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P17457

- P19_CRV

UniProt

P17457 - P19_CRV

Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Suppressor of RNA silencing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA silencing suppressor p19
    Alternative name(s):
    19 kDa symptom severity modulator
    Gene namesi
    ORF Names:ORF4
    OrganismiCymbidium ringspot virus (CymRSV)
    Taxonomic identifieri12144 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCymbidium [TaxID: 14366]
    Trifolium repens (Creeping white clover) [TaxID: 3899]
    ProteomesiUP000008567: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172RNA silencing suppressor p19PRO_0000222874Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP17457.
    SMRiP17457. Positions 9-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tombusvirus protein p19 family.Curated

    Family and domain databases

    InterProiIPR004905. Tombusvirus_p19.
    [Graphical view]
    PfamiPF03220. Tombus_P19. 1 hit.
    [Graphical view]
    ProDomiPD005743. Tombus_P19. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF103145. SSF103145. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P17457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERAIQGSDV REQADSECWD GGGGGTTSPF KLPDESPSLH EWRLHHSEES    50
    ENKDNPLGFK ESWSFGKVVF KRYLRYDGAE TSLHRALGSW ERDSVNDAAS 100
    RFLGLSQIGC TYSIRFRGTR LTLSGGSGTL QRLIEMAIRT KRTMLQPTPS 150
    EREGNVSRRR PEGTEAFKEE SE 172
    Length:172
    Mass (Da):19,385
    Last modified:August 1, 1990 - v1
    Checksum:iF1069F14366D5D48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15511 Genomic RNA. Translation: CAA33535.1.
    PIRiJS0271. NKVGD2.
    RefSeqiNP_613264.1. NC_003532.1.

    Genome annotation databases

    GeneIDi935903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15511 Genomic RNA. Translation: CAA33535.1 .
    PIRi JS0271. NKVGD2.
    RefSeqi NP_613264.1. NC_003532.1.

    3D structure databases

    ProteinModelPortali P17457.
    SMRi P17457. Positions 9-151.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 935903.

    Family and domain databases

    InterProi IPR004905. Tombusvirus_p19.
    [Graphical view ]
    Pfami PF03220. Tombus_P19. 1 hit.
    [Graphical view ]
    ProDomi PD005743. Tombus_P19. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF103145. SSF103145. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the 3'-terminal region of cymbidium ringspot virus RNA."
      Grieco F., Burgyan J., Russo M.
      J. Gen. Virol. 70:2533-2538(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "The nucleotide sequence of cymbidium ringspot virus RNA."
      Grieco F., Burgyan J., Russo M.
      Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs."
      Silhavy D., Molnar A., Lucioli A., Szittya G., Hornyik C., Tavazza M., Burgyan J.
      EMBO J. 21:3070-3080(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiP19_CRV
    AccessioniPrimary (citable) accession number: P17457
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3