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P17342

- ANPRC_HUMAN

UniProt

P17342 - ANPRC_HUMAN

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Protein

Atrial natriuretic peptide receptor 3

Gene
NPR3, ANPRC, C5orf23, NPRC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Chloride
Binding sitei135 – 1351Chloride; via amide nitrogen
Binding sitei136 – 1361Chloride; via amide nitrogen

GO - Molecular functioni

  1. G-protein coupled peptide receptor activity Source: BHF-UCL
  2. hormone binding Source: UniProtKB
  3. natriuretic peptide receptor activity Source: UniProtKB
  4. peptide hormone binding Source: BHF-UCL

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. negative regulation of adenylate cyclase activity Source: Ensembl
  3. negative regulation of smooth muscle cell proliferation Source: Ensembl
  4. osteoclast proliferation Source: UniProtKB
  5. pancreatic juice secretion Source: Ensembl
  6. phosphatidylinositol-mediated signaling Source: Ensembl
  7. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  8. positive regulation of nitric-oxide synthase activity Source: BHF-UCL
  9. positive regulation of urine volume Source: UniProtKB
  10. regulation of blood pressure Source: UniProtKB
  11. regulation of osteoblast proliferation Source: UniProtKB
  12. skeletal system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Atrial natriuretic peptide receptor 3
Alternative name(s):
Atrial natriuretic peptide clearance receptor
Atrial natriuretic peptide receptor type C
Short name:
ANP-C
Short name:
ANPR-C
Short name:
NPR-C
Gene namesi
Name:NPR3
Synonyms:ANPRC, C5orf23, NPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:7945. NPR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 481455Extracellular Reviewed predictionAdd
BLAST
Transmembranei482 – 50423Helical; Reviewed predictionAdd
BLAST
Topological domaini505 – 54137Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 541515Atrial natriuretic peptide receptor 3PRO_0000012370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi108 ↔ 1363 Publications
Disulfide bondi213 ↔ 2613 Publications
Glycosylationi293 – 2931N-linked (GlcNAc...) (high mannose)3 Publications
Glycosylationi394 – 3941N-linked (GlcNAc...) (complex)3 Publications
Disulfide bondi473 – 473Interchain3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP17342.
PaxDbiP17342.
PRIDEiP17342.

PTM databases

PhosphoSiteiP17342.

Expressioni

Gene expression databases

ArrayExpressiP17342.
BgeeiP17342.
CleanExiHS_NPR3.
GenevestigatoriP17342.

Organism-specific databases

HPAiHPA031065.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.3 Publications

Protein-protein interaction databases

BioGridi110943. 4 interactions.
STRINGi9606.ENSP00000398028.

Structurei

Secondary structure

1
541
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 598
Helixi69 – 8315
Beta strandi98 – 1058
Helixi111 – 12212
Turni123 – 1253
Beta strandi129 – 1324
Helixi137 – 15014
Beta strandi154 – 1574
Helixi162 – 1654
Turni167 – 1737
Beta strandi174 – 1763
Helixi181 – 19515
Beta strandi199 – 2057
Beta strandi208 – 2103
Helixi212 – 22716
Beta strandi230 – 2367
Beta strandi238 – 2403
Helixi244 – 25411
Beta strandi256 – 2627
Helixi264 – 27613
Turni280 – 2834
Beta strandi285 – 2895
Helixi291 – 2933
Turni297 – 2993
Helixi309 – 3157
Helixi316 – 3183
Beta strandi319 – 3246
Helixi330 – 34415
Turni345 – 3473
Helixi356 – 37722
Helixi385 – 3928
Beta strandi393 – 3997
Beta strandi402 – 4065
Beta strandi410 – 4123
Beta strandi415 – 4239
Turni424 – 4274
Beta strandi428 – 4369
Turni437 – 4404
Beta strandi441 – 4444
Beta strandi451 – 4533
Helixi454 – 4563

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JDNX-ray2.90A44-485[»]
1JDPX-ray2.00A/B44-485[»]
1YK0X-ray2.40A/B1-480[»]
1YK1X-ray2.90A/B2-480[»]
ProteinModelPortaliP17342.
SMRiP17342. Positions 46-446.

Miscellaneous databases

EvolutionaryTraceiP17342.

