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P17301

- ITA2_HUMAN

UniProt

P17301 - ITA2_HUMAN

Protein

Integrin alpha-2

Gene

ITGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 172 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi499 – 5079Sequence Analysis
    Calcium bindingi563 – 5719Sequence Analysis
    Calcium bindingi627 – 6359Sequence Analysis

    GO - Molecular functioni

    1. collagen binding Source: UniProtKB
    2. collagen receptor activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. blood coagulation Source: Reactome
    3. cell adhesion Source: ProtInc
    4. cell adhesion mediated by integrin Source: UniProtKB
    5. cell-matrix adhesion Source: UniProtKB
    6. cell proliferation Source: Ensembl
    7. cell-substrate adhesion Source: UniProtKB
    8. cellular response to hormone stimulus Source: Ensembl
    9. collagen-activated signaling pathway Source: UniProtKB
    10. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
    11. establishment of protein localization Source: Ensembl
    12. extracellular matrix organization Source: Reactome
    13. hepatocyte differentiation Source: Ensembl
    14. hypotonic response Source: Ensembl
    15. integrin-mediated signaling pathway Source: UniProtKB-KW
    16. mammary gland development Source: Ensembl
    17. organ morphogenesis Source: ProtInc
    18. positive regulation of alkaline phosphatase activity Source: Ensembl
    19. positive regulation of cell adhesion Source: Ensembl
    20. positive regulation of cell projection organization Source: Ensembl
    21. positive regulation of collagen binding Source: Ensembl
    22. positive regulation of collagen biosynthetic process Source: Ensembl
    23. positive regulation of DNA binding Source: Ensembl
    24. positive regulation of epithelial cell migration Source: Ensembl
    25. positive regulation of inflammatory response Source: Ensembl
    26. positive regulation of leukocyte migration Source: Ensembl
    27. positive regulation of phagocytosis, engulfment Source: Ensembl
    28. positive regulation of positive chemotaxis Source: Ensembl
    29. positive regulation of smooth muscle cell migration Source: Ensembl
    30. positive regulation of smooth muscle cell proliferation Source: Ensembl
    31. positive regulation of smooth muscle contraction Source: Ensembl
    32. positive regulation of translation Source: Ensembl
    33. positive regulation of transmission of nerve impulse Source: Ensembl
    34. response to amine Source: Ensembl
    35. response to drug Source: Ensembl
    36. response to hypoxia Source: Ensembl
    37. response to L-ascorbic acid Source: Ensembl
    38. response to muscle activity Source: Ensembl
    39. response to organic cyclic compound Source: Ensembl
    40. skin morphogenesis Source: Ensembl
    41. substrate-dependent cell migration Source: UniProtKB
    42. tissue homeostasis Source: Ensembl
    43. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion, Host-virus interaction

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
    REACT_13552. Integrin cell surface interactions.
    REACT_163906. ECM proteoglycans.
    REACT_163942. Syndecan interactions.
    REACT_169262. Laminin interactions.
    REACT_22292. CHL1 interactions.
    SignaLinkiP17301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-2
    Alternative name(s):
    CD49 antigen-like family member B
    Collagen receptor
    Platelet membrane glycoprotein Ia
    Short name:
    GPIa
    VLA-2 subunit alpha
    CD_antigen: CD49b
    Gene namesi
    Name:ITGA2
    Synonyms:CD49B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6137. ITGA2.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. basal part of cell Source: Ensembl
    3. cell outer membrane Source: Ensembl
    4. cell surface Source: UniProtKB
    5. external side of plasma membrane Source: Ensembl
    6. focal adhesion Source: UniProtKB
    7. integrin complex Source: ProtInc
    8. nucleus Source: Ensembl
    9. perinuclear region of cytoplasm Source: Ensembl
    10. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1159 – 11591F → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1160 and A-1162. 1 Publication
    Mutagenesisi1160 – 11601K → A: No effect on RAB21-binding. Significant reduction of RAB21-binding; when associated with A-1161. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1161. 2 Publications
    Mutagenesisi1161 – 11611R → A: Significant reduction of RAB21-binding; when associated with A-1160. Shows defective cytokinesis on collagen, but not on fibronectin; when associated with A-1160. 2 Publications
    Mutagenesisi1162 – 11621K → A: No significant reduction of RAB21-binding by co-immunoprecipitation assay; when associated with A-1159 and A-1160. 2 Publications
    Mutagenesisi1162 – 11621K → P: Markedly weakens RAB21-binding. Shows defective cytokinesis on collagen, but not on fibronectin. 2 Publications
    Mutagenesisi1164 – 11641E → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1165. 1 Publication
    Mutagenesisi1165 – 11651K → A: Significant reduction of RAB21-binding; when associated with A-1160; A-1161 and A-1164. 1 Publication

    Organism-specific databases

    MIMi192974. gene+phenotype.
    Orphaneti853. Fetal and neonatal alloimmune thrombocytopenia.
    PharmGKBiPA204.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 11811152Integrin alpha-2PRO_0000016233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 92By similarity
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)3 Publications
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi680 ↔ 737By similarity
    Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi789 ↔ 795By similarity
    Disulfide bondi865 ↔ 876By similarity
    Disulfide bondi1019 ↔ 1050By similarity
    Disulfide bondi1055 ↔ 1060By similarity
    Glycosylationi1057 – 10571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1074 – 10741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1081 – 10811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP17301.
    PaxDbiP17301.
    PRIDEiP17301.

