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P17326

- AT1A_ARTSF

UniProt

P17326 - AT1A_ARTSF

Protein

Sodium/potassium-transporting ATPase subunit alpha-A

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei353 – 35314-aspartylphosphate intermediateCurated
    Binding sitei483 – 4831ATPBy similarity
    Metal bindingi692 – 6921MagnesiumBy similarity
    Metal bindingi696 – 6961MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-A (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-A subunit
    Alternative name(s):
    Sodium pump subunit alpha-A
    OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
    Taxonomic identifieri6661 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 996996Sodium/potassium-transporting ATPase subunit alpha-APRO_0000046306Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP17326.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP17326.
    SMRiP17326. Positions 4-996.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalBy similarityAdd
    BLAST
    Transmembranei107 – 12317HelicalBy similarityAdd
    BLAST
    Transmembranei268 – 29023HelicalBy similarityAdd
    BLAST
    Transmembranei297 – 32529HelicalBy similarityAdd
    BLAST
    Transmembranei762 – 78524HelicalBy similarityAdd
    BLAST
    Transmembranei820 – 84728HelicalBy similarityAdd
    BLAST
    Transmembranei889 – 90921HelicalBy similarityAdd
    BLAST
    Transmembranei926 – 95126HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17326-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKKQGKQLS DLKKELELDQ HKIPLEELCR RLGTNTETGL TSSQAKSHLE    50
    KYGPNALTPP RTTPEWIKFC KQLFGGFQML LWIGSILCFI AYTMEKYKNP 100
    DVLGDNLYLG LALLFVVIMT GCFAYYQDHN ASKIMDSFKN LMPQFAFVIR 150
    DGKKIQLKAE EVTVGDLVEV KFGDRIPADI RITSCQSMKV DNSSLTGESE 200
    PQSRSTECTN DNPLETKNLA FFFTNTLEGT GRGIVINVGD DSVMGRIACL 250
    ASSLDSGKTP IAREIEHFIH IITAMAVSLA AVFAVISFLY GYTWLEAAIF 300
    MIGIIVAKVP EGLLATVTVC LTLTAKRMAK KNCLVRNLEA VETLGSTSTI 350
    CSDKTGTLTQ NRMTVAHMWF DQKIVTADTT ENQSGNQLYR GSKGFPELIR 400
    VASLCSRAEF KTEHAHLPVL KRDVNGDASE AAILKFAEMS TGSVMNIRSK 450
    QKKVSEIPFN SANKYQVSVH EREDKSGYFL VMKGAPERIL ERCSTILIDG 500
    TEIPLDNHMK ECFNNAYMEL GGMGERVLGF CDFELPSDQY PRGYVFDADE 550
    PNFPISGLRF VGLMSMIDPP RAAVPDAVSK CRSAGIKVIM VTGDHPITAK 600
    AIARQVGIIS EGHETVDDIA ARLNIPVSEV NPRSAQAAVI HGNDLKDMNS 650
    DQLDDILRHY REIVFARTSP QQKLIIVEGV QRQGEFVAVT GDGVNDSPAL 700
    KKADIGVAMG IAGSDVSKQA ADMILLDDNF ASIVTGVEEG RLIFDNIKKS 750
    IAYTLTSKIP ELSPFLMYIL FDLPLAIGTV TILCIDLGTD VVPAISMAYE 800
    GPEADPRKPR DPVKEKLVNE RLISMAYGQI GVMQAFGGFF TYFVIMGECG 850
    FLPNRLFGLR KWWESKAYND LTDSYGQEWT WDARKQLEYT CHTAFFISIV 900
    IVQWTDLIIC KTRRLSLFQQ GMKNGTLNFA LVFETCVAAF LSYTPGMDKG 950
    LRMYPLKIWW WFPPMPFSLL ILVYDECRKF LMRRNPGGFL ERETYY 996
    Length:996
    Mass (Da):111,022
    Last modified:August 1, 1990 - v1
    Checksum:i92A4D129F327A42C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07513 mRNA. Translation: CAA68811.1.
    PIRiS06635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07513 mRNA. Translation: CAA68811.1 .
    PIRi S06635.

    3D structure databases

    ProteinModelPortali P17326.
    SMRi P17326. Positions 4-996.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P17326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the Na,K-ATPase alpha-subunit in developing brine shrimp and sequence comparison with higher organisms."
      Baxter-Lowe L.A., Guo J.Z., Bergstroem E.E., Hokin L.E.
      FEBS Lett. 257:181-187(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAT1A_ARTSF
    AccessioniPrimary (citable) accession number: P17326
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3