SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17330

- G3P3_CAEEL

UniProt

P17330 - G3P3_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glyceraldehyde-3-phosphate dehydrogenase 3

Gene
gpd-3, K10B3.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NAD By similarity
Binding sitei85 – 851NAD; via carbonyl oxygen By similarity
Active sitei158 – 1581Nucleophile By similarity
Sitei185 – 1851Activates thiol group during catalysis By similarity
Binding sitei188 – 1881Glyceraldehyde 3-phosphate By similarity
Binding sitei240 – 2401Glyceraldehyde 3-phosphate By similarity
Binding sitei322 – 3221NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 142NAD By similarity

GO - Molecular functioni

  1. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. NADP binding Source: InterPro

GO - Biological processi

  1. glucose metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00109; UER00184.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase 3 (EC:1.2.1.12)
Short name:
GAPDH-3
Gene namesi
Name:gpd-3
ORF Names:K10B3.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiK10B3.7; CE07370; WBGene00001685; gpd-3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Glyceraldehyde-3-phosphate dehydrogenase 3PRO_0000145512Add
BLAST

Proteomic databases

PaxDbiP17330.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi45544. 10 interactions.
DIPiDIP-26747N.
IntActiP17330. 4 interactions.
MINTiMINT-116081.
STRINGi6239.K10B3.7.2.

Structurei

3D structure databases

ProteinModelPortaliP17330.
SMRiP17330. Positions 2-340.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1593Glyceraldehyde 3-phosphate binding By similarity
Regioni217 – 2182Glyceraldehyde 3-phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0057.
GeneTreeiENSGT00720000108591.
HOGENOMiHOG000071678.
InParanoidiP17330.
KOiK00134.
OMAiFIDTEYA.
PhylomeDBiP17330.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01534. GAPDH-I. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17330-1 [UniParc]FASTAAdd to Basket

« Hide

MTKPSVGING FGRIGRLVLR AAVEKDSVNV VAVNDPFISI DYMVYLFQYD    50
STHGRFKGTV AHEGDYLLVA KEGKSQHKIK VYNSRDPAEI QWGASGADYV 100
VESTGVFTTI EKANAHLKGG AKKVIISAPS ADAPMFVVGV NHEKYDHAND 150
HIISNASCTT NCLAPLAKVI NDNFGIIEGL MTTVHAVTAT QKTVDGPSGK 200
LWRDGRGAGQ NIIPASTGAA KAVGKVIPEL NGKLTGMAFR VPTPDVSVVD 250
LTARLEKPAS LDDIKKVIKA AADGPMKGIL AYTEDQVVST DFVSDTNSSI 300
FDAGASISLN PHFVKLVSWY DNEFGYSNRV VDLISYIATK A 341
Length:341
Mass (Da):36,459
Last modified:August 1, 1990 - v1
Checksum:i88938B34676637F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15254 Genomic DNA. Translation: CAA33327.1.
FO080552 Genomic DNA. Translation: CCD64599.1.
PIRiS03914. DEKWG3.
RefSeqiNP_508534.3. NM_076133.5.
UniGeneiCel.34171.

Genome annotation databases

EnsemblMetazoaiK10B3.7.1; K10B3.7.1; WBGene00001685.
K10B3.7.2; K10B3.7.2; WBGene00001685.
GeneIDi180601.
KEGGicel:CELE_K10B3.7.
UCSCiK10B3.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15254 Genomic DNA. Translation: CAA33327.1 .
FO080552 Genomic DNA. Translation: CCD64599.1 .
PIRi S03914. DEKWG3.
RefSeqi NP_508534.3. NM_076133.5.
UniGenei Cel.34171.

3D structure databases

ProteinModelPortali P17330.
SMRi P17330. Positions 2-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45544. 10 interactions.
DIPi DIP-26747N.
IntActi P17330. 4 interactions.
MINTi MINT-116081.
STRINGi 6239.K10B3.7.2.

Proteomic databases

PaxDbi P17330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K10B3.7.1 ; K10B3.7.1 ; WBGene00001685 .
K10B3.7.2 ; K10B3.7.2 ; WBGene00001685 .
GeneIDi 180601.
KEGGi cel:CELE_K10B3.7.
UCSCi K10B3.7.1. c. elegans.

Organism-specific databases

CTDi 180601.
WormBasei K10B3.7 ; CE07370 ; WBGene00001685 ; gpd-3.

Phylogenomic databases

eggNOGi COG0057.
GeneTreei ENSGT00720000108591.
HOGENOMi HOG000071678.
InParanoidi P17330.
KOi K00134.
OMAi FIDTEYA.
PhylomeDBi P17330.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00184 .

Miscellaneous databases

NextBioi 910066.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10836. PTHR10836. 1 hit.
Pfami PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000149. GAP_DH. 1 hit.
PRINTSi PR00078. G3PDHDRGNASE.
SMARTi SM00846. Gp_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01534. GAPDH-I. 1 hit.
PROSITEi PS00071. GAPDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans."
    Huang X.Y., Barrios L.A.M., Vonkhorporn P., Honda S., Albertson D.G., Hecht R.M.
    J. Mol. Biol. 206:411-424(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiG3P3_CAEEL
AccessioniPrimary (citable) accession number: P17330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi