Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17457

- P19_CRV

UniProt

P17457 - P19_CRV

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiCymbidium ringspot virus (CymRSV)
Taxonomic identifieri12144 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]
ProteomesiUP000008567: Genome

Subcellular locationi

GO - Cellular componenti

  1. virion Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172RNA silencing suppressor p19PRO_0000222874Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP17457.
SMRiP17457. Positions 9-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

InterProiIPR004905. Tombusvirus_p19.
[Graphical view]
PfamiPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomiPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103145. SSF103145. 1 hit.

Sequencei

Sequence statusi: Complete.

P17457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERAIQGSDV REQADSECWD GGGGGTTSPF KLPDESPSLH EWRLHHSEES
60 70 80 90 100
ENKDNPLGFK ESWSFGKVVF KRYLRYDGAE TSLHRALGSW ERDSVNDAAS
110 120 130 140 150
RFLGLSQIGC TYSIRFRGTR LTLSGGSGTL QRLIEMAIRT KRTMLQPTPS
160 170
EREGNVSRRR PEGTEAFKEE SE
Length:172
Mass (Da):19,385
Last modified:August 1, 1990 - v1
Checksum:iF1069F14366D5D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33535.1.
PIRiJS0271. NKVGD2.
RefSeqiNP_613264.1. NC_003532.1.

Genome annotation databases

GeneIDi935903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33535.1 .
PIRi JS0271. NKVGD2.
RefSeqi NP_613264.1. NC_003532.1.

3D structure databases

ProteinModelPortali P17457.
SMRi P17457. Positions 9-151.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 935903.

Family and domain databases

InterProi IPR004905. Tombusvirus_p19.
[Graphical view ]
Pfami PF03220. Tombus_P19. 1 hit.
[Graphical view ]
ProDomi PD005743. Tombus_P19. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF103145. SSF103145. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the 3'-terminal region of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    J. Gen. Virol. 70:2533-2538(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The nucleotide sequence of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs."
    Silhavy D., Molnar A., Lucioli A., Szittya G., Hornyik C., Tavazza M., Burgyan J.
    EMBO J. 21:3070-3080(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiP19_CRV
AccessioniPrimary (citable) accession number: P17457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3