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Protein

Catalase

Gene

Cat

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1
Active sitei146PROSITE-ProRule annotation1
Metal bindingi356Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • antioxidant activity Source: FlyBase
  • catalase activity Source: FlyBase
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • aging Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • heart morphogenesis Source: FlyBase
  • hydrogen peroxide catabolic process Source: GO_Central
  • intestinal stem cell homeostasis Source: FlyBase
  • paracrine signaling Source: FlyBase
  • reactive oxygen species metabolic process Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • response to endoplasmic reticulum stress Source: FlyBase
  • response to ethanol Source: FlyBase
  • response to hydrogen peroxide Source: FlyBase

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-3299685 Detoxification of Reactive Oxygen Species
R-DME-6798695 Neutrophil degranulation
R-DME-9033241 Peroxisomal protein import

Protein family/group databases

PeroxiBasei8425 DmKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:Cat
ORF Names:CG6871
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000261 Cat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849121 – 506CatalaseAdd BLAST506

Proteomic databases

PaxDbiP17336
PRIDEiP17336

Expressioni

Gene expression databases

BgeeiFBgn0000261
GenevisibleiP17336 DM

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi65329, 27 interactors
DIPiDIP-18768N
IntActiP17336, 31 interactors
STRINGi7227.FBpp0074825

Structurei

3D structure databases

ProteinModelPortaliP17336
SMRiP17336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi504 – 506Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
GeneTreeiENSGT00390000018100
InParanoidiP17336
KOiK03781
OMAiHADFGRM
OrthoDBiEOG091G04V5
PhylomeDBiP17336

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P17336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRDAASNQ LIDYKNSQTV SPGAITTGNG APIGIKDASQ TVGPRGPILL
60 70 80 90 100
QDVNFLDEMS HFDRERIPER VVHAKGAGAF GYFEVTHDIT QYCAAKIFDK
110 120 130 140 150
VKKRTPLAVR FSTVGGESGS ADTARDPRGF AVKFYTEDGV WDLVGNNTPV
160 170 180 190 200
FFIRDPILFP SFIHTQKRNP QTHLKDPDMF WDFLTLRPES AHQVCILFSD
210 220 230 240 250
RGTPDGYCHM NGYGSHTFKL INAKGEPIYA KFHFKTDQGI KNLDVKTADQ
260 270 280 290 300
LASTDPDYSI RDLYNRIKTC KFPSWTMYIQ VMTYEQAKKF KYNPFDVTKV
310 320 330 340 350
WSQKEYPLIP VGKMVLDRNP KNYFAEVEQI AFSPAHLVPG VEPSPDKMLH
360 370 380 390 400
GRLFSYSDTH RHRLGPNYLQ IPVNCPYKVK IENFQRDGAM NVTDNQDGAP
410 420 430 440 450
NYFPNSFNGP QECPRARALS SCCPVTGDVY RYSSGDTEDN FGQVTDFWVH
460 470 480 490 500
VLDKCAKKRL VQNIAGHLSN ASQFLQERAV KNFTQVHADF GRMLTEELNL

AKSSKF
Length:506
Mass (Da):57,150
Last modified:October 1, 1996 - v2
Checksum:i396377DC5F784ECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00145 Genomic DNA Translation: AAC13738.1
X52286 mRNA Translation: CAA36529.1
AE014296 Genomic DNA Translation: AAF49228.1
AY084154 mRNA Translation: AAL89892.1
PIRiS12725 CSFF
RefSeqiNP_536731.1, NM_080483.3
UniGeneiDm.6950

Genome annotation databases

EnsemblMetazoaiFBtr0075058; FBpp0074825; FBgn0000261
GeneIDi40048
KEGGidme:Dmel_CG6871

Similar proteinsi

Entry informationi

Entry nameiCATA_DROME
AccessioniPrimary (citable) accession number: P17336
Secondary accession number(s): Q9VVT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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