Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar transcription factor 1

Gene

UBTF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 180HMG box 1PROSITE-ProRule annotationAdd BLAST69
DNA bindingi196 – 264HMG box 2PROSITE-ProRule annotationAdd BLAST69
DNA bindingi298 – 362HMG box 3PROSITE-ProRule annotationAdd BLAST65
DNA bindingi407 – 475HMG box 4PROSITE-ProRule annotationAdd BLAST69
DNA bindingi482 – 549HMG box 5PROSITE-ProRule annotationAdd BLAST68
DNA bindingi568 – 634HMG box 6PROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase I upstream control element sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108312-MONOMER.
ReactomeiR-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.
SIGNORiP17480.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar transcription factor 1
Alternative name(s):
Autoantigen NOR-90
Upstream-binding factor 1
Short name:
UBF-1
Gene namesi
Name:UBTF
Synonyms:UBF, UBF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12511. UBTF.

Subcellular locationi

GO - Cellular componenti

  • fibrillar center Source: Ensembl
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7343.
OpenTargetsiENSG00000108312.
PharmGKBiPA37158.

Polymorphism and mutation databases

BioMutaiUBTF.
DMDMi136652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486251 – 764Nucleolar transcription factor 1Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei336PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1
Modified residuei412PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei546PhosphoserineBy similarity1
Modified residuei584PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated and activated by PIK3CA.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP17480.
MaxQBiP17480.
PaxDbiP17480.
PeptideAtlasiP17480.
PRIDEiP17480.

PTM databases

iPTMnetiP17480.
PhosphoSitePlusiP17480.
SwissPalmiP17480.

Expressioni

Gene expression databases

BgeeiENSG00000108312.
CleanExiHS_UBTF.
ExpressionAtlasiP17480. baseline and differential.
GenevisibleiP17480. HS.

Organism-specific databases

HPAiCAB004611.
HPA006385.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with TBP (PubMed:7982918). Interacts with TAF1A (PubMed:7491500). Interacts with RASL11A (By similarity). Binds to IRS1 and PIK3CA (By similarity). Interacts with DHX33 (PubMed:21930779). Interacts with PHF6 (PubMed:23229552). Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868). Interacts with DDX11 (PubMed:26089203).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011062EBI-396235,EBI-447544
SETQ011054EBI-396235,EBI-1053182

Protein-protein interaction databases

BioGridi113190. 82 interactors.
DIPiDIP-640N.
IntActiP17480. 24 interactors.
MINTiMINT-1348764.
STRINGi9606.ENSP00000302640.

Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi107 – 111Combined sources5
Helixi118 – 131Combined sources14
Helixi140 – 152Combined sources13
Helixi158 – 176Combined sources19
Helixi177 – 181Combined sources5
Helixi488 – 503Combined sources16
Turni504 – 506Combined sources3
Helixi508 – 521Combined sources14
Helixi524 – 545Combined sources22
Helixi551 – 553Combined sources3
Beta strandi554 – 558Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K99NMR-A103-192[»]
1L8YNMR-A479-560[»]
1L8ZNMR-A479-560[»]
2HDZX-ray2.00A479-560[»]
ProteinModelPortaliP17480.
SMRiP17480.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17480.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi675 – 764Asp/Glu/Ser-rich (acidic)Add BLAST90

Sequence similaritiesi

Contains 6 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00530000063934.
HOGENOMiHOG000232068.
HOVERGENiHBG008708.
InParanoidiP17480.
KOiK09273.
OMAiCSQRWKL.
OrthoDBiEOG091G0GL0.
PhylomeDBiP17480.
TreeFamiTF328989.

Family and domain databases

Gene3Di1.10.30.10. 6 hits.
InterProiIPR029215. HMG_box_5.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 3 hits.
PF09011. HMG_box_2. 1 hit.
PF14887. HMG_box_5. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 6 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 6 hits.
PROSITEiPS50118. HMG_BOX_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform UBF1 (identifier: P17480-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE
60 70 80 90 100
SHMDWEKVAF KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY
110 120 130 140 150
KGKKLKKHPD FPKKPLTPYF RFFMEKRAKY AKLHPEMSNL DLTKILSKKY
160 170 180 190 200
KELPEKKKMK YIQDFQREKQ EFERNLARFR EDHPDLIQNA KKSDIPEKPK
210 220 230 240 250
TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK KRLKWIHKAL
260 270 280 290 300
EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP
310 320 330 340 350
PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK
360 370 380 390 400
KKDYEVELLR FLESLPEEEQ QRVLGEEKML NINKKQATSP ASKKPAQEGG
410 420 430 440 450
KGGSEKPKRP VSAMFIFSEE KRRQLQEERP ELSESELTRL LARMWNDLSE
460 470 480 490 500
KKKAKYKARE AALKAQSERK PGGEREERGK LPESPKRAEE IWQQSVIGDY
510 520 530 540 550
LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR YERELSEMRA
560 570 580 590 600
PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI
610 620 630 640 650
GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS
660 670 680 690 700
NKRKSMTKLR GPNPKSSRTT LQSKSESEED DEEDEDDEDE DEEEEDDENG
710 720 730 740 750
DSSEDGGDSS ESSSEDESED GDENEEDDED EDDDEDDDED EDNESEGSSS
760
SSSSSGDSSD SDSN
Length:764
Mass (Da):89,406
Last modified:August 1, 1990 - v1
Checksum:iD4F0F8BB180E757D
GO
Isoform UBF2 (identifier: P17480-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     221-257: Missing.

