P17322 (EDN1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-1
Short name=ET-1

Alternative name(s):
Preproendothelin-1
Short name=PPET1

Gene names

Name:

EDN1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location	Secreted.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	body fluid secretion Inferred from electronic annotation. Source: Compara calcium-mediated signaling Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara glucose transport Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara inositol phosphate-mediated signaling Inferred from electronic annotation. Source: Compara middle ear morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of cellular protein metabolic process Inferred from electronic annotation. Source: Compara negative regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara neural crest cell development Inferred from electronic annotation. Source: Compara nitric oxide transport Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara peptide hormone secretion Inferred from electronic annotation. Source: Compara phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara phospholipase D-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell size Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin-endoperoxide synthase activity Inferred from electronic annotation. Source: Compara positive regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of sarcomere organization Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara prostaglandin biosynthetic process Inferred from electronic annotation. Source: Compara protein kinase C deactivation Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of blood pressure Non-traceable author statement PubMed 3056409. Source: AgBase regulation of pH Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by endothelin Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Non-traceable author statement PubMed 3056409. Source: AgBase respiratory gaseous exchange Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara rhythmic excitation Inferred from electronic annotation. Source: Compara vein smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 50	25			PRO_0000008046
	Peptide	53 – 73	21	Endothelin-1		PRO_0000008047
	Propeptide	74 – 202	129			PRO_0000008048
Regions
	Region	110 – 124	15	Endothelin-like
Sites
	Site	73 – 74	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	53 ↔ 67		By similarity
	Disulfide bond	55 ↔ 63		By similarity
Experimental info
	Sequence conflict	132	1	D → A in CAA37117. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P17322 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 42EB2AF07C85A5A3	FASTA	202	22,977
	10 20 30 40 50 60 MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS KRCSCSSLMD 70 80 90 100 110 120 KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP TKATVHRKRC QCASQTDKKC 130 140 150 160 170 180 WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS 190 200 FRVAKLKAQL YRDKKVIYNR AH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a bovine preproendothelin cDNA." Price G.J., Malone L. Nucleic Acids Res. 18:3658-3658(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.
[2]	"Nucleotide sequence of endothelin cDNA from bovine endothelial cells." Elshourbagy N.A., Kmetz P., Sathe G.M. Nucleic Acids Res. 18:4273-4273(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pulmonary artery.
[3]	"Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells." Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F. Hypertension 19:753-757(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Carotid artery.
[4]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52740 mRNA. Translation: CAA36954.1. X52942 mRNA. Translation: CAA37117.1. S37093 mRNA. Translation: AAB22241.1. BC102459 mRNA. Translation: AAI02460.1.
IPI	IPI00690598.
PIR	S10488.
RefSeq	NP_851353.1. NM_181010.2.
UniGene	Bt.59529.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000010649.
Proteomic databases
PRIDE	P17322.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneID	281137.
KEGG	bta:281137.
Organism-specific databases
CTD	1906.
Phylogenomic databases
eggNOG	NOG46593.
GeneTree	ENSGT00530000063310.
HOGENOM	HOG000231110.
HOVERGEN	HBG051441.
InParanoid	P17322.
KO	K16366.
OMA	RCQCASQ.
OrthoDB	EOG4QZ7N8.
Enzyme and pathway databases
BioCyc	CATTLE:281137-MONOMER.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. [Graphical view]
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805204.

Entry information

Entry name

EDN1_BOVIN

Accession

Primary (citable) accession number: P17322
Secondary accession number(s): Q3T0C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program