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P17278 (HXD4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-A
Short name=Chox-A
Gene names
Name:HOXD4
Synonyms:CHOX-A, HOXD-4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Homeobox protein Hox-D4
PRO_0000200213

Regions

DNA binding144 – 20360Homeobox
Motif123 – 1286Antp-type hexapeptide
Compositional bias212 – 2176Ser-rich

Sequences

Sequence LengthMass (Da)Tools
P17278 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: B7115D434033E4B5

FASTA23526,662
        10         20         30         40         50         60 
MAMSSYMVNS YVDPKFPPCE EYLQSSYLGE QGAEYYGASQ GSDFQHQGLY PRSNYSEQPF 

        70         80         90        100        110        120 
WLAGAQGSAV QPRGHGQEQS APPSHFPGQA EHCPPPPCPI PSCGQQPALK APHGSAVKQP 

       130        140        150        160        170        180 
AVVYPWMKKV HVNSVNPNYS GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT 

       190        200        210        220        230 
LCLSERQIKI WFQNRRMKWK KDHKLPNTKG RSSSSASNPH LQTVPKDHQT DLTTL 

« Hide

References

[1]"Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
Sasaki H., Yokoyama E., Kuroiwa A.
Nucleic Acids Res. 18:1739-1747(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52671 Genomic DNA. Translation: CAA36897.1.
X52672 mRNA. Translation: CAA36898.1.
PIRS09256.
UniGeneGga.54375.

3D structure databases

ProteinModelPortalP17278.
SMRP17278. Positions 118-204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG314883.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidP17278.
PhylomeDBP17278.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP17278.

Entry information

Entry nameHXD4_CHICK
AccessionPrimary (citable) accession number: P17278
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries