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P17460

- RDRP_TCV

UniProt

P17460 - RDRP_TCV

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Turnip crinkle virus (TCV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p88
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiTurnip crinkle virus (TCV)
    Taxonomic identifieri11988 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
    Virus hostiBrassica napus subsp. rapifera [TaxID: 3709]
    Hypomyces [TaxID: 5130]
    Moricandia arvensis (Purple mistress) (Brassica arvensis) [TaxID: 180540]
    ProteomesiUP000007403: Genome, UP000009133: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 775775RNA-directed RNA polymerasePRO_0000040204Add
    BLAST
    Chaini1 – 250250Protein p28PRO_0000040205Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP17460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini473 – 586114RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17460-1 [UniParc]FASTAAdd to Basket

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    MPLLHTLNTA LAVGLLGARY YPEVQTFLGL PDYVGHMKNV VRSVFQGSGL    50
    VVVSSDTVGV RGTYSNRGQI GSSLGCILAV PDSGADIEID LDRLVGTEEE 100
    ATSCLVEAVG STADVPRRRV RQKGRFAMHA VNAAKLHFCG VPKPTEANRL 150
    AVSKWLVQYC KERHVVDSHI RTIVNTALPR VFTPDAEDIQ VVLDLHSVRA 200
    HDHRNALAEA GKVRKWWVNL AMHPMTGRSW SRAWRRLCRL PDDQAISFVR 250
    XGCLRELVGR ETQISRGENP AMRVFPLANP PKVRRIFHIC GMGNGLDFGV 300
    HNNSLNNLRR GLMERVFYVE DAQKQLKPAP QPIPGIFGKL SGIRRRLVRL 350
    AGNHTPVPRE KYPSFYKGRR ATIYQKALDS LHDRPVSRKD AELKTFVKAE 400
    KINFTAKKDP APRVIQPRDP RYNIEVGKYL KPYEHHLYRA IDAMWGGPTV 450
    LKGYDVGELG NIMSNTWDKF RKTCAIGFDM KRFDQHVSVD ALRWEHSVYN 500
    AGFNCPELAQ LLTWQLTNKG VGRASDGFIK YQVDGCRMSG DVNTALGNCL 550
    LACSITKYLM KGIKCKLINN GDDCVLFFEA DEVDRVRERL HHWIDFGFQC 600
    IAEEPQYELE KVEFCQMSPI FDGEGWVMVR NPRVSLSKDS YSTTQWANEK 650
    DAARWLAAIG ECGLAIAGGV PVLQSYYSCL KRNFGPLAGD YKKKMQDVSF 700
    DSGFYRLSKN GMRGSKDVSQ DARFSFYRGF GYTPDEQEAL EEYYDNLQLL 750
    CEWDPTGYKE ELSDRWILNE FPTTL 775
    Length:775
    Mass (Da):87,648
    Last modified:October 5, 2010 - v3
    Checksum:iA19CE0848C75253F
    GO

    Sequence cautioni

    The sequence AAA96969.2 differs from that shown. Reason: Frameshift at position 380.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421R → Q in strain: Infectious clone UK.
    Natural varianti56 – 561D → S in strain: Infectious clone UK.
    Natural varianti202 – 2021D → N in strain: Infectious clone UK.
    Natural varianti345 – 3451R → K in strain: Infectious clone UK.
    Natural varianti581 – 5811D → E in strain: Infectious clone UK.
    Natural varianti717 – 7171D → N in strain: Infectious clone UK.
    Natural varianti748 – 7481Q → E in strain: Infectious clone UK.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22445 Genomic RNA. Translation: AAA96968.2.
    M22445 Genomic RNA. Translation: AAA96969.2. Frameshift.
    AY312063 Genomic RNA. Translation: AAP78490.1.
    AY312063 Genomic RNA. Translation: AAP78486.1.
    PIRiJA0110. RRVETC.
    RefSeqiNP_620720.3. NC_003821.3.
    NP_620721.2. NC_003821.3.

    Genome annotation databases

    GeneIDi944391.
    944392.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22445 Genomic RNA. Translation: AAA96968.2 .
    M22445 Genomic RNA. Translation: AAA96969.2 . Frameshift.
    AY312063 Genomic RNA. Translation: AAP78490.1 .
    AY312063 Genomic RNA. Translation: AAP78486.1 .
    PIRi JA0110. RRVETC.
    RefSeqi NP_620720.3. NC_003821.3.
    NP_620721.2. NC_003821.3.

    3D structure databases

    ProteinModelPortali P17460.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 944391.
    944392.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Ryabov E.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Infectious clone UK.

    Entry informationi

    Entry nameiRDRP_TCV
    AccessioniPrimary (citable) accession number: P17460
    Secondary accession number(s): Q7TD17, Q7TD21, Q88486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 70 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 251.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3