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P17459

- RDRP_CRV

UniProt

P17459 - RDRP_CRV

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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p92
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCymbidium ringspot virus (CymRSV)
Taxonomic identifieri12144 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]
ProteomesiUP000008567: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818RNA-directed RNA polymerasePRO_0000041334Add
BLAST
Chaini1 – 296296Protein p33PRO_0000041335Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini524 – 641118RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17459-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METIKRLIWP KKEIFVGDFA IGVNRTVPVD VFQLVCRVVL RYMRTGKIEC
60 70 80 90 100
ESDSLSKFVV ELLKTDCAAK WEWFMKRRQG GDYIVPLSIA TIPLMPLLSC
110 120 130 140 150
TTSVRAVSVG VLGCGFSSNI PIPRLSVPRK GLLLRLAAGL ALAPICALAV
160 170 180 190 200
YATLPREKLS VYKLRTEART HMEDEKEATD CLVVESAREL KGKDGEDLLT
210 220 230 240 250
GSRMTKVVAS TGRRRRTPYA AKVAQVARAK VGYLRNTPEN RLIYQRVIIE
260 270 280 290 300
IMDKDCVRYV DRDVILPMAI GCCFVYQDGV EESAALWGSQ DSLGVKXGGL
310 320 330 340 350
VRLPGVVTQI NRDIPSDVLL PQEVLEVRTG PPIAKDRNIF MVAGCPSQAR
360 370 380 390 400
FLVHNHCLKN LKRGLVERVF CVEKDGKLTR TPQPTKGSFG RLSPFRKAVC
410 420 430 440 450
EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK
460 470 480 490 500
AEKISTSKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDDVFGETT
510 520 530 540 550
CIKGYTADEV GAIFRRKWDR FDKPVAIGLD ASRFDQHCSV EALQYEHSFY
560 570 580 590 600
RALYPGNKLL SKLLEWQLHN KGKGYVPDGT ITYKKEGCRM SGDINTSLGN
610 620 630 640 650
YLLMCAMVHG YMRHLGINEF SLANCGDDCV LIIERRNLKR VQGTLPGYFL
660 670 680 690 700
NLGYTMKVES PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN
710 720 730 740 750
NIRDLATRRA WSNAQHHGGL ALSAGIPVVE RFYSRFPLYD MPVKHQRIDT
760 770 780 790 800
VTNVHKWRGS GGNYHVTPES RASFWAAFGL TGDEQVALED RLDRWEMDLF
810
GREGVDAHEP SILDSAVA
Length:818
Mass (Da):91,948
Last modified:October 5, 2010 - v2
Checksum:iDC4E84499410F42D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33532.1.
X15511 Genomic RNA. Translation: CAB38439.1.
PIRiS05456. RRVGCR.
RefSeqiNP_613260.1. NC_003532.1.
NP_613261.1. NC_003532.1.

Genome annotation databases

GeneIDi935900.
935901.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33532.1 .
X15511 Genomic RNA. Translation: CAB38439.1 .
PIRi S05456. RRVGCR.
RefSeqi NP_613260.1. NC_003532.1.
NP_613261.1. NC_003532.1.

3D structure databases

ProteinModelPortali P17459.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 935900.
935901.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CRV
AccessioniPrimary (citable) accession number: P17459
Secondary accession number(s): Q9WJD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 5, 2010
Last modified: October 1, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 297.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3