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P17460

- RDRP_TCV

UniProt

P17460 - RDRP_TCV

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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Turnip crinkle virus (TCV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiTurnip crinkle virus (TCV)
Taxonomic identifieri11988 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostiBrassica napus subsp. rapifera [TaxID: 3709]
Hypomyces [TaxID: 5130]
Moricandia arvensis (Purple mistress) (Brassica arvensis) [TaxID: 180540]
ProteomesiUP000007403: Genome, UP000009133: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775RNA-directed RNA polymerasePRO_0000040204Add
BLAST
Chaini1 – 250250Protein p28PRO_0000040205Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini473 – 586114RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLHTLNTA LAVGLLGARY YPEVQTFLGL PDYVGHMKNV VRSVFQGSGL
60 70 80 90 100
VVVSSDTVGV RGTYSNRGQI GSSLGCILAV PDSGADIEID LDRLVGTEEE
110 120 130 140 150
ATSCLVEAVG STADVPRRRV RQKGRFAMHA VNAAKLHFCG VPKPTEANRL
160 170 180 190 200
AVSKWLVQYC KERHVVDSHI RTIVNTALPR VFTPDAEDIQ VVLDLHSVRA
210 220 230 240 250
HDHRNALAEA GKVRKWWVNL AMHPMTGRSW SRAWRRLCRL PDDQAISFVR
260 270 280 290 300
XGCLRELVGR ETQISRGENP AMRVFPLANP PKVRRIFHIC GMGNGLDFGV
310 320 330 340 350
HNNSLNNLRR GLMERVFYVE DAQKQLKPAP QPIPGIFGKL SGIRRRLVRL
360 370 380 390 400
AGNHTPVPRE KYPSFYKGRR ATIYQKALDS LHDRPVSRKD AELKTFVKAE
410 420 430 440 450
KINFTAKKDP APRVIQPRDP RYNIEVGKYL KPYEHHLYRA IDAMWGGPTV
460 470 480 490 500
LKGYDVGELG NIMSNTWDKF RKTCAIGFDM KRFDQHVSVD ALRWEHSVYN
510 520 530 540 550
AGFNCPELAQ LLTWQLTNKG VGRASDGFIK YQVDGCRMSG DVNTALGNCL
560 570 580 590 600
LACSITKYLM KGIKCKLINN GDDCVLFFEA DEVDRVRERL HHWIDFGFQC
610 620 630 640 650
IAEEPQYELE KVEFCQMSPI FDGEGWVMVR NPRVSLSKDS YSTTQWANEK
660 670 680 690 700
DAARWLAAIG ECGLAIAGGV PVLQSYYSCL KRNFGPLAGD YKKKMQDVSF
710 720 730 740 750
DSGFYRLSKN GMRGSKDVSQ DARFSFYRGF GYTPDEQEAL EEYYDNLQLL
760 770
CEWDPTGYKE ELSDRWILNE FPTTL
Length:775
Mass (Da):87,648
Last modified:October 5, 2010 - v3
Checksum:iA19CE0848C75253F
GO

Sequence cautioni

The sequence AAA96969.2 differs from that shown. Reason: Frameshift at position 380.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421R → Q in strain: Infectious clone UK.
Natural varianti56 – 561D → S in strain: Infectious clone UK.
Natural varianti202 – 2021D → N in strain: Infectious clone UK.
Natural varianti345 – 3451R → K in strain: Infectious clone UK.
Natural varianti581 – 5811D → E in strain: Infectious clone UK.
Natural varianti717 – 7171D → N in strain: Infectious clone UK.
Natural varianti748 – 7481Q → E in strain: Infectious clone UK.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22445 Genomic RNA. Translation: AAA96968.2.
M22445 Genomic RNA. Translation: AAA96969.2. Frameshift.
AY312063 Genomic RNA. Translation: AAP78490.1.
AY312063 Genomic RNA. Translation: AAP78486.1.
PIRiJA0110. RRVETC.
RefSeqiNP_620720.3. NC_003821.3.
NP_620721.2. NC_003821.3.

Genome annotation databases

GeneIDi944391.
944392.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22445 Genomic RNA. Translation: AAA96968.2 .
M22445 Genomic RNA. Translation: AAA96969.2 . Frameshift.
AY312063 Genomic RNA. Translation: AAP78490.1 .
AY312063 Genomic RNA. Translation: AAP78486.1 .
PIRi JA0110. RRVETC.
RefSeqi NP_620720.3. NC_003821.3.
NP_620721.2. NC_003821.3.

3D structure databases

ProteinModelPortali P17460.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 944391.
944392.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Ryabov E.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Infectious clone UK.

Entry informationi

Entry nameiRDRP_TCV
AccessioniPrimary (citable) accession number: P17460
Secondary accession number(s): Q7TD17, Q7TD21, Q88486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 5, 2010
Last modified: October 1, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 251.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3