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P17480

- UBF1_HUMAN

UniProt

P17480 - UBF1_HUMAN

Protein

Nucleolar transcription factor 1

Gene

UBTF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi112 – 18069HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi196 – 26469HMG box 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi298 – 36265HMG box 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi407 – 47569HMG box 4PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi482 – 54968HMG box 5PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi568 – 63467HMG box 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing at rDNA Source: Ensembl
    2. gene expression Source: Reactome
    3. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
    4. regulation of transcription from RNA polymerase I promoter Source: ProtInc
    5. termination of RNA polymerase I transcription Source: Reactome
    6. transcription elongation from RNA polymerase I promoter Source: Reactome
    7. transcription from RNA polymerase I promoter Source: Reactome
    8. transcription initiation from RNA polymerase I promoter Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_2232. RNA Polymerase I Promoter Opening.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar transcription factor 1
    Alternative name(s):
    Autoantigen NOR-90
    Upstream-binding factor 1
    Short name:
    UBF-1
    Gene namesi
    Name:UBTF
    Synonyms:UBF, UBF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12511. UBTF.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37158.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Nucleolar transcription factor 1PRO_0000048625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei201 – 2011Phosphothreonine1 Publication
    Modified residuei273 – 2731PhosphoserineBy similarity
    Modified residuei336 – 3361PhosphoserineBy similarity
    Modified residuei364 – 3641PhosphoserineBy similarity
    Modified residuei389 – 3891PhosphoserineBy similarity
    Modified residuei412 – 4121Phosphoserine2 Publications
    Modified residuei433 – 4331PhosphoserineBy similarity
    Modified residuei484 – 4841Phosphoserine2 Publications
    Modified residuei495 – 4951Phosphoserine1 Publication
    Modified residuei546 – 5461PhosphoserineBy similarity
    Modified residuei584 – 5841PhosphoserineBy similarity
    Modified residuei638 – 6381Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated and activated by PIK3CA.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP17480.
    PaxDbiP17480.
    PRIDEiP17480.

    PTM databases

    PhosphoSiteiP17480.

    Expressioni

    Gene expression databases

    ArrayExpressiP17480.
    BgeeiP17480.
    CleanExiHS_UBTF.
    GenevestigatoriP17480.

    Organism-specific databases

    HPAiCAB004611.
    HPA006385.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with TBP. Interacts with RASL11A, TAF1A and TAF1D. Binds to IRS1 and PIK3CA By similarity. Interacts with DHX33. Interacts with PHF6.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYCP011062EBI-396235,EBI-447544
    SETQ011054EBI-396235,EBI-1053182

    Protein-protein interaction databases

    BioGridi113190. 44 interactions.
    DIPiDIP-640N.
    IntActiP17480. 10 interactions.
    MINTiMINT-1348764.
    STRINGi9606.ENSP00000302640.

    Structurei

    Secondary structure

    1
    764
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi107 – 1115
    Helixi118 – 13114
    Helixi140 – 15213
    Helixi158 – 17619
    Helixi177 – 1815
    Helixi488 – 50316
    Turni504 – 5063
    Helixi508 – 52114
    Helixi524 – 54522
    Helixi551 – 5533
    Beta strandi554 – 5585

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K99NMR-A103-192[»]
    1L8YNMR-A479-560[»]
    1L8ZNMR-A479-560[»]
    2HDZX-ray2.00A479-560[»]
    ProteinModelPortaliP17480.
    SMRiP17480. Positions 103-192, 288-383, 394-472, 481-546, 567-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17480.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi675 – 76490Asp/Glu/Ser-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 6 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG327891.
    HOGENOMiHOG000232068.
    HOVERGENiHBG008708.
    InParanoidiP17480.
    KOiK09273.
    OMAiCSQRWKL.
    OrthoDBiEOG7P2XTJ.
    PhylomeDBiP17480.
    TreeFamiTF328989.

