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P17459

- RDRP_CRV

UniProt

P17459 - RDRP_CRV

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p92
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiCymbidium ringspot virus (CymRSV)
    Taxonomic identifieri12144 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCymbidium [TaxID: 14366]
    Trifolium repens (Creeping white clover) [TaxID: 3899]
    ProteomesiUP000008567: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 818818RNA-directed RNA polymerasePRO_0000041334Add
    BLAST
    Chaini1 – 296296Protein p33PRO_0000041335Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP17459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini524 – 641118RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17459-1 [UniParc]FASTAAdd to Basket

    « Hide

    METIKRLIWP KKEIFVGDFA IGVNRTVPVD VFQLVCRVVL RYMRTGKIEC    50
    ESDSLSKFVV ELLKTDCAAK WEWFMKRRQG GDYIVPLSIA TIPLMPLLSC 100
    TTSVRAVSVG VLGCGFSSNI PIPRLSVPRK GLLLRLAAGL ALAPICALAV 150
    YATLPREKLS VYKLRTEART HMEDEKEATD CLVVESAREL KGKDGEDLLT 200
    GSRMTKVVAS TGRRRRTPYA AKVAQVARAK VGYLRNTPEN RLIYQRVIIE 250
    IMDKDCVRYV DRDVILPMAI GCCFVYQDGV EESAALWGSQ DSLGVKXGGL 300
    VRLPGVVTQI NRDIPSDVLL PQEVLEVRTG PPIAKDRNIF MVAGCPSQAR 350
    FLVHNHCLKN LKRGLVERVF CVEKDGKLTR TPQPTKGSFG RLSPFRKAVC 400
    EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK 450
    AEKISTSKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDDVFGETT 500
    CIKGYTADEV GAIFRRKWDR FDKPVAIGLD ASRFDQHCSV EALQYEHSFY 550
    RALYPGNKLL SKLLEWQLHN KGKGYVPDGT ITYKKEGCRM SGDINTSLGN 600
    YLLMCAMVHG YMRHLGINEF SLANCGDDCV LIIERRNLKR VQGTLPGYFL 650
    NLGYTMKVES PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN 700
    NIRDLATRRA WSNAQHHGGL ALSAGIPVVE RFYSRFPLYD MPVKHQRIDT 750
    VTNVHKWRGS GGNYHVTPES RASFWAAFGL TGDEQVALED RLDRWEMDLF 800
    GREGVDAHEP SILDSAVA 818
    Length:818
    Mass (Da):91,948
    Last modified:October 5, 2010 - v2
    Checksum:iDC4E84499410F42D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15511 Genomic RNA. Translation: CAA33532.1.
    X15511 Genomic RNA. Translation: CAB38439.1.
    PIRiS05456. RRVGCR.
    RefSeqiNP_613260.1. NC_003532.1.
    NP_613261.1. NC_003532.1.

    Genome annotation databases

    GeneIDi935900.
    935901.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15511 Genomic RNA. Translation: CAA33532.1 .
    X15511 Genomic RNA. Translation: CAB38439.1 .
    PIRi S05456. RRVGCR.
    RefSeqi NP_613260.1. NC_003532.1.
    NP_613261.1. NC_003532.1.

    3D structure databases

    ProteinModelPortali P17459.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 935900.
    935901.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of cymbidium ringspot virus RNA."
      Grieco F., Burgyan J., Russo M.
      Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_CRV
    AccessioniPrimary (citable) accession number: P17459
    Secondary accession number(s): Q9WJD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 297.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3