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Protein

Lysis inhibition accessory protein

Gene

rIII

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably binds to the cytoplasmic part of the holin during lysis inhibition and stabilizes the holin-antiholin complex thereby resulting in a robust block of the hole formation.UniRule annotation1 Publication

GO - Biological processi

  • negative regulation of holin activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Lysis inhibition accessory proteinUniRule annotation
Alternative name(s):
Protein rIII1 Publication
Gene namesi
Name:rIII
Synonyms:31.-1
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42H → R in r67; r-type (rapid lysis) plaque morphology. 1 Publication1
Mutagenesisi82K → E in rES40 and rBB9; r-type (rapid lysis) plaque morphology. Loss of interaction with holin. No effect on homooligomerization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001650721 – 82Lysis inhibition accessory proteinAdd BLAST82

Interactioni

Subunit structurei

Homooligomer. Interacts with holin (via N-terminus).UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei42Interaction with holinUniRule annotation1 Publication1

Family & Domainsi

Sequence similaritiesi

Belongs to the T4likevirus lysis inhibition accessory protein rIII family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090001LF.

Family and domain databases

HAMAPiMF_04112. Linr3_BPT4. 1 hit.
InterProiView protein in InterPro
IPR034688. Linr3.

Sequencei

Sequence statusi: Complete.

P17309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKQLQHALE LQRNAWNNGH ENYGASIDVE AEALEILRYF KHLNPAQTAL
60 70 80
AAELQEKDEL KYAKPLASAA RKAVRHFVVT LK
Length:82
Mass (Da):9,325
Last modified:October 1, 1993 - v2
Checksum:iCFE8DF45AB9CC2CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64 – 82KPLAS…VVTLK → NLWLLLHEKQFVTLW in CAA35652 (PubMed:2362813).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17657 Genomic DNA. Translation: CAA35652.1.
M37882 Genomic DNA. Translation: AAA32507.1.
X54536 Genomic DNA. Translation: CAA38406.1.
AF158101 Genomic DNA. Translation: AAD42650.1.
PIRiJT0765.
RefSeqiNP_049824.1. NC_000866.4.

Genome annotation databases

GeneIDi1258761.
KEGGivg:1258761.

Similar proteinsi

Entry informationi

Entry nameiLINR3_BPT4
AccessioniPrimary (citable) accession number: P17309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 1, 1993
Last modified: April 12, 2017
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families