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Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

Zfp36l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable regulatory protein involved in regulating the response to growth factors.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • AU-rich element binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • mRNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
EGF-inducible protein CMG1
Protein TIS11B
Gene namesi
Name:Zfp36l1
Synonyms:Brf1, Cmg1, Tis11b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi62009. Zfp36l1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei318 – 3181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP17431.
PhosphoSiteiP17431.

Expressioni

Inductioni

By EGF.

Gene expression databases

GenevisibleiP17431. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-1210346.

Structurei

3D structure databases

ProteinModelPortaliP17431.
SMRiP17431. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 31610Poly-Ser

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP17431.
KOiK18753.
PhylomeDBiP17431.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPTLS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Length:338
Mass (Da):36,399
Last modified:August 1, 1990 - v1
Checksum:iA1547C8BF566196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52590 mRNA. Translation: CAA36826.1.
X86571 Genomic DNA. Translation: CAA60379.1.
PIRiS10471.
RefSeqiNP_058868.1. NM_017172.1.
UniGeneiRn.6142.

Genome annotation databases

EnsembliENSRNOT00000083677; ENSRNOP00000075412; ENSRNOG00000058646.
GeneIDi29344.
KEGGirno:29344.
UCSCiRGD:62009. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52590 mRNA. Translation: CAA36826.1.
X86571 Genomic DNA. Translation: CAA60379.1.
PIRiS10471.
RefSeqiNP_058868.1. NM_017172.1.
UniGeneiRn.6142.

3D structure databases

ProteinModelPortaliP17431.
SMRiP17431. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1210346.

PTM databases

iPTMnetiP17431.
PhosphoSiteiP17431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083677; ENSRNOP00000075412; ENSRNOG00000058646.
GeneIDi29344.
KEGGirno:29344.
UCSCiRGD:62009. rat.

Organism-specific databases

CTDi677.
RGDi62009. Zfp36l1.

Phylogenomic databases

GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP17431.
KOiK18753.
PhylomeDBiP17431.

Enzyme and pathway databases

ReactomeiR-RNO-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.

Miscellaneous databases

PROiP17431.

Gene expression databases

GenevisibleiP17431. RN.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes."
    Gomperts M., Pascall J.C., Brown K.D.
    Oncogene 5:1081-1083(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Identification of a functional promoter element in the 5'-flanking region of the rat cMG1/TIS11b gene."
    Corps A.N., Pascall J.C., Hadfield K.M., Brown K.D.
    Biochem. J. 311:251-258(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19.

Entry informationi

Entry nameiTISB_RAT
AccessioniPrimary (citable) accession number: P17431
Secondary accession number(s): Q6LAU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.