Family & Domainsi

Sequence similaritiesi

Belongs to the ANF receptor family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255055.
HOGENOMiHOG000236252.
HOVERGENiHBG060145.
InParanoidiP17342.
KOiK12325.
OMAiFQVAYED.
OrthoDBiEOG7BZVS0.
PhylomeDBiP17342.
TreeFamiTF106339.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR001170. Ntpep_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00458. ANF_RECEPTORS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17342-1) [UniParc]FASTAAdd to Basket

Also known as: NPR-C5

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP    50
QKIEVLVLLP QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ 100
VAYEDSDCGN RALFSLVDRV AAARGAKPDL ILGPVCEYAA APVARLASHW 150
DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA YAKMGEMMLA LFRHHHWSRA 200
ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK DLDLEDIVRN 250
IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG 300
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM 350
EDYVNMFVEG FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI 400
AGQVSIDANG DRYGDFSVIA MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY 450
PWGPLKLRID ENRIVEHTNS SPCKSSGGLE ESAVTGIVVG ALLGAGLLMA 500
FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A 541
Length:541
Mass (Da):59,808
Last modified:January 10, 2003 - v2
Checksum:i8A66415F7F7D62B7
GO
Isoform 2 (identifier: P17342-2) [UniParc]FASTAAdd to Basket

Also known as: NPR-C6

The sequence of this isoform differs from the canonical sequence as follows:
     476-477: SG → C

Show »
Length:540
Mass (Da):59,767
Checksum:i53EE0020A296D6F5
GO
Isoform 3 (identifier: P17342-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MPSLLVLTFS...GGGGGAGIGG → MEPSALGPWS...FRRECGQNEK
     41-256: Missing.
     476-477: SG → C

Note: No experimental confirmation available.

Show »
Length:324
Mass (Da):36,656
Checksum:iC38DFF9C771B1A8B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040MPSLL…AGIGG → MEPSALGPWSLFPDLAPRDQ EGQVLAPRRCFRRECGQNEK in isoform 3. VSP_045901Add
BLAST
Alternative sequencei41 – 256216Missing in isoform 3. VSP_045902Add
BLAST
Alternative sequencei476 – 4772SG → C in isoform 2 and isoform 3. VSP_001812

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti522 – 5221N → D in BAG61896. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52282 mRNA. Translation: CAA36523.1.
M59305 mRNA. Translation: AAA51734.1.
AF025998 mRNA. Translation: AAB88801.1.
AK300094 mRNA. Translation: BAG61896.1.
AC008766 Genomic DNA. No translation available.
AC026703 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10799.1.
BC131540 mRNA. Translation: AAI31541.1.
CCDSiCCDS47196.1. [P17342-2]
CCDS56356.1. [P17342-3]
CCDS56357.1. [P17342-1]
PIRiS10150. OYHUCR.
RefSeqiNP_000899.1. NM_000908.3. [P17342-2]
NP_001191304.1. NM_001204375.1. [P17342-1]
NP_001191305.1. NM_001204376.1. [P17342-3]
UniGeneiHs.13528.
Hs.619466.

Genome annotation databases

EnsembliENST00000265074; ENSP00000265074; ENSG00000113389. [P17342-1]
ENST00000415167; ENSP00000398028; ENSG00000113389. [P17342-2]
ENST00000415685; ENSP00000402490; ENSG00000113389. [P17342-3]
GeneIDi4883.
KEGGihsa:4883.
UCSCiuc003jhv.3. human. [P17342-1]

Polymorphism databases

DMDMi27735161.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52282 mRNA. Translation: CAA36523.1 .
M59305 mRNA. Translation: AAA51734.1 .
AF025998 mRNA. Translation: AAB88801.1 .
AK300094 mRNA. Translation: BAG61896.1 .
AC008766 Genomic DNA. No translation available.
AC026703 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10799.1 .
BC131540 mRNA. Translation: AAI31541.1 .
CCDSi CCDS47196.1. [P17342-2 ]
CCDS56356.1. [P17342-3 ]
CCDS56357.1. [P17342-1 ]
PIRi S10150. OYHUCR.
RefSeqi NP_000899.1. NM_000908.3. [P17342-2 ]
NP_001191304.1. NM_001204375.1. [P17342-1 ]
NP_001191305.1. NM_001204376.1. [P17342-3 ]
UniGenei Hs.13528.
Hs.619466.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JDN X-ray 2.90 A 44-485 [» ]
1JDP X-ray 2.00 A/B 44-485 [» ]
1YK0 X-ray 2.40 A/B 1-480 [» ]
1YK1 X-ray 2.90 A/B 2-480 [» ]
ProteinModelPortali P17342.
SMRi P17342. Positions 46-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110943. 4 interactions.
STRINGi 9606.ENSP00000398028.

