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Protein

Nitrogen regulatory protein areA

Gene

areA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. Activates the transcription of uapA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri673 – 69725GATA-typePROSITE-ProRule annotationAdd
BLAST
DNA bindingi721 – 74222H-T-H motifSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • chromatin remodeling Source: ASPGD
  • nitrate assimilation Source: UniProtKB-KW
  • regulation of arginine metabolic process Source: ASPGD
  • regulation of cellular amide catabolic process Source: ASPGD
  • regulation of gene expression Source: ASPGD
  • regulation of nitrogen utilization Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Nitrate assimilation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein areA
Gene namesi
Name:areA
ORF Names:AN8667
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN8667.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ASPGD
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Nitrogen regulatory protein areAPRO_0000083465Add
BLAST

Expressioni

Inductioni

Down-regulated in nitrogen-sufficient conditions and up-regulated in nitrogen-limiting conditions.1 Publication

Interactioni

Subunit structurei

Interacts with nmrA.4 Publications

GO - Molecular functioni

Structurei

Secondary structure

1
876
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi667 – 6704Combined sources
Beta strandi674 – 6763Combined sources
Beta strandi682 – 6865Combined sources
Turni688 – 6903Combined sources
Beta strandi692 – 6943Combined sources
Helixi695 – 70410Combined sources
Helixi710 – 7123Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VUSX-ray2.60I/J/K/L/M/N/O/P670-712[»]
2VUTX-ray2.30I/J/K/L/M/N/O/P670-712[»]
2VUUX-ray2.80I/J/K/L/M/N/O/P670-712[»]
4GATNMR-A663-727[»]
5GATNMR-A663-727[»]
6GATNMR-A663-727[»]
7GATNMR-A663-727[»]
ProteinModelPortaliP17429.
SMRiP17429. Positions 663-727.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17429.

Family & Domainsi

Sequence similaritiesi

Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri673 – 69725GATA-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000202599.
InParanoidiP17429.
KOiK09184.
OMAiPQEWEWL.
OrthoDBiEOG092C43RR.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR011420. AreA_N.
IPR013860. DUF1752_fun.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF07573. AreA_N. 1 hit.
PF08550. DUF1752. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLTLGGGS GRVRPTQAAA AFPTSHDFAD PDRSSVARNA NRPSRRFAAP
60 70 80 90 100
PQLSDDFSLE SPTDSAQVHD NLLQDALFPE WKANSPRGVD SPDEMQKKDP
110 120 130 140 150
LATQIWKLYS RTKAQLPNQE RMENLTWRMM ALSLRRQERE RAQQQARASS
160 170 180 190 200
QKSPVPGMSG IAQLRLSDRV SNTPTTTADT VSDAMNLDDF IIPFSPSDHP
210 220 230 240 250
SPSTTKASEA TTGAIPIKAR RDQSASEATP VPASFPHPAQ DQRRESEFGY
260 270 280 290 300
VPRRVRKTSI DERQFFNLQI PSRKRPAESS PHVPPVSTSM LAHDPDFSHA
310 320 330 340 350
VPEYTLDTSH GLSLQNQMNA QQLANAQNHT SPNMAFALDT FNLGDDPILP
360 370 380 390 400
SAGPYQQQFT FSPSESPMTS GNPFANLYAQ TPIASSLNST DFFSPPPSGY
410 420 430 440 450
QSTASTPQPA YDGEHSKYFD MPVDARSQRR VVPAYITQRS SNLSASLQPR
460 470 480 490 500
YMYNQGGSSQ DITQQNAHMG AQSSSMQSPG FSIPQHVDPT QVLNPNEFNG
510 520 530 540 550
NHAAMFSFGA DSDVEDDDGN QFSAGGLAMP AEFGDDSISD MNSNMAWETS
560 570 580 590 600
YPNSFQSLPA FAAQHRKHVT IGSADMMDTP SEWNQGGSLG RTHESAASVS
610 620 630 640 650
EVRNRDQDPR RQKIARTSST PNTAQLLRQS MQNQSSHTSP NTPPESGLNS
660 670 680 690 700
AAPSRPASPG GTKNGEQNGP TTCTNCFTQT TPLWRRNPEG QPLCNACGLF
710 720 730 740 750
LKLHGVVRPL SLKTDVIKKR NRNSANSLAV GSSRVSKKSA RKNSVQQVTP
760 770 780 790 800
TAPTSSRAQS NTTSESPPAM PGSSGRGSGV VPIAAAPPKS SSAATTSPGT
810 820 830 840 850
NNGCGAVQVA PKRQRRLEKA SDVDMAESPS STSSGGRSKV VPLAPAMPPA
860 870
AVNPANHSIA AGQGASQEWE WLTMSL
Length:876
Mass (Da):94,196
Last modified:February 1, 1996 - v2
Checksum:i9ADC2273EE536F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52491 Genomic DNA. Translation: CAA36731.1.
AACD01000158 Genomic DNA. Translation: EAA60701.1.
BN001303 Genomic DNA. Translation: CBF78221.1.
PIRiA57988.
RefSeqiXP_681936.1. XM_676844.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006378; CADANIAP00006378; CADANIAG00006378.
EAA60701; EAA60701; AN8667.2.
GeneIDi2868505.
KEGGiani:AN8667.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52491 Genomic DNA. Translation: CAA36731.1.
AACD01000158 Genomic DNA. Translation: EAA60701.1.
BN001303 Genomic DNA. Translation: CBF78221.1.
PIRiA57988.
RefSeqiXP_681936.1. XM_676844.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VUSX-ray2.60I/J/K/L/M/N/O/P670-712[»]
2VUTX-ray2.30I/J/K/L/M/N/O/P670-712[»]
2VUUX-ray2.80I/J/K/L/M/N/O/P670-712[»]
4GATNMR-A663-727[»]
5GATNMR-A663-727[»]
6GATNMR-A663-727[»]
7GATNMR-A663-727[»]
ProteinModelPortaliP17429.
SMRiP17429. Positions 663-727.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00006378; CADANIAP00006378; CADANIAG00006378.
EAA60701; EAA60701; AN8667.2.
GeneIDi2868505.
KEGGiani:AN8667.2.

Organism-specific databases

EuPathDBiFungiDB:AN8667.

Phylogenomic databases

HOGENOMiHOG000202599.
InParanoidiP17429.
KOiK09184.
OMAiPQEWEWL.
OrthoDBiEOG092C43RR.

Miscellaneous databases

EvolutionaryTraceiP17429.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR011420. AreA_N.
IPR013860. DUF1752_fun.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF07573. AreA_N. 1 hit.
PF08550. DUF1752. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAREA_EMENI
AccessioniPrimary (citable) accession number: P17429
Secondary accession number(s): C8VA54, Q5ASR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.