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P17301 (ITA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 167. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name=GPIa
VLA-2 subunit alpha
CD_antigen=CD49b
Gene names
Name:ITGA2
Synonyms:CD49B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor. Ref.5 Ref.6 Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Polymorphism

Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Ontologies

Keywords
   Biological processCell adhesion
Host-virus interaction
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
Metal-binding
   Molecular functionHost cell receptor for virus entry
Integrin
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Traceable author statement. Source: Reactome

blood coagulation

Traceable author statement. Source: Reactome

cell adhesion

Traceable author statement PubMed 10201960PubMed 10942362. Source: ProtInc

cell proliferation

Inferred from electronic annotation. Source: Ensembl

cell-matrix adhesion

Traceable author statement Ref.1. Source: ProtInc

cellular response to hormone stimulus

Inferred from electronic annotation. Source: Ensembl

detection of mechanical stimulus involved in sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

establishment of protein localization

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Traceable author statement. Source: Reactome

hepatocyte differentiation

Inferred from electronic annotation. Source: Ensembl

hypotonic response

Inferred from electronic annotation. Source: Ensembl

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

mammary gland development

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Traceable author statement PubMed 9391074. Source: ProtInc

positive regulation of DNA binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of alkaline phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell projection organization

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis, engulfment

Inferred from electronic annotation. Source: Ensembl

positive regulation of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

response to L-ascorbic acid

Inferred from electronic annotation. Source: Ensembl

response to amine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to muscle activity

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

skin morphogenesis

Inferred from electronic annotation. Source: Ensembl

tissue homeostasis

Inferred from electronic annotation. Source: Ensembl

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

basal part of cell

Inferred from electronic annotation. Source: Ensembl

cell outer membrane

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from direct assay PubMed 21310825. Source: BHF-UCL

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: Ensembl

integrin complex

Traceable author statement Ref.1. Source: ProtInc

nucleus

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 21310825. Source: BHF-UCL

   Molecular_functioncollagen binding

Traceable author statement PubMed 9391074. Source: ProtInc

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

virus receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ITGB1P055563EBI-702960,EBI-703066
Rab21P352827EBI-702960,EBI-1993555From a different organism.
SHARPINQ9H0F65EBI-702960,EBI-3942966

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.1
Chain30 – 11811152Integrin alpha-2
PRO_0000016233

Regions

Topological domain30 – 11321103Extracellular Potential
Transmembrane1133 – 115422Helical; Potential
Topological domain1155 – 118127Cytoplasmic Potential
Repeat34 – 9259FG-GAP 1
Repeat101 – 16161FG-GAP 2
Domain188 – 365178VWFA
Repeat366 – 42055FG-GAP 3
Repeat423 – 47755FG-GAP 4
Repeat478 – 53962FG-GAP 5
Repeat540 – 59859FG-GAP 6
Repeat602 – 66463FG-GAP 7
Calcium binding499 – 5079 Potential
Calcium binding563 – 5719 Potential
Calcium binding627 – 6359 Potential
Region1155 – 11617Interaction with HPS5
Motif1157 – 11615GFFKR motif

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Ref.8 Ref.12 Ref.13
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4601N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Glycosylation6991N-linked (GlcNAc...) Potential
Glycosylation10571N-linked (GlcNAc...) Potential
Glycosylation10741N-linked (GlcNAc...) Potential
Glycosylation10811N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 92 By similarity
Disulfide bond680 ↔ 737 By similarity
Disulfide bond789 ↔ 795 By similarity
Disulfide bond865 ↔ 876 By similarity
Disulfide bond1019 ↔ 1050 By similarity
Disulfide bond1055 ↔ 1060 By similarity

Natural variations

Natural variant5341K → E in alloantigen HPA-5B. Ref.3 Ref.16 Ref.17
Corresponds to variant rs1801106 [ dbSNP | Ensembl ].
VAR_003977
Natural variant6911N → K. Ref.2
Corresponds to variant rs3212557 [ dbSNP | Ensembl ].
VAR_029146
Natural variant9271N → S.
Corresponds to variant rs2287870 [ dbSNP | Ensembl ].
VAR_021855
Natural variant11271K → Q. Ref.2
Corresponds to variant rs3212645 [ dbSNP | Ensembl ].
VAR_020036

Experimental info

Mutagenesis11591F → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1160 and A-1162. Ref.7
Mutagenesis11601K → A: No effect on RAB21-binding. Significant reduction of RAB21-binding; when associated with A-1161. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1161. Ref.7 Ref.9
Mutagenesis11611R → A: Significant reduction of RAB21-binding; when associated with A-1160. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1160. Ref.7 Ref.9
Mutagenesis11621K → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1159 and A-1160. Ref.7 Ref.9
Mutagenesis11621K → P: Markedly weakens RAB21-binding. Shows defective cytokinesis on collagen, but not on fibronectin. Ref.7 Ref.9
Mutagenesis11641E → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1165. Ref.7 Ref.9
Mutagenesis11651K → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1164. Ref.7 Ref.9
Sequence conflict171L → V in AAA16619. Ref.3

Secondary structure

............................... 1181
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17301 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 7E1B7ED968A94070

FASTA1,181129,295
        10         20         30         40         50         60 
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG 

