Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-2

Gene

ITGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.1 Publication
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi499 – 507Sequence analysis9
Calcium bindingi563 – 571Sequence analysis9
Calcium bindingi627 – 635Sequence analysis9

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • collagen binding Source: UniProtKB
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • collagen receptor activity Source: UniProtKB
  • heparan sulfate proteoglycan binding Source: ARUK-UCL
  • integrin binding Source: Ensembl
  • laminin binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein-containing complex binding Source: UniProtKB
  • protein heterodimerization activity Source: Ensembl
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Integrin, Receptor
Biological processCell adhesion, Host-virus interaction
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-447041 CHL1 interactions
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-8874081 MET activates PTK2 signaling
SignaLinkiP17301
SIGNORiP17301

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:ITGA2
Synonyms:CD49B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164171.10
HGNCiHGNC:6137 ITGA2
MIMi192974 gene+phenotype
neXtProtiNX_P17301

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1132ExtracellularSequence analysisAdd BLAST1103
Transmembranei1133 – 1154HelicalSequence analysisAdd BLAST22
Topological domaini1155 – 1181CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1159F → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1160 and A-1162. 1 Publication1
Mutagenesisi1160K → A: No effect on RAB21-binding. Significant reduction of RAB21-binding; when associated with A-1161. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1161. 2 Publications1
Mutagenesisi1161R → A: Significant reduction of RAB21-binding; when associated with A-1160. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1160. 2 Publications1
Mutagenesisi1162K → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1159 and A-1160. 2 Publications1
Mutagenesisi1162K → P: Markedly weakens RAB21-binding. Shows defective cytokinesis on collagen, but not on fibronectin. 2 Publications1
Mutagenesisi1164E → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1165. 1 Publication1
Mutagenesisi1165K → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1164. 1 Publication1

Organism-specific databases

DisGeNETi3673
MalaCardsiITGA2
MIMi192974 gene+phenotype
Orphaneti853 Fetal and neonatal alloimmune thrombocytopenia
PharmGKBiPA204

Chemistry databases

ChEMBLiCHEMBL4998
GuidetoPHARMACOLOGYi2441

Polymorphism and mutation databases

BioMutaiITGA2
DMDMi124942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000001623330 – 1181Integrin alpha-2Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 92By similarity
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi680 ↔ 737By similarity
Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi789 ↔ 795By similarity
Disulfide bondi865 ↔ 876By similarity
Disulfide bondi1019 ↔ 1050By similarity
Disulfide bondi1055 ↔ 1060By similarity
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1074N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1081N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP17301
MaxQBiP17301
PaxDbiP17301
PeptideAtlasiP17301
PRIDEiP17301

PTM databases

iPTMnetiP17301
PhosphoSitePlusiP17301
SwissPalmiP17301

Expressioni

Gene expression databases

BgeeiENSG00000164171
CleanExiHS_ITGA2
ExpressionAtlasiP17301 baseline and differential
GenevisibleiP17301 HS

Organism-specific databases

HPAiCAB017690
HPA060991
HPA063556

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.1 Publication
(Microbial infection) Integrin ITGA2:ITGB1 interacts (via ITAG2 I-domain) with rotavirus A VP4 protein.1 Publication
(Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109880, 31 interactors
CORUMiP17301
DIPiDIP-67N
IntActiP17301, 20 interactors
MINTiP17301
STRINGi9606.ENSP00000296585

Chemistry databases

BindingDBiP17301

Structurei

Secondary structure

11181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi173 – 180Combined sources8
Helixi188 – 200Combined sources13
Beta strandi208 – 224Combined sources17
Turni226 – 228Combined sources3
Helixi232 – 241Combined sources10
Helixi252 – 262Combined sources11
Helixi266 – 268Combined sources3
Beta strandi274 – 284Combined sources11
Helixi289 – 291Combined sources3
Helixi292 – 301Combined sources10
Beta strandi304 – 311Combined sources8
Helixi313 – 317Combined sources5
Helixi323 – 332Combined sources10
Helixi337 – 340Combined sources4
Beta strandi341 – 347Combined sources7
Helixi348 – 353Combined sources6
Helixi354 – 362Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOXX-ray2.10A/B169-367[»]
1DZIX-ray2.10A172-355[»]
1PQBmodel-A/B169-366[»]
1V7PX-ray1.90C167-366[»]
4BJ3X-ray3.04A/B171-368[»]
5HJ2X-ray2.15A/B/C/D/E/F170-366[»]
5THPX-ray3.01C/F/I/L/O/R170-366[»]
ProteinModelPortaliP17301
SMRiP17301
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17301

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 92FG-GAP 1PROSITE-ProRule annotationAdd BLAST59
Repeati101 – 161FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
Domaini188 – 365VWFAPROSITE-ProRule annotationAdd BLAST178
Repeati366 – 420FG-GAP 3PROSITE-ProRule annotationAdd BLAST55
Repeati423 – 475FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati477 – 539FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati540 – 598FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati602 – 664FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1155 – 1161Interaction with HPS57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1157 – 1161GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB9 Eukaryota
ENOG4110534 LUCA
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiP17301
KOiK06481
OrthoDBiEOG091G00TK
PhylomeDBiP17301
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY
60 70 80 90 100
AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS
110 120 130 140 150
TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS
160 170 180 190 200
DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ
210 220 230 240 250
GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT
260 270 280 290 300
NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN
310 320 330 340 350
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL
360 370 380 390 400
LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG
410 420 430 440 450
AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST
460 470 480 490 500
HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV
510 520 530 540 550
DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH QFLEGPEGIE
560 570 580 590 600
NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY
610 620 630 640 650
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ
660 670 680 690 700
SIADVAIEAS FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI
710 720 730 740 750
TLDADGFSSR VTSRGLFKEN NERCLQKNMV VNQAQSCPEH IIYIQEPSDV
760 770 780 790 800
VNSLDLRVDI SLENPGTSPA LEAYSETAKV FSIPFHKDCG EDGLCISDLV
810 820 830 840 850
LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG IVVDFSENLF
860 870 880 890 900
FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ
910 920 930 940 950
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE
960 970 980 990 1000
ISSDGNVPSI VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK
1010 1020 1030 1040 1050
NPLMYLTGVQ TDKAGDISCN ADINPLKIGQ TSSSVSFKSE NFRHTKELNC
1060 1070 1080 1090 1100
RTASCSNVTC WLKDVHMKGE YFVNVTTRIW NGTFASSTFQ TVQLTAAAEI
1110 1120 1130 1140 1150
NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII AGILLLLALV
1160 1170 1180
AILWKLGFFK RKYEKMTKNP DEIDETTELS S
Length:1,181
Mass (Da):129,295
Last modified:August 1, 1990 - v1
Checksum:i7E1B7ED968A94070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17L → V in AAA16619 (PubMed:15372022).Curated1

Polymorphismi

Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076939532I → L1 Publication1
Natural variantiVAR_003977534K → E in alloantigen HPA-5B. 3 PublicationsCorresponds to variant dbSNP:rs1801106Ensembl.1
Natural variantiVAR_029146691N → K1 PublicationCorresponds to variant dbSNP:rs3212557Ensembl.1
Natural variantiVAR_021855927N → S. Corresponds to variant dbSNP:rs2287870Ensembl.1
Natural variantiVAR_0200361127K → Q1 PublicationCorresponds to variant dbSNP:rs3212645Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17033 mRNA Translation: CAA34894.1
AF512556 Genomic DNA Translation: AAM34795.1
L24121 Genomic DNA Translation: AAA16619.2
CCDSiCCDS3957.1
PIRiA33998
RefSeqiNP_002194.2, NM_002203.3
UniGeneiHs.482077

Genome annotation databases

EnsembliENST00000296585; ENSP00000296585; ENSG00000164171
GeneIDi3673
KEGGihsa:3673
UCSCiuc003joy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITA2_HUMAN
AccessioniPrimary (citable) accession number: P17301
Secondary accession number(s): Q14595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 25, 2018
This is version 204 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health