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P17301

- ITA2_HUMAN

UniProt

P17301 - ITA2_HUMAN

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Protein
Integrin alpha-2
Gene
ITGA2, CD49B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi499 – 5079 Reviewed prediction
Calcium bindingi563 – 5719 Reviewed prediction
Calcium bindingi627 – 6359 Reviewed prediction

GO - Molecular functioni

  1. collagen binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. axon guidance Source: Reactome
  2. blood coagulation Source: Reactome
  3. cell adhesion Source: ProtInc
  4. cell proliferation Source: Ensembl
  5. cell-matrix adhesion Source: ProtInc
  6. cellular response to hormone stimulus Source: Ensembl
  7. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  8. establishment of protein localization Source: Ensembl
  9. extracellular matrix organization Source: Reactome
  10. hepatocyte differentiation Source: Ensembl
  11. hypotonic response Source: Ensembl
  12. integrin-mediated signaling pathway Source: UniProtKB-KW
  13. mammary gland development Source: Ensembl
  14. organ morphogenesis Source: ProtInc
  15. positive regulation of DNA binding Source: Ensembl
  16. positive regulation of alkaline phosphatase activity Source: Ensembl
  17. positive regulation of cell adhesion Source: Ensembl
  18. positive regulation of cell projection organization Source: Ensembl
  19. positive regulation of collagen binding Source: Ensembl
  20. positive regulation of collagen biosynthetic process Source: Ensembl
  21. positive regulation of epithelial cell migration Source: Ensembl
  22. positive regulation of inflammatory response Source: Ensembl
  23. positive regulation of leukocyte migration Source: Ensembl
  24. positive regulation of phagocytosis, engulfment Source: Ensembl
  25. positive regulation of positive chemotaxis Source: Ensembl
  26. positive regulation of smooth muscle cell migration Source: Ensembl
  27. positive regulation of smooth muscle cell proliferation Source: Ensembl
  28. positive regulation of smooth muscle contraction Source: Ensembl
  29. positive regulation of translation Source: Ensembl
  30. positive regulation of transmission of nerve impulse Source: Ensembl
  31. response to L-ascorbic acid Source: Ensembl
  32. response to amine Source: Ensembl
  33. response to drug Source: Ensembl
  34. response to hypoxia Source: Ensembl
  35. response to muscle activity Source: Ensembl
  36. response to organic cyclic compound Source: Ensembl
  37. skin morphogenesis Source: Ensembl
  38. tissue homeostasis Source: Ensembl
  39. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_22292. CHL1 interactions.
SignaLinkiP17301.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:ITGA2
Synonyms:CD49B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6137. ITGA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 11321103Extracellular Reviewed prediction
Add
BLAST
Transmembranei1133 – 115422Helical; Reviewed prediction
Add
BLAST
Topological domaini1155 – 118127Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. basal part of cell Source: Ensembl
  3. cell outer membrane Source: Ensembl
  4. cell surface Source: BHF-UCL
  5. external side of plasma membrane Source: Ensembl
  6. focal adhesion Source: Ensembl
  7. integrin complex Source: ProtInc
  8. nucleus Source: Ensembl
  9. perinuclear region of cytoplasm Source: Ensembl
  10. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1159 – 11591F → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1160 and A-1162. 1 Publication
Mutagenesisi1160 – 11601K → A: No effect on RAB21-binding. Significant reduction of RAB21-binding; when associated with A-1161. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1161. 2 Publications
Mutagenesisi1161 – 11611R → A: Significant reduction of RAB21-binding; when associated with A-1160. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1160. 2 Publications
Mutagenesisi1162 – 11621K → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1159 and A-1160. 2 Publications
Mutagenesisi1162 – 11621K → P: Markedly weakens RAB21-binding. Shows defective cytokinesis on collagen, but not on fibronectin. 2 Publications
Mutagenesisi1164 – 11641E → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1165. 2 Publications
Mutagenesisi1165 – 11651K → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1164. 2 Publications

Organism-specific databases

MIMi192974. gene+phenotype.
Orphaneti853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBiPA204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 Publication
Add
BLAST
Chaini30 – 11811152Integrin alpha-2
PRO_0000016233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 92 By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...)3 Publications
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi680 ↔ 737 By similarity
Glycosylationi699 – 6991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi789 ↔ 795 By similarity
Disulfide bondi865 ↔ 876 By similarity
Disulfide bondi1019 ↔ 1050 By similarity
Disulfide bondi1055 ↔ 1060 By similarity
Glycosylationi1057 – 10571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1074 – 10741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1081 – 10811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP17301.
PaxDbiP17301.
PRIDEiP17301.

