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P17322

- EDN1_BOVIN

UniProt

P17322 - EDN1_BOVIN

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Protein

Endothelin-1

Gene
EDN1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL By similarity

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. inositol phosphate-mediated signaling Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell size Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of heart rate Source: Ensembl
  25. positive regulation of hormone secretion Source: Ensembl
  26. positive regulation of JUN kinase activity Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. protein kinase C deactivation Source: Ensembl
  37. regulation of blood pressure Source: AgBase
  38. regulation of pH Source: Ensembl
  39. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  40. regulation of vasoconstriction Source: AgBase
  41. respiratory gaseous exchange Source: Ensembl
  42. response to hypoxia Source: Ensembl
  43. rhythmic excitation Source: Ensembl
  44. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 23

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Propeptidei26 – 5025PRO_0000008046Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008047Add
BLAST
Propeptidei74 – 202129PRO_0000008048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67 By similarity
Disulfide bondi55 ↔ 63 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP17322.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010649.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP17322.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17322-1 [UniParc]FASTAAdd to Basket

« Hide

MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS    50
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP 100
TKATVHRKRC QCASQTDKKC WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS 150
KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS FRVAKLKAQL YRDKKVIYNR 200
AH 202
Length:202
Mass (Da):22,977
Last modified:August 1, 1990 - v1
Checksum:i42EB2AF07C85A5A3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → A in CAA37117. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52740 mRNA. Translation: CAA36954.1.
X52942 mRNA. Translation: CAA37117.1.
S37093 mRNA. Translation: AAB22241.1.
BC102459 mRNA. Translation: AAI02460.1.
PIRiS10488.
RefSeqiNP_851353.1. NM_181010.2.
UniGeneiBt.59529.

Genome annotation databases

EnsembliENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneIDi281137.
KEGGibta:281137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52740 mRNA. Translation: CAA36954.1 .
X52942 mRNA. Translation: CAA37117.1 .
S37093 mRNA. Translation: AAB22241.1 .
BC102459 mRNA. Translation: AAI02460.1 .
PIRi S10488.
RefSeqi NP_851353.1. NM_181010.2.
UniGenei Bt.59529.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000010649.

Proteomic databases

PRIDEi P17322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000010649 ; ENSBTAP00000010649 ; ENSBTAG00000008096 .
GeneIDi 281137.
KEGGi bta:281137.

Organism-specific databases

CTDi 1906.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P17322.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_209521. G alpha (q) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 20805204.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a bovine preproendothelin cDNA."
    Price G.J., Malone L.
    Nucleic Acids Res. 18:3658-3658(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Nucleotide sequence of endothelin cDNA from bovine endothelial cells."
    Elshourbagy N.A., Kmetz P., Sathe G.M.
    Nucleic Acids Res. 18:4273-4273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pulmonary artery.
  3. "Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells."
    Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F.
    Hypertension 19:753-757(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carotid artery.
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiEDN1_BOVIN
AccessioniPrimary (citable) accession number: P17322
Secondary accession number(s): Q3T0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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