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Protein

Malate synthase, glyoxysomal

Gene
N/A
Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathway:iglyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Isocitrate lyase
  2. Malate synthase, glyoxysomal
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Proton acceptorBy similarity
Active sitei468 – 4681Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifieri3635 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Malate synthase, glyoxysomalPRO_0000166869Add
BLAST

Proteomic databases

PRIDEiP17432.

Structurei

3D structure databases

ProteinModelPortaliP17432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi565 – 5673Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGLGSYGYT APSSKKINAY DVPQGVDIRG RFDEEFAKIL TKDALQFVAD
60 70 80 90 100
LQREFRNHIK YAMECRKEAK RRYNEGALPG FDPATRYIRE GKWTCVPFPP
110 120 130 140 150
AVADRRVEIT GPVERKMIIN ALNSGAKVFM ADFEDALSPS WENLMRGQIN
160 170 180 190 200
LKDAVEGTIT FNDKARNRVY KLNNEIAKLF VRPRGWHLPE AHIFIDGEPA
210 220 230 240 250
TGCLVDFGLY FYHNYATFRN TQGQGFGPFF YLPKMENSRE AKIWNSVFEK
260 270 280 290 300
AEKMAGIEKG SIRATVLIET LPAVFQMDEI FYELRDHSVG LNCGRWDYIF
310 320 330 340 350
SYVKTFQGHP DRLLPDRGQV GMTQHFMRSY SDLLIRTCHR RGVHAMGGMA
360 370 380 390 400
AQIPIRDDPT ANEAAFELVR KDKQREVKAG HDGTWAAHPG LIKTCMEVFT
410 420 430 440 450
NNMGNTPNQI ETVKRDYASN LTEDDLLQRP RGVRTMEGLR LNTRVGIQYL
460 470 480 490 500
AAWLTGSGSV PLYNLMEDAA TAEISRVQIW QWLKYGVELD GDGLGVRVNH
510 520 530 540 550
VFGRVVEEEM ARIEREVGKE KFKKGMYKEA CKIFTRQCTA STLDDFLTLD
560
AYNYIVIHHP KDVSSKL
Length:567
Mass (Da):64,669
Last modified:August 1, 1990 - v1
Checksum:iAC69D3BE20C91204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52305 mRNA. Translation: CAA36546.1.
PIRiS12735. SYCNMU.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52305 mRNA. Translation: CAA36546.1.
PIRiS12735. SYCNMU.

3D structure databases

ProteinModelPortaliP17432.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP17432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cottonseed malate synthase."
    Turley R.B., Choe S.M., Ni W., Trelease R.N.
    Nucleic Acids Res. 18:3643-3643(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Seed.

Entry informationi

Entry nameiMASY_GOSHI
AccessioniPrimary (citable) accession number: P17432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.