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Protein

Colicin I receptor

Gene

cirA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.

GO - Molecular functioni

  • colicin transmembrane transporter activity Source: EcoCyc
  • receptor activity Source: InterPro
  • siderophore transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • iron assimilation Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG10155-MONOMER.
ECOL316407:JW2142-MONOMER.
MetaCyc:EG10155-MONOMER.

Protein family/group databases

TCDBi1.B.14.1.4. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin I receptor
Gene namesi
Name:cirA
Synonyms:cir, feuA
Ordered Locus Names:b2155, JW2142
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10155. cirA.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 663638Colicin I receptorPRO_0000034744Add
BLAST

Proteomic databases

EPDiP17315.
PaxDbiP17315.
PRIDEiP17315.

2D gel databases

SWISS-2DPAGEP17315.

Expressioni

Inductioni

By iron and by a cAMP/cAMP receptor protein complex.

Interactioni

Protein-protein interaction databases

BioGridi4260473. 90 interactions.
DIPiDIP-9282N.
IntActiP17315. 7 interactions.
MINTiMINT-4794244.
STRINGi511145.b2155.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 408Combined sources
Helixi44 – 463Combined sources
Beta strandi48 – 547Combined sources
Helixi56 – 605Combined sources
Helixi68 – 714Combined sources
Beta strandi77 – 815Combined sources
Beta strandi83 – 853Combined sources
Beta strandi87 – 915Combined sources
Helixi96 – 983Combined sources
Beta strandi99 – 1035Combined sources
Turni111 – 1133Combined sources
Helixi120 – 1223Combined sources
Beta strandi123 – 1253Combined sources
Helixi127 – 1293Combined sources
Beta strandi130 – 1389Combined sources
Helixi141 – 1444Combined sources
Turni146 – 1494Combined sources
Beta strandi150 – 1578Combined sources
Beta strandi165 – 17713Combined sources
Beta strandi183 – 19513Combined sources
Turni196 – 1983Combined sources
Beta strandi199 – 21012Combined sources
Beta strandi231 – 24313Combined sources
Beta strandi249 – 26315Combined sources
Beta strandi271 – 28414Combined sources
Beta strandi289 – 30214Combined sources
Beta strandi306 – 3083Combined sources
Beta strandi310 – 32516Combined sources
Helixi326 – 3283Combined sources
Beta strandi330 – 34415Combined sources
Helixi346 – 3483Combined sources
Beta strandi349 – 3513Combined sources
Turni353 – 3553Combined sources
Beta strandi357 – 37317Combined sources
Beta strandi376 – 38712Combined sources
Turni388 – 3903Combined sources
Beta strandi391 – 41929Combined sources
Helixi423 – 4264Combined sources
Beta strandi430 – 4345Combined sources
Helixi435 – 4373Combined sources
Beta strandi439 – 4424Combined sources
Beta strandi450 – 46213Combined sources
Helixi466 – 4683Combined sources
Beta strandi472 – 48716Combined sources
Beta strandi490 – 4923Combined sources
Turni494 – 4963Combined sources
Helixi497 – 4993Combined sources
Beta strandi503 – 5086Combined sources
Beta strandi512 – 5198Combined sources
Beta strandi521 – 53818Combined sources
Beta strandi540 – 55617Combined sources
Helixi558 – 5603Combined sources
Beta strandi563 – 57917Combined sources
Beta strandi582 – 5854Combined sources
Beta strandi587 – 59610Combined sources
Beta strandi612 – 62413Combined sources
Beta strandi627 – 6359Combined sources
Beta strandi654 – 66310Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDFX-ray2.65A26-663[»]
2HDIX-ray2.50A26-663[»]
ProteinModelPortaliP17315.
SMRiP17315. Positions 31-663.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17315.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi31 – 388TonB box
Motifi646 – 66318TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105D05. Bacteria.
COG4771. LUCA.
HOGENOMiHOG000276828.
InParanoidiP17315.
KOiK16089.
OMAiFQNNVDD.
PhylomeDBiP17315.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010916. TonB_box_CS.
IPR010917. TonB_rcpt_CS.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
PROSITEiPS00430. TONB_DEPENDENT_REC_1. 1 hit.
PS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS
60 70 80 90 100
ISVITQEDLQ RKPVQNLKDV LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL
110 120 130 140 150
ILVDGKRVNS RNAVFRHNDF DLNWIPVDSI ERIEVVRGPM SSLYGSDALG
160 170 180 190 200
GVVNIITKKI GQKWSGTVTV DTTIQEHRDR GDTYNGQFFT SGPLIDGVLG
210 220 230 240 250
MKAYGSLAKR EKDDPQNSTT TDTGETPRIE GFSSRDGNVE FAWTPNQNHD
260 270 280 290 300
FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS HNGRWDYGTS ELKYYGEKVE
310 320 330 340 350
NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT
360 370 380 390 400
GGTSSKTSAS QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL
410 420 430 440 450
VYNATDTVTV KGGWATAFKA PSLLQLSPDW TSNSCRGACK IVGSPDLKPE
460 470 480 490 500
TSESWELGLY YMGEEGWLEG VESSVTVFRN DVKDRISISR TSDVNAAPGY
510 520 530 540 550
QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN DEWKLSINYT
560 570 580 590 600
YNDGRDVSNG ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR
610 620 630 640 650
ADSATAKTPG GYTIWNTGAA WQVTKDVKLR AGVLNLGDKD LSRDDYSYNE
660
DGRRYFMAVD YRF
Length:663
Mass (Da):73,896
Last modified:November 1, 1997 - v2
Checksum:i2C68A45D4B5EE414
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971S → D in AAA17054 (PubMed:1315732).Curated
Sequence conflicti528 – 5281I → N in AAA75183 (PubMed:2644220).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04229 Genomic DNA. Translation: AAA75183.1.
U00007 Genomic DNA. Translation: AAA60531.1.
U00096 Genomic DNA. Translation: AAC75216.1.
AP009048 Genomic DNA. Translation: BAE76632.1.
M19295 Genomic DNA. Translation: AAA23581.1.
M89774 Genomic DNA. Translation: AAA17054.1.
PIRiB64984. QRECIC.
RefSeqiNP_416660.1. NC_000913.3.
WP_000489247.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75216; AAC75216; b2155.
BAE76632; BAE76632; BAE76632.
GeneIDi949042.
KEGGiecj:JW2142.
eco:b2155.
PATRICi32119657. VBIEscCol129921_2239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04229 Genomic DNA. Translation: AAA75183.1.
U00007 Genomic DNA. Translation: AAA60531.1.
U00096 Genomic DNA. Translation: AAC75216.1.
AP009048 Genomic DNA. Translation: BAE76632.1.
M19295 Genomic DNA. Translation: AAA23581.1.
M89774 Genomic DNA. Translation: AAA17054.1.
PIRiB64984. QRECIC.
RefSeqiNP_416660.1. NC_000913.3.
WP_000489247.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDFX-ray2.65A26-663[»]
2HDIX-ray2.50A26-663[»]
ProteinModelPortaliP17315.
SMRiP17315. Positions 31-663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260473. 90 interactions.
DIPiDIP-9282N.
IntActiP17315. 7 interactions.
MINTiMINT-4794244.
STRINGi511145.b2155.

Protein family/group databases

TCDBi1.B.14.1.4. the outer membrane receptor (omr) family.

2D gel databases

SWISS-2DPAGEP17315.

Proteomic databases

EPDiP17315.
PaxDbiP17315.
PRIDEiP17315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75216; AAC75216; b2155.
BAE76632; BAE76632; BAE76632.
GeneIDi949042.
KEGGiecj:JW2142.
eco:b2155.
PATRICi32119657. VBIEscCol129921_2239.

Organism-specific databases

EchoBASEiEB0153.
EcoGeneiEG10155. cirA.

Phylogenomic databases

eggNOGiENOG4105D05. Bacteria.
COG4771. LUCA.
HOGENOMiHOG000276828.
InParanoidiP17315.
KOiK16089.
OMAiFQNNVDD.
PhylomeDBiP17315.

Enzyme and pathway databases

BioCyciEcoCyc:EG10155-MONOMER.
ECOL316407:JW2142-MONOMER.
MetaCyc:EG10155-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP17315.
PROiP17315.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010916. TonB_box_CS.
IPR010917. TonB_rcpt_CS.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
PROSITEiPS00430. TONB_DEPENDENT_REC_1. 1 hit.
PS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIRA_ECOLI
AccessioniPrimary (citable) accession number: P17315
Secondary accession number(s): Q2MAS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.