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Protein

Fumarate reductase flavoprotein subunit

Gene

frdA

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.1 Publication

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FADNote: Binds 1 FAD covalently per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Active sitei273 – 2731By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 2315FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Protein family/group databases

TCDBi3.D.10.1.3. the prokaryotic succinate dehydrogenase (sdh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase flavoprotein subunit (EC:1.3.5.4)
Gene namesi
Name:frdA
Ordered Locus Names:WS0831
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Fumarate reductase flavoprotein subunitPRO_0000158667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Tele-8alpha-FAD histidine

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Protein-protein interaction databases

STRINGi273121.WS0831.

Structurei

Secondary structure

1
656
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi7 – 115Combined sources
Helixi15 – 2511Combined sources
Turni26 – 283Combined sources
Beta strandi31 – 344Combined sources
Helixi39 – 413Combined sources
Helixi43 – 464Combined sources
Helixi59 – 613Combined sources
Helixi66 – 7611Combined sources
Turni77 – 793Combined sources
Helixi83 – 10220Combined sources
Beta strandi112 – 1165Combined sources
Beta strandi119 – 1224Combined sources
Beta strandi125 – 1284Combined sources
Helixi130 – 1323Combined sources
Helixi156 – 17116Combined sources
Beta strandi174 – 1763Combined sources
Beta strandi178 – 18710Combined sources
Beta strandi190 – 1989Combined sources
Turni199 – 2013Combined sources
Beta strandi204 – 2085Combined sources
Beta strandi210 – 2145Combined sources
Helixi220 – 2223Combined sources
Beta strandi223 – 2286Combined sources
Helixi235 – 2417Combined sources
Beta strandi244 – 2463Combined sources
Beta strandi254 – 2585Combined sources
Turni262 – 2643Combined sources
Helixi271 – 2755Combined sources
Beta strandi278 – 2803Combined sources
Beta strandi282 – 2854Combined sources
Helixi288 – 2914Combined sources
Turni293 – 2953Combined sources
Helixi296 – 2983Combined sources
Helixi301 – 31313Combined sources
Turni314 – 3163Combined sources
Beta strandi317 – 3204Combined sources
Beta strandi325 – 3295Combined sources
Helixi331 – 3333Combined sources
Helixi335 – 3417Combined sources
Helixi343 – 3519Combined sources
Turni357 – 3593Combined sources
Beta strandi362 – 3643Combined sources
Beta strandi367 – 3715Combined sources
Beta strandi374 – 3763Combined sources
Beta strandi384 – 3863Combined sources
Beta strandi388 – 3903Combined sources
Helixi392 – 3943Combined sources
Helixi408 – 43023Combined sources
Beta strandi434 – 4363Combined sources
Helixi437 – 45620Combined sources
Helixi463 – 47715Combined sources
Beta strandi478 – 4825Combined sources
Helixi484 – 50118Combined sources
Beta strandi511 – 5133Combined sources
Helixi515 – 53925Combined sources
Beta strandi547 – 5493Combined sources
Beta strandi554 – 5563Combined sources
Turni557 – 5593Combined sources
Beta strandi562 – 5676Combined sources
Beta strandi570 – 5723Combined sources
Beta strandi577 – 5826Combined sources
Helixi585 – 5873Combined sources
Beta strandi596 – 5983Combined sources
Helixi607 – 62519Combined sources
Helixi630 – 6378Combined sources
Helixi644 – 6463Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10A/D/G/J1-656[»]
1QLBX-ray2.33A/D1-656[»]
2BS2X-ray1.78A/D1-656[»]
2BS3X-ray2.19A/D1-656[»]
2BS4X-ray2.76A/D1-656[»]
ProteinModelPortaliP17412.
SMRiP17412. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17412.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00244.
OMAiFHPTPLF.
OrthoDBiPOG091H02TE.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 3 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQYCDSLV IGGGLAGLRA AVATQQKGLS TIVLSLIPVK RSHSAAAQGG
60 70 80 90 100
MQASLGNSKM SDGDNEDLHF MDTVKGSDWG CDQKVARMFV NTAPKAIREL
110 120 130 140 150
AAWGVPWTRI HKGDRMAIIN AQKTTITEED FRHGLIHSRD FGGTKKWRTC
160 170 180 190 200
YTADATGHTM LFAVANECLK LGVSIQDRKE AIALIHQDGK CYGAVVRDLV
210 220 230 240 250
TGDIIAYVAK GTLIATGGYG RIYKNTTNAV VCEGTGTAIA LETGIAQLGN
260 270 280 290 300
MEAVQFHPTP LFPSGILLTE GCRGDGGILR DVDGHRFMPD YEPEKKELAS
310 320 330 340 350
RDVVSRRMIE HIRKGKGVQS PYGQHLWLDI SILGRKHIET NLRDVQEICE
360 370 380 390 400
YFAGIDPAEK WAPVLPMQHY SMGGIRTDYR GEAKLKGLFS AGEAACWDMH
410 420 430 440 450
GFNRLGGNSV SEAVVAGMIV GEYFAEHCAN TQVDLETKTL EKFVKGQEAY
460 470 480 490 500
MKSLVESKGT EDVFKIKNRM KDVMDDNVGI FRDGPHLEKA VKELEELYKK
510 520 530 540 550
SKNVGIKNKR LHANPELEEA YRVPMMLKVA LCVAKGALDR TESRGAHNRE
560 570 580 590 600
DYPKRDDINW LNRTLASWPN PEQTLPTLEY EALDVNEMEI APGYRGYGAK
610 620 630 640 650
GNYIENPLSV KRQEEIDKIQ SELEAAGKDR HAIQEALMPY ELPAKYKARN

ERLGDK
Length:656
Mass (Da):72,719
Last modified:October 3, 2003 - v3
Checksum:iBFEE6E8316F7F618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA. Translation: CAA04214.2.
BX571659 Genomic DNA. Translation: CAE09942.1.
M28294 Genomic DNA. Translation: AAA27586.1.
PIRiB44954.
RefSeqiWP_011138739.1. NC_005090.1.

Genome annotation databases

EnsemblBacteriaiCAE09942; CAE09942; WS0831.
KEGGiwsu:WS0831.
PATRICi24038708. VBIWolSuc63014_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA. Translation: CAA04214.2.
BX571659 Genomic DNA. Translation: CAE09942.1.
M28294 Genomic DNA. Translation: AAA27586.1.
PIRiB44954.
RefSeqiWP_011138739.1. NC_005090.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10A/D/G/J1-656[»]
1QLBX-ray2.33A/D1-656[»]
2BS2X-ray1.78A/D1-656[»]
2BS3X-ray2.19A/D1-656[»]
2BS4X-ray2.76A/D1-656[»]
ProteinModelPortaliP17412.
SMRiP17412. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273121.WS0831.

Protein family/group databases

TCDBi3.D.10.1.3. the prokaryotic succinate dehydrogenase (sdh) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE09942; CAE09942; WS0831.
KEGGiwsu:WS0831.
PATRICi24038708. VBIWolSuc63014_0783.

Phylogenomic databases

eggNOGiENOG4105C00. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00244.
OMAiFHPTPLF.
OrthoDBiPOG091H02TE.

Miscellaneous databases

EvolutionaryTraceiP17412.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 3 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRDA_WOLSU
AccessioniPrimary (citable) accession number: P17412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 3, 2003
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.