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P17377

- RDRP_REOVJ

UniProt

P17377 - RDRP_REOVJ

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Protein

RNA-directed RNA polymerase lambda-3

Gene

L1

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase lambda-3 (EC:2.7.7.48)
Short name:
Lambda3
Alternative name(s):
Lambda3(Pol)
Gene namesi
Name:L1
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion Curated
Note: Found in the inner capsid (12 copies).

GO - Cellular componenti

  1. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12671267RNA-directed RNA polymerase lambda-3PRO_0000222744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 792238RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamiPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17377-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTILTQFG PFIESISGII DQSNDIFEEA AKAFSAFTRS DVYKALDEIP
60 70 80 90 100
FHDHATVHIP PTIYSKPSHD SYYYVDALNR VRRRTYQGDD DVYVPNCSIV
110 120 130 140 150
ELLEPHETLT SYGRLSSAIE ARAKEGDPQA RIATTYARIS ESQARQIKAP
160 170 180 190 200
LEKFVLALLV AESGDALYDP ILQKYDDVAD LTHNCPLWCF REICRHVSGP
210 220 230 240 250
LPDRAPYLYL SAGVFWLMSP RMTSAIPPLL SDLVNLAILQ QTAGLDPSLV
260 270 280 290 300
KMGVQVCLQA AASASYAWYV LKTKSVFPQN TLHSMYETLE GGFCPNLAWL
310 320 330 340 350
EPRSDYKFMY MGATPLSGKY ARTAPSNETR ARQLGEKYGL STIIGDLRQR
360 370 380 390 400
TRQFTKHDFA SVRYIRDAMA CTSGIFLVRT PTETVLQEYT QSPEIKVPIP
410 420 430 440 450
QKDWTGPIGE IRVLKDTTSS IARYLYRTWY LAAARMASQP RTWDPLFQAI
460 470 480 490 500
MRSQYVTARG GSGAALRESL YAINVSLPDF KGLPVKAATK IFQAAQLANL
510 520 530 540 550
PFSHTSVAIL ADTSMGLRNQ VQRRPRSIMP LNVPQQQVSA PHTLTADYIN
560 570 580 590 600
YHMNLSTTSG SAVIEKVIPL GVYASSPPNQ SINIDISACD ASITWDFFLS
610 620 630 640 650
VIMAAIHEGV ASSSIGKPFM GVPASIVNDE SVVGVRAARP ISGMQNMVQH
660 670 680 690 700
LSKLYKRGFS YRVNDSFSPG NDFTHMTTTF PSGSTATSTE HTANNSTMME
710 720 730 740 750
TFLNVWGPEH TNDPDVLRLM RSLTIQRNYV CQGDDGLMII DGTTAGKVSS
760 770 780 790 800
ETIQKMLELI SAYGEEFGWK YDIAYDGTAE YLKLYFIFGC RIPNLSRHPI
810 820 830 840 850
VGKERANSSA EEPWPAILDQ VMGIFFNGVH DGLQWQRWIR YCSSLCCAFS
860 870 880 890 900
RQRTMIGEEV RYLQYPMWSF VYWGLPPVKL FGSDPWIFSW YMPTGDLGMY
910 920 930 940 950
SWISLIRPLM TRWMVANGYV SERCSSIFGN ADYRRCFNDI RLYQGYYMAR
960 970 980 990 1000
LPRNPKKSGR AAPRETREQF TQALSDYLMQ NPELKSRVLR GRSEWEKYGA
1010 1020 1030 1040 1050
GIIHNPPSLF DVPHKWYQGA QEAATATREE LSDMDDTLLR SRRHTYSSFS
1060 1070 1080 1090 1100
KLLEAYLRVR WRMCEAREPS VDLRLPLCAG IDPLNSDPFL KMVSVGPMLQ
1110 1120 1130 1140 1150
STRKYFAQTL FMAKTVSGLD VNAIDSALLR LRTLGADKKA LTAQLLMVGL
1160 1170 1180 1190 1200
QESEADALAG KIMLQDVNTV QLARVVNLAV PDTWMSLDFD SMFKHHVNLL
1210 1220 1230 1240 1250
PKDGRHLNTD IPPRMGWLRA ILRFLGAGVA MTATGVAVNV YLEDIDGGGR
1260
SLGQRFMTWM RQEGRSA
Length:1,267
Mass (Da):142,289
Last modified:August 1, 1990 - v1
Checksum:iB3F74EEBF257B604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31057 Genomic RNA. Translation: AAA47245.1.
PIRiB30121. MWXR32.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31057 Genomic RNA. Translation: AAA47245.1 .
PIRi B30121. MWXR32.

3D structure databases

ProteinModelPortali P17377.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view ]
Pfami PF07925. RdRP_5. 1 hit.
[Graphical view ]
PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequences of the reovirus serotype 1, 2, and 3 L1 genome segments and analysis of the mode of divergence of the reovirus serotypes."
    Wiener J.R., Joklik W.K.
    Virology 169:194-203(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_REOVJ
AccessioniPrimary (citable) accession number: P17377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3