ID   HXD4_CHICK              Reviewed;         235 AA.
AC   P17278;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   08-NOV-2023, entry version 141.
DE   RecName: Full=Homeobox protein Hox-D4;
DE   AltName: Full=Homeobox protein Hox-A;
DE            Short=Chox-A;
GN   Name=HOXD4; Synonyms=CHOX-A, HOXD-4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=1970866; DOI=10.1093/nar/18.7.1739;
RA   Sasaki H., Yokoyama E., Kuroiwa A.;
RT   "Specific DNA binding of the two chicken Deformed family homeodomain
RT   proteins, Chox-1.4 and Chox-a.";
RL   Nucleic Acids Res. 18:1739-1747(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds to sites in
CC       the 5'-flanking sequence of its coding region with various affinities.
CC       The consensus sequences of the high and low affinity binding sites are
CC       5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X52671; CAA36897.1; -; Genomic_DNA.
DR   EMBL; X52672; CAA36898.1; -; mRNA.
DR   PIR; S09256; S09256.
DR   AlphaFoldDB; P17278; -.
DR   SMR; P17278; -.
DR   STRING; 9031.ENSGALP00000037899; -.
DR   PaxDb; 9031-ENSGALP00000037899; -.
DR   VEuPathDB; HostDB:geneid_424139; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P17278; -.
DR   PhylomeDB; P17278; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45771:SF5; HOMEOBOX PROTEIN HOX-D4; 1.
DR   PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..235
FT                   /note="Homeobox protein Hox-D4"
FT                   /id="PRO_0000200213"
FT   DNA_BIND        144..203
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          66..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           123..128
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        209..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   235 AA;  26662 MW;  B7115D434033E4B5 CRC64;
     MAMSSYMVNS YVDPKFPPCE EYLQSSYLGE QGAEYYGASQ GSDFQHQGLY PRSNYSEQPF
     WLAGAQGSAV QPRGHGQEQS APPSHFPGQA EHCPPPPCPI PSCGQQPALK APHGSAVKQP
     AVVYPWMKKV HVNSVNPNYS GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT
     LCLSERQIKI WFQNRRMKWK KDHKLPNTKG RSSSSASNPH LQTVPKDHQT DLTTL
//