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P17301

- ITA2_HUMAN

UniProt

P17301 - ITA2_HUMAN

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Protein

Integrin alpha-2

Gene

ITGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi499 – 5079Sequence Analysis
Calcium bindingi563 – 5719Sequence Analysis
Calcium bindingi627 – 6359Sequence Analysis

GO - Molecular functioni

  1. collagen binding Source: UniProtKB
  2. collagen binding involved in cell-matrix adhesion Source: UniProtKB
  3. collagen receptor activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. axon guidance Source: Reactome
  2. blood coagulation Source: Reactome
  3. cell adhesion Source: ProtInc
  4. cell adhesion mediated by integrin Source: UniProtKB
  5. cell-matrix adhesion Source: UniProtKB
  6. cell proliferation Source: Ensembl
  7. cell-substrate adhesion Source: UniProtKB
  8. cellular response to hormone stimulus Source: Ensembl
  9. collagen-activated signaling pathway Source: UniProtKB
  10. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  11. establishment of protein localization Source: Ensembl
  12. extracellular matrix organization Source: Reactome
  13. hepatocyte differentiation Source: Ensembl
  14. hypotonic response Source: Ensembl
  15. integrin-mediated signaling pathway Source: UniProtKB
  16. mammary gland development Source: Ensembl
  17. mesodermal cell differentiation Source: UniProtKB
  18. organ morphogenesis Source: ProtInc
  19. positive regulation of alkaline phosphatase activity Source: Ensembl
  20. positive regulation of cell adhesion Source: Ensembl
  21. positive regulation of cell projection organization Source: Ensembl
  22. positive regulation of collagen binding Source: Ensembl
  23. positive regulation of collagen biosynthetic process Source: Ensembl
  24. positive regulation of DNA binding Source: Ensembl
  25. positive regulation of epithelial cell migration Source: Ensembl
  26. positive regulation of inflammatory response Source: Ensembl
  27. positive regulation of leukocyte migration Source: Ensembl
  28. positive regulation of phagocytosis, engulfment Source: Ensembl
  29. positive regulation of positive chemotaxis Source: Ensembl
  30. positive regulation of smooth muscle cell migration Source: Ensembl
  31. positive regulation of smooth muscle cell proliferation Source: Ensembl
  32. positive regulation of smooth muscle contraction Source: Ensembl
  33. positive regulation of translation Source: Ensembl
  34. positive regulation of transmission of nerve impulse Source: Ensembl
  35. response to amine Source: Ensembl
  36. response to drug Source: Ensembl
  37. response to hypoxia Source: Ensembl
  38. response to L-ascorbic acid Source: Ensembl
  39. response to muscle activity Source: Ensembl
  40. response to organic cyclic compound Source: Ensembl
  41. skin morphogenesis Source: Ensembl
  42. substrate-dependent cell migration Source: UniProtKB
  43. tissue homeostasis Source: Ensembl
  44. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_22292. CHL1 interactions.
SignaLinkiP17301.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:ITGA2
Synonyms:CD49B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6137. ITGA2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 11321103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1133 – 115422HelicalSequence AnalysisAdd
BLAST
Topological domaini1155 – 118127CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. basal part of cell Source: Ensembl
  3. cell outer membrane Source: Ensembl
  4. cell surface Source: UniProtKB
  5. external side of plasma membrane Source: Ensembl
  6. focal adhesion Source: UniProtKB
  7. integrin alpha2-beta1 complex Source: UniProtKB
  8. integrin complex Source: ProtInc
  9. nucleus Source: Ensembl
  10. perinuclear region of cytoplasm Source: Ensembl
  11. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1159 – 11591F → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1160 and A-1162. 1 Publication
Mutagenesisi1160 – 11601K → A: No effect on RAB21-binding. Significant reduction of RAB21-binding; when associated with A-1161. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1161. 2 Publications
Mutagenesisi1161 – 11611R → A: Significant reduction of RAB21-binding; when associated with A-1160. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1160. 2 Publications
Mutagenesisi1162 – 11621K → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1159 and A-1160. 2 Publications
Mutagenesisi1162 – 11621K → P: Markedly weakens RAB21-binding. Shows defective cytokinesis on collagen, but not on fibronectin. 2 Publications
Mutagenesisi1164 – 11641E → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1165. 1 Publication
Mutagenesisi1165 – 11651K → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1164. 1 Publication

Organism-specific databases

MIMi192974. gene+phenotype.
Orphaneti853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBiPA204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 11811152Integrin alpha-2PRO_0000016233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 92By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)3 Publications
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi680 ↔ 737By similarity
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi789 ↔ 795By similarity
Disulfide bondi865 ↔ 876By similarity
Disulfide bondi1019 ↔ 1050By similarity
Disulfide bondi1055 ↔ 1060By similarity
Glycosylationi1057 – 10571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1074 – 10741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1081 – 10811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP17301.
PaxDbiP17301.
PRIDEiP17301.