        70         80         90        100        110        120 
NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT 

       130        140        150        160        170        180 
RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD 

       190        200        210        220        230        240 
ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS 

       250        260        270        280        290        300 
QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 

       310        320        330        340        350        360 
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ 

       370        380        390        400        410        420 
IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP 

       430        440        450        460        470        480 
KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ 

       490        500        510        520        530        540 
AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH 

       550        560        570        580        590        600 
QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 

       610        620        630        640        650        660 
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS 

       670        680        690        700        710        720 
FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN 

       730        740        750        760        770        780 
NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV 

       790        800        810        820        830        840 
FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG 

       850        860        870        880        890        900 
IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 

       910        920        930        940        950        960 
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI 

       970        980        990       1000       1010       1020 
VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN 

      1030       1040       1050       1060       1070       1080 
ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW 

      1090       1100       1110       1120       1130       1140 
NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII 

      1150       1160       1170       1180 
AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain."
Takada Y., Hemler M.E.
J. Cell Biol. 109:397-407(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-44.
Tissue: Endothelial cell.
[2]SeattleSNPs variation discovery resource
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-691 AND GLN-1127.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-534.
[4]"The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression."
Zutter M.M., Santoro S.A., Painter A.S., Tsung Y.L., Gafford A.
J. Biol. Chem. 269:463-469(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
[5]"Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."
Bergelson J.M., St John N., Kawaguchi S., Chan M., Stubdal H., Modlin J., Finberg R.W.
J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN ECHOVIRUS 1 AND HUMAN ECHOVIRUS 8 CAPSID PROTEINS.
[6]"Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry."
Graham K.L., Halasz P., Tan Y., Hewish M.J., Takada Y., Mackow E.R., Robinson M.K., Coulson B.S.
J. Virol. 77:9969-9978(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ROTAVIRUS A VP4.
[7]"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB21, MUTAGENESIS OF PHE-1159; LYS-1160; ARG-1161; LYS-1162; GLU-1164 AND LYS-1165.
[8]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
Tissue: Platelet.
[9]"Integrin trafficking regulated by Rab21 is necessary for cytokinesis."
Pellinen T., Tuomi S., Arjonen A., Wolf M., Edgren H., Meyer H., Grosse R., Kitzing T., Rantala J.K., Kallioniemi O., Faessler R., Kallio M., Ivaska J.
Dev. Cell 15:371-385(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF LYS-1160; ARG-1161 AND LYS-1162.
[10]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
Tissue: Liver.
[13]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
Tissue: Leukemic T-cell.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Crystal structure of the I domain from integrin alpha2beta1."
Emsley J., King S.L., Bergelson J.M., Liddington R.C.
J. Biol. Chem. 272:28512-28517(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 168-368.
[16]"The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2)."
Santoso S., Kalb R., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
J. Clin. Invest. 92:2427-2432(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLU-534.
[17]"The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction."
Kroll H., Gardemann A., Fechter A., Haberbosch W., Santoso S.
Thromb. Haemost. 83:392-396(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLU-534.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17033 mRNA. Translation: CAA34894.1.
AF512556 Genomic DNA. Translation: AAM34795.1.
L24121 Genomic DNA. Translation: AAA16619.2.
PIRA33998.
RefSeqNP_002194.2. NM_002203.3.
UniGeneHs.482077.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AOXX-ray2.10A/B169-366[»]
1DZIX-ray2.10A172-355[»]
1PQBmodel-A/B169-366[»]
1V7PX-ray1.90C170-366[»]
4BJ3X-ray3.04A/B171-368[»]
ProteinModelPortalP17301.
SMRP17301. Positions 30-1169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109880. 14 interactions.
DIPDIP-67N.
IntActP17301. 12 interactions.
MINTMINT-5004079.
STRING9606.ENSP00000296585.

Chemistry

BindingDBP17301.
ChEMBLCHEMBL2111461.

PTM databases

PhosphoSiteP17301.

Polymorphism databases

DMDM124942.

Proteomic databases

PaxDbP17301.
PRIDEP17301.

Protocols and materials databases

DNASU3673.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296585; ENSP00000296585; ENSG00000164171.
GeneID3673.
KEGGhsa:3673.
UCSCuc003joy.3. human.

Organism-specific databases

CTD3673.
GeneCardsGC05P052321.
H-InvDBHIX0032121.
HGNCHGNC:6137. ITGA2.
HPACAB017690.
MIM192974. gene+phenotype.
neXtProtNX_P17301.
Orphanet853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBPA204.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237277.
HOGENOMHOG000059610.
HOVERGENHBG006185.
InParanoidP17301.
KOK06481.
OrthoDBEOG71RXHT.
PhylomeDBP17301.
TreeFamTF105391.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.
SignaLinkP17301.

Gene expression databases

ArrayExpressP17301.
BgeeP17301.
CleanExHS_ITGA2.
GenevestigatorP17301.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17301.
GeneWikiCD49b.
GenomeRNAi3673.
NextBio14377.
PROP17301.
SOURCESearch...

Entry information

Entry nameITA2_HUMAN
AccessionPrimary (citable) accession number: P17301
Secondary accession number(s): Q14595
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries