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P17460 (RDRP_TCV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p88

Cleaved into the following chain:

  1. Protein p28
Gene names
ORF Names:ORF1
OrganismTurnip crinkle virus (TCV) [Complete proteome]
Taxonomic identifier11988 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostBrassica napus subsp. rapifera [TaxID: 3709]
Hypomyces [TaxID: 5130]
Moricandia arvensis (Purple mistress) (Brassica arvensis) [TaxID: 180540]

Protein attributes

Sequence length775 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 251.

Sequence similarities

Contains 1 RdRp catalytic domain.

Sequence caution

The sequence AAA96969.2 differs from that shown. Reason: Frameshift at position 380.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 775775RNA-directed RNA polymerase
PRO_0000040204
Chain1 – 250250Protein p28
PRO_0000040205

Regions

Domain473 – 586114RdRp catalytic

Natural variations

Natural variant421R → Q in strain: Infectious clone UK.
Natural variant561D → S in strain: Infectious clone UK.
Natural variant2021D → N in strain: Infectious clone UK.
Natural variant3451R → K in strain: Infectious clone UK.
Natural variant5811D → E in strain: Infectious clone UK.
Natural variant7171D → N in strain: Infectious clone UK.
Natural variant7481Q → E in strain: Infectious clone UK.

Sequences

Sequence LengthMass (Da)Tools
P17460 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: A19CE0848C75253F

FASTA77587,648
        10         20         30         40         50         60 
MPLLHTLNTA LAVGLLGARY YPEVQTFLGL PDYVGHMKNV VRSVFQGSGL VVVSSDTVGV 

        70         80         90        100        110        120 
RGTYSNRGQI GSSLGCILAV PDSGADIEID LDRLVGTEEE ATSCLVEAVG STADVPRRRV 

       130        140        150        160        170        180 
RQKGRFAMHA VNAAKLHFCG VPKPTEANRL AVSKWLVQYC KERHVVDSHI RTIVNTALPR 

       190        200        210        220        230        240 
VFTPDAEDIQ VVLDLHSVRA HDHRNALAEA GKVRKWWVNL AMHPMTGRSW SRAWRRLCRL 

       250        260        270        280        290        300 
PDDQAISFVR XGCLRELVGR ETQISRGENP AMRVFPLANP PKVRRIFHIC GMGNGLDFGV 

       310        320        330        340        350        360 
HNNSLNNLRR GLMERVFYVE DAQKQLKPAP QPIPGIFGKL SGIRRRLVRL AGNHTPVPRE 

       370        380        390        400        410        420 
KYPSFYKGRR ATIYQKALDS LHDRPVSRKD AELKTFVKAE KINFTAKKDP APRVIQPRDP 

       430        440        450        460        470        480 
RYNIEVGKYL KPYEHHLYRA IDAMWGGPTV LKGYDVGELG NIMSNTWDKF RKTCAIGFDM 

       490        500        510        520        530        540 
KRFDQHVSVD ALRWEHSVYN AGFNCPELAQ LLTWQLTNKG VGRASDGFIK YQVDGCRMSG 

       550        560        570        580        590        600 
DVNTALGNCL LACSITKYLM KGIKCKLINN GDDCVLFFEA DEVDRVRERL HHWIDFGFQC 

       610        620        630        640        650        660 
IAEEPQYELE KVEFCQMSPI FDGEGWVMVR NPRVSLSKDS YSTTQWANEK DAARWLAAIG 

       670        680        690        700        710        720 
ECGLAIAGGV PVLQSYYSCL KRNFGPLAGD YKKKMQDVSF DSGFYRLSKN GMRGSKDVSQ 

       730        740        750        760        770 
DARFSFYRGF GYTPDEQEAL EEYYDNLQLL CEWDPTGYKE ELSDRWILNE FPTTL 

« Hide

References

[1]"The genome structure of turnip crinkle virus."
Carrington J.C., Heaton L.A., Zuidema D., Hillman B.I., Morris T.J.
Virology 170:219-226(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Ryabov E.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Infectious clone UK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22445 Genomic RNA. Translation: AAA96968.2.
M22445 Genomic RNA. Translation: AAA96969.2. Frameshift.
AY312063 Genomic RNA. Translation: AAP78490.1.
AY312063 Genomic RNA. Translation: AAP78486.1.
PIRRRVETC. JA0110.
RefSeqNP_620720.3. NC_003821.3.
NP_620721.2. NC_003821.3.

3D structure databases

ProteinModelPortalP17460.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID944391.
944392.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_TCV
AccessionPrimary (citable) accession number: P17460
Secondary accession number(s): Q7TD17, Q7TD21, Q88486
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families