PTM databases

PhosphoSiteiP17301.

Expressioni

Gene expression databases

BgeeiP17301.
CleanExiHS_ITGA2.
ExpressionAtlasiP17301. baseline and differential.
GenevestigatoriP17301.

Organism-specific databases

HPAiCAB017690.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB1P055563EBI-702960,EBI-703066
KDRP359682EBI-702960,EBI-1005487
Rab21P352827EBI-702960,EBI-1993555From a different organism.
SHARPINQ9H0F65EBI-702960,EBI-3942966

Protein-protein interaction databases

BioGridi109880. 18 interactions.
DIPiDIP-67N.
IntActiP17301. 13 interactions.
MINTiMINT-5004079.
STRINGi9606.ENSP00000296585.

Structurei

Secondary structure

1
1181
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi173 – 1808Combined sources
Helixi188 – 20013Combined sources
Beta strandi208 – 22417Combined sources
Turni226 – 2283Combined sources
Helixi232 – 24110Combined sources
Helixi252 – 26211Combined sources
Helixi266 – 2683Combined sources
Beta strandi274 – 28411Combined sources
Helixi289 – 2913Combined sources
Helixi292 – 30110Combined sources
Beta strandi304 – 3118Combined sources
Helixi313 – 3175Combined sources
Helixi323 – 33210Combined sources
Helixi337 – 3404Combined sources
Beta strandi341 – 3477Combined sources
Helixi348 – 3536Combined sources
Helixi354 – 3629Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AOXX-ray2.10A/B169-367[»]
1DZIX-ray2.10A172-355[»]
1PQBmodel-A/B169-366[»]
1V7PX-ray1.90C167-366[»]
4BJ3X-ray3.04A/B171-368[»]
ProteinModelPortaliP17301.
SMRiP17301. Positions 45-934.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17301.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 9259FG-GAP 1Add
BLAST
Repeati101 – 16161FG-GAP 2Add
BLAST
Domaini188 – 365178VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati366 – 42055FG-GAP 3Add
BLAST
Repeati423 – 47755FG-GAP 4Add
BLAST
Repeati478 – 53962FG-GAP 5Add
BLAST
Repeati540 – 59859FG-GAP 6Add
BLAST
Repeati602 – 66463FG-GAP 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1155 – 11617Interaction with HPS5

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1157 – 11615GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237277.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP17301.
KOiK06481.
OrthoDBiEOG71RXHT.
PhylomeDBiP17301.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17301-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY
60 70 80 90 100
AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS
110 120 130 140 150
TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS
160 170 180 190 200
DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ
210 220 230 240 250
GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT
260 270 280 290 300
NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN
310 320 330 340 350
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL
360 370 380 390 400
LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG
410 420 430 440 450
AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST
460 470 480 490 500
HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV
510 520 530 540 550
DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH QFLEGPEGIE
560 570 580 590 600
NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY
610 620 630 640 650
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ
660 670 680 690 700
SIADVAIEAS FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI
710 720 730 740 750
TLDADGFSSR VTSRGLFKEN NERCLQKNMV VNQAQSCPEH IIYIQEPSDV
760 770 780 790 800
VNSLDLRVDI SLENPGTSPA LEAYSETAKV FSIPFHKDCG EDGLCISDLV
810 820 830 840 850
LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG IVVDFSENLF
860 870 880 890 900
FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ
910 920 930 940 950
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE
960 970 980 990 1000
ISSDGNVPSI VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK
1010 1020 1030 1040 1050
NPLMYLTGVQ TDKAGDISCN ADINPLKIGQ TSSSVSFKSE NFRHTKELNC
1060 1070 1080 1090 1100
RTASCSNVTC WLKDVHMKGE YFVNVTTRIW NGTFASSTFQ TVQLTAAAEI
1110 1120 1130 1140 1150
NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII AGILLLLALV
1160 1170 1180
AILWKLGFFK RKYEKMTKNP DEIDETTELS S
Length:1,181
Mass (Da):129,295
Last modified:August 1, 1990 - v1
Checksum:i7E1B7ED968A94070
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171L → V in AAA16619. (PubMed:15372022)Curated

Polymorphismi

Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti534 – 5341K → E in alloantigen HPA-5B. 3 Publications
Corresponds to variant rs1801106 [ dbSNP | Ensembl ].
VAR_003977
Natural varianti691 – 6911N → K.1 Publication
Corresponds to variant rs3212557 [ dbSNP | Ensembl ].
VAR_029146
Natural varianti927 – 9271N → S.
Corresponds to variant rs2287870 [ dbSNP | Ensembl ].
VAR_021855
Natural varianti1127 – 11271K → Q.1 Publication
Corresponds to variant rs3212645 [ dbSNP | Ensembl ].
VAR_020036

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17033 mRNA. Translation: CAA34894.1.
AF512556 Genomic DNA. Translation: AAM34795.1.
L24121 Genomic DNA. Translation: AAA16619.2.
CCDSiCCDS3957.1.
PIRiA33998.
RefSeqiNP_002194.2. NM_002203.3.
UniGeneiHs.482077.

