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Protein

Endothelin-1

Gene

EDN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_287476. G alpha (q) signalling events.
REACT_297846. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 5025PRO_0000008046Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008047Add
BLAST
Propeptidei74 – 202129PRO_0000008048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP17322.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010649.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP17322.
KOiK16366.
OMAiRCQCASQ.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP
110 120 130 140 150
TKATVHRKRC QCASQTDKKC WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS
160 170 180 190 200
KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS FRVAKLKAQL YRDKKVIYNR

AH
Length:202
Mass (Da):22,977
Last modified:August 1, 1990 - v1
Checksum:i42EB2AF07C85A5A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → A in CAA37117 (PubMed:2198541).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52740 mRNA. Translation: CAA36954.1.
X52942 mRNA. Translation: CAA37117.1.
S37093 mRNA. Translation: AAB22241.1.
BC102459 mRNA. Translation: AAI02460.1.
PIRiS10488.
RefSeqiNP_851353.1. NM_181010.2.
UniGeneiBt.59529.

Genome annotation databases

EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneIDi281137.
KEGGibta:281137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52740 mRNA. Translation: CAA36954.1.
X52942 mRNA. Translation: CAA37117.1.
S37093 mRNA. Translation: AAB22241.1.
BC102459 mRNA. Translation: AAI02460.1.
PIRiS10488.
RefSeqiNP_851353.1. NM_181010.2.
UniGeneiBt.59529.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010649.

Proteomic databases

PRIDEiP17322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneIDi281137.
KEGGibta:281137.

Organism-specific databases

CTDi1906.

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP17322.
KOiK16366.
OMAiRCQCASQ.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiREACT_287476. G alpha (q) signalling events.
REACT_297846. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi20805204.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a bovine preproendothelin cDNA."
    Price G.J., Malone L.
    Nucleic Acids Res. 18:3658-3658(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Nucleotide sequence of endothelin cDNA from bovine endothelial cells."
    Elshourbagy N.A., Kmetz P., Sathe G.M.
    Nucleic Acids Res. 18:4273-4273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pulmonary artery.
  3. "Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells."
    Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F.
    Hypertension 19:753-757(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carotid artery.
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiEDN1_BOVIN
AccessioniPrimary (citable) accession number: P17322
Secondary accession number(s): Q3T0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.