Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P17322

- EDN1_BOVIN

UniProt

P17322 - EDN1_BOVIN

Protein

Endothelin-1

Gene

EDN1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Biological processi

    1. body fluid secretion Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. glucose transport Source: Ensembl
    6. heart development Source: Ensembl
    7. inositol phosphate-mediated signaling Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. middle ear morphogenesis Source: Ensembl
    10. negative regulation of cAMP biosynthetic process Source: Ensembl
    11. negative regulation of cellular protein metabolic process Source: Ensembl
    12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. neural crest cell development Source: Ensembl
    15. nitric oxide transport Source: Ensembl
    16. patterning of blood vessels Source: Ensembl
    17. peptide hormone secretion Source: Ensembl
    18. phosphatidylinositol 3-kinase signaling Source: Ensembl
    19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    21. positive regulation of cell migration Source: Ensembl
    22. positive regulation of cell size Source: Ensembl
    23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    24. positive regulation of heart rate Source: Ensembl
    25. positive regulation of hormone secretion Source: Ensembl
    26. positive regulation of JUN kinase activity Source: Ensembl
    27. positive regulation of mitosis Source: Ensembl
    28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    29. positive regulation of receptor biosynthetic process Source: Ensembl
    30. positive regulation of renal sodium excretion Source: Ensembl
    31. positive regulation of sarcomere organization Source: Ensembl
    32. positive regulation of smooth muscle cell proliferation Source: Ensembl
    33. positive regulation of urine volume Source: Ensembl
    34. prostaglandin biosynthetic process Source: Ensembl
    35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    36. protein kinase C deactivation Source: Ensembl
    37. regulation of blood pressure Source: AgBase
    38. regulation of pH Source: Ensembl
    39. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    40. regulation of vasoconstriction Source: AgBase
    41. respiratory gaseous exchange Source: Ensembl
    42. response to hypoxia Source: Ensembl
    43. rhythmic excitation Source: Ensembl
    44. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Short name:
    ET-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Gene namesi
    Name:EDN1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 23

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 5025PRO_0000008046Add
    BLAST
    Peptidei53 – 7321Endothelin-1PRO_0000008047Add
    BLAST
    Propeptidei74 – 202129PRO_0000008048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi55 ↔ 63By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP17322.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000010649.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12415Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    InParanoidiP17322.
    KOiK16366.
    OMAiMDYFPMI.
    OrthoDBiEOG7PS1H7.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17322-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP 100
    TKATVHRKRC QCASQTDKKC WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS 150
    KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS FRVAKLKAQL YRDKKVIYNR 200
    AH 202
    Length:202
    Mass (Da):22,977
    Last modified:August 1, 1990 - v1
    Checksum:i42EB2AF07C85A5A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321D → A in CAA37117. (PubMed:2198541)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52740 mRNA. Translation: CAA36954.1.
    X52942 mRNA. Translation: CAA37117.1.
    S37093 mRNA. Translation: AAB22241.1.
    BC102459 mRNA. Translation: AAI02460.1.
    PIRiS10488.
    RefSeqiNP_851353.1. NM_181010.2.
    UniGeneiBt.59529.

    Genome annotation databases

    EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
    GeneIDi281137.
    KEGGibta:281137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52740 mRNA. Translation: CAA36954.1 .
    X52942 mRNA. Translation: CAA37117.1 .
    S37093 mRNA. Translation: AAB22241.1 .
    BC102459 mRNA. Translation: AAI02460.1 .
    PIRi S10488.
    RefSeqi NP_851353.1. NM_181010.2.
    UniGenei Bt.59529.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000010649.

    Proteomic databases

    PRIDEi P17322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010649 ; ENSBTAP00000010649 ; ENSBTAG00000008096 .
    GeneIDi 281137.
    KEGGi bta:281137.

    Organism-specific databases

    CTDi 1906.

    Phylogenomic databases

    eggNOGi NOG46593.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    InParanoidi P17322.
    KOi K16366.
    OMAi MDYFPMI.
    OrthoDBi EOG7PS1H7.
    TreeFami TF333184.

    Enzyme and pathway databases

    Reactomei REACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Miscellaneous databases

    NextBioi 20805204.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a bovine preproendothelin cDNA."
      Price G.J., Malone L.
      Nucleic Acids Res. 18:3658-3658(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aorta.
    2. "Nucleotide sequence of endothelin cDNA from bovine endothelial cells."
      Elshourbagy N.A., Kmetz P., Sathe G.M.
      Nucleic Acids Res. 18:4273-4273(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pulmonary artery.
    3. "Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells."
      Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F.
      Hypertension 19:753-757(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carotid artery.
    4. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiEDN1_BOVIN
    AccessioniPrimary (citable) accession number: P17322
    Secondary accession number(s): Q3T0C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3