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P17326

- AT1A_ARTSF

UniProt

P17326 - AT1A_ARTSF

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Protein

Sodium/potassium-transporting ATPase subunit alpha-A

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 35314-aspartylphosphate intermediateCurated
Binding sitei483 – 4831ATPBy similarity
Metal bindingi692 – 6921MagnesiumBy similarity
Metal bindingi696 – 6961MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-A (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-A subunit
Alternative name(s):
Sodium pump subunit alpha-A
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 996996Sodium/potassium-transporting ATPase subunit alpha-APRO_0000046306Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP17326.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP17326.
SMRiP17326. Positions 4-996.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalBy similarityAdd
BLAST
Transmembranei107 – 12317HelicalBy similarityAdd
BLAST
Transmembranei268 – 29023HelicalBy similarityAdd
BLAST
Transmembranei297 – 32529HelicalBy similarityAdd
BLAST
Transmembranei762 – 78524HelicalBy similarityAdd
BLAST
Transmembranei820 – 84728HelicalBy similarityAdd
BLAST
Transmembranei889 – 90921HelicalBy similarityAdd
BLAST
Transmembranei926 – 95126HelicalBy similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17326-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKKQGKQLS DLKKELELDQ HKIPLEELCR RLGTNTETGL TSSQAKSHLE
60 70 80 90 100
KYGPNALTPP RTTPEWIKFC KQLFGGFQML LWIGSILCFI AYTMEKYKNP
110 120 130 140 150
DVLGDNLYLG LALLFVVIMT GCFAYYQDHN ASKIMDSFKN LMPQFAFVIR
160 170 180 190 200
DGKKIQLKAE EVTVGDLVEV KFGDRIPADI RITSCQSMKV DNSSLTGESE
210 220 230 240 250
PQSRSTECTN DNPLETKNLA FFFTNTLEGT GRGIVINVGD DSVMGRIACL
260 270 280 290 300
ASSLDSGKTP IAREIEHFIH IITAMAVSLA AVFAVISFLY GYTWLEAAIF
310 320 330 340 350
MIGIIVAKVP EGLLATVTVC LTLTAKRMAK KNCLVRNLEA VETLGSTSTI
360 370 380 390 400
CSDKTGTLTQ NRMTVAHMWF DQKIVTADTT ENQSGNQLYR GSKGFPELIR
410 420 430 440 450
VASLCSRAEF KTEHAHLPVL KRDVNGDASE AAILKFAEMS TGSVMNIRSK
460 470 480 490 500
QKKVSEIPFN SANKYQVSVH EREDKSGYFL VMKGAPERIL ERCSTILIDG
510 520 530 540 550
TEIPLDNHMK ECFNNAYMEL GGMGERVLGF CDFELPSDQY PRGYVFDADE
560 570 580 590 600
PNFPISGLRF VGLMSMIDPP RAAVPDAVSK CRSAGIKVIM VTGDHPITAK
610 620 630 640 650
AIARQVGIIS EGHETVDDIA ARLNIPVSEV NPRSAQAAVI HGNDLKDMNS
660 670 680 690 700
DQLDDILRHY REIVFARTSP QQKLIIVEGV QRQGEFVAVT GDGVNDSPAL
710 720 730 740 750
KKADIGVAMG IAGSDVSKQA ADMILLDDNF ASIVTGVEEG RLIFDNIKKS
760 770 780 790 800
IAYTLTSKIP ELSPFLMYIL FDLPLAIGTV TILCIDLGTD VVPAISMAYE
810 820 830 840 850
GPEADPRKPR DPVKEKLVNE RLISMAYGQI GVMQAFGGFF TYFVIMGECG
860 870 880 890 900
FLPNRLFGLR KWWESKAYND LTDSYGQEWT WDARKQLEYT CHTAFFISIV
910 920 930 940 950
IVQWTDLIIC KTRRLSLFQQ GMKNGTLNFA LVFETCVAAF LSYTPGMDKG
960 970 980 990
LRMYPLKIWW WFPPMPFSLL ILVYDECRKF LMRRNPGGFL ERETYY
Length:996
Mass (Da):111,022
Last modified:August 1, 1990 - v1
Checksum:i92A4D129F327A42C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07513 mRNA. Translation: CAA68811.1.
PIRiS06635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07513 mRNA. Translation: CAA68811.1 .
PIRi S06635.

3D structure databases

ProteinModelPortali P17326.
SMRi P17326. Positions 4-996.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P17326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the Na,K-ATPase alpha-subunit in developing brine shrimp and sequence comparison with higher organisms."
    Baxter-Lowe L.A., Guo J.Z., Bergstroem E.E., Hokin L.E.
    FEBS Lett. 257:181-187(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A_ARTSF
AccessioniPrimary (citable) accession number: P17326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3