    PTM databases

    PhosphoSiteiP17301.

    Expressioni

    Gene expression databases

    ArrayExpressiP17301.
    BgeeiP17301.
    CleanExiHS_ITGA2.
    GenevestigatoriP17301.

    Organism-specific databases

    HPAiCAB017690.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITGB1P055563EBI-702960,EBI-703066
    Rab21P352827EBI-702960,EBI-1993555From a different organism.
    SHARPINQ9H0F65EBI-702960,EBI-3942966

    Protein-protein interaction databases

    BioGridi109880. 14 interactions.
    DIPiDIP-67N.
    IntActiP17301. 12 interactions.
    MINTiMINT-5004079.
    STRINGi9606.ENSP00000296585.

    Structurei

    Secondary structure

    1
    1181
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi173 – 1808
    Helixi188 – 20013
    Beta strandi208 – 22417
    Turni226 – 2283
    Helixi232 – 24110
    Helixi252 – 26211
    Helixi266 – 2683
    Beta strandi274 – 28411
    Helixi289 – 2913
    Helixi292 – 30110
    Beta strandi304 – 3118
    Helixi313 – 3175
    Helixi323 – 33210
    Helixi337 – 3404
    Beta strandi341 – 3477
    Helixi348 – 3536
    Helixi354 – 3629

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AOXX-ray2.10A/B169-367[»]
    1DZIX-ray2.10A172-355[»]
    1PQBmodel-A/B169-366[»]
    1V7PX-ray1.90C167-366[»]
    4BJ3X-ray3.04A/B171-368[»]
    ProteinModelPortaliP17301.
    SMRiP17301. Positions 30-1169.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17301.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 11321103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1155 – 118127CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1133 – 115422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 9259FG-GAP 1Add
    BLAST
    Repeati101 – 16161FG-GAP 2Add
    BLAST
    Domaini188 – 365178VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati366 – 42055FG-GAP 3Add
    BLAST
    Repeati423 – 47755FG-GAP 4Add
    BLAST
    Repeati478 – 53962FG-GAP 5Add
    BLAST
    Repeati540 – 59859FG-GAP 6Add
    BLAST
    Repeati602 – 66463FG-GAP 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1155 – 11617Interaction with HPS5

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1157 – 11615GFFKR motif

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237277.
    HOGENOMiHOG000059610.
    HOVERGENiHBG006185.
    InParanoidiP17301.
    KOiK06481.
    OrthoDBiEOG71RXHT.
    PhylomeDBiP17301.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY     50
    AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS 100
    TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS 150
    DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ 200
    GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT 250
    NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 300
    HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL 350
    LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG 400
    AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST 450
    HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV 500
    DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH QFLEGPEGIE 550
    NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 600
    SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ 650
    SIADVAIEAS FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI 700
    TLDADGFSSR VTSRGLFKEN NERCLQKNMV VNQAQSCPEH IIYIQEPSDV 750
    VNSLDLRVDI SLENPGTSPA LEAYSETAKV FSIPFHKDCG EDGLCISDLV 800
    LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG IVVDFSENLF 850
    FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 900
    NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE 950
    ISSDGNVPSI VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK 1000
    NPLMYLTGVQ TDKAGDISCN ADINPLKIGQ TSSSVSFKSE NFRHTKELNC 1050
    RTASCSNVTC WLKDVHMKGE YFVNVTTRIW NGTFASSTFQ TVQLTAAAEI 1100
    NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII AGILLLLALV 1150
    AILWKLGFFK RKYEKMTKNP DEIDETTELS S 1181
    Length:1,181
    Mass (Da):129,295
    Last modified:August 1, 1990 - v1
    Checksum:i7E1B7ED968A94070
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171L → V in AAA16619. (PubMed:15372022)Curated

    Polymorphismi

    Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti534 – 5341K → E in alloantigen HPA-5B. 3 Publications
    Corresponds to variant rs1801106 [ dbSNP | Ensembl ].
    VAR_003977
    Natural varianti691 – 6911N → K.1 Publication
    Corresponds to variant rs3212557 [ dbSNP | Ensembl ].
    VAR_029146
    Natural varianti927 – 9271N → S.
    Corresponds to variant rs2287870 [ dbSNP | Ensembl ].
    VAR_021855
    Natural varianti1127 – 11271K → Q.1 Publication
    Corresponds to variant rs3212645 [ dbSNP | Ensembl ].
    VAR_020036

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17033 mRNA. Translation: CAA34894.1.
    AF512556 Genomic DNA. Translation: AAM34795.1.
    L24121 Genomic DNA. Translation: AAA16619.2.
    CCDSiCCDS3957.1.
    PIRiA33998.
    RefSeqiNP_002194.2. NM_002203.3.
    UniGeneiHs.482077.

