Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelin-1

Gene

EDN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:28327 EDN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000804626 – 50By similarityAdd BLAST25
PeptideiPRO_000043639353 – 91Big endothelin-1By similarityAdd BLAST39
PeptideiPRO_000000804753 – 73Endothelin-1Add BLAST21
PropeptideiPRO_000000804874 – 202Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP17322
PRIDEiP17322

Expressioni

Gene expression databases

BgeeiENSBTAG00000008096

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010649

Structurei

3D structure databases

SMRiP17322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 124Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWVG Eukaryota
ENOG4111WED LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051441
InParanoidiP17322
KOiK16366
OMAiWVNTPEH
OrthoDBiEOG091G0LEL
TreeFamiTF333184

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP
110 120 130 140 150
TKATVHRKRC QCASQTDKKC WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS
160 170 180 190 200
KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS FRVAKLKAQL YRDKKVIYNR

AH
Length:202
Mass (Da):22,977
Last modified:August 1, 1990 - v1
Checksum:i42EB2AF07C85A5A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → A in CAA37117 (PubMed:2198541).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52740 mRNA Translation: CAA36954.1
X52942 mRNA Translation: CAA37117.1
S37093 mRNA Translation: AAB22241.1
BC102459 mRNA Translation: AAI02460.1
PIRiS10488
RefSeqiNP_851353.1, NM_181010.2
UniGeneiBt.59529

Genome annotation databases

EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096
GeneIDi281137
KEGGibta:281137

Similar proteinsi

Entry informationi

Entry nameiEDN1_BOVIN
AccessioniPrimary (citable) accession number: P17322
Secondary accession number(s): Q3T0C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health