PTM databases

PhosphoSiteiP17301.

Expressioni

Gene expression databases

ArrayExpressiP17301.
BgeeiP17301.
CleanExiHS_ITGA2.
GenevestigatoriP17301.

Organism-specific databases

HPAiCAB017690.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB1P055563EBI-702960,EBI-703066
Rab21P352827EBI-702960,EBI-1993555From a different organism.
SHARPINQ9H0F65EBI-702960,EBI-3942966

Protein-protein interaction databases

BioGridi109880. 14 interactions.
DIPiDIP-67N.
IntActiP17301. 12 interactions.
MINTiMINT-5004079.
STRINGi9606.ENSP00000296585.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi173 – 1808
Helixi188 – 20013
Beta strandi208 – 22417
Turni226 – 2283
Helixi232 – 24110
Helixi252 – 26211
Helixi266 – 2683
Beta strandi274 – 28411
Helixi289 – 2913
Helixi292 – 30110
Beta strandi304 – 3118
Helixi313 – 3175
Helixi323 – 33210
Helixi337 – 3404
Beta strandi341 – 3477
Helixi348 – 3536
Helixi354 – 3629

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AOXX-ray2.10A/B169-367[»]
1DZIX-ray2.10A172-355[»]
1PQBmodel-A/B169-366[»]
1V7PX-ray1.90C167-366[»]
4BJ3X-ray3.04A/B171-368[»]
ProteinModelPortaliP17301.
SMRiP17301. Positions 30-1169.

Miscellaneous databases

EvolutionaryTraceiP17301.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 9259FG-GAP 1
Add
BLAST
Repeati101 – 16161FG-GAP 2
Add
BLAST
Domaini188 – 365178VWFA
Add
BLAST
Repeati366 – 42055FG-GAP 3
Add
BLAST
Repeati423 – 47755FG-GAP 4
Add
BLAST
Repeati478 – 53962FG-GAP 5
Add
BLAST
Repeati540 – 59859FG-GAP 6
Add
BLAST
Repeati602 – 66463FG-GAP 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1155 – 11617Interaction with HPS5

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1157 – 11615GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237277.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP17301.
KOiK06481.
OrthoDBiEOG71RXHT.
PhylomeDBiP17301.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17301-1 [UniParc]FASTAAdd to Basket

« Hide

MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY     50
AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS 100
TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS 150
DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ 200
GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT 250
NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 300
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL 350
LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG 400
AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST 450
HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV 500
DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH QFLEGPEGIE 550
NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 600
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ 650
SIADVAIEAS FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI 700
TLDADGFSSR VTSRGLFKEN NERCLQKNMV VNQAQSCPEH IIYIQEPSDV 750
VNSLDLRVDI SLENPGTSPA LEAYSETAKV FSIPFHKDCG EDGLCISDLV 800
LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG IVVDFSENLF 850
FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 900
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE 950
ISSDGNVPSI VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK 1000
NPLMYLTGVQ TDKAGDISCN ADINPLKIGQ TSSSVSFKSE NFRHTKELNC 1050
RTASCSNVTC WLKDVHMKGE YFVNVTTRIW NGTFASSTFQ TVQLTAAAEI 1100
NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII AGILLLLALV 1150
AILWKLGFFK RKYEKMTKNP DEIDETTELS S 1181
Length:1,181
Mass (Da):129,295
Last modified:August 1, 1990 - v1
Checksum:i7E1B7ED968A94070
GO

Polymorphismi

Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti534 – 5341K → E in alloantigen HPA-5B. 3 Publications
Corresponds to variant rs1801106 [ dbSNP | Ensembl ].
VAR_003977
Natural varianti691 – 6911N → K.1 Publication
Corresponds to variant rs3212557 [ dbSNP | Ensembl ].
VAR_029146
Natural varianti927 – 9271N → S.
Corresponds to variant rs2287870 [ dbSNP | Ensembl ].
VAR_021855
Natural varianti1127 – 11271K → Q.1 Publication
Corresponds to variant rs3212645 [ dbSNP | Ensembl ].
VAR_020036

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171L → V in AAA16619. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17033 mRNA. Translation: CAA34894.1.
AF512556 Genomic DNA. Translation: AAM34795.1.
L24121 Genomic DNA. Translation: AAA16619.2.
CCDSiCCDS3957.1.
PIRiA33998.
RefSeqiNP_002194.2. NM_002203.3.
UniGeneiHs.482077.