Genome annotation databases

EnsembliENST00000296585; ENSP00000296585; ENSG00000164171.
GeneIDi3673.
KEGGihsa:3673.
UCSCiuc003joy.3. human.

Polymorphism databases

DMDMi124942.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17033 mRNA. Translation: CAA34894.1 .
AF512556 Genomic DNA. Translation: AAM34795.1 .
L24121 Genomic DNA. Translation: AAA16619.2 .
CCDSi CCDS3957.1.
PIRi A33998.
RefSeqi NP_002194.2. NM_002203.3.
UniGenei Hs.482077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AOX X-ray 2.10 A/B 169-367 [» ]
1DZI X-ray 2.10 A 172-355 [» ]
1PQB model - A/B 169-366 [» ]
1V7P X-ray 1.90 C 167-366 [» ]
4BJ3 X-ray 3.04 A/B 171-368 [» ]
ProteinModelPortali P17301.
SMRi P17301. Positions 45-934.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109880. 18 interactions.
DIPi DIP-67N.
IntActi P17301. 13 interactions.
MINTi MINT-5004079.
STRINGi 9606.ENSP00000296585.

Chemistry

BindingDBi P17301.
ChEMBLi CHEMBL3137268.

PTM databases

PhosphoSitei P17301.

Polymorphism databases

DMDMi 124942.

Proteomic databases

MaxQBi P17301.
PaxDbi P17301.
PRIDEi P17301.

Protocols and materials databases

DNASUi 3673.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296585 ; ENSP00000296585 ; ENSG00000164171 .
GeneIDi 3673.
KEGGi hsa:3673.
UCSCi uc003joy.3. human.

Organism-specific databases

CTDi 3673.
GeneCardsi GC05P052321.
H-InvDB HIX0032121.
HGNCi HGNC:6137. ITGA2.
HPAi CAB017690.
MIMi 192974. gene+phenotype.
neXtProti NX_P17301.
Orphaneti 853. Fetal and neonatal alloimmune thrombocytopenia.
PharmGKBi PA204.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237277.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000059610.
HOVERGENi HBG006185.
InParanoidi P17301.
KOi K06481.
OrthoDBi EOG71RXHT.
PhylomeDBi P17301.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_22292. CHL1 interactions.
SignaLinki P17301.

Miscellaneous databases

ChiTaRSi ITGA2. human.
EvolutionaryTracei P17301.
GeneWikii CD49b.
GenomeRNAii 3673.
NextBioi 14377.
PROi P17301.
SOURCEi Search...

Gene expression databases

Bgeei P17301.
CleanExi HS_ITGA2.
ExpressionAtlasi P17301. baseline and differential.
Genevestigatori P17301.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain."
    Takada Y., Hemler M.E.
    J. Cell Biol. 109:397-407(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-44.
    Tissue: Endothelial cell.
  2. SeattleSNPs variation discovery resource
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-691 AND GLN-1127.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-534.
  4. "The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression."
    Zutter M.M., Santoro S.A., Painter A.S., Tsung Y.L., Gafford A.
    J. Biol. Chem. 269:463-469(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  5. "Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."
    Bergelson J.M., St John N., Kawaguchi S., Chan M., Stubdal H., Modlin J., Finberg R.W.
    J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN ECHOVIRUS 1 AND HUMAN ECHOVIRUS 8 CAPSID PROTEINS.
  6. "Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry."
    Graham K.L., Halasz P., Tan Y., Hewish M.J., Takada Y., Mackow E.R., Robinson M.K., Coulson B.S.
    J. Virol. 77:9969-9978(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ROTAVIRUS A VP4.
  7. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
    Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
    J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB21, MUTAGENESIS OF PHE-1159; LYS-1160; ARG-1161; LYS-1162; GLU-1164 AND LYS-1165.
  8. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Platelet.
  9. Cited for: MUTAGENESIS OF LYS-1160; ARG-1161 AND LYS-1162.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Liver.
  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Crystal structure of the I domain from integrin alpha2beta1."
    Emsley J., King S.L., Bergelson J.M., Liddington R.C.
    J. Biol. Chem. 272:28512-28517(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 168-368.
  16. "The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2)."
    Santoso S., Kalb R., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
    J. Clin. Invest. 92:2427-2432(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-534.
  17. "The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction."
    Kroll H., Gardemann A., Fechter A., Haberbosch W., Santoso S.
    Thromb. Haemost. 83:392-396(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-534.

Entry informationi

Entry nameiITA2_HUMAN
AccessioniPrimary (citable) accession number: P17301
Secondary accession number(s): Q14595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 26, 2014
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3