    Genome annotation databases

    EnsembliENST00000296585; ENSP00000296585; ENSG00000164171.
    GeneIDi3673.
    KEGGihsa:3673.
    UCSCiuc003joy.3. human.

    Polymorphism databases

    DMDMi124942.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17033 mRNA. Translation: CAA34894.1 .
    AF512556 Genomic DNA. Translation: AAM34795.1 .
    L24121 Genomic DNA. Translation: AAA16619.2 .
    CCDSi CCDS3957.1.
    PIRi A33998.
    RefSeqi NP_002194.2. NM_002203.3.
    UniGenei Hs.482077.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AOX X-ray 2.10 A/B 169-367 [» ]
    1DZI X-ray 2.10 A 172-355 [» ]
    1PQB model - A/B 169-366 [» ]
    1V7P X-ray 1.90 C 167-366 [» ]
    4BJ3 X-ray 3.04 A/B 171-368 [» ]
    ProteinModelPortali P17301.
    SMRi P17301. Positions 30-1169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109880. 14 interactions.
    DIPi DIP-67N.
    IntActi P17301. 12 interactions.
    MINTi MINT-5004079.
    STRINGi 9606.ENSP00000296585.

    Chemistry

    BindingDBi P17301.
    ChEMBLi CHEMBL2111461.

    PTM databases

    PhosphoSitei P17301.

    Polymorphism databases

    DMDMi 124942.

    Proteomic databases

    MaxQBi P17301.
    PaxDbi P17301.
    PRIDEi P17301.

    Protocols and materials databases

    DNASUi 3673.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296585 ; ENSP00000296585 ; ENSG00000164171 .
    GeneIDi 3673.
    KEGGi hsa:3673.
    UCSCi uc003joy.3. human.

    Organism-specific databases

    CTDi 3673.
    GeneCardsi GC05P052321.
    H-InvDB HIX0032121.
    HGNCi HGNC:6137. ITGA2.
    HPAi CAB017690.
    MIMi 192974. gene+phenotype.
    neXtProti NX_P17301.
    Orphaneti 853. Fetal and neonatal alloimmune thrombocytopenia.
    PharmGKBi PA204.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237277.
    HOGENOMi HOG000059610.
    HOVERGENi HBG006185.
    InParanoidi P17301.
    KOi K06481.
    OrthoDBi EOG71RXHT.
    PhylomeDBi P17301.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
    REACT_13552. Integrin cell surface interactions.
    REACT_163906. ECM proteoglycans.
    REACT_163942. Syndecan interactions.
    REACT_169262. Laminin interactions.
    REACT_22292. CHL1 interactions.
    SignaLinki P17301.

    Miscellaneous databases

    EvolutionaryTracei P17301.
    GeneWikii CD49b.
    GenomeRNAii 3673.
    NextBioi 14377.
    PROi P17301.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17301.
    Bgeei P17301.
    CleanExi HS_ITGA2.
    Genevestigatori P17301.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain."
      Takada Y., Hemler M.E.
      J. Cell Biol. 109:397-407(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-44.
      Tissue: Endothelial cell.
    2. SeattleSNPs variation discovery resource
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-691 AND GLN-1127.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-534.
    4. "The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression."
      Zutter M.M., Santoro S.A., Painter A.S., Tsung Y.L., Gafford A.
      J. Biol. Chem. 269:463-469(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
    5. "Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."
      Bergelson J.M., St John N., Kawaguchi S., Chan M., Stubdal H., Modlin J., Finberg R.W.
      J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HUMAN ECHOVIRUS 1 AND HUMAN ECHOVIRUS 8 CAPSID PROTEINS.
    6. "Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry."
      Graham K.L., Halasz P., Tan Y., Hewish M.J., Takada Y., Mackow E.R., Robinson M.K., Coulson B.S.
      J. Virol. 77:9969-9978(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ROTAVIRUS A VP4.
    7. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
      Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
      J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB21, MUTAGENESIS OF PHE-1159; LYS-1160; ARG-1161; LYS-1162; GLU-1164 AND LYS-1165.
    8. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
      Tissue: Platelet.
    9. Cited for: MUTAGENESIS OF LYS-1160; ARG-1161 AND LYS-1162.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
      Tissue: Liver.
    13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-343.
      Tissue: Leukemic T-cell.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Crystal structure of the I domain from integrin alpha2beta1."
      Emsley J., King S.L., Bergelson J.M., Liddington R.C.
      J. Biol. Chem. 272:28512-28517(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 168-368.
    16. "The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2)."
      Santoso S., Kalb R., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
      J. Clin. Invest. 92:2427-2432(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLU-534.
    17. "The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction."
      Kroll H., Gardemann A., Fechter A., Haberbosch W., Santoso S.
      Thromb. Haemost. 83:392-396(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLU-534.

    Entry informationi

    Entry nameiITA2_HUMAN
    AccessioniPrimary (citable) accession number: P17301
    Secondary accession number(s): Q14595
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 172 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3