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P17459

- RDRP_CRV

UniProt

P17459 - RDRP_CRV

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Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p92
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCymbidium ringspot virus (CymRSV)
Taxonomic identifieri12144 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]
ProteomesiUP000008567: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818RNA-directed RNA polymerase
PRO_0000041334Add
BLAST
Chaini1 – 296296Protein p33
PRO_0000041335Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17459.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini524 – 641118RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17459-1 [UniParc]FASTAAdd to Basket

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METIKRLIWP KKEIFVGDFA IGVNRTVPVD VFQLVCRVVL RYMRTGKIEC    50
ESDSLSKFVV ELLKTDCAAK WEWFMKRRQG GDYIVPLSIA TIPLMPLLSC 100
TTSVRAVSVG VLGCGFSSNI PIPRLSVPRK GLLLRLAAGL ALAPICALAV 150
YATLPREKLS VYKLRTEART HMEDEKEATD CLVVESAREL KGKDGEDLLT 200
GSRMTKVVAS TGRRRRTPYA AKVAQVARAK VGYLRNTPEN RLIYQRVIIE 250
IMDKDCVRYV DRDVILPMAI GCCFVYQDGV EESAALWGSQ DSLGVKXGGL 300
VRLPGVVTQI NRDIPSDVLL PQEVLEVRTG PPIAKDRNIF MVAGCPSQAR 350
FLVHNHCLKN LKRGLVERVF CVEKDGKLTR TPQPTKGSFG RLSPFRKAVC 400
EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK 450
AEKISTSKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDDVFGETT 500
CIKGYTADEV GAIFRRKWDR FDKPVAIGLD ASRFDQHCSV EALQYEHSFY 550
RALYPGNKLL SKLLEWQLHN KGKGYVPDGT ITYKKEGCRM SGDINTSLGN 600
YLLMCAMVHG YMRHLGINEF SLANCGDDCV LIIERRNLKR VQGTLPGYFL 650
NLGYTMKVES PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN 700
NIRDLATRRA WSNAQHHGGL ALSAGIPVVE RFYSRFPLYD MPVKHQRIDT 750
VTNVHKWRGS GGNYHVTPES RASFWAAFGL TGDEQVALED RLDRWEMDLF 800
GREGVDAHEP SILDSAVA 818
Length:818
Mass (Da):91,948
Last modified:October 5, 2010 - v2
Checksum:iDC4E84499410F42D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15511 Genomic RNA. Translation: CAA33532.1.
X15511 Genomic RNA. Translation: CAB38439.1.
PIRiS05456. RRVGCR.
RefSeqiNP_613260.1. NC_003532.1.
NP_613261.1. NC_003532.1.

Genome annotation databases

GeneIDi935900.
935901.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15511 Genomic RNA. Translation: CAA33532.1 .
X15511 Genomic RNA. Translation: CAB38439.1 .
PIRi S05456. RRVGCR.
RefSeqi NP_613260.1. NC_003532.1.
NP_613261.1. NC_003532.1.

3D structure databases

ProteinModelPortali P17459.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 935900.
935901.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CRV
AccessioniPrimary (citable) accession number: P17459
Secondary accession number(s): Q9WJD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 297.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi