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Protein

Tryptophan 5-hydroxylase 1

Gene

TPH1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactori

Pathwayi: serotonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes serotonin from L-tryptophan.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 5-hydroxylase 1 (TPH1)
  2. no protein annotated in this organism
This subpathway is part of the pathway serotonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes serotonin from L-tryptophan, the pathway serotonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei235TryptophanBy similarity1
Binding sitei257TryptophanBy similarity1
Binding sitei265TryptophanBy similarity1
Metal bindingi272IronBy similarity1
Metal bindingi277IronBy similarity1
Metal bindingi317IronBy similarity1
Binding sitei336TryptophanBy similarity1
Binding sitei366Tryptophan; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSerotonin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

SABIO-RKP17290
UniPathwayiUPA00846; UER00799

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 5-hydroxylase 1 (EC:1.14.16.4)
Alternative name(s):
Tryptophan 5-monooxygenase 1
Gene namesi
Name:TPH1
Synonyms:TPH
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055701 – 444Tryptophan 5-hydroxylase 1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP17290

PTM databases

iPTMnetiP17290

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP17290
SMRiP17290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 94ACTPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006841
InParanoidiP17290
KOiK00502

Family and domain databases

Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR002912 ACT_dom
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005963 Trp_5_mOase
IPR019773 Tyrosine_3-monooxygenase-like
PANTHERiPTHR11473 PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351 Biopterin_H, 1 hit
PIRSFiPIRSF000336 TH, 1 hit
PRINTSiPR00372 FYWHYDRXLASE
SUPFAMiSSF56534 SSF56534, 1 hit
TIGRFAMsiTIGR01270 Trp_5_monoox, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS00367 BH4_AAA_HYDROXYL_1, 1 hit
PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEDNKENKD HSLERGRATL IFSLKNEVGG LIKALKIFQE KHVNLLHIES
60 70 80 90 100
RKSKRRNSEF EIFVDCDTNR EQLNDIFHLL KSHTNVLSVT PPDNFTMKEE
110 120 130 140 150
GMESVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD
160 170 180 190 200
LAMSYKYGDP IPKVEFTEEE IKTWGTVFRE LNKLYPTHAC REYLKNLPLL
210 220 230 240 250
SKYCGYREDN IPQLEDISNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF
260 270 280 290 300
HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA
310 320 330 340 350
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHVLSGHAK
360 370 380 390 400
VKPFDPKITY KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK
410 420 430 440
YNPYTRSIQI LKDAKSITNA MNELRHDLDV VSDALGKVSR QLSV
Length:444
Mass (Da):51,118
Last modified:November 1, 1997 - v2
Checksum:iBF182451B28ECD80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102M → L in AAA31487 (PubMed:3475690).Curated1
Sequence conflicti151L → S in AAA67051 (PubMed:7986090).Curated1
Sequence conflicti202 – 203KY → ND in AAA31487 (PubMed:3475690).Curated2
Sequence conflicti207R → Q in AAA67051 (PubMed:7986090).Curated1
Sequence conflicti390T → K in AAA31487 (PubMed:3475690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17250 mRNA Translation: AAA31487.1
L29305 mRNA Translation: AAA67051.1
PIRiS51199
RefSeqiNP_001075741.1, NM_001082272.1
NP_001093425.1, NM_001099955.1
UniGeneiOcu.2025
Ocu.6909

Genome annotation databases

GeneIDi100009100
100101558
KEGGiocu:100009100
ocu:100101558

Similar proteinsi

Entry informationi

Entry nameiTPH1_RABIT
AccessioniPrimary (citable) accession number: P17290
Secondary accession number(s): Q29523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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