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Protein

Glyceraldehyde-3-phosphate dehydrogenase 2

Gene

gpd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.PROSITE-ProRule annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADBy similarity1
Binding sitei85NAD; via carbonyl oxygenBy similarity1
Active sitei158NucleophilePROSITE-ProRule annotation1
Sitei185Activates thiol group during catalysisBy similarity1
Binding sitei188Glyceraldehyde 3-phosphateBy similarity1
Binding sitei240Glyceraldehyde 3-phosphateBy similarity1
Binding sitei322NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 14NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-70171 Glycolysis
R-CEL-70263 Gluconeogenesis
UniPathwayiUPA00109; UER00184

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase 2 (EC:1.2.1.12)
Short name:
GAPDH-2
Gene namesi
Name:gpd-2
ORF Names:K10B3.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK10B3.8 ; CE07371 ; WBGene00001684 ; gpd-2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001455111 – 341Glyceraldehyde-3-phosphate dehydrogenase 2Add BLAST341

Proteomic databases

EPDiP17329
PaxDbiP17329
PeptideAtlasiP17329
PRIDEiP17329

PTM databases

iPTMnetiP17329

Expressioni

Gene expression databases

BgeeiWBGene00001684

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-26337N
IntActiP17329, 3 interactors
MINTiP17329
STRINGi6239.K10B3.8.2

Structurei

3D structure databases

ProteinModelPortaliP17329
SMRiP17329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 159Glyceraldehyde 3-phosphate bindingBy similarity3
Regioni217 – 218Glyceraldehyde 3-phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0657 Eukaryota
COG0057 LUCA
GeneTreeiENSGT00760000119172
HOGENOMiHOG000071678
InParanoidiP17329
KOiK00134
OMAiTRIMMED
OrthoDBiEOG091G0B1Y
PhylomeDBiP17329

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequencei

Sequence statusi: Complete.

P17329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKPSVGING FGRIGRLVLR AAVEKDSVNV VAVNDPFISI DYMVYLFQYD
60 70 80 90 100
STHGRFKGTV AHEGDYLLVA KEGKSQHKIK VYNSRDPAEI QWGASGADYV
110 120 130 140 150
VESTGVFTTI EKANAHLKGG AKKVIISAPS ADAPMFVVGV NHEKYDHAND
160 170 180 190 200
HIISNASCTT NCLAPLAKVI NDNFGIIEGL MTTVHAVTAT QKTVDGPSGK
210 220 230 240 250
LWRDGRGAGQ NIIPASTGAA KAVGKVIPEL NGKLTGMAFR VPTPDVSVVD
260 270 280 290 300
LTARLEKPAS LDDIKKVIKA AADGPMKGIL AYTEDQVVST DFVSDTNSSI
310 320 330 340
FDAGASISLN PHFVKLVSWY DNEFGYSNRV VDLISYIATK A
Length:341
Mass (Da):36,455
Last modified:July 22, 2008 - v2
Checksum:iE355331B65E39CF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5S → N in CAA33326 (PubMed:2716055).Curated1
Sequence conflicti31V → D in CAA33326 (PubMed:2716055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15254 Genomic DNA Translation: CAA33326.1
FO080552 Genomic DNA Translation: CCD64600.1
PIRiA89491
S03913 DEKWG2
RefSeqiNP_508535.1, NM_076134.5
UniGeneiCel.23529

Genome annotation databases

EnsemblMetazoaiK10B3.8.1; K10B3.8.1; WBGene00001684
K10B3.8.2; K10B3.8.2; WBGene00001684
GeneIDi3565504
KEGGicel:CELE_K10B3.8
UCSCiK10B3.8.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiG3P2_CAEEL
AccessioniPrimary (citable) accession number: P17329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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