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Protein

Fumarate reductase flavoprotein subunit

Gene

frdA

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.1 Publication

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FADNote: Binds 1 FAD covalently per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei257By similarity1
Active sitei273By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 23FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Protein family/group databases

TCDBi3.D.10.1.3. the prokaryotic succinate dehydrogenase (sdh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase flavoprotein subunit (EC:1.3.5.4)
Gene namesi
Name:frdA
Ordered Locus Names:WS0831
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586671 – 656Fumarate reductase flavoprotein subunitAdd BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43Tele-8alpha-FAD histidine1

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Protein-protein interaction databases

STRINGi273121.WS0831.

Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi7 – 11Combined sources5
Helixi15 – 25Combined sources11
Turni26 – 28Combined sources3
Beta strandi31 – 34Combined sources4
Helixi39 – 41Combined sources3
Helixi43 – 46Combined sources4
Helixi59 – 61Combined sources3
Helixi66 – 76Combined sources11
Turni77 – 79Combined sources3
Helixi83 – 102Combined sources20
Beta strandi112 – 116Combined sources5
Beta strandi119 – 122Combined sources4
Beta strandi125 – 128Combined sources4
Helixi130 – 132Combined sources3
Helixi156 – 171Combined sources16
Beta strandi174 – 176Combined sources3
Beta strandi178 – 187Combined sources10
Beta strandi190 – 198Combined sources9
Turni199 – 201Combined sources3
Beta strandi204 – 208Combined sources5
Beta strandi210 – 214Combined sources5
Helixi220 – 222Combined sources3
Beta strandi223 – 228Combined sources6
Helixi235 – 241Combined sources7
Beta strandi244 – 246Combined sources3
Beta strandi254 – 258Combined sources5
Turni262 – 264Combined sources3
Helixi271 – 275Combined sources5
Beta strandi278 – 280Combined sources3
Beta strandi282 – 285Combined sources4
Helixi288 – 291Combined sources4
Turni293 – 295Combined sources3
Helixi296 – 298Combined sources3
Helixi301 – 313Combined sources13
Turni314 – 316Combined sources3
Beta strandi317 – 320Combined sources4
Beta strandi325 – 329Combined sources5
Helixi331 – 333Combined sources3
Helixi335 – 341Combined sources7
Helixi343 – 351Combined sources9
Turni357 – 359Combined sources3
Beta strandi362 – 364Combined sources3
Beta strandi367 – 371Combined sources5
Beta strandi374 – 376Combined sources3
Beta strandi384 – 386Combined sources3
Beta strandi388 – 390Combined sources3
Helixi392 – 394Combined sources3
Helixi408 – 430Combined sources23
Beta strandi434 – 436Combined sources3
Helixi437 – 456Combined sources20
Helixi463 – 477Combined sources15
Beta strandi478 – 482Combined sources5
Helixi484 – 501Combined sources18
Beta strandi511 – 513Combined sources3
Helixi515 – 539Combined sources25
Beta strandi547 – 549Combined sources3
Beta strandi554 – 556Combined sources3
Turni557 – 559Combined sources3
Beta strandi562 – 567Combined sources6
Beta strandi570 – 572Combined sources3
Beta strandi577 – 582Combined sources6
Helixi585 – 587Combined sources3
Beta strandi596 – 598Combined sources3
Helixi607 – 625Combined sources19
Helixi630 – 637Combined sources8
Helixi644 – 646Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10A/D/G/J1-656[»]
1QLBX-ray2.33A/D1-656[»]
2BS2X-ray1.78A/D1-656[»]
2BS3X-ray2.19A/D1-656[»]
2BS4X-ray2.76A/D1-656[»]
ProteinModelPortaliP17412.
SMRiP17412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17412.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00244.
OMAiFHPTPLF.
OrthoDBiPOG091H02TE.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 3 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQYCDSLV IGGGLAGLRA AVATQQKGLS TIVLSLIPVK RSHSAAAQGG
60 70 80 90 100
MQASLGNSKM SDGDNEDLHF MDTVKGSDWG CDQKVARMFV NTAPKAIREL
110 120 130 140 150
AAWGVPWTRI HKGDRMAIIN AQKTTITEED FRHGLIHSRD FGGTKKWRTC
160 170 180 190 200
YTADATGHTM LFAVANECLK LGVSIQDRKE AIALIHQDGK CYGAVVRDLV
210 220 230 240 250
TGDIIAYVAK GTLIATGGYG RIYKNTTNAV VCEGTGTAIA LETGIAQLGN
260 270 280 290 300
MEAVQFHPTP LFPSGILLTE GCRGDGGILR DVDGHRFMPD YEPEKKELAS
310 320 330 340 350
RDVVSRRMIE HIRKGKGVQS PYGQHLWLDI SILGRKHIET NLRDVQEICE
360 370 380 390 400
YFAGIDPAEK WAPVLPMQHY SMGGIRTDYR GEAKLKGLFS AGEAACWDMH
410 420 430 440 450
GFNRLGGNSV SEAVVAGMIV GEYFAEHCAN TQVDLETKTL EKFVKGQEAY
460 470 480 490 500
MKSLVESKGT EDVFKIKNRM KDVMDDNVGI FRDGPHLEKA VKELEELYKK
510 520 530 540 550
SKNVGIKNKR LHANPELEEA YRVPMMLKVA LCVAKGALDR TESRGAHNRE
560 570 580 590 600
DYPKRDDINW LNRTLASWPN PEQTLPTLEY EALDVNEMEI APGYRGYGAK
610 620 630 640 650
GNYIENPLSV KRQEEIDKIQ SELEAAGKDR HAIQEALMPY ELPAKYKARN

ERLGDK
Length:656
Mass (Da):72,719
Last modified:October 3, 2003 - v3
Checksum:iBFEE6E8316F7F618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA. Translation: CAA04214.2.
BX571659 Genomic DNA. Translation: CAE09942.1.
M28294 Genomic DNA. Translation: AAA27586.1.
PIRiB44954.
RefSeqiWP_011138739.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE09942; CAE09942; WS0831.
KEGGiwsu:WS0831.
PATRICi24038708. VBIWolSuc63014_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA. Translation: CAA04214.2.
BX571659 Genomic DNA. Translation: CAE09942.1.
M28294 Genomic DNA. Translation: AAA27586.1.
PIRiB44954.
RefSeqiWP_011138739.1. NC_005090.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10A/D/G/J1-656[»]
1QLBX-ray2.33A/D1-656[»]
2BS2X-ray1.78A/D1-656[»]
2BS3X-ray2.19A/D1-656[»]
2BS4X-ray2.76A/D1-656[»]
ProteinModelPortaliP17412.
SMRiP17412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273121.WS0831.

Protein family/group databases

TCDBi3.D.10.1.3. the prokaryotic succinate dehydrogenase (sdh) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE09942; CAE09942; WS0831.
KEGGiwsu:WS0831.
PATRICi24038708. VBIWolSuc63014_0783.

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00244.
OMAiFHPTPLF.
OrthoDBiPOG091H02TE.

Miscellaneous databases

EvolutionaryTraceiP17412.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 3 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRDA_WOLSU
AccessioniPrimary (citable) accession number: P17412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 3, 2003
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.