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Protein

Sodium/potassium-transporting ATPase subunit alpha-A

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3534-aspartylphosphate intermediateCurated1
Binding sitei483ATPBy similarity1
Metal bindingi692MagnesiumBy similarity1
Metal bindingi696MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-A (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-A subunit
Alternative name(s):
Sodium pump subunit alpha-A
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalBy similarityAdd BLAST21
Transmembranei107 – 123HelicalBy similarityAdd BLAST17
Transmembranei268 – 290HelicalBy similarityAdd BLAST23
Transmembranei297 – 325HelicalBy similarityAdd BLAST29
Transmembranei762 – 785HelicalBy similarityAdd BLAST24
Transmembranei820 – 847HelicalBy similarityAdd BLAST28
Transmembranei889 – 909HelicalBy similarityAdd BLAST21
Transmembranei926 – 951HelicalBy similarityAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463061 – 996Sodium/potassium-transporting ATPase subunit alpha-AAdd BLAST996

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP17326.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP17326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKQGKQLS DLKKELELDQ HKIPLEELCR RLGTNTETGL TSSQAKSHLE
60 70 80 90 100
KYGPNALTPP RTTPEWIKFC KQLFGGFQML LWIGSILCFI AYTMEKYKNP
110 120 130 140 150
DVLGDNLYLG LALLFVVIMT GCFAYYQDHN ASKIMDSFKN LMPQFAFVIR
160 170 180 190 200
DGKKIQLKAE EVTVGDLVEV KFGDRIPADI RITSCQSMKV DNSSLTGESE
210 220 230 240 250
PQSRSTECTN DNPLETKNLA FFFTNTLEGT GRGIVINVGD DSVMGRIACL
260 270 280 290 300
ASSLDSGKTP IAREIEHFIH IITAMAVSLA AVFAVISFLY GYTWLEAAIF
310 320 330 340 350
MIGIIVAKVP EGLLATVTVC LTLTAKRMAK KNCLVRNLEA VETLGSTSTI
360 370 380 390 400
CSDKTGTLTQ NRMTVAHMWF DQKIVTADTT ENQSGNQLYR GSKGFPELIR
410 420 430 440 450
VASLCSRAEF KTEHAHLPVL KRDVNGDASE AAILKFAEMS TGSVMNIRSK
460 470 480 490 500
QKKVSEIPFN SANKYQVSVH EREDKSGYFL VMKGAPERIL ERCSTILIDG
510 520 530 540 550
TEIPLDNHMK ECFNNAYMEL GGMGERVLGF CDFELPSDQY PRGYVFDADE
560 570 580 590 600
PNFPISGLRF VGLMSMIDPP RAAVPDAVSK CRSAGIKVIM VTGDHPITAK
610 620 630 640 650
AIARQVGIIS EGHETVDDIA ARLNIPVSEV NPRSAQAAVI HGNDLKDMNS
660 670 680 690 700
DQLDDILRHY REIVFARTSP QQKLIIVEGV QRQGEFVAVT GDGVNDSPAL
710 720 730 740 750
KKADIGVAMG IAGSDVSKQA ADMILLDDNF ASIVTGVEEG RLIFDNIKKS
760 770 780 790 800
IAYTLTSKIP ELSPFLMYIL FDLPLAIGTV TILCIDLGTD VVPAISMAYE
810 820 830 840 850
GPEADPRKPR DPVKEKLVNE RLISMAYGQI GVMQAFGGFF TYFVIMGECG
860 870 880 890 900
FLPNRLFGLR KWWESKAYND LTDSYGQEWT WDARKQLEYT CHTAFFISIV
910 920 930 940 950
IVQWTDLIIC KTRRLSLFQQ GMKNGTLNFA LVFETCVAAF LSYTPGMDKG
960 970 980 990
LRMYPLKIWW WFPPMPFSLL ILVYDECRKF LMRRNPGGFL ERETYY
Length:996
Mass (Da):111,022
Last modified:August 1, 1990 - v1
Checksum:i92A4D129F327A42C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07513 mRNA. Translation: CAA68811.1.
PIRiS06635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07513 mRNA. Translation: CAA68811.1.
PIRiS06635.

3D structure databases

ProteinModelPortaliP17326.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP17326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A_ARTSF
AccessioniPrimary (citable) accession number: P17326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.