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Protein

Fumarate reductase cytochrome b subunit

Gene

frdC

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme axial ligand)1
Metal bindingi93Iron (heme axial ligand)1
Metal bindingi143Iron (heme axial ligand)1
Metal bindingi182Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Protein family/group databases

TCDBi3.D.10.1.3. the prokaryotic succinate dehydrogenase (sdh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase cytochrome b subunit
Gene namesi
Name:frdC
Ordered Locus Names:WS0832
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicAdd BLAST30
Transmembranei31 – 52HelicalAdd BLAST22
Topological domaini53 – 76PeriplasmicAdd BLAST24
Transmembranei77 – 98HelicalAdd BLAST22
Topological domaini99 – 124CytoplasmicAdd BLAST26
Transmembranei125 – 149HelicalAdd BLAST25
Topological domaini150 – 165PeriplasmicAdd BLAST16
Transmembranei166 – 188HelicalAdd BLAST23
Topological domaini189 – 206CytoplasmicAdd BLAST18
Transmembranei207 – 230HelicalAdd BLAST24
Topological domaini231 – 256PeriplasmicAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44H → A: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi93H → A: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi114H → A: Slight reduction in fumarate reductase activity. 1 Publication1
Mutagenesisi120H → A: Reduction in fumarate reductase activity. 1 Publication1
Mutagenesisi143H → A, M or K: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi182H → A: Loss of fumarate reductase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586851 – 256Fumarate reductase cytochrome b subunitAdd BLAST256

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Protein-protein interaction databases

STRINGi273121.WS0832.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9
Helixi22 – 48Combined sources27
Helixi49 – 52Combined sources4
Helixi55 – 64Combined sources10
Beta strandi65 – 67Combined sources3
Turni68 – 70Combined sources3
Beta strandi71 – 73Combined sources3
Helixi77 – 97Combined sources21
Helixi98 – 100Combined sources3
Helixi105 – 118Combined sources14
Helixi121 – 149Combined sources29
Helixi151 – 153Combined sources3
Helixi158 – 164Combined sources7
Turni165 – 167Combined sources3
Helixi169 – 194Combined sources26
Turni195 – 197Combined sources3
Helixi202 – 235Combined sources34
Turni246 – 252Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10C/F/I/L1-256[»]
1QLBX-ray2.33C/F1-256[»]
2BS2X-ray1.78C/F1-254[»]
2BS3X-ray2.19C/F1-256[»]
2BS4X-ray2.76C/F1-256[»]
ProteinModelPortaliP17413.
SMRiP17413.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17413.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108S24. Bacteria.
COG2009. LUCA.
HOGENOMiHOG000286335.
KOiK00246.
OMAiLLAHLHF.
OrthoDBiPOG091H2D6G.

Family and domain databases

CDDicd00581. QFR_TypeB_TM. 1 hit.
InterProiView protein in InterPro
IPR004224. Fum_red_B_TM.
IPR034804. SQR/QFR_C/D.
IPR000701. SuccDH_FuR_B_TM-su.
PfamiView protein in Pfam
PF01127. Sdh_cyt. 1 hit.
PIRSFiPIRSF000177. Fumar_rd_cyt_b. 1 hit.
SUPFAMiSSF81343. SSF81343. 1 hit.

Sequencei

Sequence statusi: Complete.

P17413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNESILESY SGVTPERKKS RMPAKLDWWQ SATGLFLGLF MIGHMFFVST
60 70 80 90 100
ILLGDNVMLW VTKKFELDFI FEGGKPIVVS FLAAFVFAVF IAHAFLAMRK
110 120 130 140 150
FPINYRQYLT FKTHKDLMRH GDTTLWWIQA MTGFAMFFLG SVHLYIMMTQ
160 170 180 190 200
PQTIGPVSSS FRMVSEWMWP LYLVLLFAVE LHGSVGLYRL AVKWGWFDGE
210 220 230 240 250
TPDKTRANLK KLKTLMSAFL IVLGLLTFGA YVKKGLEQTD PNIDYKYFDY

KRTHHR
Length:256
Mass (Da):29,723
Last modified:August 1, 1990 - v1
Checksum:iE8459B884BA9E20B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA. Translation: CAA04213.1.
BX571659 Genomic DNA. Translation: CAE09943.1.
PIRiS10164.
RefSeqiWP_011138740.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE09943; CAE09943; WS0832.
KEGGiwsu:WS0832.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFRDC_WOLSU
AccessioniPrimary (citable) accession number: P17413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references