Genome annotation databases

EnsembliENST00000296585; ENSP00000296585; ENSG00000164171.
GeneIDi3673.
KEGGihsa:3673.
UCSCiuc003joy.3. human.

Polymorphism databases

DMDMi124942.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17033 mRNA. Translation: CAA34894.1 .
AF512556 Genomic DNA. Translation: AAM34795.1 .
L24121 Genomic DNA. Translation: AAA16619.2 .
CCDSi CCDS3957.1.
PIRi A33998.
RefSeqi NP_002194.2. NM_002203.3.
UniGenei Hs.482077.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AOX X-ray 2.10 A/B 169-367 [» ]
1DZI X-ray 2.10 A 172-355 [» ]
1PQB model - A/B 169-366 [» ]
1V7P X-ray 1.90 C 167-366 [» ]
4BJ3 X-ray 3.04 A/B 171-368 [» ]
ProteinModelPortali P17301.
SMRi P17301. Positions 30-1169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109880. 14 interactions.
DIPi DIP-67N.
IntActi P17301. 12 interactions.
MINTi MINT-5004079.
STRINGi 9606.ENSP00000296585.

Chemistry

BindingDBi P17301.
ChEMBLi CHEMBL2111461.

PTM databases

PhosphoSitei P17301.

Polymorphism databases

DMDMi 124942.

Proteomic databases

MaxQBi P17301.
PaxDbi P17301.
PRIDEi P17301.

Protocols and materials databases

DNASUi 3673.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296585 ; ENSP00000296585 ; ENSG00000164171 .
GeneIDi 3673.
KEGGi hsa:3673.
UCSCi uc003joy.3. human.

Organism-specific databases

CTDi 3673.
GeneCardsi GC05P052321.
H-InvDB HIX0032121.
HGNCi HGNC:6137. ITGA2.
HPAi CAB017690.
MIMi 192974. gene+phenotype.
neXtProti NX_P17301.
Orphaneti 853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBi PA204.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237277.
HOGENOMi HOG000059610.
HOVERGENi HBG006185.
InParanoidi P17301.
KOi K06481.
OrthoDBi EOG71RXHT.
PhylomeDBi P17301.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_22292. CHL1 interactions.
SignaLinki P17301.

Miscellaneous databases

EvolutionaryTracei P17301.
GeneWikii CD49b.
GenomeRNAii 3673.
NextBioi 14377.
PROi P17301.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17301.
Bgeei P17301.
CleanExi HS_ITGA2.
Genevestigatori P17301.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain."
    Takada Y., Hemler M.E.
    J. Cell Biol. 109:397-407(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-44.
    Tissue: Endothelial cell.
  2. SeattleSNPs variation discovery resource
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-691 AND GLN-1127.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-534.
  4. "The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression."
    Zutter M.M., Santoro S.A., Painter A.S., Tsung Y.L., Gafford A.
    J. Biol. Chem. 269:463-469(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  5. "Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."
    Bergelson J.M., St John N., Kawaguchi S., Chan M., Stubdal H., Modlin J., Finberg R.W.
    J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN ECHOVIRUS 1 AND HUMAN ECHOVIRUS 8 CAPSID PROTEINS.
  6. "Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry."
    Graham K.L., Halasz P., Tan Y., Hewish M.J., Takada Y., Mackow E.R., Robinson M.K., Coulson B.S.
    J. Virol. 77:9969-9978(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ROTAVIRUS A VP4.
  7. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
    Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
    J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB21, MUTAGENESIS OF PHE-1159; LYS-1160; ARG-1161; LYS-1162; GLU-1164 AND LYS-1165.
  8. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Platelet.
  9. Cited for: MUTAGENESIS OF LYS-1160; ARG-1161 AND LYS-1162.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Liver.
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Crystal structure of the I domain from integrin alpha2beta1."
    Emsley J., King S.L., Bergelson J.M., Liddington R.C.
    J. Biol. Chem. 272:28512-28517(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 168-368.
  16. "The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2)."
    Santoso S., Kalb R., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
    J. Clin. Invest. 92:2427-2432(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-534.
  17. "The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction."
    Kroll H., Gardemann A., Fechter A., Haberbosch W., Santoso S.
    Thromb. Haemost. 83:392-396(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-534.

Entry informationi

Entry nameiITA2_HUMAN
AccessioniPrimary (citable) accession number: P17301
Secondary accession number(s): Q14595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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