-640N.
IntActi P17480. 10 interactions.
MINTi MINT-1348764.
STRINGi 9606.ENSP00000302640.

PTM databases

PhosphoSitei P17480.

Polymorphism databases

DMDMi 136652.

Proteomic databases

MaxQBi P17480.
PaxDbi P17480.
PRIDEi P17480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302904 ; ENSP00000302640 ; ENSG00000108312 . [P17480-1 ]
ENST00000343638 ; ENSP00000345297 ; ENSG00000108312 . [P17480-2 ]
ENST00000393606 ; ENSP00000377231 ; ENSG00000108312 . [P17480-2 ]
ENST00000436088 ; ENSP00000390669 ; ENSG00000108312 . [P17480-1 ]
ENST00000526094 ; ENSP00000432925 ; ENSG00000108312 . [P17480-2 ]
ENST00000529383 ; ENSP00000435708 ; ENSG00000108312 . [P17480-1 ]
ENST00000533177 ; ENSP00000437180 ; ENSG00000108312 . [P17480-2 ]
GeneIDi 7343.
KEGGi hsa:7343.
UCSCi uc002igc.3. human. [P17480-2 ]
uc010czs.3. human. [P17480-1 ]

Organism-specific databases

CTDi 7343.
GeneCardsi GC17M042282.
HGNCi HGNC:12511. UBTF.
HPAi CAB004611.
HPA006385.
MIMi 600673. gene.
neXtProti NX_P17480.
PharmGKBi PA37158.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327891.
HOGENOMi HOG000232068.
HOVERGENi HBG008708.
InParanoidi P17480.
KOi K09273.
OMAi CSQRWKL.
OrthoDBi EOG7P2XTJ.
PhylomeDBi P17480.
TreeFami TF328989.

Enzyme and pathway databases

Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_2232. RNA Polymerase I Promoter Opening.
REACT_953. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

ChiTaRSi UBTF. human.
EvolutionaryTracei P17480.
GeneWikii UBTF.
GenomeRNAii 7343.
NextBioi 28746.
PROi P17480.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17480.
Bgeei P17480.
CleanExi HS_UBTF.
Genevestigatori P17480.

Family and domain databases

Gene3Di 1.10.30.10. 6 hits.
InterProi IPR029215. HMG_box_5.
IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 3 hits.
PF09011. HMG_box_2. 1 hit.
PF14887. HMG_box_5. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 6 hits.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 6 hits.
PROSITEi PS50118. HMG_BOX_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins."
    Jantzen H.M., Admon A., Bell S.P., Tjian R.
    Nature 344:830-836(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM UBF1).
  2. "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor."
    Chan E.K.L., Imai H., Hamel J.C., Tan E.M.
    J. Exp. Med. 174:1239-1244(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM UBF2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM UBF1).
    Tissue: Placenta and Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM UBF2).
    Tissue: Testis.
  5. "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."
    Kwon H., Green M.R.
    J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TBP.
  6. "Coactivator and promoter-selective properties of RNA polymerase I TAFs."
    Beckmann H., Chen J.L., O'Brien T., Tjian R.
    Science 270:1506-1509(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TAF1A.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-201; SER-412 AND SER-638, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-484 AND SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."
    Zhang Y., Forys J.T., Miceli A.P., Gwinn A.S., Weber J.D.
    Mol. Cell. Biol. 31:4676-4691(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DHX33.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis."
    Wang J., Leung J.W., Gong Z., Feng L., Shi X., Chen J.
    J. Biol. Chem. 288:3174-3183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PHF6.
  15. "Solution structure of the first HMG box domain in human upstream binding factor."
    Xu Y., Yang W., Wu J., Shi Y.
    Biochemistry 41:5415-5420(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 103-192.
  16. "Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor."
    Yang W., Xu Y., Wu J., Zeng W., Shi Y.
    Biochemistry 42:1930-1938(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 479-560.

Entry informationi

Entry nameiUBF1_HUMAN
AccessioniPrimary (citable) accession number: P17480
Secondary accession number(s): A8K6R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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