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Protein

Atrial natriuretic peptide receptor 3

Gene

NPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Chloride1
Binding sitei135Chloride; via amide nitrogen1
Binding sitei136Chloride; via amide nitrogen1

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: BHF-UCL
  • hormone binding Source: UniProtKB
  • natriuretic peptide receptor activity Source: UniProtKB
  • peptide hormone binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Chloride

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Atrial natriuretic peptide receptor 3
Alternative name(s):
Atrial natriuretic peptide clearance receptor
Atrial natriuretic peptide receptor type C
Short name:
ANP-C
Short name:
ANPR-C
Short name:
NPR-C
Gene namesi
Name:NPR3
Synonyms:ANPRC, C5orf23, NPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:7945. NPR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 481ExtracellularSequence analysisAdd BLAST455
Transmembranei482 – 504HelicalSequence analysisAdd BLAST23
Topological domaini505 – 541CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4883.
OpenTargetsiENSG00000113389.
PharmGKBiPA31737.

Chemistry databases

ChEMBLiCHEMBL2247.
DrugBankiDB04899. Nesiritide.
GuidetoPHARMACOLOGYi1749.

Polymorphism and mutation databases

BioMutaiNPR3.
DMDMi27735161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001237027 – 541Atrial natriuretic peptide receptor 3Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) (complex)2 Publications1
Disulfide bondi108 ↔ 136
Disulfide bondi213 ↔ 261
Glycosylationi293N-linked (GlcNAc...) (high mannose)3 Publications1
Glycosylationi394N-linked (GlcNAc...) (complex)3 Publications1
Disulfide bondi473Interchain

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP17342.
PaxDbiP17342.
PeptideAtlasiP17342.
PRIDEiP17342.

PTM databases

iPTMnetiP17342.
PhosphoSitePlusiP17342.

Expressioni

Gene expression databases

BgeeiENSG00000113389.
CleanExiHS_NPR3.
ExpressionAtlasiP17342. baseline and differential.
GenevisibleiP17342. HS.

Organism-specific databases

HPAiHPA031065.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.3 Publications

Protein-protein interaction databases

BioGridi110943. 3 interactors.
STRINGi9606.ENSP00000265074.

Chemistry databases

BindingDBiP17342.

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 59Combined sources8
Helixi69 – 83Combined sources15
Beta strandi98 – 105Combined sources8
Helixi111 – 122Combined sources12
Turni123 – 125Combined sources3
Beta strandi129 – 132Combined sources4
Helixi137 – 150Combined sources14
Beta strandi154 – 157Combined sources4
Helixi162 – 165Combined sources4
Turni167 – 173Combined sources7
Beta strandi174 – 176Combined sources3
Helixi181 – 195Combined sources15
Beta strandi199 – 205Combined sources7
Beta strandi208 – 210Combined sources3
Helixi212 – 227Combined sources16
Beta strandi230 – 236Combined sources7
Beta strandi238 – 240Combined sources3
Helixi244 – 254Combined sources11
Beta strandi256 – 262Combined sources7
Helixi264 – 276Combined sources13
Turni280 – 283Combined sources4
Beta strandi285 – 289Combined sources5
Helixi291 – 293Combined sources3
Turni297 – 299Combined sources3
Helixi309 – 315Combined sources7
Helixi316 – 318Combined sources3
Beta strandi319 – 324Combined sources6
Helixi330 – 344Combined sources15
Turni345 – 347Combined sources3
Helixi356 – 377Combined sources22
Helixi385 – 392Combined sources8
Beta strandi393 – 399Combined sources7
Beta strandi402 – 406Combined sources5
Beta strandi410 – 412Combined sources3
Beta strandi415 – 423Combined sources9
Turni424 – 427Combined sources4
Beta strandi428 – 436Combined sources9
Turni437 – 440Combined sources4
Beta strandi441 – 444Combined sources4
Beta strandi451 – 453Combined sources3
Helixi454 – 456Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JDNX-ray2.90A44-485[»]
1JDPX-ray2.00A/B44-485[»]
1YK0X-ray2.40A/B1-480[»]
1YK1X-ray2.90A/B2-480[»]
ProteinModelPortaliP17342.
SMRiP17342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17342.

Family & Domainsi

Sequence similaritiesi

Belongs to the ANF receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00440000033872.
HOGENOMiHOG000236252.
HOVERGENiHBG060145.
InParanoidiP17342.
KOiK12325.
OMAiFQVAYED.
OrthoDBiEOG091G04YV.
PhylomeDBiP17342.
TreeFamiTF106339.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00458. ANF_RECEPTORS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17342-1) [UniParc]FASTAAdd to basket
Also known as: NPR-C5

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP
60 70 80 90 100
QKIEVLVLLP QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ
110 120 130 140 150
VAYEDSDCGN RALFSLVDRV AAARGAKPDL ILGPVCEYAA APVARLASHW
160 170 180 190 200
DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA YAKMGEMMLA LFRHHHWSRA
210 220 230 240 250
ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK DLDLEDIVRN
260 270 280 290 300
IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG
310 320 330 340 350
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM
360 370 380 390 400
EDYVNMFVEG FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI
410 420 430 440 450
AGQVSIDANG DRYGDFSVIA MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY
460 470 480 490 500
PWGPLKLRID ENRIVEHTNS SPCKSSGGLE ESAVTGIVVG ALLGAGLLMA
510 520 530 540
FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A
Length:541
Mass (Da):59,808
Last modified:January 10, 2003 - v2
Checksum:i8A66415F7F7D62B7
GO
Isoform 2 (identifier: P17342-2) [UniParc]FASTAAdd to basket
Also known as: NPR-C6

