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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Cymbidium ringspot virus (CymRSV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiCymbidium ringspot virus (CymRSV)
Taxonomic identifieri12144 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCymbidium [TaxID: 14366]
Trifolium repens (Creeping white clover) [TaxID: 3899]
ProteomesiUP000008567 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  1. virion Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172RNA silencing suppressor p19PRO_0000222874Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP17457.
SMRiP17457. Positions 9-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

InterProiIPR004905. Tombusvirus_p19.
[Graphical view]
PfamiPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomiPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103145. SSF103145. 1 hit.

Sequencei

Sequence statusi: Complete.

P17457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAIQGSDV REQADSECWD GGGGGTTSPF KLPDESPSLH EWRLHHSEES
60 70 80 90 100
ENKDNPLGFK ESWSFGKVVF KRYLRYDGAE TSLHRALGSW ERDSVNDAAS
110 120 130 140 150
RFLGLSQIGC TYSIRFRGTR LTLSGGSGTL QRLIEMAIRT KRTMLQPTPS
160 170
EREGNVSRRR PEGTEAFKEE SE
Length:172
Mass (Da):19,385
Last modified:August 1, 1990 - v1
Checksum:iF1069F14366D5D48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33535.1.
PIRiJS0271. NKVGD2.
RefSeqiNP_613264.1. NC_003532.1.

Genome annotation databases

GeneIDi935903.
KEGGivg:935903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15511 Genomic RNA. Translation: CAA33535.1.
PIRiJS0271. NKVGD2.
RefSeqiNP_613264.1. NC_003532.1.

3D structure databases

ProteinModelPortaliP17457.
SMRiP17457. Positions 9-151.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi935903.
KEGGivg:935903.

Family and domain databases

InterProiIPR004905. Tombusvirus_p19.
[Graphical view]
PfamiPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomiPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103145. SSF103145. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the 3'-terminal region of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    J. Gen. Virol. 70:2533-2538(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The nucleotide sequence of cymbidium ringspot virus RNA."
    Grieco F., Burgyan J., Russo M.
    Nucleic Acids Res. 17:6383-6383(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs."
    Silhavy D., Molnar A., Lucioli A., Szittya G., Hornyik C., Tavazza M., Burgyan J.
    EMBO J. 21:3070-3080(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiP19_CRV
AccessioniPrimary (citable) accession number: P17457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 1, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.