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Protein

HTH-type transcriptional regulator ChbR

Gene

chbR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon.1 Publication

Miscellaneous

Under prolonged growth on cellobiose as the sole carbon source, spontaneous mutations in chbR and nagC alter the regulation of the chbBCARFG operon, allowing the uptake and metabolism of cellobiose. The mutated regulator makes stronger contact with the target DNA sequence within the chb promoter and has enhanced recognition of cellobiose 6-phosphate as an inducer.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi242 – 261H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10143-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ChbR
Alternative name(s):
Chb operon repressor
Gene namesi
Name:chbR
Synonyms:celD
Ordered Locus Names:b1735, JW1724
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10143 chbR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945061 – 280HTH-type transcriptional regulator ChbRAdd BLAST280

Proteomic databases

PaxDbiP17410
PRIDEiP17410

Expressioni

Inductioni

By N,N'-diacetylchitobiose.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4259133, 10 interactors
IntActiP17410, 7 interactors
STRINGi316385.ECDH10B_1873

Structurei

3D structure databases

ProteinModelPortaliP17410
SMRiP17410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105EZV Bacteria
ENOG410XRRP LUCA
HOGENOMiHOG000121054
InParanoidiP17410
KOiK03490
OMAiNRLRHHR
PhylomeDBiP17410

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR013096 Cupin_2
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF07883 Cupin_2, 1 hit
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQPVINAPE IATAREQQLF NGKNFHVFIY NKTESISGLH QHDYYEFTLV
60 70 80 90 100
LTGRYFQEIN GKRVLLERGD FVFIPLGSHH QSFYEFGATR ILNVGISKRF
110 120 130 140 150
FEQHYLPLLP YCFVASQVYR TNNAFLTYVE TVISSLNFRE TGLEEFVEMV
160 170 180 190 200
TFYVINRLRH YREEQVIDDV PQWLKSTVEK MHDKEQFSES ALENMVALSA
210 220 230 240 250
KSQEYLTRAT QRYYGKTPMQ IINEIRINFA KKQLEMTNYS VTDIAFEAGY
260 270 280
SSPSLFIKTF KKLTSFTPKS YRKKLTEFNQ
Length:280
Mass (Da):32,968
Last modified:August 1, 1990 - v1
Checksum:i281152CAEF363B2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52890 Genomic DNA Translation: CAA37072.1
U00096 Genomic DNA Translation: AAC74805.1
AP009048 Genomic DNA Translation: BAA15516.1
PIRiS10873
RefSeqiNP_416249.1, NC_000913.3
WP_000983647.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74805; AAC74805; b1735
BAA15516; BAA15516; BAA15516
GeneIDi946247
KEGGiecj:JW1724
eco:b1735
PATRICifig|511145.12.peg.1807

Similar proteinsi

Entry informationi

Entry nameiCHBR_ECOLI
AccessioniPrimary (citable) accession number: P17410
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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