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P17457 (P19_CRV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene names
ORF Names:ORF4
OrganismCymbidium ringspot virus (CymRSV) [Complete proteome]
Taxonomic identifier12144 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity. Ref.3

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the tombusvirus protein p19 family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvirion

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172RNA silencing suppressor p19
PRO_0000222874

Sequences

Sequence LengthMass (Da)Tools
P17457 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: F1069F14366D5D48

FASTA17219,385
        10         20         30         40         50         60 
MERAIQGSDV REQADSECWD GGGGGTTSPF KLPDESPSLH EWRLHHSEES ENKDNPLGFK 

        70         80         90        100        110        120 
ESWSFGKVVF KRYLRYDGAE TSLHRALGSW ERDSVNDAAS RFLGLSQIGC TYSIRFRGTR 

       130        140        150        160        170 
LTLSGGSGTL QRLIEMAIRT KRTMLQPTPS EREGNVSRRR PEGTEAFKEE SE 

« Hide

References

[1]"Nucleotide sequence of the 3'-terminal region of cymbidium ringspot virus RNA."
Grieco F., Burgyan J., Russo M.
J. Gen. Virol. 70:2533-2538(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"The nucleotide sequence of cymbidium ringspot virus RNA."
Grieco F., Burgyan J., Russo M.
Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs."
Silhavy D., Molnar A., Lucioli A., Szittya G., Hornyik C., Tavazza M., Burgyan J.
EMBO J. 21:3070-3080(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15511 Genomic RNA. Translation: CAA33535.1.
PIRNKVGD2. JS0271.
RefSeqNP_613264.1. NC_003532.1.

3D structure databases

ProteinModelPortalP17457.
SMRP17457. Positions 9-151.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID935903.

Family and domain databases

InterProIPR004905. Tombusvirus_p19.
[Graphical view]
PfamPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF103145. SSF103145. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP19_CRV
AccessionPrimary (citable) accession number: P17457
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 16, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families