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P17459 (RDRP_CRV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p92

Cleaved into the following chain:

  1. Protein p33
Gene names
ORF Names:ORF1
OrganismCymbidium ringspot virus (CymRSV) [Complete proteome]
Taxonomic identifier12144 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 297.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818RNA-directed RNA polymerase
PRO_0000041334
Chain1 – 296296Protein p33
PRO_0000041335

Regions

Domain524 – 641118RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P17459 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: DC4E84499410F42D

FASTA81891,948
        10         20         30         40         50         60 
METIKRLIWP KKEIFVGDFA IGVNRTVPVD VFQLVCRVVL RYMRTGKIEC ESDSLSKFVV 

        70         80         90        100        110        120 
ELLKTDCAAK WEWFMKRRQG GDYIVPLSIA TIPLMPLLSC TTSVRAVSVG VLGCGFSSNI 

       130        140        150        160        170        180 
PIPRLSVPRK GLLLRLAAGL ALAPICALAV YATLPREKLS VYKLRTEART HMEDEKEATD 

       190        200        210        220        230        240 
CLVVESAREL KGKDGEDLLT GSRMTKVVAS TGRRRRTPYA AKVAQVARAK VGYLRNTPEN 

       250        260        270        280        290        300 
RLIYQRVIIE IMDKDCVRYV DRDVILPMAI GCCFVYQDGV EESAALWGSQ DSLGVKXGGL 

       310        320        330        340        350        360 
VRLPGVVTQI NRDIPSDVLL PQEVLEVRTG PPIAKDRNIF MVAGCPSQAR FLVHNHCLKN 

       370        380        390        400        410        420 
LKRGLVERVF CVEKDGKLTR TPQPTKGSFG RLSPFRKAVC EKVGVAHRLG YDGFLSYYSG 

       430        440        450        460        470        480 
AKLRTYTRAV ESLHITPVSE RDSHLTTFVK AEKISTSKGD PAPRVIQPRN PRYNVELGRY 

       490        500        510        520        530        540 
LRHMESKLMK AVDDVFGETT CIKGYTADEV GAIFRRKWDR FDKPVAIGLD ASRFDQHCSV 

       550        560        570        580        590        600 
EALQYEHSFY RALYPGNKLL SKLLEWQLHN KGKGYVPDGT ITYKKEGCRM SGDINTSLGN 

       610        620        630        640        650        660 
YLLMCAMVHG YMRHLGINEF SLANCGDDCV LIIERRNLKR VQGTLPGYFL NLGYTMKVES 

       670        680        690        700        710        720 
PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN NIRDLATRRA WSNAQHHGGL 

       730        740        750        760        770        780 
ALSAGIPVVE RFYSRFPLYD MPVKHQRIDT VTNVHKWRGS GGNYHVTPES RASFWAAFGL 

       790        800        810 
TGDEQVALED RLDRWEMDLF GREGVDAHEP SILDSAVA 

« Hide

References

[1]"The nucleotide sequence of cymbidium ringspot virus RNA."
Grieco F., Burgyan J., Russo M.
Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15511 Genomic RNA. Translation: CAA33532.1.
X15511 Genomic RNA. Translation: CAB38439.1.
PIRRRVGCR. S05456.
RefSeqNP_613260.1. NC_003532.1.
NP_613261.1. NC_003532.1.

3D structure databases

ProteinModelPortalP17459.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID935900.
935901.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_CRV
AccessionPrimary (citable) accession number: P17459
Secondary accession number(s): Q9WJD6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families