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P17377

- RDRP_REOVJ

UniProt

P17377 - RDRP_REOVJ

Protein

RNA-directed RNA polymerase lambda-3

Gene

L1

Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase lambda-3 (EC:2.7.7.48)
    Short name:
    Lambda3
    Alternative name(s):
    Lambda3(Pol)
    Gene namesi
    Name:L1
    OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
    Taxonomic identifieri10885 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000006370: Genome

    Subcellular locationi

    Virion Curated
    Note: Found in the inner capsid (12 copies).

    GO - Cellular componenti

    1. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12671267RNA-directed RNA polymerase lambda-3PRO_0000222744Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP17377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini555 – 792238RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR012915. RdRP_5.
    IPR007097. RNA-dir_pol_reovirus.
    [Graphical view]
    PfamiPF07925. RdRP_5. 1 hit.
    [Graphical view]
    PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17377-1 [UniParc]FASTAAdd to Basket

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    MSSTILTQFG PFIESISGII DQSNDIFEEA AKAFSAFTRS DVYKALDEIP     50
    FHDHATVHIP PTIYSKPSHD SYYYVDALNR VRRRTYQGDD DVYVPNCSIV 100
    ELLEPHETLT SYGRLSSAIE ARAKEGDPQA RIATTYARIS ESQARQIKAP 150
    LEKFVLALLV AESGDALYDP ILQKYDDVAD LTHNCPLWCF REICRHVSGP 200
    LPDRAPYLYL SAGVFWLMSP RMTSAIPPLL SDLVNLAILQ QTAGLDPSLV 250
    KMGVQVCLQA AASASYAWYV LKTKSVFPQN TLHSMYETLE GGFCPNLAWL 300
    EPRSDYKFMY MGATPLSGKY ARTAPSNETR ARQLGEKYGL STIIGDLRQR 350
    TRQFTKHDFA SVRYIRDAMA CTSGIFLVRT PTETVLQEYT QSPEIKVPIP 400
    QKDWTGPIGE IRVLKDTTSS IARYLYRTWY LAAARMASQP RTWDPLFQAI 450
    MRSQYVTARG GSGAALRESL YAINVSLPDF KGLPVKAATK IFQAAQLANL 500
    PFSHTSVAIL ADTSMGLRNQ VQRRPRSIMP LNVPQQQVSA PHTLTADYIN 550
    YHMNLSTTSG SAVIEKVIPL GVYASSPPNQ SINIDISACD ASITWDFFLS 600
    VIMAAIHEGV ASSSIGKPFM GVPASIVNDE SVVGVRAARP ISGMQNMVQH 650
    LSKLYKRGFS YRVNDSFSPG NDFTHMTTTF PSGSTATSTE HTANNSTMME 700
    TFLNVWGPEH TNDPDVLRLM RSLTIQRNYV CQGDDGLMII DGTTAGKVSS 750
    ETIQKMLELI SAYGEEFGWK YDIAYDGTAE YLKLYFIFGC RIPNLSRHPI 800
    VGKERANSSA EEPWPAILDQ VMGIFFNGVH DGLQWQRWIR YCSSLCCAFS 850
    RQRTMIGEEV RYLQYPMWSF VYWGLPPVKL FGSDPWIFSW YMPTGDLGMY 900
    SWISLIRPLM TRWMVANGYV SERCSSIFGN ADYRRCFNDI RLYQGYYMAR 950
    LPRNPKKSGR AAPRETREQF TQALSDYLMQ NPELKSRVLR GRSEWEKYGA 1000
    GIIHNPPSLF DVPHKWYQGA QEAATATREE LSDMDDTLLR SRRHTYSSFS 1050
    KLLEAYLRVR WRMCEAREPS VDLRLPLCAG IDPLNSDPFL KMVSVGPMLQ 1100
    STRKYFAQTL FMAKTVSGLD VNAIDSALLR LRTLGADKKA LTAQLLMVGL 1150
    QESEADALAG KIMLQDVNTV QLARVVNLAV PDTWMSLDFD SMFKHHVNLL 1200
    PKDGRHLNTD IPPRMGWLRA ILRFLGAGVA MTATGVAVNV YLEDIDGGGR 1250
    SLGQRFMTWM RQEGRSA 1267
    Length:1,267
    Mass (Da):142,289
    Last modified:August 1, 1990 - v1
    Checksum:iB3F74EEBF257B604
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31057 Genomic RNA. Translation: AAA47245.1.
    PIRiB30121. MWXR32.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31057 Genomic RNA. Translation: AAA47245.1 .
    PIRi B30121. MWXR32.

    3D structure databases

    ProteinModelPortali P17377.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR012915. RdRP_5.
    IPR007097. RNA-dir_pol_reovirus.
    [Graphical view ]
    Pfami PF07925. RdRP_5. 1 hit.
    [Graphical view ]
    PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequences of the reovirus serotype 1, 2, and 3 L1 genome segments and analysis of the mode of divergence of the reovirus serotypes."
      Wiener J.R., Joklik W.K.
      Virology 169:194-203(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_REOVJ
    AccessioniPrimary (citable) accession number: P17377
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3