Chemistry

BindingDBi P17342.
ChEMBLi CHEMBL2247.
DrugBanki DB04899. Nesiritide.
GuidetoPHARMACOLOGYi 1749.

PTM databases

PhosphoSitei P17342.

Polymorphism databases

DMDMi 27735161.

Proteomic databases

MaxQBi P17342.
PaxDbi P17342.
PRIDEi P17342.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265074 ; ENSP00000265074 ; ENSG00000113389 . [P17342-1 ]
ENST00000415167 ; ENSP00000398028 ; ENSG00000113389 . [P17342-2 ]
ENST00000415685 ; ENSP00000402490 ; ENSG00000113389 . [P17342-3 ]
GeneIDi 4883.
KEGGi hsa:4883.
UCSCi uc003jhv.3. human. [P17342-1 ]

Organism-specific databases

CTDi 4883.
GeneCardsi GC05P032747.
HGNCi HGNC:7945. NPR3.
HPAi HPA031065.
MIMi 108962. gene.
neXtProti NX_P17342.
PharmGKBi PA31737.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255055.
HOGENOMi HOG000236252.
HOVERGENi HBG060145.
InParanoidi P17342.
KOi K12325.
OMAi FQVAYED.
OrthoDBi EOG7BZVS0.
PhylomeDBi P17342.
TreeFami TF106339.

Miscellaneous databases

EvolutionaryTracei P17342.
GeneWikii NPR3.
GenomeRNAii 4883.
NextBioi 18796.
PROi P17342.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17342.
Bgeei P17342.
CleanExi HS_NPR3.
Genevestigatori P17342.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR001170. Ntpep_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
[Graphical view ]
PRINTSi PR00255. NATPEPTIDER.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00458. ANF_RECEPTORS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence of the human atrial natriuretic peptide clearance receptor."
    Lowe D.G., Camerato T.R., Goeddel D.V.
    Nucleic Acids Res. 18:3412-3412(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Kidney.
  2. "Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA."
    Porter J.G., Arfsten A., Fuller F., Miller J.A., Gregory L.C., Lewicki J.A.
    Biochem. Biophys. Res. Commun. 171:796-803(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Human lens epithelial mRNA for atrial natriuretic peptide clearance receptor."
    Rae J.L., Shepard A.R.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Lens epithelium.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Pericardium.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer."
    Stults J.T., O'Connell K.L., Garcia C., Wong S., Engel A.M., Garbers D.L., Lowe D.G.
    Biochemistry 33:11372-11381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE (ISOFORMS 1 AND 2), DISULFIDE BONDS, GLYCOSYLATION AT ASN-86; ASN-293 AND ASN-394, STRUCTURE OF CARBOHYDRATES.
  9. "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
    Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
    J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  10. "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone."
    He X.-L., Chow D.-C., Martick M.M., Garcia K.C.
    Science 293:1657-1662(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 44-485 IN COMPLEX WITH NATRIURETIC PEPTIDE, GLYCOSYLATION AT ASN-293 AND ASN-394, DISULFIDE BONDS, SUBUNIT.
  11. "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
    He X.-L., Dukkipati A., Garcia K.C.
    J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-480 IN COMPLEX WITH NATRIURETIC PEPTIDE AND CHLORIDE IONS, GLYCOSYLATION AT ASN-86; ASN-293 AND ASN-394, DISULFIDE BONDS.

Entry informationi

Entry nameiANPRC_HUMAN
AccessioniPrimary (citable) accession number: P17342
Secondary accession number(s): A2RRD1, B4DT84, E7EPG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2003
Last modified: September 3, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has low affinity for peptide hormones in the absence of bound chloride.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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