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P17322

- EDN1_BOVIN

UniProt

P17322 - EDN1_BOVIN

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Protein

Endothelin-1

Gene

EDN1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. inositol phosphate-mediated signaling Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell size Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of heart rate Source: Ensembl
  25. positive regulation of hormone secretion Source: Ensembl
  26. positive regulation of JUN kinase activity Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. protein kinase C deactivation Source: Ensembl
  37. regulation of blood pressure Source: AgBase
  38. regulation of pH Source: Ensembl
  39. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  40. regulation of vasoconstriction Source: AgBase
  41. respiratory gaseous exchange Source: Ensembl
  42. response to hypoxia Source: Ensembl
  43. rhythmic excitation Source: Ensembl
  44. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 23

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 5025PRO_0000008046Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008047Add
BLAST
Propeptidei74 – 202129PRO_0000008048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP17322.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010649.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP17322.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17322-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP
110 120 130 140 150
TKATVHRKRC QCASQTDKKC WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS
160 170 180 190 200
KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS FRVAKLKAQL YRDKKVIYNR

AH
Length:202
Mass (Da):22,977
Last modified:August 1, 1990 - v1
Checksum:i42EB2AF07C85A5A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → A in CAA37117. (PubMed:2198541)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52740 mRNA. Translation: CAA36954.1.
X52942 mRNA. Translation: CAA37117.1.
S37093 mRNA. Translation: AAB22241.1.
BC102459 mRNA. Translation: AAI02460.1.
PIRiS10488.
RefSeqiNP_851353.1. NM_181010.2.
UniGeneiBt.59529.

Genome annotation databases

EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneIDi281137.
KEGGibta:281137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52740 mRNA. Translation: CAA36954.1 .
X52942 mRNA. Translation: CAA37117.1 .
S37093 mRNA. Translation: AAB22241.1 .
BC102459 mRNA. Translation: AAI02460.1 .
PIRi S10488.
RefSeqi NP_851353.1. NM_181010.2.
UniGenei Bt.59529.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000010649.

Proteomic databases

PRIDEi P17322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000010649 ; ENSBTAP00000010649 ; ENSBTAG00000008096 .
GeneIDi 281137.
KEGGi bta:281137.

Organism-specific databases

CTDi 1906.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P17322.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 20805204.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a bovine preproendothelin cDNA."
    Price G.J., Malone L.
    Nucleic Acids Res. 18:3658-3658(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Nucleotide sequence of endothelin cDNA from bovine endothelial cells."
    Elshourbagy N.A., Kmetz P., Sathe G.M.
    Nucleic Acids Res. 18:4273-4273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pulmonary artery.
  3. "Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells."
    Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F.
    Hypertension 19:753-757(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carotid artery.
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiEDN1_BOVIN
AccessioniPrimary (citable) accession number: P17322
Secondary accession number(s): Q3T0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3