Show »
Length:727
Mass (Da):84,937
Checksum:i9E5ECB321567DB64
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002193221 – 257Missing in isoform UBF2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53390 mRNA. Translation: CAA37469.1.
X53461 mRNA. Translation: CAA37548.1.
X56687 mRNA. Translation: CAA40016.1.
AK291733 mRNA. Translation: BAF84422.1.
AK292518 mRNA. Translation: BAF85207.1.
BC042297 mRNA. Translation: AAH42297.1.
CCDSiCCDS11480.1. [P17480-1]
CCDS42346.1. [P17480-2]
PIRiS09318.
S18193.
RefSeqiNP_001070151.1. NM_001076683.1. [P17480-2]
NP_001070152.1. NM_001076684.2. [P17480-2]
NP_055048.1. NM_014233.3. [P17480-1]
XP_006722122.1. XM_006722059.3. [P17480-1]
XP_006722123.1. XM_006722060.2. [P17480-1]
XP_006722124.1. XM_006722061.2. [P17480-1]
XP_016880492.1. XM_017025003.1. [P17480-2]
XP_016880493.1. XM_017025004.1. [P17480-2]
UniGeneiHs.89781.

Genome annotation databases

EnsembliENST00000302904; ENSP00000302640; ENSG00000108312. [P17480-1]
ENST00000343638; ENSP00000345297; ENSG00000108312. [P17480-2]
ENST00000393606; ENSP00000377231; ENSG00000108312. [P17480-2]
ENST00000436088; ENSP00000390669; ENSG00000108312. [P17480-1]
ENST00000526094; ENSP00000432925; ENSG00000108312. [P17480-2]
ENST00000529383; ENSP00000435708; ENSG00000108312. [P17480-1]
ENST00000533177; ENSP00000437180; ENSG00000108312. [P17480-2]
GeneIDi7343.
KEGGihsa:7343.
UCSCiuc002igc.4. human. [P17480-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53390 mRNA. Translation: CAA37469.1.
X53461 mRNA. Translation: CAA37548.1.
X56687 mRNA. Translation: CAA40016.1.
AK291733 mRNA. Translation: BAF84422.1.
AK292518 mRNA. Translation: BAF85207.1.
BC042297 mRNA. Translation: AAH42297.1.
CCDSiCCDS11480.1. [P17480-1]
CCDS42346.1. [P17480-2]
PIRiS09318.
S18193.
RefSeqiNP_001070151.1. NM_001076683.1. [P17480-2]
NP_001070152.1. NM_001076684.2. [P17480-2]
NP_055048.1. NM_014233.3. [P17480-1]
XP_006722122.1. XM_006722059.3. [P17480-1]
XP_006722123.1. XM_006722060.2. [P17480-1]
XP_006722124.1. XM_006722061.2. [P17480-1]
XP_016880492.1. XM_017025003.1. [P17480-2]
XP_016880493.1. XM_017025004.1. [P17480-2]
UniGeneiHs.89781.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K99NMR-A103-192[»]
1L8YNMR-A479-560[»]
1L8ZNMR-A479-560[»]
2HDZX-ray2.00A479-560[»]
ProteinModelPortaliP17480.
SMRiP17480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113190. 82 interactors.
DIPiDIP-640N.
IntActiP17480. 24 interactors.
MINTiMINT-1348764.
STRINGi9606.ENSP00000302640.

PTM databases

iPTMnetiP17480.
PhosphoSitePlusiP17480.
SwissPalmiP17480.

Polymorphism and mutation databases

BioMutaiUBTF.
DMDMi136652.

Proteomic databases

EPDiP17480.
MaxQBiP17480.
PaxDbiP17480.
PeptideAtlasiP17480.
PRIDEiP17480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302904; ENSP00000302640; ENSG00000108312. [P17480-1]
ENST00000343638; ENSP00000345297; ENSG00000108312. [P17480-2]
ENST00000393606; ENSP00000377231; ENSG00000108312. [P17480-2]
ENST00000436088; ENSP00000390669; ENSG00000108312. [P17480-1]
ENST00000526094; ENSP00000432925; ENSG00000108312. [P17480-2]
ENST00000529383; ENSP00000435708; ENSG00000108312. [P17480-1]
ENST00000533177; ENSP00000437180; ENSG00000108312. [P17480-2]
GeneIDi7343.
KEGGihsa:7343.
UCSCiuc002igc.4. human. [P17480-1]

Organism-specific databases

CTDi7343.
DisGeNETi7343.
GeneCardsiUBTF.
HGNCiHGNC:12511. UBTF.
HPAiCAB004611.
HPA006385.
MIMi600673. gene.
neXtProtiNX_P17480.
OpenTargetsiENSG00000108312.
PharmGKBiPA37158.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00530000063934.
HOGENOMiHOG000232068.
HOVERGENiHBG008708.
InParanoidiP17480.
KOiK09273.
OMAiCSQRWKL.
OrthoDBiEOG091G0GL0.
PhylomeDBiP17480.
TreeFamiTF328989.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108312-MONOMER.
ReactomeiR-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-73728. RNA Polymerase I Promoter Opening.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.
SIGNORiP17480.

Miscellaneous databases

ChiTaRSiUBTF. human.
EvolutionaryTraceiP17480.
GeneWikiiUBTF.
GenomeRNAii7343.
PROiP17480.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108312.
CleanExiHS_UBTF.
ExpressionAtlasiP17480. baseline and differential.
GenevisibleiP17480. HS.

Family and domain databases

Gene3Di1.10.30.10. 6 hits.
InterProiIPR029215. HMG_box_5.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 3 hits.
PF09011. HMG_box_2. 1 hit.
PF14887. HMG_box_5. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 6 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 6 hits.
PROSITEiPS50118. HMG_BOX_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBF1_HUMAN
AccessioniPrimary (citable) accession number: P17480
Secondary accession number(s): A8K6R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 184 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.