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P17377

- RDRP_REOVJ

UniProt

P17377 - RDRP_REOVJ

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Protein
RNA-directed RNA polymerase lambda-3
Gene
L1
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase lambda-3 (EC:2.7.7.48)
Short name:
Lambda3
Alternative name(s):
Lambda3(Pol)
Gene namesi
Name:L1
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Found in the inner capsid (12 copies).

GO - Cellular componenti

  1. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12671267RNA-directed RNA polymerase lambda-3
PRO_0000222744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17377.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 792238RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamiPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17377-1 [UniParc]FASTAAdd to Basket

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MSSTILTQFG PFIESISGII DQSNDIFEEA AKAFSAFTRS DVYKALDEIP     50
FHDHATVHIP PTIYSKPSHD SYYYVDALNR VRRRTYQGDD DVYVPNCSIV 100
ELLEPHETLT SYGRLSSAIE ARAKEGDPQA RIATTYARIS ESQARQIKAP 150
LEKFVLALLV AESGDALYDP ILQKYDDVAD LTHNCPLWCF REICRHVSGP 200
LPDRAPYLYL SAGVFWLMSP RMTSAIPPLL SDLVNLAILQ QTAGLDPSLV 250
KMGVQVCLQA AASASYAWYV LKTKSVFPQN TLHSMYETLE GGFCPNLAWL 300
EPRSDYKFMY MGATPLSGKY ARTAPSNETR ARQLGEKYGL STIIGDLRQR 350
TRQFTKHDFA SVRYIRDAMA CTSGIFLVRT PTETVLQEYT QSPEIKVPIP 400
QKDWTGPIGE IRVLKDTTSS IARYLYRTWY LAAARMASQP RTWDPLFQAI 450
MRSQYVTARG GSGAALRESL YAINVSLPDF KGLPVKAATK IFQAAQLANL 500
PFSHTSVAIL ADTSMGLRNQ VQRRPRSIMP LNVPQQQVSA PHTLTADYIN 550
YHMNLSTTSG SAVIEKVIPL GVYASSPPNQ SINIDISACD ASITWDFFLS 600
VIMAAIHEGV ASSSIGKPFM GVPASIVNDE SVVGVRAARP ISGMQNMVQH 650
LSKLYKRGFS YRVNDSFSPG NDFTHMTTTF PSGSTATSTE HTANNSTMME 700
TFLNVWGPEH TNDPDVLRLM RSLTIQRNYV CQGDDGLMII DGTTAGKVSS 750
ETIQKMLELI SAYGEEFGWK YDIAYDGTAE YLKLYFIFGC RIPNLSRHPI 800
VGKERANSSA EEPWPAILDQ VMGIFFNGVH DGLQWQRWIR YCSSLCCAFS 850
RQRTMIGEEV RYLQYPMWSF VYWGLPPVKL FGSDPWIFSW YMPTGDLGMY 900
SWISLIRPLM TRWMVANGYV SERCSSIFGN ADYRRCFNDI RLYQGYYMAR 950
LPRNPKKSGR AAPRETREQF TQALSDYLMQ NPELKSRVLR GRSEWEKYGA 1000
GIIHNPPSLF DVPHKWYQGA QEAATATREE LSDMDDTLLR SRRHTYSSFS 1050
KLLEAYLRVR WRMCEAREPS VDLRLPLCAG IDPLNSDPFL KMVSVGPMLQ 1100
STRKYFAQTL FMAKTVSGLD VNAIDSALLR LRTLGADKKA LTAQLLMVGL 1150
QESEADALAG KIMLQDVNTV QLARVVNLAV PDTWMSLDFD SMFKHHVNLL 1200
PKDGRHLNTD IPPRMGWLRA ILRFLGAGVA MTATGVAVNV YLEDIDGGGR 1250
SLGQRFMTWM RQEGRSA 1267
Length:1,267
Mass (Da):142,289
Last modified:August 1, 1990 - v1
Checksum:iB3F74EEBF257B604
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31057 Genomic RNA. Translation: AAA47245.1.
PIRiB30121. MWXR32.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31057 Genomic RNA. Translation: AAA47245.1 .
PIRi B30121. MWXR32.

3D structure databases

ProteinModelPortali P17377.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view ]
Pfami PF07925. RdRP_5. 1 hit.
[Graphical view ]
PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequences of the reovirus serotype 1, 2, and 3 L1 genome segments and analysis of the mode of divergence of the reovirus serotypes."
    Wiener J.R., Joklik W.K.
    Virology 169:194-203(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_REOVJ
AccessioniPrimary (citable) accession number: P17377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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