    Family and domain databases

    Gene3Di1.10.30.10. 6 hits.
    InterProiIPR029215. HMG_box_5.
    IPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 3 hits.
    PF09011. HMG_box_2. 1 hit.
    PF14887. HMG_box_5. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 6 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 6 hits.
    PROSITEiPS50118. HMG_BOX_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform UBF1 (identifier: P17480-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE    50
    SHMDWEKVAF KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY 100
    KGKKLKKHPD FPKKPLTPYF RFFMEKRAKY AKLHPEMSNL DLTKILSKKY 150
    KELPEKKKMK YIQDFQREKQ EFERNLARFR EDHPDLIQNA KKSDIPEKPK 200
    TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK KRLKWIHKAL 250
    EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP 300
    PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK 350
    KKDYEVELLR FLESLPEEEQ QRVLGEEKML NINKKQATSP ASKKPAQEGG 400
    KGGSEKPKRP VSAMFIFSEE KRRQLQEERP ELSESELTRL LARMWNDLSE 450
    KKKAKYKARE AALKAQSERK PGGEREERGK LPESPKRAEE IWQQSVIGDY 500
    LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR YERELSEMRA 550
    PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI 600
    GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS 650
    NKRKSMTKLR GPNPKSSRTT LQSKSESEED DEEDEDDEDE DEEEEDDENG 700
    DSSEDGGDSS ESSSEDESED GDENEEDDED EDDDEDDDED EDNESEGSSS 750
    SSSSSGDSSD SDSN 764
    Length:764
    Mass (Da):89,406
    Last modified:August 1, 1990 - v1
    Checksum:iD4F0F8BB180E757D
    GO
    Isoform UBF2 (identifier: P17480-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         221-257: Missing.

    Show »
    Length:727
    Mass (Da):84,937
    Checksum:i9E5ECB321567DB64
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei221 – 25737Missing in isoform UBF2. 2 PublicationsVSP_002193Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53390 mRNA. Translation: CAA37469.1.
    X53461 mRNA. Translation: CAA37548.1.
    X56687 mRNA. Translation: CAA40016.1.
    AK291733 mRNA. Translation: BAF84422.1.
    AK292518 mRNA. Translation: BAF85207.1.
    BC042297 mRNA. Translation: AAH42297.1.
    CCDSiCCDS11480.1. [P17480-1]
    CCDS42346.1. [P17480-2]
    PIRiS09318.
    S18193.
    RefSeqiNP_001070151.1. NM_001076683.1. [P17480-2]
    NP_001070152.1. NM_001076684.2. [P17480-2]
    NP_055048.1. NM_014233.3. [P17480-1]
    XP_006722122.1. XM_006722059.1. [P17480-1]
    XP_006722123.1. XM_006722060.1. [P17480-1]
    XP_006722124.1. XM_006722061.1. [P17480-1]
    UniGeneiHs.89781.

    Genome annotation databases

    EnsembliENST00000302904; ENSP00000302640; ENSG00000108312. [P17480-1]
    ENST00000343638; ENSP00000345297; ENSG00000108312. [P17480-2]
    ENST00000393606; ENSP00000377231; ENSG00000108312. [P17480-2]
    ENST00000436088; ENSP00000390669; ENSG00000108312. [P17480-1]
    ENST00000526094; ENSP00000432925; ENSG00000108312. [P17480-2]
    ENST00000529383; ENSP00000435708; ENSG00000108312. [P17480-1]
    ENST00000533177; ENSP00000437180; ENSG00000108312. [P17480-2]
    GeneIDi7343.
    KEGGihsa:7343.
    UCSCiuc002igc.3. human. [P17480-2]
    uc010czs.3. human. [P17480-1]

    Polymorphism databases

    DMDMi136652.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53390 mRNA. Translation: CAA37469.1 .
    X53461 mRNA. Translation: CAA37548.1 .
    X56687 mRNA. Translation: CAA40016.1 .
    AK291733 mRNA. Translation: BAF84422.1 .
    AK292518 mRNA. Translation: BAF85207.1 .
    BC042297 mRNA. Translation: AAH42297.1 .
    CCDSi CCDS11480.1. [P17480-1 ]
    CCDS42346.1. [P17480-2 ]
    PIRi S09318.
    S18193.
    RefSeqi NP_001070151.1. NM_001076683.1. [P17480-2 ]
    NP_001070152.1. NM_001076684.2. [P17480-2 ]
    NP_055048.1. NM_014233.3. [P17480-1 ]
    XP_006722122.1. XM_006722059.1. [P17480-1 ]
    XP_006722123.1. XM_006722060.1. [P17480-1 ]
    XP_006722124.1. XM_006722061.1. [P17480-1 ]
    UniGenei Hs.89781.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K99 NMR - A 103-192 [» ]
    1L8Y NMR - A 479-560 [» ]
    1L8Z NMR - A 479-560 [» ]
    2HDZ X-ray 2.00 A 479-560 [» ]
    ProteinModelPortali P17480.
    SMRi P17480. Positions 103-192, 288-383, 394-472, 481-546, 567-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113190. 44 interactions.
    DIPi DIP-640N.
    IntActi P17480. 10 interactions.
    MINTi MINT-1348764.
    STRINGi 9606.ENSP00000302640.

    PTM databases

    PhosphoSitei P17480.

    Polymorphism databases

    DMDMi 136652.

    Proteomic databases

    MaxQBi P17480.
    PaxDbi P17480.
    PRIDEi P17480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302904 ; ENSP00000302640 ; ENSG00000108312 . [P17480-1 ]
    ENST00000343638 ; ENSP00000345297 ; ENSG00000108312 . [P17480-2 ]
    ENST00000393606 ; ENSP00000377231 ; ENSG00000108312 . [P17480-2 ]
    ENST00000436088 ; ENSP00000390669 ; ENSG00000108312 . [P17480-1 ]
    ENST00000526094 ; ENSP00000432925 ; ENSG00000108312 . [P17480-2 ]
    ENST00000529383 ; ENSP00000435708 ; ENSG00000108312 . [P17480-1 ]
    ENST00000533177 ; ENSP00000437180 ; ENSG00000108312 . [P17480-2 ]
    GeneIDi 7343.
    KEGGi hsa:7343.
    UCSCi uc002igc.3. human. [P17480-2 ]
    uc010czs.3. human. [P17480-1 ]

    Organism-specific databases

    CTDi 7343.
    GeneCardsi GC17M042282.
    HGNCi HGNC:12511. UBTF.
    HPAi CAB004611.
    HPA006385.
    MIMi 600673. gene.
    neXtProti NX_P17480.
    PharmGKBi PA37158.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327891.
    HOGENOMi HOG000232068.
    HOVERGENi HBG008708.
    InParanoidi P17480.
    KOi K09273.
    OMAi CSQRWKL.
    OrthoDBi EOG7P2XTJ.
    PhylomeDBi P17480.
    TreeFami TF328989.

    Enzyme and pathway databases

    Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_2232. RNA Polymerase I Promoter Opening.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    ChiTaRSi UBTF. human.
    EvolutionaryTracei P17480.
    GeneWikii UBTF.
    GenomeRNAii 7343.
    NextBioi 28746.
    PROi P17480.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17480.
    Bgeei P17480.
    CleanExi HS_UBTF.
    Genevestigatori P17480.

    Family and domain databases

    Gene3Di 1.10.30.10. 6 hits.
    InterProi IPR029215. HMG_box_5.
    IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 3 hits.
    PF09011. HMG_box_2. 1 hit.
    PF14887. HMG_box_5. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 6 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 6 hits.
    PROSITEi PS50118. HMG_BOX_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins."
      Jantzen H.M., Admon A., Bell S.P., Tjian R.
      Nature 344:830-836(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM UBF1).
    2. "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor."
      Chan E.K.L., Imai H., Hamel J.C., Tan E.M.
      J. Exp. Med. 174:1239-1244(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM UBF2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM UBF1).
      Tissue: Placenta and Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM UBF2).
      Tissue: Testis.
    5. "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."
      Kwon H., Green M.R.
      J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TBP.
    6. "Coactivator and promoter-selective properties of RNA polymerase I TAFs."
      Beckmann H., Chen J.L., O'Brien T., Tjian R.
      Science 270:1506-1509(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TAF1A.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-201; SER-412 AND SER-638, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-484 AND SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."
      Zhang Y., Forys J.T., Miceli A.P., Gwinn A.S., Weber J.D.
      Mol. Cell. Biol. 31:4676-4691(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DHX33.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis."
      Wang J., Leung J.W., Gong Z., Feng L., Shi X., Chen J.
      J. Biol. Chem. 288:3174-3183(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PHF6.
    15. "Solution structure of the first HMG box domain in human upstream binding factor."
      Xu Y., Yang W., Wu J., Shi Y.
      Biochemistry 41:5415-5420(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 103-192.
    16. "Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor."
      Yang W., Xu Y., Wu J., Zeng W., Shi Y.
      Biochemistry 42:1930-1938(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 479-560.

    Entry informationi

    Entry nameiUBF1_HUMAN
    AccessioniPrimary (citable) accession number: P17480
    Secondary accession number(s): A8K6R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 160 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3