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P17326 (AT1A_ARTSF) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit alpha-A

Short name=Na(+)/K(+) ATPase alpha-A subunit
EC=3.6.3.9
Alternative name(s):
Sodium pump subunit alpha-A
OrganismArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifier6661 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Protein attributes

Sequence length996 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activity

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 996996Sodium/potassium-transporting ATPase subunit alpha-A
PRO_0000046306

Regions

Transmembrane73 – 9321Helical; By similarity
Transmembrane107 – 12317Helical; By similarity
Transmembrane268 – 29023Helical; By similarity
Transmembrane297 – 32529Helical; By similarity
Transmembrane762 – 78524Helical; By similarity
Transmembrane820 – 84728Helical; By similarity
Transmembrane889 – 90921Helical; By similarity
Transmembrane926 – 95126Helical; By similarity

Sites

Active site35314-aspartylphosphate intermediate Probable
Metal binding6921Magnesium By similarity
Metal binding6961Magnesium By similarity
Binding site4831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P17326 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 92A4D129F327A42C

FASTA996111,022
        10         20         30         40         50         60 
MGKKQGKQLS DLKKELELDQ HKIPLEELCR RLGTNTETGL TSSQAKSHLE KYGPNALTPP 

        70         80         90        100        110        120 
RTTPEWIKFC KQLFGGFQML LWIGSILCFI AYTMEKYKNP DVLGDNLYLG LALLFVVIMT 

       130        140        150        160        170        180 
GCFAYYQDHN ASKIMDSFKN LMPQFAFVIR DGKKIQLKAE EVTVGDLVEV KFGDRIPADI 

       190        200        210        220        230        240 
RITSCQSMKV DNSSLTGESE PQSRSTECTN DNPLETKNLA FFFTNTLEGT GRGIVINVGD 

       250        260        270        280        290        300 
DSVMGRIACL ASSLDSGKTP IAREIEHFIH IITAMAVSLA AVFAVISFLY GYTWLEAAIF 

       310        320        330        340        350        360 
MIGIIVAKVP EGLLATVTVC LTLTAKRMAK KNCLVRNLEA VETLGSTSTI CSDKTGTLTQ 

       370        380        390        400        410        420 
NRMTVAHMWF DQKIVTADTT ENQSGNQLYR GSKGFPELIR VASLCSRAEF KTEHAHLPVL 

       430        440        450        460        470        480 
KRDVNGDASE AAILKFAEMS TGSVMNIRSK QKKVSEIPFN SANKYQVSVH EREDKSGYFL 

       490        500        510        520        530        540 
VMKGAPERIL ERCSTILIDG TEIPLDNHMK ECFNNAYMEL GGMGERVLGF CDFELPSDQY 

       550        560        570        580        590        600 
PRGYVFDADE PNFPISGLRF VGLMSMIDPP RAAVPDAVSK CRSAGIKVIM VTGDHPITAK 

       610        620        630        640        650        660 
AIARQVGIIS EGHETVDDIA ARLNIPVSEV NPRSAQAAVI HGNDLKDMNS DQLDDILRHY 

       670        680        690        700        710        720 
REIVFARTSP QQKLIIVEGV QRQGEFVAVT GDGVNDSPAL KKADIGVAMG IAGSDVSKQA 

       730        740        750        760        770        780 
ADMILLDDNF ASIVTGVEEG RLIFDNIKKS IAYTLTSKIP ELSPFLMYIL FDLPLAIGTV 

       790        800        810        820        830        840 
TILCIDLGTD VVPAISMAYE GPEADPRKPR DPVKEKLVNE RLISMAYGQI GVMQAFGGFF 

       850        860        870        880        890        900 
TYFVIMGECG FLPNRLFGLR KWWESKAYND LTDSYGQEWT WDARKQLEYT CHTAFFISIV 

       910        920        930        940        950        960 
IVQWTDLIIC KTRRLSLFQQ GMKNGTLNFA LVFETCVAAF LSYTPGMDKG LRMYPLKIWW 

       970        980        990 
WFPPMPFSLL ILVYDECRKF LMRRNPGGFL ERETYY 

« Hide

References

[1]"Molecular cloning of the Na,K-ATPase alpha-subunit in developing brine shrimp and sequence comparison with higher organisms."
Baxter-Lowe L.A., Guo J.Z., Bergstroem E.E., Hokin L.E.
FEBS Lett. 257:181-187(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07513 mRNA. Translation: CAA68811.1.
PIRS06635.

3D structure databases

ProteinModelPortalP17326.
SMRP17326. Positions 4-996.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP17326.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAT1A_ARTSF
AccessionPrimary (citable) accession number: P17326
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families