The sequence of this isoform differs from the canonical sequence as follows:
     476-477: SG → C

Show »
Length:540
Mass (Da):59,767
Checksum:i53EE0020A296D6F5
GO
Isoform 3 (identifier: P17342-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MPSLLVLTFS...GGGGGAGIGG → MEPSALGPWS...FRRECGQNEK
     41-256: Missing.
     476-477: SG → C

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,656
Checksum:iC38DFF9C771B1A8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti522N → D in BAG61896 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459011 – 40MPSLL…AGIGG → MEPSALGPWSLFPDLAPRDQ EGQVLAPRRCFRRECGQNEK in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04590241 – 256Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_001812476 – 477SG → C in isoform 2 and isoform 3. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52282 mRNA. Translation: CAA36523.1.
M59305 mRNA. Translation: AAA51734.1.
AF025998 mRNA. Translation: AAB88801.1.
AK300094 mRNA. Translation: BAG61896.1.
AC008766 Genomic DNA. No translation available.
AC026703 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10799.1.
BC131540 mRNA. Translation: AAI31541.1.
CCDSiCCDS47196.1. [P17342-2]
CCDS56356.1. [P17342-3]
CCDS56357.1. [P17342-1]
PIRiS10150. OYHUCR.
RefSeqiNP_000899.1. NM_000908.3. [P17342-2]
NP_001191304.1. NM_001204375.1. [P17342-1]
NP_001191305.1. NM_001204376.1. [P17342-3]
UniGeneiHs.13528.
Hs.619466.

Genome annotation databases

EnsembliENST00000265074; ENSP00000265074; ENSG00000113389. [P17342-1]
ENST00000326958; ENSP00000318340; ENSG00000113389. [P17342-3]
ENST00000415167; ENSP00000398028; ENSG00000113389. [P17342-2]
GeneIDi4883.
KEGGihsa:4883.
UCSCiuc003jhv.4. human. [P17342-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52282 mRNA. Translation: CAA36523.1.
M59305 mRNA. Translation: AAA51734.1.
AF025998 mRNA. Translation: AAB88801.1.
AK300094 mRNA. Translation: BAG61896.1.
AC008766 Genomic DNA. No translation available.
AC026703 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10799.1.
BC131540 mRNA. Translation: AAI31541.1.
CCDSiCCDS47196.1. [P17342-2]
CCDS56356.1. [P17342-3]
CCDS56357.1. [P17342-1]
PIRiS10150. OYHUCR.
RefSeqiNP_000899.1. NM_000908.3. [P17342-2]
NP_001191304.1. NM_001204375.1. [P17342-1]
NP_001191305.1. NM_001204376.1. [P17342-3]
UniGeneiHs.13528.
Hs.619466.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JDNX-ray2.90A44-485[»]
1JDPX-ray2.00A/B44-485[»]
1YK0X-ray2.40A/B1-480[»]
1YK1X-ray2.90A/B2-480[»]
ProteinModelPortaliP17342.
SMRiP17342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110943. 3 interactors.
STRINGi9606.ENSP00000265074.

Chemistry databases

BindingDBiP17342.
ChEMBLiCHEMBL2247.
DrugBankiDB04899. Nesiritide.
GuidetoPHARMACOLOGYi1749.

PTM databases

iPTMnetiP17342.
PhosphoSitePlusiP17342.

Polymorphism and mutation databases

BioMutaiNPR3.
DMDMi27735161.

Proteomic databases

MaxQBiP17342.
PaxDbiP17342.
PeptideAtlasiP17342.
PRIDEiP17342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265074; ENSP00000265074; ENSG00000113389. [P17342-1]
ENST00000326958; ENSP00000318340; ENSG00000113389. [P17342-3]
ENST00000415167; ENSP00000398028; ENSG00000113389. [P17342-2]
GeneIDi4883.
KEGGihsa:4883.
UCSCiuc003jhv.4. human. [P17342-1]

Organism-specific databases

CTDi4883.
DisGeNETi4883.
GeneCardsiNPR3.
HGNCiHGNC:7945. NPR3.
HPAiHPA031065.
MIMi108962. gene.
neXtProtiNX_P17342.
OpenTargetsiENSG00000113389.
PharmGKBiPA31737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00440000033872.
HOGENOMiHOG000236252.
HOVERGENiHBG060145.
InParanoidiP17342.
KOiK12325.
OMAiFQVAYED.
OrthoDBiEOG091G04YV.
PhylomeDBiP17342.
TreeFamiTF106339.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113389-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP17342.
GeneWikiiNPR3.
GenomeRNAii4883.
PROiP17342.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113389.
CleanExiHS_NPR3.
ExpressionAtlasiP17342. baseline and differential.
GenevisibleiP17342. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00458. ANF_RECEPTORS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANPRC_HUMAN
AccessioniPrimary (citable) accession number: P17342
Secondary accession number(s): A2RRD1, B4DT84, E7EPG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2003
Last modified: November 2, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has low affinity for peptide hormones in the absence of bound chloride.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.