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Reviewed, UniProtKB/Swiss-Prot P17325 (JUN_RAT)

Last modified November 3, 2009. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Transcription factor AP-1
Alternative name(s):
    Activator protein 1
      Short name=AP1
    Proto-oncogene c-jun
    V-jun avian sarcoma virus 17 oncogene homolog
Gene names
Name: Jun
Synonyms: Rjg-9
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Subunit structure

Heterodimer with either FOS or BATF3. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3 By similarity.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC By similarity.

Sequence similarities

Belongs to the bZIP family. Jun subfamily.

Contains 1 bZIP domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DiseaseProto-oncogene
   LigandDNA-binding
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processaging

Inferred from expression pattern. Source: RGD

angiogenesis

Inferred from mutant phenotype. Source: RGD

cellular response to potassium ion starvation

Inferred from mutant phenotype. Source: RGD

circadian rhythm

Inferred from expression pattern. Source: RGD

learning

Inferred from mutant phenotype. Source: RGD

membrane depolarization

Inferred from direct assay. Source: RGD

positive regulation of DNA replication

Inferred from mutant phenotype. Source: RGD

positive regulation of monocyte differentiation

Inferred from direct assay. Source: RGD

positive regulation of neuron apoptosis

Inferred from mutant phenotype. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from direct assay. Source: RGD

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype. Source: RGD

release of cytochrome c from mitochondria

Inferred from mutant phenotype. Source: RGD

response to cAMP

Inferred from expression pattern. Source: RGD

response to cytokine stimulus

Inferred from expression pattern. Source: RGD

response to drug

Inferred from expression pattern. Source: RGD

response to hydrogen peroxide

Inferred from expression pattern. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern. Source: RGD

response to mechanical stimulus

Inferred from expression pattern. Source: RGD

response to organic cyclic substance

Inferred from expression pattern. Source: RGD

transcription from RNA polymerase II promoter

Inferred from mutant phenotype. Source: RGD

   Cellular componentcytosol

Inferred from direct assay. Source: RGD

transcription factor complex

Inferred from mutant phenotype. Source: RGD

   Molecular functionRNA polymerase II transcription factor activity

Inferred from mutant phenotype. Source: RGD

double-stranded DNA binding

Inferred from direct assay. Source: RGD

protein heterodimerization activity

Inferred from physical interaction. Source: RGD

protein homodimerization activity

Inferred from direct assay. Source: RGD

sequence-specific DNA binding

Inferred from direct assay. Source: RGD

transcription activator activity

Traceable author statement. Source: RGD

transcription factor activity

Inferred from mutant phenotype. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Transcription factor AP-1
PRO_0000076432

Regions

Domain283 – 31129Leucine-zipper
DNA binding260 – 27920Basic motif

Amino acid modifications

Modified residue581Phosphoserine By similarity
Modified residue631Phosphoserine; by MAPK8 By similarity
Modified residue731Phosphoserine; by MAPK8 By similarity
Modified residue2421Phosphothreonine By similarity
Modified residue2461Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P17325-1 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: AFD9DF7D7C791B58

FASTA33436,001
        10         20         30         40         50         60 
MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGNLK PHLRAKNSDL 

        70         80         90        100        110        120 
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 

       130        140        150        160        170        180 
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 

       190        200        210        220        230        240 
LSSGGGAPSY GATGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 

       250        260        270        280        290        300 
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 

       310        320        330 
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis."
Sakai M., Okuda A., Hatayama I., Sato K., Nishi S., Muramatsu M.
Cancer Res. 49:5633-5637(1989) [PubMed: 2507134] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Nucleotide sequence of rat c-jun protooncogene."
Kitabayashi I., Saka F., Gachelin G., Yokoyama K.
Nucleic Acids Res. 18:3400-3400(1990) [PubMed: 2113275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Fischer.
[3]"Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells."
Kitabayashi I., Kawakami Z., Chiu R., Ozawa K., Matsuoka T., Toyoshima S., Umesono K., Evans R.M., Gachelin G., Yokoyama K.
EMBO J. 11:167-175(1992) [PubMed: 1310930] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions."
Aronheim A., Zandi E., Hennemann H., Elledge S.J., Karin M.
Mol. Cell. Biol. 17:3094-3102(1997) [PubMed: 9154808] [Abstract]
Cited for: INTERACTION WITH BATF3.
+Additional computationally mapped references.

Cross-references

Sequence databases

X17163 mRNA. Translation: CAA35041.1.
X17215 Genomic DNA. Translation: CAA35084.1.
BC078738 mRNA. Translation: AAH78738.1.
IPIIPI00215370.
PIRS12742.
RefSeqNP_068607.1.
UniGeneRn.93714

3D structure databases

HSSPHSSP built from PDB template 1FOS based on UniProtKB P05412.
SMRP17325. Positions 256-317.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:653N.
STRINGP17325.

PTM databases

PhosphoSiteP17325.

Proteomic databases

PRIDEP17325.

Genome annotation databases

EnsemblENSRNOT00000011731; ENSRNOP00000011732; ENSRNOG00000026293; Rattus norvegicus. [Genome view]
GeneID24516.
KEGGrno:24516.
UCSCNM_021835. rat.

Organism-specific databases

CTD24516.
RGD2943. Jun.

Phylogenomic databases

HOVERGENP17325.
OMAKPHLRNK.

Gene expression databases

ArrayExpressP17325.
GenevestigatorP17325.
GermOnlineENSRNOG00000026293. Rattus norvegicus.

Family and domain databases

InterProIPR011616. bZIP_1.
IPR015558. C_Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR004827. TF_bZIP.
[Graphical view]
PANTHERPTHR11462:SF8. C_Jun. 1 hit.
PfamPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSPR00043. LEUZIPPRJUN.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio603545.

Entry information

Entry nameJUN_RAT
AccessionPrimary (citable) accession number: P17325
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 3, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents